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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"


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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables IDA
ISO
IBA		 (PMID:11397787), (PMID:15084279), (PMID:29366904)
(MGI:6271573|PMID:29366904), (PMID:11397787), (PMID:15084279)
GO_REF:0000033
(PMID:29366904)
(PMID:16790700), (PMID:1696265), (PMID:23348765)
PMID:15284189		 RGD
GO_Central		 PMID:1696265 PMID:11397787 PMID:15084279 PMID:16790700 PMID:23348765 More... GO_REF:0000033 MGI:6271573, RGD:1580399, RGD:1582674, RGD:12793029 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gja10 gap junction protein, alpha 10 enables IBA
ISO		 GO_REF:0000033
(PMID:10329667)		 GO_Central
RGD		 PMID:10329667 GO_REF:0000033 NCBI chr 5:46,991,051...47,002,902
Ensembl chr 5:46,992,946...46,996,570 		JBrowse link
G Gja3 gap junction protein, alpha 3 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:1659572 GO_REF:0000033, RGD:728416 NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810 		JBrowse link
G Gja4 gap junction protein, alpha 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925 		JBrowse link
G Gja5 gap junction protein, alpha 5 IDA RGD PMID:1328644 RGD:728713 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Gja6 gap junction protein, alpha 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:33,840,689...33,845,585
Ensembl chr  X:33,840,549...33,845,614 		JBrowse link
G Gja8 gap junction protein, alpha 8 contributes_to
enables		 IDA
ISO		 (PMID:19756179) RGD PMID:19756179 PMID:16123426 RGD:1598965 NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456 		JBrowse link
G Gjb1 gap junction protein, beta 1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:12119284 GO_REF:0000033, RGD:728476 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gjb2 gap junction protein, beta 2 enables TAS
IBA
ISO
ISS
IMP		 GO_REF:0000033
(MGI:3603482|PMID:15692151)
GO_REF:0000024
(PMID:12767933), (PMID:21094651)		 GO_Central
RGD
UniProt		 PMID:12767933 PMID:15692151 PMID:21094651 PMID:12064607 PMID:23232329 GO_REF:0000024 GO_REF:0000033 MGI:3603482, RGD:1299562, RGD:7349364 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Gjb3 gap junction protein, beta 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:139,649,227...139,654,970
Ensembl chr 5:139,649,195...139,654,980 		JBrowse link
G Gjb4 gap junction protein, beta 4 enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:15692151)
GO_REF:0000033
(MGI:3603482|PMID:15692151)
GO_REF:0000107		 UniProt
RGD
GO_Central
Ensembl		 PMID:15692151 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3603482 NCBI chr 5:139,675,776...139,679,551
Ensembl chr 5:139,675,780...139,679,667 		JBrowse link
G Gjb5 gap junction protein, beta 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:139,680,670...139,683,588
Ensembl chr 5:139,680,671...139,683,583 		JBrowse link
G Gjb6 gap junction protein, beta 6 enables ISO
IBA		 (PMID:12767933)
GO_REF:0000033		 RGD
GO_Central		 PMID:12767933 GO_REF:0000033 NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582 		JBrowse link
G Gjc1 gap junction protein, gamma 1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:11668048 GO_REF:0000033, RGD:628534 NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867 		JBrowse link
G Gjc2 gap junction protein, gamma 2 enables IBA
ISO		 GO_REF:0000033
(PMID:11160382)		 GO_Central
RGD		 PMID:11160382 GO_REF:0000033 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467 		JBrowse link
G Gjc3 gap junction protein, gamma 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:16,899,846...16,912,309
Ensembl chr12:16,896,813...16,964,246 		JBrowse link
G Gjd2 gap junction protein, delta 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:100,771,450...100,776,134
Ensembl chr 3:100,772,062...100,775,061 		JBrowse link
G Gjd3 gap junction protein, delta 3 IMP RGD PMID:23385797 RGD:7364769 NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971 		JBrowse link
G Gjd4 gap junction protein, delta 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:57,348,844...57,352,601
Ensembl chr17:57,349,877...57,352,446 		JBrowse link
G Gje1 gap junction protein, epsilon 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:9,085,789...9,088,204
Ensembl chr 1:9,086,348...9,088,138 		JBrowse link
G Panx1 Pannexin 1 IMP RGD PMID:14597722 RGD:1299639 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Panx2 pannexin 2 IMP RGD PMID:14597722 RGD:1299639 NCBI chr 7:120,139,259...120,153,056
Ensembl chr 7:120,139,294...120,152,361 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO
IBA		 (PMID:16790700), (PMID:20606116), (PMID:23348765)
GO_REF:0000033		 RGD
GO_Central		 PMID:16790700 PMID:20606116 PMID:23348765 GO_REF:0000033 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO (PMID:22247482) RGD PMID:22247482 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Gjc1 gap junction protein, gamma 1 enables ISO (MGI:5544102|PMID:22982984) RGD PMID:22982984 MGI:5544102 NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867 		JBrowse link
G Gjd3 gap junction protein, delta 3 enables ISO
IBA		 (MGI:5544102|PMID:22982984)
(PMID:22982984)
GO_REF:0000033		 RGD
GO_Central		 PMID:22982984 GO_REF:0000033 MGI:5544102 NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO (PMID:22247482)
(PMID:26786475)
(MGI:6101691|PMID:26786475)		 RGD PMID:22247482 PMID:26786475 MGI:6101691 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO (PMID:16790700), (PMID:23348765) RGD PMID:16790700 PMID:23348765 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISO (PMID:1696265) RGD PMID:1696265 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb2 gap junction protein, beta 2 enables ISO (PMID:12767933) RGD PMID:12767933 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Gjb6 gap junction protein, beta 6 enables ISO (PMID:12767933) RGD PMID:12767933 NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582 		JBrowse link
G Gjc2 gap junction protein, gamma 2 enables ISO (PMID:17344063) RGD PMID:17344063 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISS
ISO		 GO_REF:0000024
(PMID:29366904)		 UniProt
RGD		 PMID:29366904 GO_REF:0000024 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gja3 gap junction protein, alpha 3 enables ISS
IDA
IEA
ISO		 GO_REF:0000024
PMID:17715132
GO_REF:0000107
(PMID:30044662)		 UniProt
Ensembl
RGD		 PMID:30044662 PMID:17715132 GO_REF:0000024 GO_REF:0000107, RGD:15090844 NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810 		JBrowse link
G Gja5 gap junction protein, alpha 5 enables ISO (PMID:23348765) RGD PMID:23348765 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Panx1 Pannexin 1 NOT|enables IDA PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Panx2 pannexin 2 NOT|enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 7:120,139,259...120,153,056
Ensembl chr 7:120,139,294...120,152,361 		JBrowse link
G Panx3 pannexin 3 NOT|enables ISS
ISO		 GO_REF:0000024
(PMID:21690309)
(MGI:5052205|PMID:21690309)		 UniProt
RGD		 PMID:21690309 GO_REF:0000024 MGI:5052205 NCBI chr 8:37,366,758...37,377,640
Ensembl chr 8:37,366,862...37,377,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    transporter activity 1234
      transmembrane transporter activity 1136
        passive transmembrane transporter activity 503
          channel activity 503
            wide pore channel activity 39
              gap junction channel activity 23
                gap junction channel activity involved in cell communication by electrical coupling + 7
                gap junction hemi-channel activity 6
paths to the root