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ONTOLOGY REPORT - ANNOTATIONS

Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"


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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:15048573 PMID:16731531 GO_REF:0000118 RGD:1580399 RGD:1582674 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:87,774,889...87,776,520
Ensembl chr 6:91,046,601...91,072,335 		JBrowse link
G GJA3 gap junction protein alpha 3 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000118 RGD:728416 NCBI chr13:1,464,542...1,488,240
Ensembl chr13:19,784,372...19,785,679 		JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:16123426 GO_REF:0000107 GO_REF:0000118 RGD:1598965 NCBI chr 1:123,352,801...123,355,625
Ensembl chr 1:112,174,365...112,177,893 		JBrowse link
G GJA9 gap junction protein alpha 9 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:38,146,515...38,159,985
Ensembl chr 1:39,492,609...39,494,156 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12119284 GO_REF:0000118 RGD:728476 NCBI chr  X:60,490,579...60,492,606
Ensembl chr  X:70,547,110...70,547,961 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:23232329 GO_REF:0000107 GO_REF:0000118 RGD:7349364 NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:34,027,433...34,029,415
Ensembl chr 1:35,209,877...35,210,677 		JBrowse link
G GJB5 gap junction protein beta 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:34,022,109...34,025,606
Ensembl chr 1:35,205,953...35,206,774 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr13:1,549,089...1,559,452
Ensembl chr13:19,864,939...19,865,724 		JBrowse link
G GJB7 gap junction protein beta 7 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:85,160,188...85,206,448
Ensembl chr 6:88,415,983...88,437,581 		JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:11668048 GO_REF:0000118 RGD:628534 NCBI chr17:12,492,285...12,524,615
Ensembl chr17:12,689,251...12,690,441 		JBrowse link
G GJC2 gap junction protein gamma 2 enables ISO (PMID:11160382) MGI PMID:11160382 NCBI chr 1:203,551,556...203,561,702 JBrowse link
G GJC3 gap junction protein gamma 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 7:91,956,757...91,963,417
Ensembl chr 7:105,390,567...105,396,643 		JBrowse link
G GJD2 gap junction protein delta 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:13,668,639...13,672,691
Ensembl chr15:31,928,157...31,931,474 		JBrowse link
G GJD3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chr17:16,925,395...16,929,683 JBrowse link
G GJD4 gap junction protein delta 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr10:35,698,294...35,735,764
Ensembl chr10:36,306,919...36,322,448 		JBrowse link
G GJE1 gap junction protein epsilon 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 6:139,901,021...139,902,784
Ensembl chr 6:143,974,781...143,976,543 		JBrowse link
G LOC100975396 gap junction alpha-1 protein-like enables IEA TreeGrafter GO_REF:0000118 NCBI chr 5:104,401,975...104,403,855 JBrowse link
G LOC129397801 gap junction alpha-1 protein-like enables IEA TreeGrafter GO_REF:0000118
G PANX1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chr11:89,142,686...89,295,972
Ensembl chr11:92,628,760...92,685,109 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr22:30,398,717...30,408,358
Ensembl chr22:49,404,624...49,408,045 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G GJC1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chr17:12,492,285...12,524,615
Ensembl chr17:12,689,251...12,690,441 		JBrowse link
G GJD3 gap junction protein delta 3 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chr17:16,925,395...16,929,683 JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO (PMID:1696265) BHF-UCL PMID:1696265 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJB2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr13:1,549,089...1,559,452
Ensembl chr13:19,864,939...19,865,724 		JBrowse link
G GJC2 gap junction protein gamma 2 enables ISO (PMID:17344063) UniProt PMID:17344063 NCBI chr 1:203,551,556...203,561,702 JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO (PMID:29366904) UniProt PMID:29366904 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chr13:1,464,542...1,488,240
Ensembl chr13:19,784,372...19,785,679 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G PANX1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr11:89,142,686...89,295,972
Ensembl chr11:92,628,760...92,685,109 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chr11:119,438,866...119,452,174
Ensembl chr11:123,354,919...123,363,463 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 17686
    transporter activity 1156
      transmembrane transporter activity 1064
        passive transmembrane transporter activity 495
          channel activity 495
            wide pore channel activity 37
              gap junction channel activity 24
                gap junction channel activity involved in cell communication by electrical coupling + 7
                gap junction hemi-channel activity 5
paths to the root