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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear receptor activity
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Accession:GO:0004879 term browser browse the term
Definition:A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Comment:Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
Synonyms:exact_synonym: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
 narrow_synonym: 1,25-(OH)2D3 receptor activity;   9-cis retinoic acid receptor activity;   RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding;   RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding;   RXR;   androgen receptor activity;   calcitriol receptor activity;   ecdysteroid hormone receptor activity;   estrogen nuclear receptor activity;   glucocorticoid receptor activity;   juvenile hormone receptor activity;   nuclear hormone receptor;   retinoic acid receptor activity;   retinoid-X receptor activity;   thyroid hormone receptor activity;   vitamin A receptor activity;   vitamin D receptor activity;   vitamin D3 receptor activity
 related_synonym: ligand-dependent nuclear receptor activity;   ligand-dependent transcription factor activity
 alt_id: GO:0003708;   GO:0004880;   GO:0004882;   GO:0004884;   GO:0004886;   GO:0004887;   GO:0008434;   GO:0038050;   GO:0038051;   GO:0038052

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nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor enables
contributes_to		 IEA
ISO		 (PMID:34521881) Ensembl
TreeGrafter
UniProt
UniProt		 PMID:34521881 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chrNW_004936546:3,737,908...3,783,492
Ensembl chrNW_004936546:3,737,851...3,783,588 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936815:1,031,696...1,045,032 JBrowse link
G Ar androgen receptor enables
NOT|enables		 ISO
IEA		 (PMID:19244107) RGD
Ensembl
InterPro
UniProt		 PMID:2341409 PMID:19244107 GO_REF:0000002 GO_REF:0000107 RGD:1298681 NCBI chrNW_004936635:485,903...647,820
Ensembl chrNW_004936635:485,903...647,932 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator contributes_to
enables		 ISO
IEA		 (PMID:34521881)
(PMID:11043581)		 UniProt
MGI
Ensembl		 PMID:11043581 PMID:34521881 GO_REF:0000107 NCBI chrNW_004936580:1,038,420...1,093,319
Ensembl chrNW_004936580:1,036,973...1,082,984 		JBrowse link
G Esr1 estrogen receptor 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171 		JBrowse link
G Esr2 estrogen receptor 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936530:2,401,053...2,425,989
Ensembl chrNW_004936530:2,401,043...2,454,466 		JBrowse link
G LOC101962886 bile acid receptor-like enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936627:203,136...236,479 JBrowse link
G Nkx3-1 NK3 homeobox 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936555:7,087,677...7,091,334
Ensembl chrNW_004936555:7,088,577...7,091,334 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1 group D member 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936490:15,206,194...15,213,858
Ensembl chrNW_004936490:15,206,191...15,213,867 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1 group D member 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936473:15,624,597...15,646,875 JBrowse link
G Nr1h2 nuclear receptor subfamily 1 group H member 2 enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936889:223,137...229,968
Ensembl chrNW_004936889:223,101...229,990 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1 group H member 3 contributes_to
enables		 ISO
IEA		 (PMID:17107947) BHF-UCL
Ensembl
InterPro
TreeGrafter		 PMID:17107947 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936562:1,937,665...1,946,680
Ensembl chrNW_004936562:1,937,667...1,946,669 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 enables IEA TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936492:13,315,265...13,365,186
Ensembl chrNW_004936492:13,315,265...13,374,034 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1 group I member 2 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:10967130 GO_REF:0000107 GO_REF:0000118 RGD:61490 NCBI chrNW_004936536:6,691,590...6,726,421
Ensembl chrNW_004936536:6,691,590...6,726,704 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1 group I member 3 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936903:527,838...533,930
Ensembl chrNW_004936903:527,871...533,790 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2 group F member 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:6,886,447...6,900,986
Ensembl chrNW_004936483:6,886,153...6,900,997 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936504:10,960,069...11,056,834
