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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"

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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:15048573 PMID:16731531 GO_REF:0000107 GO_REF:0000118 RGD:1580399 RGD:1582674 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gja10 gap junction protein alpha 10 enables ISO (PMID:10329667) MGI PMID:10329667 NCBI chrNW_004624799:4,278,097...4,279,588 JBrowse link
G Gja3 gap junction protein alpha 3 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000118 RGD:728416 NCBI chrNW_004624776:17,562,050...17,585,308
Ensembl chrNW_004624776:17,579,913...17,581,121 		JBrowse link
G Gja4 gap junction protein alpha 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:17,842,566...17,845,011
Ensembl chrNW_004624764:17,836,180...17,845,011 		JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Gja8 gap junction protein alpha 8 contributes_to
enables		 ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:16123426 GO_REF:0000107 GO_REF:0000118 RGD:1598965 NCBI chrNW_004624772:16,959,615...16,960,937
Ensembl chrNW_004624772:16,959,615...16,960,937 		JBrowse link
G Gjb1 gap junction protein beta 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12119284 GO_REF:0000118 RGD:728476 NCBI chrNW_004624903:1,511,347...1,519,265
Ensembl chrNW_004624903:1,517,324...1,519,265 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO
IEA		 RGD
TreeGrafter		 PMID:23232329 GO_REF:0000118 RGD:7349364 NCBI chrNW_004624776:17,517,824...17,522,683
Ensembl chrNW_004624776:17,518,284...17,522,936 		JBrowse link
G Gjb3 gap junction protein beta 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:17,829,214...17,833,509
Ensembl chrNW_004624764:17,829,467...17,833,465 		JBrowse link
G Gjb4 gap junction protein beta 4 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624764:17,812,152...17,814,987
Ensembl chrNW_004624764:17,813,922...17,814,722 		JBrowse link
G Gjb5 gap junction protein beta 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:17,807,943...17,811,404
Ensembl chrNW_004624764:17,808,161...17,811,372 		JBrowse link
G Gjb6 gap junction protein beta 6 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624776:17,477,947...17,487,304
Ensembl chrNW_004624776:17,477,966...17,487,303 		JBrowse link
G Gjb7 gap junction protein beta 7 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624799:7,053,954...7,067,571
Ensembl chrNW_004624799:7,057,990...7,065,205 		JBrowse link
G Gjc1 gap junction protein gamma 1 ISO RGD PMID:11668048 RGD:628534 NCBI chrNW_004624795:443,234...466,222
Ensembl chrNW_004624795:461,691...464,454 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables ISO (PMID:11160382) MGI PMID:11160382 NCBI chrNW_004624937:898,876...905,247 JBrowse link
G Gjd2 gap junction protein delta 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624804:1,962,597...1,965,598
Ensembl chrNW_004624804:1,961,865...1,965,673 		JBrowse link
G Gjd3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chrNW_004624795:2,930,425...2,933,411
Ensembl chrNW_004624795:2,930,925...2,931,767 		JBrowse link
G Gjd4 gap junction protein delta 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624805:10,006,548...10,009,592
Ensembl chrNW_004624805:10,006,616...10,009,618 		JBrowse link
G Panx1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004624735:38,766,973...38,823,284
Ensembl chrNW_004624735:38,766,981...38,819,092 		JBrowse link
G Panx2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004624752:565,357...575,064
Ensembl chrNW_004624752:565,357...575,069 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Gjc1 gap junction protein gamma 1 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chrNW_004624795:443,234...466,222
Ensembl chrNW_004624795:461,691...464,454 		JBrowse link
G Gjd3 gap junction protein delta 3 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chrNW_004624795:2,930,425...2,933,411
Ensembl chrNW_004624795:2,930,925...2,931,767 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004624776:17,517,824...17,522,683
Ensembl chrNW_004624776:17,518,284...17,522,936 		JBrowse link
G Gjb6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624776:17,477,947...17,487,304
Ensembl chrNW_004624776:17,477,966...17,487,303 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables ISO (PMID:17344063) UniProt PMID:17344063 NCBI chrNW_004624937:898,876...905,247 JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gja3 gap junction protein alpha 3 enables ISO PMID:17715132
(PMID:30044662)		 UniProt PMID:17715132 PMID:30044662 RGD:15090844 NCBI chrNW_004624776:17,562,050...17,585,308
Ensembl chrNW_004624776:17,579,913...17,581,121 		JBrowse link
G Gja5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Panx1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chrNW_004624735:38,766,973...38,823,284
Ensembl chrNW_004624735:38,766,981...38,819,092 		JBrowse link
G Panx3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624927:612,686...621,282
Ensembl chrNW_004624927:612,750...620,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16462
    transporter activity 1084
      transmembrane transporter activity 993
        passive transmembrane transporter activity 463
          channel activity 463
            wide pore channel activity 31
              gap junction channel activity 21
                gap junction channel activity involved in cell communication by electrical coupling + 7
                gap junction hemi-channel activity 5
paths to the root