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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"


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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IBA
IEA
IDA		 (PMID:16790700), (PMID:1696265), (PMID:23348765), (PMID:29366904) RGD
GO_Central
Ensembl
BHF-UCL		 PMID:1696265 PMID:15048573 PMID:16731531 PMID:16790700 PMID:23348765 More... GO_REF:0000033 GO_REF:0000107 RGD:1580399 RGD:1582674 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:89,894,469...89,896,120
Ensembl chr 6:89,894,469...89,921,760 		JBrowse link
G GJA3 gap junction protein alpha 3 enables ISO
IBA
IEA		 RGD
GO_Central
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000033 RGD:728416 NCBI chr13:20,138,255...20,161,565
Ensembl chr13:20,138,255...20,161,052 		JBrowse link
G GJA4 gap junction protein alpha 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:34,792,999...34,795,747
Ensembl chr 1:34,792,999...34,795,747 		JBrowse link
G GJA5 gap junction protein alpha 5 enables ISO
IEA		 RGD
Ensembl		 PMID:1328644 GO_REF:0000107 RGD:728713 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IBA
IDA
IEA		 (PMID:19756179) RGD
GO_Central
UniProt
Ensembl		 PMID:16123426 PMID:19756179 GO_REF:0000033 GO_REF:0000107 RGD:1598965 NCBI chr 1:147,902,795...147,914,486
Ensembl chr 1:147,902,795...147,909,269 		JBrowse link
G GJA9 gap junction protein alpha 9 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:38,874,069...38,881,587
Ensembl chr 1:38,874,069...38,881,587 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IBA
TAS
IEA		 RGD
GO_Central
Reactome
Ensembl		 PMID:12119284 GO_REF:0000033 GO_REF:0000107 RGD:728476 Reactome:R-HSA-190681 NCBI chr  X:71,215,239...71,225,516
Ensembl chr  X:71,212,811...71,225,516 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IBA
IDA
IEA		 (PMID:12767933), (PMID:21094651) RGD
GO_Central
ARUK-UCL
Ensembl		 PMID:12767933 PMID:21094651 PMID:23232329 GO_REF:0000033 GO_REF:0000107 RGD:7349364 NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938 		JBrowse link
G GJB3 gap junction protein beta 3 enables NAS
IBA		 (PMID:9704026) UniProt
GO_Central		 PMID:9704026 GO_REF:0000033 NCBI chr 1:34,781,214...34,786,364
Ensembl chr 1:34,781,214...34,786,369 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA
IBA
ISS		 InterPro
GO_Central
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:34,759,740...34,762,327
Ensembl chr 1:34,759,740...34,762,327 		JBrowse link
G GJB5 gap junction protein beta 5 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:34,755,047...34,758,512
Ensembl chr 1:34,755,047...34,758,512 		JBrowse link
G GJB6 gap junction protein beta 6 enables IDA
IBA		 (PMID:12767933) ARUK-UCL
GO_Central		 PMID:12767933 GO_REF:0000033 NCBI chr13:20,221,962...20,232,319
Ensembl chr13:20,221,962...20,232,365 		JBrowse link
G GJB7 gap junction protein beta 7 enables IDA
IBA		 (PMID:12064583) UniProt
GO_Central		 PMID:12064583 GO_REF:0000033 NCBI chr 6:87,282,980...87,329,278
Ensembl chr 6:87,282,980...87,329,278 		JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:11668048 GO_REF:0000033 GO_REF:0000107 RGD:628534 NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:228,149,930...228,159,826
Ensembl chr 1:228,149,930...228,159,826 		JBrowse link
G GJC3 gap junction protein gamma 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:99,923,266...99,930,747
Ensembl chr 7:99,923,266...99,929,620 		JBrowse link
G GJD2 gap junction protein delta 2 enables IBA GO_Central GO_REF:0000033 NCBI chr15:34,751,032...34,754,998
Ensembl chr15:34,751,032...34,754,998 		JBrowse link
G GJD3 gap junction protein delta 3 enables ISO
IEA		 RGD
Ensembl		 PMID:23385797 GO_REF:0000107 RGD:7364769 NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737 		JBrowse link
G GJD4 gap junction protein delta 4 enables IBA GO_Central GO_REF:0000033 NCBI chr10:35,605,341...35,608,935
Ensembl chr10:35,605,341...35,608,935 		JBrowse link
