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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear receptor activity
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Accession:GO:0004879 term browser browse the term
Definition:A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Comment:Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
Synonyms:exact_synonym: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
 narrow_synonym: 1,25-(OH)2D3 receptor activity;   9-cis retinoic acid receptor activity;   RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding;   RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding;   RXR;   androgen receptor activity;   calcitriol receptor activity;   ecdysteroid hormone receptor activity;   estrogen nuclear receptor activity;   glucocorticoid receptor activity;   juvenile hormone receptor activity;   nuclear hormone receptor;   retinoic acid receptor activity;   retinoid-X receptor activity;   thyroid hormone receptor activity;   vitamin A receptor activity;   vitamin D receptor activity;   vitamin D3 receptor activity
 related_synonym: ligand-dependent nuclear receptor activity;   ligand-dependent transcription factor activity
 alt_id: GO:0003708;   GO:0004880;   GO:0004882;   GO:0004884;   GO:0004886;   GO:0004887;   GO:0008434;   GO:0038050;   GO:0038051;   GO:0038052


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nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC019117.1 novel protein enables IEA UniProt GO_REF:0000117 Ensembl chr 7:17,299,295...17,467,234 JBrowse link
G AHR aryl hydrocarbon receptor contributes_to
enables		 IDA
IBA
IEA		 (PMID:34521881)
(PMID:10395741), (PMID:28602820), (PMID:32818467), (PMID:32866000)		 UniProt
GO_Central		 PMID:10395741 PMID:28602820 PMID:32818467 PMID:32866000 PMID:34521881 GO_REF:0000033 GO_REF:0000117 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AHRR aryl hydrocarbon receptor repressor enables IBA GO_Central GO_REF:0000033 NCBI chr 5:321,714...438,285
Ensembl chr 5:321,714...438,291 		JBrowse link
G AR androgen receptor enables
NOT|enables		 ISO
IBA
IEA
IDA
IMP
TAS		 (PMID:19244107)
(PMID:19345326)
(PMID:12799378), (PMID:17277772), (PMID:19886863), (PMID:20048160), (PMID:25091737)
(PMID:15572661)		 RGD
GO_Central
InterPro
Ensembl
UniProt
BHF-UCL		 PMID:2341409 PMID:12799378 PMID:15572661 PMID:17277772 PMID:19244107 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1298681 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator enables
contributes_to		 IEA
IDA		 (PMID:34521881) Ensembl
UniProt		 PMID:34521881 GO_REF:0000107 NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708 		JBrowse link
G ESR1 estrogen receptor 1 enables IGI
IDA
IBA
IEA		 (PMID:18722177)
(PMID:15831516)		 MGI
BHF-UCL
GO_Central
Ensembl		 PMID:15831516 PMID:18722177 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 enables NAS
IBA
IDA		 (PMID:9671811)
(PMID:19126643)		 UniProt
GO_Central
ParkinsonsUK-UCL		 PMID:9671811 PMID:19126643 GO_REF:0000033 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G ESRRA estrogen related receptor alpha enables IBA GO_Central GO_REF:0000033 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743 		JBrowse link
G ESRRB estrogen related receptor beta enables IBA
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 NCBI chr14:76,310,777...76,501,837
Ensembl chr14:76,310,712...76,501,837 		JBrowse link
G ESRRG estrogen related receptor gamma enables IBA GO_Central GO_REF:0000033 NCBI chr 1:216,503,246...217,137,702
Ensembl chr 1:216,503,246...217,137,755 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha enables IDA
IBA		 (PMID:12193589) GO_Central PMID:12193589 GO_REF:0000033 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845 		JBrowse link
G HNF4G hepatocyte nuclear factor 4 gamma enables IBA GO_Central GO_REF:0000033 NCBI chr 8:75,407,649...75,566,834
Ensembl chr 8:75,407,914...75,566,834 		JBrowse link
G NKX3-1 NK3 homeobox 1 enables IDA (PMID:19886863) UniProt PMID:19886863 NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 enables TAS
IBA		 (PMID:8622974) PINC
GO_Central		 PMID:8622974 GO_REF:0000033 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589 		JBrowse link
G NR1D2 nuclear receptor subfamily 1 group D member 2 enables TAS
IBA		 (PMID:7997240) UniProt
GO_Central		 PMID:7997240 GO_REF:0000033 NCBI chr 3:23,945,286...23,980,617
Ensembl chr 3:23,945,286...23,980,637 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 enables IEA
IBA
