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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear receptor activity
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Accession:GO:0004879 term browser browse the term
Definition:A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Comment:Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
Synonyms:exact_synonym: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
 narrow_synonym: 1,25-(OH)2D3 receptor activity;   9-cis retinoic acid receptor activity;   RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding;   RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding;   RXR;   androgen receptor activity;   calcitriol receptor activity;   ecdysteroid hormone receptor activity;   estrogen nuclear receptor activity;   glucocorticoid receptor activity;   juvenile hormone receptor activity;   nuclear hormone receptor;   retinoic acid receptor activity;   retinoid-X receptor activity;   thyroid hormone receptor activity;   vitamin A receptor activity;   vitamin D receptor activity;   vitamin D3 receptor activity
 related_synonym: ligand-dependent nuclear receptor activity;   ligand-dependent transcription factor activity
 alt_id: GO:0003708;   GO:0004880;   GO:0004882;   GO:0004884;   GO:0004886;   GO:0004887;   GO:0008434;   GO:0038050;   GO:0038051;   GO:0038052

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nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor contributes_to
enables		 ISO
IEA		 (PMID:34521881) UniProt
TreeGrafter
UniProt		 PMID:34521881 GO_REF:0000117 GO_REF:0000118 NCBI chrNW_004624739:12,939,183...12,987,574
Ensembl chrNW_004624739:12,942,165...12,987,973 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624751:128,596...212,170
Ensembl chrNW_004624751:139,085...209,546 		JBrowse link
G Ar androgen receptor enables
NOT|enables		 ISO
IEA		 (PMID:19244107) RGD
InterPro
UniProt		 PMID:2341409 PMID:19244107 GO_REF:0000002 RGD:1298681 NCBI chrNW_004624891:3,135,824...3,330,487
Ensembl chrNW_004624891:3,138,848...3,329,459 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator contributes_to ISO (PMID:34521881)
(PMID:11043581)		 UniProt
MGI		 PMID:11043581 PMID:34521881 NCBI chrNW_004624772:18,949,221...19,016,672
Ensembl chrNW_004624772:18,949,108...19,015,504 		JBrowse link
G Esr1 estrogen receptor 1 enables ISO (PMID:18722177)
(PMID:15831516)
(PMID:15322135)		 MGI
BHF-UCL		 PMID:15322135 PMID:15831516 PMID:18722177 NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326 		JBrowse link
G Esr2 estrogen receptor 2 enables ISO (PMID:19126643) ParkinsonsUK-UCL PMID:19126643 NCBI chrNW_004624734:36,742,913...36,862,993
Ensembl chrNW_004624734:36,759,104...36,825,295 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624790:10,039,344...10,065,167
Ensembl chrNW_004624790:10,038,999...10,100,649 		JBrowse link
G LOC101701774 nuclear receptor subfamily 1 group D member 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624788:1,687,804...1,722,690 JBrowse link
G LOC101706229 peroxisome proliferator-activated receptor delta-like enables IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624753:6,737,001...6,741,152 JBrowse link
G LOC101707175 nuclear receptor subfamily 1 group I member 3-like enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624807:1,684,834...1,693,416 JBrowse link
G LOC101708217 nuclear receptor subfamily 1 group D member 2-like enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624768:18,984,014...18,986,358 JBrowse link
G LOC101718819 bile acid receptor-like enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624772:10,494,253...10,521,634 JBrowse link
G LOC101726439 peroxisome proliferator-activated receptor delta-like enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624952:751,157...757,894 JBrowse link
G Nkx3-1 NK3 homeobox 1 enables ISO (PMID:19886863) UniProt PMID:19886863 NCBI chrNW_004624758:18,874,399...18,876,982
Ensembl chrNW_004624758:18,875,475...18,876,971 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1 group D member 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624795:3,102,424...3,109,497
Ensembl chrNW_004624795:3,102,439...3,109,497 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1 group H member 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624832:4,136,052...4,141,648
Ensembl chrNW_004624832:4,132,904...4,140,896 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1 group H member 3 enables
contributes_to		 IEA
ISO		 (PMID:17107947) InterPro
BHF-UCL
TreeGrafter		 PMID:17107947 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624767:1,459,601...1,473,224
Ensembl chrNW_004624767:1,459,601...1,467,795 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1 group I member 2 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:10967130 GO_REF:0000002 GO_REF:0000118 RGD:61490 NCBI chrNW_004624731:28,371,707...28,405,327
