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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear receptor activity
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Accession:GO:0004879 term browser browse the term
Definition:A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Comment:Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
Synonyms:exact_synonym: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
 narrow_synonym: 1,25-(OH)2D3 receptor activity;   9-cis retinoic acid receptor activity;   RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding;   RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding;   RXR;   androgen receptor activity;   calcitriol receptor activity;   ecdysteroid hormone receptor activity;   estrogen nuclear receptor activity;   glucocorticoid receptor activity;   juvenile hormone receptor activity;   nuclear hormone receptor;   retinoic acid receptor activity;   retinoid-X receptor activity;   thyroid hormone receptor activity;   vitamin A receptor activity;   vitamin D receptor activity;   vitamin D3 receptor activity
 related_synonym: ligand-dependent nuclear receptor activity;   ligand-dependent transcription factor activity
 alt_id: GO:0003708;   GO:0004880;   GO:0004882;   GO:0004884;   GO:0004886;   GO:0004887;   GO:0008434;   GO:0038050;   GO:0038051;   GO:0038052


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nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor enables
contributes_to		 IEA
IBA
ISO		 (PMID:34521881) Ensembl
GO_Central
UniProt
UniProt		 PMID:34521881 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943 		JBrowse link
G AHRR aryl hydrocarbon receptor repressor enables IBA GO_Central GO_REF:0000033 NCBI chr16:79,730,920...79,810,183
Ensembl chr16:79,730,926...79,810,188 		JBrowse link
G AR androgen receptor NOT|enables ISO
IBA
IEA
ISS		 (PMID:19244107) UniProt
GO_Central
InterPro
BHF-UCL
Ensembl
RGD		 PMID:2341409 PMID:19244107 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:1298681 NCBI chr  X:53,609,113...53,806,778
Ensembl chr  X:53,609,176...53,800,677 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator enables
contributes_to		 IEA
ISO		 (PMID:34521881)
(PMID:11043581)		 Ensembl
UniProt
MGI		 PMID:11043581 PMID:34521881 GO_REF:0000107 NCBI chr 4:98,333,431...98,390,012
Ensembl chr 4:98,333,459...98,389,457 		JBrowse link
G ESR1 estrogen receptor 1 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ESR2 estrogen receptor 2 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565 		JBrowse link
G ESRRA estrogen related receptor alpha enables IBA GO_Central GO_REF:0000033 NCBI chr 2:7,803,504...7,812,868
Ensembl chr 2:7,803,510...7,813,098 		JBrowse link
G ESRRB estrogen related receptor beta enables IBA GO_Central GO_REF:0000033 NCBI chr 7:99,511,135...99,699,478
Ensembl chr 7:99,514,168...99,699,011 		JBrowse link
G ESRRG estrogen related receptor gamma enables IBA GO_Central GO_REF:0000033 NCBI chr10:6,710,615...7,371,419
Ensembl chr10:6,712,860...6,941,501 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr17:46,783,772...46,847,505
Ensembl chr17:46,783,777...46,847,500 		JBrowse link
G HNF4G hepatocyte nuclear factor 4 gamma enables IBA GO_Central GO_REF:0000033 NCBI chr 4:60,505,388...60,641,052
Ensembl chr 4:60,505,385...60,595,789 		JBrowse link
G NKX3-1 NK3 homeobox 1 enables IEA Ensembl GO_REF:0000107 NCBI chr14:7,783,296...7,787,036
Ensembl chr14:7,783,323...7,787,033 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr12:22,263,549...22,274,131
Ensembl chr12:22,263,657...22,271,643 		JBrowse link
G NR1D2 nuclear receptor subfamily 1 group D member 2 enables IBA GO_Central GO_REF:0000033 NCBI chr13:10,756,954...10,791,219
Ensembl chr13:10,756,926...10,791,210 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 enables IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:55,238,536...55,245,457
Ensembl chr 6:55,239,500...55,245,456 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 enables
contributes_to		 IEA
IBA
ISO		 (PMID:17107947) InterPro
GO_Central
BHF-UCL
Ensembl		 PMID:17107947 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:15,315,283...15,336,785
Ensembl chr 2:15,315,282...15,334,820 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 enables IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 enables ISO
IBA
IEA		 RGD
GO_Central
InterPro
Ensembl		 PMID:10967130 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:61490 NCBI chr13:140,373,571...140,406,129
Ensembl chr13:140,364,075...140,406,112 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:89,226,314...89,231,781
Ensembl chr 4:89,226,690...89,236,431 		JBrowse link
G NR2C1 nuclear receptor subfamily 2 group C member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 5:88,231,180...88,278,803
Ensembl chr 5:88,231,274...88,277,997 		JBrowse link
G NR2C2 nuclear receptor subfamily 2 group C member 2 enables IBA GO_Central GO_REF:0000033 NCBI chr13:69,464,798...69,577,638
