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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"

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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO (PMID:29366904)
(PMID:11397787), (PMID:15084279)
(PMID:16790700), (PMID:1696265), (PMID:23348765), (PMID:29366904)
PMID:15284189		 RGD
UniProt
MGI
BHF-UCL
CAFA		 PMID:1696265 PMID:11397787 PMID:15048573 PMID:15084279 PMID:15284189 More... RGD:12793029 RGD:1580399 RGD:1582674 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gja10 gap junction protein alpha 10 enables ISO (PMID:10329667) MGI PMID:10329667 NCBI chrNW_004955411:16,586,673...16,601,999
Ensembl chrNW_004955411:16,593,576...16,595,042 		JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Gja8 gap junction protein alpha 8 contributes_to
enables		 ISO (PMID:19756179) RGD
UniProt		 PMID:16123426 PMID:19756179 RGD:1598965 NCBI chrNW_004955568:514,905...516,551
Ensembl chrNW_004955568:515,113...516,435 		JBrowse link
G Gjb1 gap junction protein beta 1 ISO RGD PMID:12119284 RGD:728476 NCBI chrNW_004955475:10,779,415...10,787,910
Ensembl chrNW_004955475:10,785,996...10,787,910 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO (PMID:15692151)
(PMID:12767933), (PMID:21094651)		 RGD
UniProt
ARUK-UCL		 PMID:12767933 PMID:15692151 PMID:21094651 PMID:23232329 RGD:7349364 NCBI chrNW_004955497:987,213...989,477
Ensembl chrNW_004955497:988,422...989,099 		JBrowse link
G Gjb4 gap junction protein beta 4 enables ISO (PMID:15692151) UniProt PMID:15692151 NCBI chrNW_004955452:12,871,548...12,874,019
Ensembl chrNW_004955452:12,871,548...12,874,019 		JBrowse link
G Gjb6 gap junction protein beta 6 enables ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:1,018,610...1,027,593
Ensembl chrNW_004955497:1,018,610...1,027,360 		JBrowse link
G Gjb7 gap junction protein beta 7 enables ISO (PMID:12064583) UniProt PMID:12064583 NCBI chrNW_004955411:14,285,142...14,303,036 JBrowse link
G Gjc1 gap junction protein gamma 1 ISO RGD PMID:11668048 RGD:628534 NCBI chrNW_004955451:17,626,859...17,639,002
Ensembl chrNW_004955451:17,626,859...17,630,247 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables ISO (PMID:11160382) MGI PMID:11160382 NCBI chrNW_004955581:291,537...294,752 JBrowse link
G Panx1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004955414:405,483...448,470
Ensembl chrNW_004955414:401,188...448,470 		JBrowse link
G Panx2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004955413:33,220,145...33,224,241
Ensembl chrNW_004955413:33,220,140...33,224,344 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:16790700), (PMID:20606116), (PMID:23348765) BHF-UCL PMID:16790700 PMID:20606116 PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:22247482) BHF-UCL PMID:22247482 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Gjc1 gap junction protein gamma 1 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chrNW_004955451:17,626,859...17,639,002
Ensembl chrNW_004955451:17,626,859...17,630,247 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:22247482)
(PMID:26786475)		 BHF-UCL PMID:22247482 PMID:26786475 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:16790700)
(PMID:23348765)		 BHF-UCL PMID:16790700 PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO (PMID:1696265) BHF-UCL PMID:1696265 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:987,213...989,477
Ensembl chrNW_004955497:988,422...989,099 		JBrowse link
G Gjb6 gap junction protein beta 6 enables ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:1,018,610...1,027,593
Ensembl chrNW_004955497:1,018,610...1,027,360 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables ISO (PMID:17344063) UniProt PMID:17344063 NCBI chrNW_004955581:291,537...294,752 JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO (PMID:29366904) UniProt PMID:29366904 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gja5 gap junction protein alpha 5 enables ISO (PMID:23348765) BHF-UCL PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Panx1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chrNW_004955414:405,483...448,470
Ensembl chrNW_004955414:401,188...448,470 		JBrowse link
G Panx3 pannexin 3 enables ISO (PMID:21690309) UniProt PMID:21690309 NCBI chrNW_004955412:25,676,286...25,684,841
Ensembl chrNW_004955412:25,676,286...25,684,841 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14366
    transporter activity 881
      transmembrane transporter activity 800
        passive transmembrane transporter activity 395
          channel activity 395
            wide pore channel activity 21
              gap junction channel activity 14
                gap junction channel activity involved in cell communication by electrical coupling + 6
                gap junction hemi-channel activity 4
paths to the root