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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"


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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISO
IBA
IMP
IDA		 (PMID:29366904)
(PMID:11397787), (PMID:15084279)		 RGD
GO_Central
UniProt
MGI		 PMID:11397787 PMID:15048573 PMID:15084279 PMID:16731531 PMID:29366904 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1580399 RGD:1582674 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja10 gap junction protein, alpha 10 enables IDA
IBA		 (PMID:10329667) MGI
GO_Central		 PMID:10329667 GO_REF:0000033 NCBI chr 4:32,594,595...32,607,382
Ensembl chr 4:32,596,960...32,602,760 		JBrowse link
G Gja3 gap junction protein, alpha 3 enables ISO
IBA		 RGD
GO_Central		 PMID:1659572 GO_REF:0000033 GO_REF:0000096 RGD:728416 NCBI chr14:57,271,917...57,295,487
Ensembl chr14:57,271,917...57,295,557 		JBrowse link
G Gja4 gap junction protein, alpha 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 4:127,205,213...127,207,832
Ensembl chr 4:127,205,214...127,207,832 		JBrowse link
G Gja5 gap junction protein, alpha 5 enables ISO RGD
GO_Central		 PMID:1328644 GO_REF:0000096 RGD:728713 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Gja6 gap junction protein, alpha 6 enables ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr  X:159,685,112...159,690,048
Ensembl chr  X:159,685,112...159,690,048 		JBrowse link
G Gja8 gap junction protein, alpha 8 enables
contributes_to		 ISO
IBA
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 NCBI chr 3:96,820,882...96,833,367
Ensembl chr 3:96,820,882...96,833,336 		JBrowse link
G Gjb1 gap junction protein, beta 1 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:12119284 GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 RGD:728476 NCBI chr  X:100,419,982...100,429,235
Ensembl chr  X:100,419,984...100,429,235 		JBrowse link
G Gjb2 gap junction protein, beta 2 enables ISO
IBA
IDA		 (PMID:15692151) RGD
GO_Central
UniProt		 PMID:15692151 PMID:23232329 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:7349364 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Gjb3 gap junction protein, beta 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 4:127,219,028...127,224,633
Ensembl chr 4:127,219,028...127,224,637 		JBrowse link
G Gjb4 gap junction protein, beta 4 enables IDA
IBA		 (PMID:15692151) UniProt
GO_Central		 PMID:15692151 GO_REF:0000033 NCBI chr 4:127,234,892...127,247,929
Ensembl chr 4:127,244,879...127,247,874 		JBrowse link
G Gjb5 gap junction protein, beta 5 enables IBA GO_Central GO_REF:0000033 NCBI chr 4:127,248,600...127,251,957
Ensembl chr 4:127,248,602...127,251,974 		JBrowse link
G Gjb6 gap junction protein, beta 6 enables ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr14:57,360,760...57,370,764
Ensembl chr14:57,360,760...57,371,068 		JBrowse link
G Gjc1 gap junction protein, gamma 1 enables ISO
IBA		 RGD
GO_Central		 PMID:11668048 GO_REF:0000033 GO_REF:0000096 RGD:628534 NCBI chr11:102,690,303...102,710,512
Ensembl chr11:102,690,405...102,710,526 		JBrowse link
G Gjc2 gap junction protein, gamma 2 enables IDA
IBA		 (PMID:11160382) MGI
GO_Central		 PMID:11160382 GO_REF:0000033 NCBI chr11:59,066,390...59,074,039
Ensembl chr11:59,066,394...59,074,039 		JBrowse link
G Gjc3 gap junction protein, gamma 3 enables ISA
IBA		 (PMID:11501764) MGI
GO_Central		 PMID:11501764 GO_REF:0000033 NCBI chr 5:137,949,254...137,961,360
Ensembl chr 5:137,951,723...137,961,360 		JBrowse link
G Gjd2 gap junction protein, delta 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 2:113,840,086...113,844,555
Ensembl chr 2:113,840,082...113,844,100 		JBrowse link
G Gjd3 gap junction protein, delta 3 enables ISO RGD
GO_Central		 PMID:23385797 GO_REF:0000096 RGD:7364769 NCBI chr11:98,870,773...98,873,846