Ensembl chrNW_004624731:28,371,707...28,381,357 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1 group I member 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624794:141,316...158,059 JBrowse link
G Nr2f2 nuclear receptor subfamily 2 group F member 2 enables ISO (PMID:18798693) UniProt PMID:18798693 NCBI chrNW_004624768:7,713,771...7,728,102
Ensembl chrNW_004624768:7,701,674...7,728,408 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 enables ISO (PMID:17635946) UniProt PMID:17635946 NCBI chrNW_004624774:2,496,276...2,603,894
Ensembl chrNW_004624774:2,495,304...2,602,632 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4 group A member 1 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624816:271,345...288,265
Ensembl chrNW_004624816:267,303...293,227 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624732:9,572,160...9,589,624
Ensembl chrNW_004624732:9,581,779...9,589,942 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624825:1,098,915...1,141,373
Ensembl chrNW_004624825:1,097,432...1,141,446 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5 group A member 1 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624760:10,603,504...10,626,259
Ensembl chrNW_004624760:10,605,877...10,626,386 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5 group A member 2 enables ISO
IEA		 RGD
InterPro		 PMID:8668203 GO_REF:0000002 RGD:68248 NCBI chrNW_004624798:356,953...494,877 JBrowse link
G Pgr progesterone receptor enables ISO (PMID:14681235) MGI PMID:14681235 NCBI chrNW_004624878:1,714,196...1,769,302
Ensembl chrNW_004624878:1,714,559...1,762,421 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha enables ISO
IEA		 RGD
Ensembl
TreeGrafter
InterPro		 PMID:12189208 PMID:12966092 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1580224 RGD:729665 NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672 		JBrowse link
G Ppard peroxisome proliferator activated receptor delta enables IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624754:22,021,465...22,084,320 JBrowse link
G Pparg peroxisome proliferator activated receptor gamma enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624956:84,673...207,176
Ensembl chrNW_004624956:83,842...149,481 		JBrowse link
G Rara retinoic acid receptor alpha enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624795:2,935,432...2,975,226
Ensembl chrNW_004624795:2,934,731...2,967,232 		JBrowse link
G Rarb retinoic acid receptor beta enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624788:2,738,341...3,493,140
Ensembl chrNW_004624788:3,257,697...3,493,132 		JBrowse link
G Rarg retinoic acid receptor gamma enables ISO
IEA		 RGD
InterPro		 PMID:11072095 GO_REF:0000002 RGD:1300463 NCBI chrNW_004624904:1,255,854...1,277,946 JBrowse link
G Rora RAR related orphan receptor A enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624781:11,014,185...11,688,558
Ensembl chrNW_004624781:11,014,286...11,679,678 		JBrowse link
G Rorb RAR related orphan receptor B enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624811:2,076,474...2,281,933
Ensembl chrNW_004624811:2,076,437...2,277,040 		JBrowse link
G Rorc RAR related orphan receptor C enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624772:19,478,403...19,501,184
Ensembl chrNW_004624772:19,477,093...19,501,169 		JBrowse link
G Rxra retinoid X receptor alpha contributes_to
enables		 ISO (PMID:17107947)
(PMID:1312497), (PMID:15322135)
(PMID:1651173), (PMID:20219900), (PMID:25592151), (PMID:7990953), (PMID:9267036)		 BHF-UCL
MGI		 PMID:1312497 PMID:1651173 PMID:7990953 PMID:9267036 PMID:15322135 More... NCBI chrNW_004624760:2,379,809...2,455,749
Ensembl chrNW_004624760:2,380,708...2,456,928 		JBrowse link
G Rxrb retinoid X receptor beta enables ISO (PMID:1662118), (PMID:7990953) RGD
GO_Central		 PMID:1662118 PMID:7990953 RGD:729677 NCBI chrNW_004624754:23,607,046...23,613,399
Ensembl chrNW_004624754:23,606,955...23,613,508 		JBrowse link
G Rxrg retinoid X receptor gamma enables ISO (PMID:1312497) MGI PMID:1312497 NCBI chrNW_004624826:3,723,056...3,969,597
Ensembl chrNW_004624826:3,736,290...3,780,338 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 enables ISO (PMID:23610160) ParkinsonsUK-UCL PMID:23610160 NCBI chrNW_004624849:3,602,103...3,623,922
Ensembl chrNW_004624849:3,602,261...3,623,465 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 enables ISO (PMID:17324931) BHF-UCL PMID:17324931 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200 		JBrowse link
G Thra thyroid hormone receptor alpha enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624795:3,109,663...3,132,494
Ensembl chrNW_004624795:3,108,854...3,132,464 		JBrowse link
G Thrb thyroid hormone receptor beta enables ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro		 PMID:2457590 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:729962 NCBI chrNW_004624788:1,950,888...2,348,895
Ensembl chrNW_004624788:1,950,890...2,349,343 		JBrowse link
