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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"


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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:15048573 PMID:16731531 GO_REF:0000033 GO_REF:0000107 RGD:1580399 RGD:1582674 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA Ensembl GO_REF:0000107 NCBI chr12:49,075,169...49,099,146
Ensembl chr12:49,092,747...49,097,743 		JBrowse link
G GJA3 gap junction protein alpha 3 ISO RGD PMID:1659572 RGD:728416 NCBI chr25:17,986,270...18,004,344
Ensembl chr25:18,002,817...18,004,160 		JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:16123426 GO_REF:0000033 GO_REF:0000107 RGD:1598965 NCBI chr17:58,360,313...58,428,751
Ensembl chr17:58,424,072...58,425,391 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IBA		 RGD
GO_Central		 PMID:12119284 GO_REF:0000033 RGD:728476 NCBI chr  X:55,565,995...55,575,332
Ensembl chr  X:55,573,808...55,574,659 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:23232329 GO_REF:0000033 GO_REF:0000107 RGD:7349364 NCBI chr25:17,952,851...17,958,289
Ensembl chr25:17,952,851...17,958,289 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr15:7,193,183...7,195,586 JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr25:17,912,036...17,922,310
Ensembl chr25:17,911,262...17,921,605 		JBrowse link
G GJB7 gap junction protein beta 7 enables IEA Ensembl GO_REF:0000107 NCBI chr12:46,800,875...46,812,896
Ensembl chr12:46,801,431...46,802,588 		JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IBA		 RGD
GO_Central		 PMID:11668048 GO_REF:0000033 RGD:628534 NCBI chr 9:18,642,359...18,688,128
Ensembl chr 9:18,686,527...18,687,717 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr14:810,388...819,248
Ensembl chr14:810,386...820,420 		JBrowse link
G GJD3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chr 9:22,246,891...22,248,597 JBrowse link
G PANX1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chr21:6,665,730...6,715,272
Ensembl chr21:6,668,269...6,715,858 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr10:17,052,972...17,059,756
Ensembl chr10:17,052,956...17,055,880 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G GJC1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:18,642,359...18,688,128
Ensembl chr 9:18,686,527...18,687,717 		JBrowse link
G GJD3 gap junction protein delta 3 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chr 9:22,246,891...22,248,597 JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G GJB2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chr25:17,952,851...17,958,289
Ensembl chr25:17,952,851...17,958,289 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr25:17,912,036...17,922,310
Ensembl chr25:17,911,262...17,921,605 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr14:810,388...819,248
Ensembl chr14:810,386...820,420 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G GJA3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chr25:17,986,270...18,004,344
Ensembl chr25:18,002,817...18,004,160 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G PANX1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr21:6,665,730...6,715,272
Ensembl chr21:6,668,269...6,715,858 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:9,787,513...9,794,292
Ensembl chr 5:9,787,947...9,794,166 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18610
    transporter activity 1198
      transmembrane transporter activity 1105
        passive transmembrane transporter activity 485
          channel activity 485
            wide pore channel activity 31
              gap junction channel activity 17
                gap junction channel activity involved in cell communication by electrical coupling + 7
                gap junction hemi-channel activity 6
paths to the root