Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
go back to main search page
Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:15048573 PMID:16731531 GO_REF:0000107 GO_REF:0000118 RGD:1580399 RGD:1582674 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr13:14,646,091...14,716,787
Ensembl chr13:14,651,295...14,652,926 		JBrowse link
G GJA3 gap junction protein alpha 3 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000118 RGD:728416 NCBI chr 3:820,352...852,003
Ensembl chr 3:846,982...848,286 		JBrowse link
G GJA4 gap junction protein alpha 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:98,092,282...98,095,036
Ensembl chr20:98,092,785...98,093,786 		JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:16123426 GO_REF:0000107 GO_REF:0000118 RGD:1598965
G GJA9 gap junction protein alpha 9 enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:94,009,063...94,016,927
Ensembl chr20:94,014,888...94,016,435 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12119284 GO_REF:0000118 RGD:728476 NCBI chr  X:61,013,991...61,019,222
Ensembl chr  X:61,017,716...61,018,567 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IEA		 RGD
Ensembl
TreeGrafter		 PMID:23232329 GO_REF:0000107 GO_REF:0000118 RGD:7349364 NCBI chr 3:801,786...808,165
Ensembl chr 3:807,379...808,059 		JBrowse link
G GJB3 gap junction protein beta 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:98,100,285...98,106,517
Ensembl chr20:98,102,413...98,103,225 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:98,125,073...98,126,343
Ensembl chr20:98,125,345...98,126,145 		JBrowse link
G GJB5 gap junction protein beta 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:98,128,901...98,132,640
Ensembl chr20:98,129,262...98,130,083 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:775,410...783,770
Ensembl chr 3:782,251...783,036 		JBrowse link
G GJB7 gap junction protein beta 7 enables ISO (PMID:12064583) UniProt PMID:12064583 NCBI chr13:11,780,295...11,789,625 JBrowse link
G GJB7 gap junction protein beta 7 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr13:11,781,545...11,782,198 JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:11668048 GO_REF:0000118 RGD:628534 NCBI chr16:61,575,851...61,596,488
Ensembl chr16:61,594,885...61,596,075 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr25:1,568,664...1,579,279
Ensembl chr25:1,569,427...1,570,752 		JBrowse link
G GJC3 gap junction protein gamma 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr28:13,153,447...13,160,951 JBrowse link
G GJD2 gap junction protein delta 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr26:48,149,568...48,152,466
Ensembl chr26:48,149,755...48,153,660 		JBrowse link
G GJD3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chr16:65,811,111...65,815,128
Ensembl chr16:65,811,981...65,812,862 		JBrowse link
G GJD4 gap junction protein delta 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:34,856,892...34,886,231
Ensembl chr 9:34,883,069...34,886,136 		JBrowse link
G PANX1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chr 1:85,356,507...85,413,146
Ensembl chr 1:85,356,610...85,409,275 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr19:32,662,350...32,671,536 JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107
G GJC1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chr16:61,575,851...61,596,488
Ensembl chr16:61,594,885...61,596,075 		JBrowse link
G GJD3 gap junction protein delta 3 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:65,811,111...65,815,128
Ensembl chr16:65,811,981...65,812,862 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G GJB2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:801,786...808,165
Ensembl chr 3:807,379...808,059 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:775,410...783,770
Ensembl chr 3:782,251...783,036 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr25:1,568,664...1,579,279
Ensembl chr25:1,569,427...1,570,752 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G GJA3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:820,352...852,003
Ensembl chr 3:846,982...848,286 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107
G PANX1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr 1:85,356,507...85,413,146
Ensembl chr 1:85,356,610...85,409,275 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:115,757,147...115,767,034
Ensembl chr 1:115,757,901...115,766,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18124
    transporter activity 1196
      transmembrane transporter activity 1103
        passive transmembrane transporter activity 516
          channel activity 516
            wide pore channel activity 35
              gap junction channel activity 24
                gap junction channel activity involved in cell communication by electrical coupling + 7
                gap junction hemi-channel activity 5
paths to the root