ONTOLOGY REPORT - ANNOTATIONS
Term: gap junction channel activity
Accession: GO:0005243
browse the term
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms: exact_synonym: innexin channel activity
narrow_synonym: innexin
broad_synonym: intercellular channel
related_synonym: connexin
alt_id: GO:0015285; GO:0015286
xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane"; reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication"; reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication"; reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication"; reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"
G
GJA1
gap junction protein alpha 1
enables
ISO IBA IEA IDA
(PMID:16790700), (PMID:1696265), (PMID:23348765), (PMID:29366904)
RGD GO_Central Ensembl BHF-UCL
PMID:1696265 PMID:15048573 PMID:16731531 PMID:16790700 PMID:23348765 PMID:29366904 More...
GO_REF:0000033 GO_REF:0000107 RGD:1580399 RGD:1582674
NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
G
GJA10
gap junction protein alpha 10
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 6:89,894,469...89,896,120
Ensembl chr 6:89,894,469...89,921,760
G
GJA3
gap junction protein alpha 3
enables
ISO IBA IEA
RGD GO_Central InterPro
PMID:1659572
GO_REF:0000002 GO_REF:0000033 RGD:728416
NCBI chr13:20,138,255...20,161,565
Ensembl chr13:20,138,255...20,161,052
G
GJA4
gap junction protein alpha 4
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 1:34,792,999...34,795,747
Ensembl chr 1:34,792,999...34,795,747
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GJA5
gap junction protein alpha 5
enables
ISO IEA
RGD Ensembl
PMID:1328644
GO_REF:0000107 RGD:728713
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
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GJA8
gap junction protein alpha 8
contributes_to enables
ISO IBA IDA IEA
(PMID:19756179)
RGD GO_Central UniProt Ensembl
PMID:16123426 PMID:19756179
GO_REF:0000033 GO_REF:0000107 RGD:1598965
NCBI chr 1:147,902,795...147,914,486
Ensembl chr 1:147,902,795...147,909,269
G
GJA9
gap junction protein alpha 9
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 1:38,874,069...38,881,587
Ensembl chr 1:38,874,069...38,881,587
G
GJB1
gap junction protein beta 1
enables
ISO IBA TAS IEA
RGD GO_Central Reactome Ensembl
PMID:12119284
GO_REF:0000033 GO_REF:0000107 RGD:728476 Reactome:R-HSA-190681
NCBI chr X:71,215,239...71,225,516
Ensembl chr X:71,212,811...71,225,516
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GJB2
gap junction protein beta 2
enables
ISO IBA IDA IEA
(PMID:12767933), (PMID:21094651)
RGD GO_Central ARUK-UCL Ensembl
PMID:12767933 PMID:21094651 PMID:23232329
GO_REF:0000033 GO_REF:0000107 RGD:7349364
NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938
G
GJB3
gap junction protein beta 3
enables
NAS IBA
(PMID:9704026)
UniProt GO_Central
PMID:9704026
GO_REF:0000033
NCBI chr 1:34,781,214...34,786,364
Ensembl chr 1:34,781,214...34,786,369
G
GJB4
gap junction protein beta 4
enables
IEA IBA ISS
InterPro GO_Central UniProt Ensembl
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 1:34,759,740...34,762,327
Ensembl chr 1:34,759,740...34,762,327
G
GJB5
gap junction protein beta 5
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 1:34,755,047...34,758,512
Ensembl chr 1:34,755,047...34,758,512
G
GJB6
gap junction protein beta 6
enables
IDA IBA
(PMID:12767933)
ARUK-UCL GO_Central
PMID:12767933
GO_REF:0000033
NCBI chr13:20,221,962...20,232,319
Ensembl chr13:20,221,962...20,232,365
G
GJB7
gap junction protein beta 7
enables
IDA IBA
(PMID:12064583)
UniProt GO_Central
PMID:12064583
GO_REF:0000033
NCBI chr 6:87,282,980...87,329,278
Ensembl chr 6:87,282,980...87,329,278
G
GJC1
gap junction protein gamma 1
enables
ISO IBA IEA
RGD GO_Central Ensembl
PMID:11668048
GO_REF:0000033 GO_REF:0000107 RGD:628534
NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816
G
GJC2
gap junction protein gamma 2
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 1:228,149,930...228,159,826
Ensembl chr 1:228,149,930...228,159,826
G
GJC3
gap junction protein gamma 3
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 7:99,923,266...99,930,747
Ensembl chr 7:99,923,266...99,929,620
G
GJD2
gap junction protein delta 2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr15:34,751,032...34,754,998