G GJE1 gap junction protein epsilon 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:142,132,925...142,135,358
Ensembl chr 6:142,132,925...142,135,358 		JBrowse link
G PANX1 pannexin 1 enables ISO
IEA		 RGD
Ensembl		 PMID:14597722 GO_REF:0000107 RGD:1299639 NCBI chr11:94,128,841...94,181,968
Ensembl chr11:94,128,841...94,181,968 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr22:50,170,731...50,180,295
Ensembl chr22:50,170,731...50,180,295 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IMP
IBA
NAS		 (PMID:16790700), (PMID:20606116), (PMID:23348765)
(PMID:15044680)		 BHF-UCL
GO_Central		 PMID:15044680 PMID:16790700 PMID:20606116 PMID:23348765 GO_REF:0000033 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IDA (PMID:22247482) BHF-UCL PMID:22247482 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJC1 gap junction protein gamma 1 enables IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816 		JBrowse link
G GJC3 gap junction protein gamma 3 NOT|enables NAS (PMID:21742272) BHF-UCL PMID:21742272 NCBI chr 7:99,923,266...99,930,747
Ensembl chr 7:99,923,266...99,929,620 		JBrowse link
G GJD3 gap junction protein delta 3 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IMP
ISS		 (PMID:22247482) BHF-UCL PMID:22247482 GO_REF:0000024 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables NAS (PMID:1696265) BHF-UCL PMID:1696265 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IDA
IMP		 (PMID:23348765)
(PMID:16790700)		 BHF-UCL PMID:16790700 PMID:23348765 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJD3 gap junction protein delta 3 NOT|enables NAS (PMID:19168070) BHF-UCL PMID:19168070 NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IDA (PMID:1696265) BHF-UCL PMID:1696265 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJB2 gap junction protein beta 2 enables IDA (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938 		JBrowse link
G GJB6 gap junction protein beta 6 enables IDA (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chr13:20,221,962...20,232,319
Ensembl chr13:20,221,962...20,232,365 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IMP (PMID:17344063) UniProt PMID:17344063 NCBI chr 1:228,149,930...228,159,826
Ensembl chr 1:228,149,930...228,159,826 		JBrowse link
gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables NAS (PMID:15044680) BHF-UCL PMID:15044680 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables NAS (PMID:15044680), (PMID:21357845) BHF-UCL PMID:15044680 PMID:21357845 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJC1 gap junction protein gamma 1 enables NAS (PMID:21357845) BHF-UCL PMID:21357845 NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IMP (PMID:29366904) UniProt PMID:29366904 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJA3 gap junction protein alpha 3 enables IDA (PMID:30044662) UniProt PMID:30044662 NCBI chr13:20,138,255...20,161,565
Ensembl chr13:20,138,255...20,161,052 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IDA (PMID:23348765) BHF-UCL PMID:23348765 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G PANX1 pannexin 1 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr11:94,128,841...94,181,968
Ensembl chr11:94,128,841...94,181,968 		JBrowse link
G PANX2 pannexin 2 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr22:50,170,731...50,180,295
Ensembl chr22:50,170,731...50,180,295 		JBrowse link
G PANX3 pannexin 3 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr11:124,611,428...124,620,356
Ensembl chr11:124,611,428...124,620,356 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19524
    transporter activity 1302
      transmembrane transporter activity 1183
        passive transmembrane transporter activity 535
          channel activity 535
            wide pore channel activity 37
              gap junction channel activity 24
                gap junction channel activity involved in cell communication by electrical coupling + 8
                gap junction hemi-channel activity 6
paths to the root