Ensembl chrNW_004936504:10,959,192...11,056,856 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4 group A member 1 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936512:9,486,096...9,508,338
Ensembl chrNW_004936512:9,499,754...9,508,423 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936469:21,912,118...21,920,486
Ensembl chrNW_004936469:21,912,047...21,920,486 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936524:8,252,321...8,290,747
Ensembl chrNW_004936524:8,252,381...8,289,157 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5 group A member 1 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936487:12,739,445...12,763,729
Ensembl chrNW_004936487:12,739,439...12,763,734 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5 group A member 2 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:8668203 GO_REF:0000002 GO_REF:0000107 RGD:68248 NCBI chrNW_004936567:4,084,161...4,194,858
Ensembl chrNW_004936567:4,084,608...4,212,854 		JBrowse link
G Pgr progesterone receptor enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936551:6,498,553...6,573,212
Ensembl chrNW_004936551:6,498,553...6,573,222 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha enables ISO
IEA		 RGD
Ensembl
InterPro
TreeGrafter		 PMID:12189208 PMID:12966092 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1580224 RGD:729665 NCBI chrNW_004936629:3,672,445...3,725,645
Ensembl chrNW_004936629:3,672,460...3,725,626 		JBrowse link
G Ppard peroxisome proliferator activated receptor delta enables IEA TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936476:23,799,285...23,886,606
Ensembl chrNW_004936476:23,811,641...23,828,176 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma enables IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743 		JBrowse link
G Rara retinoic acid receptor alpha enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936490:15,376,217...15,420,638
Ensembl chrNW_004936490:15,376,205...15,421,611 		JBrowse link
G Rarb retinoic acid receptor beta enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936473:16,983,829...17,146,517
Ensembl chrNW_004936473:16,983,600...17,148,885 		JBrowse link
G Rarg retinoic acid receptor gamma enables ISO
IEA		 RGD
InterPro		 PMID:11072095 GO_REF:0000002 RGD:1300463 NCBI chrNW_004936512:10,502,954...10,524,796
Ensembl chrNW_004936512:10,500,622...10,524,824 		JBrowse link
G Rora RAR related orphan receptor A enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936471:21,402,056...21,567,908
Ensembl chrNW_004936471:21,400,589...22,069,643 		JBrowse link
G Rorb RAR related orphan receptor B enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936503:10,294,530...10,473,070
Ensembl chrNW_004936503:10,295,167...10,470,813 		JBrowse link
G Rorc RAR related orphan receptor C enables IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936580:1,997,640...2,020,649
Ensembl chrNW_004936580:1,997,640...2,020,649 		JBrowse link
G Rxra retinoid X receptor alpha enables
contributes_to		 IEA
ISO		 (PMID:17107947) Ensembl
BHF-UCL		 PMID:17107947 GO_REF:0000107 NCBI chrNW_004936669:2,735,111...2,763,060
Ensembl chrNW_004936669:2,738,448...2,763,070 		JBrowse link
G Rxrb retinoid X receptor beta enables ISO
IEA		 RGD
Ensembl		 PMID:1662118 GO_REF:0000107 RGD:729677 NCBI chrNW_004936476:25,655,164...25,662,369
Ensembl chrNW_004936476:25,655,209...25,662,416 		JBrowse link
G Rxrg retinoid X receptor gamma enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:19,789,753...19,826,665
Ensembl chrNW_004936481:19,789,641...19,826,698 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936741:1,408,669...1,419,717
Ensembl chrNW_004936741:1,406,521...1,419,776 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,119,189...17,178,402
Ensembl chrNW_004936490:17,117,290...17,178,402 		JBrowse link
G Thra thyroid hormone receptor alpha enables IEA TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936490:15,188,341...15,206,032
Ensembl chrNW_004936490:15,193,150...15,206,784 		JBrowse link
G Thrb thyroid hormone receptor beta enables ISO
IEA		 RGD
InterPro
Ensembl
TreeGrafter		 PMID:2457590 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:729962 NCBI chrNW_004936473:15,766,214...15,986,389
Ensembl chrNW_004936473:15,770,146...15,986,561 		JBrowse link
G Vdr vitamin D receptor enables ISO
IEA		 RGD
Ensembl
InterPro
TreeGrafter		 PMID:9579411 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:70308 NCBI chrNW_004936512:5,741,836...5,800,999
Ensembl chrNW_004936512:5,740,748...5,801,109 		JBrowse link
bile acid nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1 group H member 4 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:13,315,265...13,365,186