TAS		 (PMID:7926814) Ensembl
GO_Central
PINC
InterPro		 PMID:7926814 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 enables
contributes_to		 IDA
IBA
ISO
TAS
IEA		 (PMID:19481530)
(PMID:17107947)
(PMID:24603323), (PMID:7744246)		 GO_Central
BHF-UCL
InterPro
Ensembl		 PMID:7744246 PMID:17107947 PMID:19481530 PMID:24603323 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 enables TAS
IBA
IDA
IEA		 (PMID:10334993)
(PMID:27471003)		 PINC
GO_Central
MGI
InterPro
Ensembl		 PMID:10334993 PMID:27471003 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 enables ISO
IBA
IDA
IEA		 (PMID:12578355) RGD
GO_Central
UniProt
InterPro
Ensembl		 PMID:10967130 PMID:12578355 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:61490 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 enables TAS
IBA
IDA
IEA		 (PMID:8114692)
(PMID:9783588)		 PINC
GO_Central
InterPro		 PMID:8114692 PMID:9783588 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G NR2C1 nuclear receptor subfamily 2 group C member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr12:95,020,229...95,073,618
Ensembl chr12:95,020,229...95,073,628 		JBrowse link
G NR2C2 nuclear receptor subfamily 2 group C member 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 3:14,947,583...15,049,273
Ensembl chr 3:14,947,583...15,053,600 		JBrowse link
G NR2E1 nuclear receptor subfamily 2 group E member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:108,166,022...108,188,809
Ensembl chr 6:108,166,022...108,188,805 		JBrowse link
G NR2E3 nuclear receptor subfamily 2 group E member 3 enables TAS
IBA		 (PMID:10220376) PINC
GO_Central		 PMID:10220376 GO_REF:0000033 NCBI chr15:71,810,554...71,818,253
Ensembl chr15:71,792,638...71,818,259 		JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 5:93,583,222...93,594,611
Ensembl chr 5:93,583,222...93,594,611 		JBrowse link
G NR2F2 nuclear receptor subfamily 2 group F member 2 enables TAS
IBA
IDA		 (PMID:1899293)
(PMID:18798693)		 PINC
GO_Central
UniProt		 PMID:1899293 PMID:18798693 GO_REF:0000033 NCBI chr15:96,326,046...96,340,263
Ensembl chr15:96,325,938...96,340,263 		JBrowse link
G NR2F6 nuclear receptor subfamily 2 group F member 6 enables IBA GO_Central GO_REF:0000033 NCBI chr19:17,231,883...17,245,919
Ensembl chr19:17,231,883...17,245,919 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 enables IDA
IBA		 (PMID:17635946) UniProt
GO_Central		 PMID:17635946 GO_REF:0000033 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 enables IEA
TAS		 (PMID:2626032) InterPro
PINC		 PMID:2626032 GO_REF:0000002 NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 enables IEA
TAS		 (PMID:16243425) InterPro
ParkinsonsUK-UCL		 PMID:16243425 GO_REF:0000002 NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348 		JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 enables IEA
TAS		 (PMID:8570200) InterPro
PINC		 PMID:8570200 GO_REF:0000002 NCBI chr 9:99,821,885...99,866,891
Ensembl chr 9:99,821,855...99,866,891 		JBrowse link
G NR5A1 nuclear receptor subfamily 5 group A member 1 enables IEA
IDA		 (PMID:23610160), (PMID:8205615) InterPro
ParkinsonsUK-UCL		 PMID:8205615 PMID:23610160 GO_REF:0000002 NCBI chr 9:124,481,236...124,507,399
Ensembl chr 9:124,481,236...124,507,420 		JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 enables ISO
IDA
IEA
TAS		 (PMID:15205472), (PMID:18410128), (PMID:21614002), (PMID:22187462), (PMID:22504882), (PMID:23737522), (PMID:26416531), (PMID:26553876), (PMID:27984042), (PMID:32433991), (PMID:38409506)
(PMID:16271724)		 RGD
UniProt
Ensembl
InterPro		 PMID:8668203 PMID:15205472 PMID:16271724 PMID:18410128 PMID:21614002 More... GO_REF:0000002 GO_REF:0000107 RGD:68248 NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420 		JBrowse link
G NR6A1 nuclear receptor subfamily 6 group A member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 9:124,517,275...124,771,311
Ensembl chr 9:124,517,275...124,771,311 		JBrowse link
G PGR progesterone receptor enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 enables IEA InterPro GO_REF:0000002 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha enables ISO
IBA
IEA
IDA		 (PMID:12955147), (PMID:19955185) RGD
GO_Central
Ensembl
BHF-UCL
InterPro		 PMID:12189208 PMID:12955147 PMID:12966092 PMID:19955185 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1580224 RGD:729665 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta enables IDA
IBA
IEA		 (PMID:12955147) UniProt
GO_Central
InterPro		 PMID:12955147 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma enables IEA
