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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"


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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:15048573 PMID:16731531 GO_REF:0000033 GO_REF:0000107 RGD:1580399 RGD:1582674 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:57,879,740...57,881,395
Ensembl chr 1:57,868,387...57,893,687 		JBrowse link
G GJA3 gap junction protein alpha 3 enables ISO
IBA		 RGD
GO_Central		 PMID:1659572 GO_REF:0000033 RGD:728416 NCBI chr11:750,658...751,889
Ensembl chr11:750,658...751,800 		JBrowse link
G GJA4 gap junction protein alpha 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:91,045,430...91,048,161
Ensembl chr 6:91,045,394...91,048,162 		JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:16123426 GO_REF:0000033 GO_REF:0000107 RGD:1598965 NCBI chr 4:99,721,754...99,724,943
Ensembl chr 4:99,723,341...99,724,672 		JBrowse link
G GJA9 gap junction protein alpha 9 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:94,815,105...94,817,183
Ensembl chr 6:94,815,600...94,817,147 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IBA		 RGD
GO_Central		 PMID:12119284 GO_REF:0000033 RGD:728476 NCBI chr  X:57,241,990...57,249,496
Ensembl chr  X:57,242,045...57,249,885 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IEA		 RGD
Ensembl		 PMID:23232329 GO_REF:0000107 RGD:7349364 NCBI chr11:774,090...781,252
Ensembl chr11:775,166...775,846 		JBrowse link
G GJB3 gap junction protein beta 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:91,031,378...91,037,548
Ensembl chr 6:91,031,849...91,037,542 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:91,004,794...91,008,231
Ensembl chr 6:91,007,200...91,008,000 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr11:793,276...800,109
Ensembl chr11:793,280...800,046 		JBrowse link
G GJB7 gap junction protein beta 7 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:55,729,842...55,741,209
Ensembl chr 1:55,730,903...55,731,691 		JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IBA		 RGD
GO_Central		 PMID:11668048 GO_REF:0000033 RGD:628534 NCBI chr12:18,526,060...18,560,221
Ensembl chr12:18,526,595...18,560,218 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:51,257,623...51,267,969
Ensembl chr 2:51,258,207...51,267,962 		JBrowse link
G GJC3 gap junction protein gamma 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 3:7,843,398...7,849,864
Ensembl chr 3:7,839,151...7,848,761 		JBrowse link
G GJD2 gap junction protein delta 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:136,310,759...136,328,060
Ensembl chr 1:136,324,192...136,327,347 		JBrowse link
G GJD3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chr12:22,040,312...22,044,238 JBrowse link
G GJD4 gap junction protein delta 4 enables IBA GO_Central GO_REF:0000033 NCBI chr10:58,069,679...58,076,738 JBrowse link
G GJE1 gap junction protein epsilon 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:22,933,885...22,936,167
Ensembl chr 1:22,933,885...22,935,121 		JBrowse link
G PANX1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chr 9:26,443,425...26,491,010
Ensembl chr 9:26,443,815...26,491,002 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr 5:497,380...506,126
Ensembl chr 5:497,385...506,013 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G GJC1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chr12:18,526,060...18,560,221
Ensembl chr12:18,526,595...18,560,218 		JBrowse link
G GJD3 gap junction protein delta 3 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chr12:22,040,312...22,044,238 JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJB2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chr11:774,090...781,252
Ensembl chr11:775,166...775,846 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr11:793,276...800,109
Ensembl chr11:793,280...800,046 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:51,257,623...51,267,969
Ensembl chr 2:51,258,207...51,267,962 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJA3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chr11:750,658...751,889
Ensembl chr11:750,658...751,800 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G PANX1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr 9:26,443,425...26,491,010
Ensembl chr 9:26,443,815...26,491,002 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:51,854,148...51,860,330
Ensembl chr 9:51,853,949...51,861,331 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18634
    transporter activity 1193
      transmembrane transporter activity 1096
        passive transmembrane transporter activity 499
          channel activity 499
            wide pore channel activity 36
              gap junction channel activity 23
                gap junction channel activity involved in cell communication by electrical coupling + 7
                gap junction hemi-channel activity 5
paths to the root