ONTOLOGY REPORT - ANNOTATIONS
Term: gap junction channel activity
Accession: GO:0005243
browse the term
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms: exact_synonym: innexin channel activity
narrow_synonym: innexin
broad_synonym: intercellular channel
related_synonym: connexin
alt_id: GO:0015285; GO:0015286
xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane"; reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication"; reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication"; reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication"; reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"
G
GJA1
gap junction protein alpha 1
enables
ISO IEA
RGD TreeGrafter
PMID:15048573 PMID:16731531
GO_REF:0000118 RGD:1580399 RGD:1582674
NCBI chr 6:119,213,513...119,227,617
G
GJA10
gap junction protein alpha 10
enables
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 6:87,774,889...87,776,520
Ensembl chr 6:91,046,601...91,072,335
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GJA3
gap junction protein alpha 3
enables
ISO IEA
RGD TreeGrafter InterPro
PMID:1659572
GO_REF:0000002 GO_REF:0000118 RGD:728416
NCBI chr13:1,464,542...1,488,240
Ensembl chr13:19,784,372...19,785,679
G
GJA5
gap junction protein alpha 5
ISO
RGD
PMID:1328644
RGD:728713
NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413
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GJA8
gap junction protein alpha 8
contributes_to enables
ISO IEA
RGD TreeGrafter Ensembl
PMID:16123426
GO_REF:0000107 GO_REF:0000118 RGD:1598965
NCBI chr 1:123,352,801...123,355,625
Ensembl chr 1:112,174,365...112,177,893
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GJA9
gap junction protein alpha 9
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:38,146,515...38,159,985
Ensembl chr 1:39,492,609...39,494,156
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GJB1
gap junction protein beta 1
enables
ISO IEA
RGD TreeGrafter
PMID:12119284
GO_REF:0000118 RGD:728476
NCBI chr X:60,490,579...60,492,606
Ensembl chr X:70,547,110...70,547,961
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GJB2
gap junction protein beta 2
enables
ISO IEA
RGD TreeGrafter Ensembl
PMID:23232329
GO_REF:0000107 GO_REF:0000118 RGD:7349364
NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954
G
GJB4
gap junction protein beta 4
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 1:34,027,433...34,029,415
Ensembl chr 1:35,209,877...35,210,677
G
GJB5
gap junction protein beta 5
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:34,022,109...34,025,606
Ensembl chr 1:35,205,953...35,206,774
G
GJB6
gap junction protein beta 6
enables
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr13:1,549,089...1,559,452
Ensembl chr13:19,864,939...19,865,724
G
GJB7
gap junction protein beta 7
enables
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 6:85,160,188...85,206,448
Ensembl chr 6:88,415,983...88,437,581
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GJC1
gap junction protein gamma 1
enables
ISO IEA
RGD TreeGrafter
PMID:11668048
GO_REF:0000118 RGD:628534
NCBI chr17:12,492,285...12,524,615
Ensembl chr17:12,689,251...12,690,441
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GJC2
gap junction protein gamma 2
enables
ISO
(PMID:11160382)
MGI
PMID:11160382
NCBI chr 1:203,551,556...203,561,702
G
GJC3
gap junction protein gamma 3
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 7:91,956,757...91,963,417
Ensembl chr 7:105,390,567...105,396,643
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GJD2
gap junction protein delta 2
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr15:13,668,639...13,672,691
Ensembl chr15:31,928,157...31,931,474
G
GJD3
gap junction protein delta 3
ISO
RGD
PMID:23385797
RGD:7364769
NCBI chr17:16,925,395...16,929,683
G
GJD4
gap junction protein delta 4
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr10:35,698,294...35,735,764
Ensembl chr10:36,306,919...36,322,448
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GJE1
gap junction protein epsilon 1
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:139,901,021...139,902,784
Ensembl chr 6:143,974,781...143,976,543
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LOC100975396
gap junction alpha-1 protein-like
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 5:104,401,975...104,403,855
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LOC129397801
gap junction alpha-1 protein-like
enables
IEA
TreeGrafter
GO_REF:0000118
G
PANX1
pannexin 1
ISO
RGD
PMID:14597722
RGD:1299639
NCBI chr11:89,142,686...89,295,972
Ensembl chr11:92,628,760...92,685,109
G
PANX2
pannexin 2
ISO
RGD
PMID:14597722
RGD:1299639
NCBI chr22:30,398,717...30,408,358
Ensembl chr22:49,404,624...49,408,045
G
GJA5
gap junction protein alpha 5
enables
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413
G
GJA5
gap junction protein alpha 5
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413
G
GJC1
gap junction protein gamma 1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr17:12,492,285...12,524,615
Ensembl chr17:12,689,251...12,690,441
G
GJD3
gap junction protein delta 3
enables
ISO
(PMID:22982984)
BHF-UCL
PMID:22982984
NCBI chr17:16,925,395...16,929,683
G
GJA5
gap junction protein alpha 5
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413
G
GJA5
gap junction protein alpha 5
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413
G
GJA1
gap junction protein alpha 1
enables
ISO
(PMID:1696265)
BHF-UCL
PMID:1696265
NCBI chr 6:119,213,513...119,227,617
G
GJB2
gap junction protein beta 2
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954
G
GJB6
gap junction protein beta 6
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr13:1,549,089...1,559,452
Ensembl chr13:19,864,939...19,865,724
G
GJC2
gap junction protein gamma 2
enables
ISO
(PMID:17344063)
UniProt
PMID:17344063
NCBI chr 1:203,551,556...203,561,702
G
GJA1
gap junction protein alpha 1
enables
ISO
(PMID:29366904)
UniProt
PMID:29366904
NCBI chr 6:119,213,513...119,227,617
G
GJA3
gap junction protein alpha 3
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr13:1,464,542...1,488,240
Ensembl chr13:19,784,372...19,785,679
G
GJA5
gap junction protein alpha 5
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413
G
PANX1
pannexin 1
NOT|enables
ISO
PMID:17715132
UniProt
PMID:17715132
RGD:15090844
NCBI chr11:89,142,686...89,295,972
Ensembl chr11:92,628,760...92,685,109
G
PANX3
pannexin 3
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr11:119,438,866...119,452,174
Ensembl chr11:123,354,919...123,363,463
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