Ensembl chr11:98,873,006...98,873,842 		JBrowse link
G Gjd4 gap junction protein, delta 4 enables IBA GO_Central GO_REF:0000033 NCBI chr18:9,278,124...9,289,808
Ensembl chr18:9,278,607...9,282,809 		JBrowse link
G Gje1 gap junction protein, epsilon 1 enables IBA GO_Central GO_REF:0000033 NCBI chr10:14,591,365...14,593,958
Ensembl chr10:14,591,367...14,593,958 		JBrowse link
G Panx1 pannexin 1 enables ISO RGD
GO_Central		 PMID:14597722 GO_REF:0000096 RGD:1299639 NCBI chr 9:14,917,081...14,956,774
Ensembl chr 9:14,913,424...14,956,774 		JBrowse link
G Panx2 pannexin 2 enables ISO RGD
GO_Central		 PMID:14597722 GO_REF:0000096 RGD:1299639 NCBI chr15:88,941,797...88,957,769
Ensembl chr15:88,943,937...88,957,770 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables IBA
ISO		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO GO_Central GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Gjc1 gap junction protein, gamma 1 enables IMP (PMID:22982984) BHF-UCL PMID:22982984 NCBI chr11:102,690,303...102,710,512
Ensembl chr11:102,690,405...102,710,526 		JBrowse link
G Gjd3 gap junction protein, delta 3 enables IBA
IMP		 (PMID:22982984) GO_Central
BHF-UCL		 PMID:22982984 GO_REF:0000033 NCBI chr11:98,870,773...98,873,846
Ensembl chr11:98,873,006...98,873,842 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO
IMP		 (PMID:26786475) GO_Central
BHF-UCL		 PMID:26786475 GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables TAS (PMID:26403541) UniProt PMID:26403541 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja5 gap junction protein, alpha 5 enables ISO GO_Central GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISO GO_Central GO_REF:0000119 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja6 gap junction protein, alpha 6 enables ISO GO_Central GO_REF:0000119 NCBI chr  X:159,685,112...159,690,048
Ensembl chr  X:159,685,112...159,690,048 		JBrowse link
G Gjb2 gap junction protein, beta 2 enables ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Gjb6 gap junction protein, beta 6 enables ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr14:57,360,760...57,370,764
Ensembl chr14:57,360,760...57,371,068 		JBrowse link
G Gjc2 gap junction protein, gamma 2 enables ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr11:59,066,390...59,074,039
Ensembl chr11:59,066,394...59,074,039 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja3 gap junction protein, alpha 3 enables ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000096 GO_REF:0000119 NCBI chr14:57,271,917...57,295,487
Ensembl chr14:57,271,917...57,295,557 		JBrowse link
G Gja5 gap junction protein, alpha 5 enables ISO GO_Central GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Gja6 gap junction protein, alpha 6 enables ISO GO_Central GO_REF:0000119 NCBI chr  X:159,685,112...159,690,048
Ensembl chr  X:159,685,112...159,690,048 		JBrowse link
G Panx1 pannexin 1 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr 9:14,917,081...14,956,774
Ensembl chr 9:14,913,424...14,956,774 		JBrowse link
G Panx2 pannexin 2 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr15:88,941,797...88,957,769
Ensembl chr15:88,943,937...88,957,770 		JBrowse link
G Panx3 pannexin 3 NOT|enables ISS
IDA		 (PMID:21690309) UniProt PMID:21690309 GO_REF:0000024 NCBI chr 9:37,571,198...37,580,518
Ensembl chr 9:37,571,198...37,580,531 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28792
    transporter activity 1221
      transmembrane transporter activity 1121
        passive transmembrane transporter activity 523
          channel activity 523
            wide pore channel activity 41
              gap junction channel activity 23
                gap junction channel activity involved in cell communication by electrical coupling + 8
                gap junction hemi-channel activity 7
paths to the root