Ensembl chr13:69,464,795...69,576,946 		JBrowse link
G NR2E1 nuclear receptor subfamily 2 group E member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:74,266,667...74,292,686
Ensembl chr 1:74,271,042...74,292,681 		JBrowse link
G NR2E3 nuclear receptor subfamily 2 group E member 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:169,358,662...169,373,175
Ensembl chr 1:169,360,729...169,366,087 		JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 2:100,447,661...100,457,510
Ensembl chr 2:100,447,705...100,457,506 		JBrowse link
G NR2F2 nuclear receptor subfamily 2 group F member 2 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:83,076,119...83,090,250
Ensembl chr 7:83,076,124...83,090,535 		JBrowse link
G NR2F6 nuclear receptor subfamily 2 group F member 6 enables IBA GO_Central GO_REF:0000033 NCBI chr 2:60,426,116...60,438,178
Ensembl chr 2:60,426,618...60,438,177 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 enables ISS
IBA
IEA		 UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 8:80,303,172...80,669,050
Ensembl chr 8:80,312,234...80,668,412 		JBrowse link
G NR4A1 nuclear receptor subfamily 4, group A, member 1 enables IEA InterPro GO_REF:0000002 NCBI chr 5:17,403,088...17,407,918
Ensembl chr 5:17,385,390...17,408,511 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 enables IEA InterPro GO_REF:0000002 NCBI chr15:63,487,051...63,506,249
Ensembl chr15:63,487,731...63,495,299 		JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 enables IEA InterPro GO_REF:0000002 NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,570,010...241,611,727 		JBrowse link
G NR5A1 nuclear receptor subfamily 5 group A member 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:265,284,491...265,311,547
Ensembl chr 1:265,284,493...265,311,417 		JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:8668203 GO_REF:0000002 GO_REF:0000107 RGD:68248 NCBI chr10:22,727,865...22,866,905
Ensembl chr10:22,715,735...22,865,364 		JBrowse link
G NR6A1 nuclear receptor subfamily 6 group A member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:265,320,597...265,570,941
Ensembl chr 1:265,322,039...265,370,026 		JBrowse link
G PGR progesterone receptor enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:32,035,684...32,129,776
Ensembl chr 9:32,035,684...32,129,221 		JBrowse link
G POU5F1 POU class 5 homeobox 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:23,564,654...23,570,691 JBrowse link
G PPARA peroxisome proliferator activated receptor alpha enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl
InterPro		 PMID:12189208 PMID:12966092 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1580224 RGD:729665 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G PPARBETA peroxisome proliferator activated receptor beta enables IEA InterPro GO_REF:0000002
G PPARD peroxisome proliferator activated receptor delta enables IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:31,222,533...31,295,221
Ensembl chr 7:31,222,585...31,295,211 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma enables IDA
IEA		 (PMID:16239304) GO_Central
InterPro		 PMID:16239304 GO_REF:0000002 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
G RARA retinoic acid receptor alpha enables IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,443...22,085,673 		JBrowse link
G RARB retinoic acid receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr13:12,336,387...12,507,688
Ensembl chr13:12,336,972...12,507,680 		JBrowse link
G RARG retinoic acid receptor gamma enables ISO
IEA		 RGD
InterPro		 PMID:11072095 GO_REF:0000002 RGD:1300463 NCBI chr 5:18,436,267...18,458,625
Ensembl chr 5:18,436,270...18,458,624 		JBrowse link
G RORA RAR related orphan receptor A enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:110,719,004...111,482,807
Ensembl chr 1:111,375,457...111,477,703 		JBrowse link
G RORB RAR related orphan receptor B enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:227,573,972...227,776,806
Ensembl chr 1:227,574,648...227,772,671 		JBrowse link
G RORC RAR related orphan receptor C enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 4:97,374,672...97,399,017
Ensembl chr 4:97,375,136...97,400,209 		JBrowse link
G RXRA retinoid X receptor alpha enables
contributes_to		 IEA
IBA
ISO		 (PMID:17107947) Ensembl
GO_Central
BHF-UCL		 PMID:17107947 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,505...273,797,620 		JBrowse link
G RXRB retinoid X receptor beta enables ISO
IEA
IBA		 RGD
Ensembl
GO_Central		 PMID:1662118 GO_REF:0000033 GO_REF:0000107 RGD:729677 NCBI chr 7:25,236,005...25,242,842
Ensembl chr 7:25,236,004...25,242,875 		JBrowse link
G RXRG retinoid X receptor gamma enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:85,158,313...85,357,116
Ensembl chr 4:85,308,508...85,357,137 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 enables IEA Ensembl GO_REF:0000107 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 enables IEA Ensembl GO_REF:0000107 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
