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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"

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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA
ISO		 Ensembl
TreeGrafter
RGD		 PMID:15048573 PMID:16731531 GO_REF:0000107 GO_REF:0000118 RGD:1580399 RGD:1582674 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gja10 gap junction protein alpha 10 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936510:2,380,114...2,395,781
Ensembl chrNW_004936510:2,379,892...2,395,851 		JBrowse link
G Gja3 gap junction protein alpha 3 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000118 RGD:728416 NCBI chrNW_004936720:1,564,680...1,586,379
Ensembl chrNW_004936720:1,583,588...1,584,904 		JBrowse link
G Gja4 gap junction protein alpha 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:17,439,250...17,440,829
Ensembl chrNW_004936474:17,439,327...17,440,331 		JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Gja8 gap junction protein alpha 8 contributes_to
enables		 ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:16123426 GO_REF:0000107 GO_REF:0000118 RGD:1598965 NCBI chrNW_004936867:374,638...378,080
Ensembl chrNW_004936867:374,638...375,933 		JBrowse link
G Gja9 gap junction protein alpha 9 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:20,866,678...20,871,540
Ensembl chrNW_004936474:20,867,307...20,868,848 		JBrowse link
G Gjb1 gap junction protein beta 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12119284 GO_REF:0000118 RGD:728476 NCBI chrNW_004936762:389,655...398,035
Ensembl chrNW_004936762:389,669...395,898 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO
IEA		 RGD
Ensembl
TreeGrafter		 PMID:23232329 GO_REF:0000107 GO_REF:0000118 RGD:7349364 NCBI chrNW_004936720:1,528,205...1,530,296
Ensembl chrNW_004936720:1,528,249...1,528,929 		JBrowse link
G Gjb3 gap junction protein beta 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:17,427,255...17,431,368
Ensembl chrNW_004936474:17,429,926...17,430,729 		JBrowse link
G Gjb4 gap junction protein beta 4 enables IEA TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:17,407,209...17,409,657
Ensembl chrNW_004936474:17,408,623...17,409,423 		JBrowse link
G Gjb5 gap junction protein beta 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:17,402,804...17,406,080
Ensembl chrNW_004936474:17,405,000...17,405,809 		JBrowse link
G Gjb6 gap junction protein beta 6 enables IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936720:1,485,895...1,494,673
Ensembl chrNW_004936720:1,493,733...1,494,518 		JBrowse link
G Gjb7 gap junction protein beta 7 enables ISO (PMID:12064583) UniProt PMID:12064583 NCBI chrNW_004936510:4,540,513...4,541,165 JBrowse link
G Gjc1 gap junction protein gamma 1 enables IEA
ISO		 TreeGrafter
RGD		 PMID:11668048 GO_REF:0000118 RGD:628534 NCBI chrNW_004936541:1,177,581...1,182,967
Ensembl chrNW_004936541:1,178,493...1,182,967 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936864:67,608...71,543
Ensembl chrNW_004936864:69,445...70,752 		JBrowse link
G Gjc3 gap junction protein gamma 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936543:73,253...74,065
Ensembl chrNW_004936543:71,138...74,065 		JBrowse link
G Gjd2 gap junction protein delta 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936673:1,129,750...1,133,229
Ensembl chrNW_004936673:1,128,930...1,134,905 		JBrowse link
G Gjd3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chrNW_004936490:15,426,699...15,429,789
Ensembl chrNW_004936490:15,427,263...15,428,141 		JBrowse link
G Gjd4 gap junction protein delta 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936574:3,878,436...3,881,704
Ensembl chrNW_004936574:3,878,383...3,881,718 		JBrowse link
G Gje1 gap junction protein epsilon 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936625:3,838,128...3,840,159
Ensembl chrNW_004936625:3,837,700...3,840,234 		JBrowse link
G Panx1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004936674:736,911...773,406
Ensembl chrNW_004936674:736,905...773,412 		JBrowse link
G Panx2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004936629:618,758...626,446
Ensembl chrNW_004936629:618,042...626,452 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:16790700), (PMID:20606116), (PMID:23348765) BHF-UCL PMID:16790700 PMID:20606116 PMID:23348765 NCBI chrNW_004936867:269,477...279,549 JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:22247482) BHF-UCL PMID:22247482 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Gjc1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936541:1,177,581...1,182,967
Ensembl chrNW_004936541:1,178,493...1,182,967 		JBrowse link
G Gjd3 gap junction protein delta 3 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936490:15,426,699...15,429,789
Ensembl chrNW_004936490:15,427,263...15,428,141 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:22247482)
(PMID:26786475)		 BHF-UCL PMID:22247482 PMID:26786475 NCBI chrNW_004936867:269,477...279,549 JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:16790700)
(PMID:23348765)		 BHF-UCL PMID:16790700 PMID:23348765 NCBI chrNW_004936867:269,477...279,549 JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gjb2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936720:1,528,205...1,530,296
Ensembl chrNW_004936720:1,528,249...1,528,929 		JBrowse link
G Gjb6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936720:1,485,895...1,494,673
Ensembl chrNW_004936720:1,493,733...1,494,518 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936864:67,608...71,543
Ensembl chrNW_004936864:69,445...70,752 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gja3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936720:1,564,680...1,586,379
Ensembl chrNW_004936720:1,583,588...1,584,904 		JBrowse link
G Gja5 gap junction protein alpha 5 enables ISO (PMID:23348765) BHF-UCL PMID:23348765 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Panx1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chrNW_004936674:736,911...773,406
Ensembl chrNW_004936674:736,905...773,412 		JBrowse link
G Panx3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936743:1,083,217...1,092,023
Ensembl chrNW_004936743:1,083,227...1,090,777 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17128
    transporter activity 1143
      transmembrane transporter activity 1051
        passive transmembrane transporter activity 483
          channel activity 483
            wide pore channel activity 35
              gap junction channel activity 24
                gap junction channel activity involved in cell communication by electrical coupling + 7
                gap junction hemi-channel activity 5
paths to the root