Ensembl chr15:34,751,032...34,754,998
G
GJD3
gap junction protein delta 3
enables
ISO IEA
RGD Ensembl
PMID:23385797
GO_REF:0000107 RGD:7364769
NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737
G
GJD4
gap junction protein delta 4
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr10:35,605,341...35,608,935
Ensembl chr10:35,605,341...35,608,935
G
GJE1
gap junction protein epsilon 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 6:142,132,925...142,135,358
Ensembl chr 6:142,132,925...142,135,358
G
PANX1
pannexin 1
enables
ISO IEA
RGD Ensembl
PMID:14597722
GO_REF:0000107 RGD:1299639
NCBI chr11:94,128,841...94,181,968
Ensembl chr11:94,128,841...94,181,968
G
PANX2
pannexin 2
ISO
RGD
PMID:14597722
RGD:1299639
NCBI chr22:50,170,731...50,180,295
Ensembl chr22:50,170,731...50,180,295
G
GJA5
gap junction protein alpha 5
enables
IMP IBA NAS
(PMID:16790700), (PMID:20606116), (PMID:23348765) (PMID:15044680)
BHF-UCL GO_Central
PMID:15044680 PMID:16790700 PMID:20606116 PMID:23348765
GO_REF:0000033
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
G
GJA5
gap junction protein alpha 5
enables
IDA
(PMID:22247482)
BHF-UCL
PMID:22247482
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
G
GJC1
gap junction protein gamma 1
enables
IEA ISS
Ensembl BHF-UCL
GO_REF:0000024 GO_REF:0000107
NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816
G
GJC3
gap junction protein gamma 3
NOT|enables
NAS
(PMID:21742272)
BHF-UCL
PMID:21742272
NCBI chr 7:99,923,266...99,930,747
Ensembl chr 7:99,923,266...99,929,620
G
GJD3
gap junction protein delta 3
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737
G
GJA5
gap junction protein alpha 5
enables
IMP ISS
(PMID:22247482)
BHF-UCL
PMID:22247482
GO_REF:0000024
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
G
GJA1
gap junction protein alpha 1
enables
NAS
(PMID:1696265)
BHF-UCL
PMID:1696265
NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
G
GJA5
gap junction protein alpha 5
enables
IDA IMP
(PMID:23348765) (PMID:16790700)
BHF-UCL
PMID:16790700 PMID:23348765
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
G
GJD3
gap junction protein delta 3
NOT|enables
NAS
(PMID:19168070)
BHF-UCL
PMID:19168070
NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737
G
GJA1
gap junction protein alpha 1
enables
IDA
(PMID:1696265)
BHF-UCL
PMID:1696265
NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
G
GJB2
gap junction protein beta 2
enables
IDA
(PMID:12767933)
ARUK-UCL
PMID:12767933
NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938
G
GJB6
gap junction protein beta 6
enables
IDA
(PMID:12767933)
ARUK-UCL
PMID:12767933
NCBI chr13:20,221,962...20,232,319
Ensembl chr13:20,221,962...20,232,365
G
GJC2
gap junction protein gamma 2
enables
IMP
(PMID:17344063)
UniProt
PMID:17344063
NCBI chr 1:228,149,930...228,159,826
Ensembl chr 1:228,149,930...228,159,826
G
GJA5
gap junction protein alpha 5
enables
NAS
(PMID:15044680)
BHF-UCL
PMID:15044680
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
G
GJA5
gap junction protein alpha 5
enables
NAS
(PMID:15044680), (PMID:21357845)
BHF-UCL
PMID:15044680 PMID:21357845
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
G
GJC1
gap junction protein gamma 1
enables
NAS
(PMID:21357845)
BHF-UCL
PMID:21357845
NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816
G
GJA1
gap junction protein alpha 1
enables
IMP
(PMID:29366904)
UniProt
PMID:29366904
NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
G
GJA3
gap junction protein alpha 3
enables
IDA
(PMID:30044662)
UniProt
PMID:30044662
NCBI chr13:20,138,255...20,161,565
Ensembl chr13:20,138,255...20,161,052
G
GJA5
gap junction protein alpha 5
enables
IDA
(PMID:23348765)
BHF-UCL
PMID:23348765
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
G
PANX1
pannexin 1
NOT|enables
ISS
UniProt
GO_REF:0000024
NCBI chr11:94,128,841...94,181,968
Ensembl chr11:94,128,841...94,181,968
G
PANX2
pannexin 2
NOT|enables
ISS
UniProt
GO_REF:0000024
NCBI chr22:50,170,731...50,180,295
Ensembl chr22:50,170,731...50,180,295
G
PANX3
pannexin 3
NOT|enables
ISS
UniProt
GO_REF:0000024
NCBI chr11:124,611,428...124,620,356
Ensembl chr11:124,611,428...124,620,356
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