G THRA thyroid hormone receptor alpha enables IEA
IBA
ISS		 Ensembl
GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr12:22,270,506...22,296,684
Ensembl chr12:22,270,062...22,296,618 		JBrowse link
G THRB thyroid hormone receptor beta enables ISO
IBA
IEA		 RGD
GO_Central
InterPro
Ensembl		 PMID:2457590 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:729962 NCBI chr13:10,900,716...11,360,587
Ensembl chr13:10,900,724...11,359,544 		JBrowse link
G VDR vitamin D receptor enables ISO
IBA
IEA
ISS		 RGD
GO_Central
Ensembl
UniProt
InterPro		 PMID:9579411 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:70308 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
bile acid nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1H4 nuclear receptor subfamily 1 group H member 4 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604 		JBrowse link
G VDR vitamin D receptor enables IEA Ensembl GO_REF:0000107 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
nuclear estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ESR2 estrogen receptor 2 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,980 		JBrowse link
G PDE3A phosphodiesterase 3A enables IEA Ensembl GO_REF:0000107 NCBI chr 5:52,413,503...52,737,771
Ensembl chr 5:52,409,882...52,738,406 		JBrowse link
nuclear glucocorticoid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451 		JBrowse link
nuclear steroid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD2 abhydrolase domain containing 2, acylglycerol lipase enables IEA Ensembl GO_REF:0000107 NCBI chr 7:54,655,694...54,776,140
Ensembl chr 7:54,655,804...54,770,131 		JBrowse link
G ESR1 estrogen receptor 1 ISO 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ESR2 estrogen receptor 2 ISO 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565 		JBrowse link
G ESRRA estrogen related receptor alpha enables IEA InterPro GO_REF:0000002 NCBI chr 2:7,803,504...7,812,868
Ensembl chr 2:7,803,510...7,813,098 		JBrowse link
G ESRRB estrogen related receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr 7:99,511,135...99,699,478
Ensembl chr 7:99,514,168...99,699,011 		JBrowse link
G ESRRG estrogen related receptor gamma enables IEA InterPro GO_REF:0000002 NCBI chr10:6,710,615...7,371,419
Ensembl chr10:6,712,860...6,941,501 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha enables IEA InterPro GO_REF:0000002 NCBI chr17:46,783,772...46,847,505
Ensembl chr17:46,783,777...46,847,500 		JBrowse link
G LOC100625684 olfactory receptor 51E2 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:5,431,098...5,434,483
Ensembl chr 9:5,432,611...5,433,573 		JBrowse link
G NR2E3 nuclear receptor subfamily 2 group E member 3 enables IEA InterPro GO_REF:0000002 NCBI chr 1:169,358,662...169,373,175
Ensembl chr 1:169,360,729...169,366,087 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 ISO RGD PMID:17260968 RGD:1600931 NCBI chr 8:80,303,172...80,669,050
Ensembl chr 8:80,312,234...80,668,412 		JBrowse link
G PAQR7 progestin and adipoQ receptor family member 7 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:83,318,408...83,329,567
Ensembl chr 6:83,318,411...83,329,639 		JBrowse link
G PAQR8 progestin and adipoQ receptor family member 8 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:46,228,478...46,231,105
Ensembl chr 7:46,104,677...46,234,449 		JBrowse link
G PGR progesterone receptor enables ISO
IEA		 RGD
UniProt
Ensembl
InterPro		 PMID:11113338 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1601290 NCBI chr 9:32,035,684...32,129,776
Ensembl chr 9:32,035,684...32,129,221 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha enables IEA Ensembl GO_REF:0000107 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G RXRA retinoid X receptor alpha enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,505...273,797,620 		JBrowse link
G RXRB retinoid X receptor beta enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 7:25,236,005...25,242,842
Ensembl chr 7:25,236,004...25,242,875 		JBrowse link
G RXRG retinoid X receptor gamma enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 4:85,158,313...85,357,116
Ensembl chr 4:85,308,508...85,357,137 		JBrowse link
G VDR vitamin D receptor enables ISO (PMID:10678179), (PMID:12016314), (PMID:17082781) UniProt PMID:10678179 PMID:12016314 PMID:17082781 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19428
    molecular transducer activity 2598
      signaling receptor activity 2598
        nuclear receptor activity 60
          bile acid nuclear receptor activity 2
          nuclear steroid receptor activity + 21
Path 2
Term Annotations click to browse term
  molecular_function 19428
    transcription regulator activity 1661
      DNA-binding transcription factor activity 1207
        DNA-binding transcription factor activity, RNA polymerase II-specific 1117
          nuclear receptor activity 60
            bile acid nuclear receptor activity 2
            nuclear steroid receptor activity + 21
paths to the root