G Vdr vitamin D receptor enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:9579411 GO_REF:0000002 GO_REF:0000118 RGD:70308 NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514 		JBrowse link
bile acid nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1 group H member 4 enables ISO PMID:12718893
PMID:10334992
(PMID:10334992), (PMID:21757002), (PMID:23767959)
(PMID:21757002)		 UniProt
ParkinsonsUK-UCL
BHF-UCL		 PMID:10334992 PMID:12718893 PMID:21757002 PMID:23767959 RGD:15090836 RGD:1625198 NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834 		JBrowse link
G Vdr vitamin D receptor enables ISO (PMID:12016314), (PMID:32354638) UniProt PMID:12016314 PMID:32354638 NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514 		JBrowse link
nuclear estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326 		JBrowse link
G Esr2 estrogen receptor 2 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624734:36,742,913...36,862,993
Ensembl chrNW_004624734:36,759,104...36,825,295 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 enables IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624740:26,627,560...26,632,483
Ensembl chrNW_004624740:26,627,473...26,632,027 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO (PMID:31420216), (PMID:35104454) UniProt PMID:31420216 PMID:35104454 NCBI chrNW_004624752:17,773,803...18,088,611
Ensembl chrNW_004624752:17,781,647...17,829,771 		JBrowse link
nuclear glucocorticoid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3 group C member 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004624774:2,496,276...2,603,894
Ensembl chrNW_004624774:2,495,304...2,602,632 		JBrowse link
nuclear steroid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase enables ISO (PMID:26989199) UniProt PMID:26989199 NCBI chrNW_004624768:16,283,369...16,404,476
Ensembl chrNW_004624768:16,297,464...16,402,624 		JBrowse link
G Esr1 estrogen receptor 1 ISO 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326 		JBrowse link
G Esr2 estrogen receptor 2 enables ISO
IEA		 17-beta-estradiol (E2) RGD
InterPro		 PMID:17928626 GO_REF:0000002 RGD:5128669 NCBI chrNW_004624734:36,742,913...36,862,993
Ensembl chrNW_004624734:36,759,104...36,825,295 		JBrowse link
G Esrra estrogen related receptor alpha enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624767:21,999,932...22,007,582
Ensembl chrNW_004624767:21,999,932...22,009,485 		JBrowse link
G Esrrb estrogen related receptor beta enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624734:25,261,493...25,369,092
Ensembl chrNW_004624734:25,261,493...25,430,045 		JBrowse link
G Esrrg estrogen related receptor gamma enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624835:815,230...1,326,376
Ensembl chrNW_004624835:812,742...1,015,767 		JBrowse link
G LOC101711499 olfactory receptor 51E2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624817:5,884,459...5,885,453
Ensembl chrNW_004624817:5,884,459...5,906,319 		JBrowse link
G Paqr7 progestin and adipoQ receptor family member 7 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:9,953,032...9,962,096
Ensembl chrNW_004624764:9,953,038...9,958,879 		JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624855:3,693,582...3,735,854
Ensembl chrNW_004624855:3,693,541...3,735,970 		JBrowse link
G Pgr progesterone receptor enables ISO
IEA		 RGD
InterPro
UniProt		 PMID:11113338 GO_REF:0000002 GO_REF:0000104 RGD:1601290 NCBI chrNW_004624878:1,714,196...1,769,302
Ensembl chrNW_004624878:1,714,559...1,762,421 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672 		JBrowse link
G Rxra retinoid X receptor alpha enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004624760:2,379,809...2,455,749
Ensembl chrNW_004624760:2,380,708...2,456,928 		JBrowse link
G Rxrb retinoid X receptor beta enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004624754:23,607,046...23,613,399
Ensembl chrNW_004624754:23,606,955...23,613,508 		JBrowse link
G Rxrg retinoid X receptor gamma enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004624826:3,723,056...3,969,597
Ensembl chrNW_004624826:3,736,290...3,780,338 		JBrowse link
G Vdr vitamin D receptor enables ISO (PMID:10678179), (PMID:12016314), (PMID:17082781) UniProt PMID:10678179 PMID:12016314 PMID:17082781 NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18442
    molecular transducer activity 1985
      signaling receptor activity 1985
        nuclear receptor activity 54
          bile acid nuclear receptor activity 2
          nuclear steroid receptor activity + 18
Path 2
Term Annotations click to browse term
  molecular_function 18442
    transcription regulator activity 1650
      DNA-binding transcription factor activity 1212
        DNA-binding transcription factor activity, RNA polymerase II-specific 1158
          nuclear receptor activity 54
            bile acid nuclear receptor activity 2
            nuclear steroid receptor activity + 18
paths to the root