Ensembl chrNW_004936492:13,315,265...13,374,034 		JBrowse link
G Vdr vitamin D receptor enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:5,741,836...5,800,999
Ensembl chrNW_004936512:5,740,748...5,801,109 		JBrowse link
nuclear estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171 		JBrowse link
G Esr2 estrogen receptor 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936754:1,288,891...1,293,555
Ensembl chrNW_004936754:1,288,912...1,293,427 		JBrowse link
G Pde3a phosphodiesterase 3A enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936548:5,758,634...6,072,195
Ensembl chrNW_004936548:5,762,507...6,070,576 		JBrowse link
nuclear glucocorticoid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3 group C member 1 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936504:10,960,069...11,056,834
Ensembl chrNW_004936504:10,959,192...11,056,856 		JBrowse link
nuclear steroid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:14,974,053...15,079,824
Ensembl chrNW_004936483:14,974,035...15,074,154 		JBrowse link
G Esr1 estrogen receptor 1 ISO 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171 		JBrowse link
G Esr2 estrogen receptor 2 enables ISO
IEA		 17-beta-estradiol (E2) RGD
InterPro		 PMID:17928626 GO_REF:0000002 RGD:5128669 NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357 		JBrowse link
G Esrra estrogen related receptor alpha enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936599:4,898,534...4,922,758
Ensembl chrNW_004936599:4,897,066...4,904,886 		JBrowse link
G Esrrb estrogen related receptor beta enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936488:5,350,133...5,452,366
Ensembl chrNW_004936488:5,292,466...5,454,689 		JBrowse link
G Esrrg estrogen related receptor gamma enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936628:1,635,161...2,058,198
Ensembl chrNW_004936628:1,830,881...2,058,269 		JBrowse link
G Hnf4g hepatocyte nuclear factor 4 gamma enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936648:3,943,632...3,968,550
Ensembl chrNW_004936648:3,943,626...3,968,622 		JBrowse link
G LOC101955772 olfactory receptor 51E2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:398,888...416,085
Ensembl chrNW_004936498:398,888...416,085 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3 group C member 2 ISO RGD PMID:17260968 RGD:1600931 NCBI chrNW_004936535:1,139,687...1,467,469
Ensembl chrNW_004936535:1,140,178...1,467,471 		JBrowse link
G Paqr7 progestin and adipoQ receptor family member 7 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:10,431,810...10,434,004
Ensembl chrNW_004936474:10,432,769...10,433,806 		JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936476:8,414,768...8,456,740
Ensembl chrNW_004936476:8,416,363...8,456,740 		JBrowse link
G Pgr progesterone receptor enables ISO
IEA		 RGD
Ensembl
UniProt
InterPro		 PMID:11113338 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1601290 NCBI chrNW_004936551:6,498,553...6,573,212
Ensembl chrNW_004936551:6,498,553...6,573,222 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936629:3,672,445...3,725,645
Ensembl chrNW_004936629:3,672,460...3,725,626 		JBrowse link
G Rxra retinoid X receptor alpha enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936669:2,735,111...2,763,060
Ensembl chrNW_004936669:2,738,448...2,763,070 		JBrowse link
G Rxrb retinoid X receptor beta enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936476:25,655,164...25,662,369
Ensembl chrNW_004936476:25,655,209...25,662,416 		JBrowse link
G Rxrg retinoid X receptor gamma enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936481:19,789,753...19,826,665
Ensembl chrNW_004936481:19,789,641...19,826,698 		JBrowse link
G Vdr vitamin D receptor enables ISO (PMID:10678179), (PMID:12016314), (PMID:17082781) UniProt PMID:10678179 PMID:12016314 PMID:17082781 NCBI chrNW_004936512:5,741,836...5,800,999
Ensembl chrNW_004936512:5,740,748...5,801,109 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18185
    molecular transducer activity 1650
      signaling receptor activity 1650
        nuclear receptor activity 52
          bile acid nuclear receptor activity 2
          nuclear steroid receptor activity + 20
Path 2
Term Annotations click to browse term
  molecular_function 18185
    transcription regulator activity 1500
      DNA-binding transcription factor activity 1071
        DNA-binding transcription factor activity, RNA polymerase II-specific 1022
          nuclear receptor activity 52
            bile acid nuclear receptor activity 2
            nuclear steroid receptor activity + 20
paths to the root