IBA
IDA		 (PMID:10622252), (PMID:12955147), (PMID:16239304), (PMID:18293083) InterPro
GO_Central
BHF-UCL		 PMID:10622252 PMID:12955147 PMID:16239304 PMID:18293083 GO_REF:0000002 GO_REF:0000033 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G RARA retinoic acid receptor alpha enables IDA
IBA
IEA		 (PMID:21131358), (PMID:2825025) ARUK-UCL
GO_Central
InterPro
Ensembl		 PMID:2825025 PMID:21131358 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G RARB retinoic acid receptor beta enables IDA
IBA
TAS
IEA		 (PMID:2177841)
(PMID:2833708)		 UniProt
GO_Central
PINC
InterPro		 PMID:2177841 PMID:2833708 GO_REF:0000002 GO_REF:0000033 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932 		JBrowse link
G RARG retinoic acid receptor gamma enables ISO
IBA
IEA		 RGD
GO_Central
InterPro
Ensembl		 PMID:11072095 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1300463 NCBI chr12:53,210,569...53,232,209
Ensembl chr12:53,210,567...53,232,980 		JBrowse link
G RORA RAR related orphan receptor A enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
G RORB RAR related orphan receptor B enables TAS
IBA
IEA		 (PMID:7935491) PINC
GO_Central
InterPro		 PMID:7935491 GO_REF:0000002 GO_REF:0000033 NCBI chr 9:74,497,335...74,693,177
Ensembl chr 9:74,497,335...74,693,177 		JBrowse link
G RORC RAR related orphan receptor C enables TAS
IBA
IEA		 (PMID:7811290) PINC
GO_Central
InterPro		 PMID:7811290 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
G RXRA retinoid X receptor alpha enables
contributes_to		 TAS
IBA
ISO
IDA		 (PMID:1310260)
(PMID:17107947)
(PMID:1651173), (PMID:20219900), (PMID:25592151), (PMID:7990953), (PMID:9267036)		 PINC
GO_Central
BHF-UCL
BHF-UCL		 PMID:1310260 PMID:1651173 PMID:7990953 PMID:9267036 PMID:17107947 More... GO_REF:0000033 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G RXRB retinoid X receptor beta enables ISO
IBA
IDA		 (PMID:1662118), (PMID:7990953) RGD
GO_Central		 PMID:1662118 PMID:7990953 GO_REF:0000033 RGD:729677 NCBI chr 6:33,193,588...33,200,853
Ensembl chr 6:33,193,588...33,200,665 		JBrowse link
G RXRG retinoid X receptor gamma enables TAS
IBA
IEA		 (PMID:8034312) PINC
GO_Central
Ensembl		 PMID:8034312 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:165,400,922...165,445,126
Ensembl chr 1:165,400,922...165,445,355 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 enables IDA (PMID:23610160) ParkinsonsUK-UCL PMID:23610160 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 enables IDA (PMID:17324931) BHF-UCL PMID:17324931 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G THRA thyroid hormone receptor alpha enables IEA
IBA
IDA		 (PMID:15466465), (PMID:18052923), (PMID:8710870) InterPro
GO_Central
Ensembl
UniProt		 PMID:8710870 PMID:15466465 PMID:18052923 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G THRB thyroid hormone receptor beta enables ISO
IBA
TAS
IEA
IDA		 (PMID:1618799)
(PMID:15466465)		 RGD
GO_Central
PINC
InterPro
UniProt
Ensembl		 PMID:1618799 PMID:2457590 PMID:15466465 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:729962 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
G VDR vitamin D receptor enables ISO
IDA
IBA
IEA
IMP		 (PMID:16549446), (PMID:17082781)
(PMID:28698609)		 RGD
BHF-UCL
GO_Central
InterPro
Ensembl
UniProt		 PMID:9579411 PMID:16549446 PMID:17082781 PMID:28698609 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:70308 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
bile acid nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1H4 nuclear receptor subfamily 1 group H member 4 enables IEA
IDA
TAS		 (PMID:10334992), (PMID:21757002), (PMID:23767959) Ensembl
ParkinsonsUK-UCL
Reactome		 PMID:10334992 PMID:21757002 PMID:23767959 GO_REF:0000107 Reactome:R-HSA-5340195 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G VDR vitamin D receptor enables IDA (PMID:12016314), (PMID:32354638) UniProt PMID:12016314 PMID:32354638 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
nuclear estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 enables TAS
IDA
IEA
NAS		 (PMID:11004670)
(PMID:15831516), (PMID:9338790), (PMID:9841876)
(PMID:3753802)		 UniProt
CAFA
InterPro		 PMID:3753802 PMID:9338790 PMID:9841876 PMID:11004670 PMID:15831516 GO_REF:0000002 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 enables TAS
IMP
IEA
IDA		 (PMID:11181953)
(PMID:29261182), (PMID:30113650)
(PMID:19126643), (PMID:24033289)		 UniProt
InterPro
ParkinsonsUK-UCL		 PMID:11181953 PMID:19126643 PMID:24033289 PMID:29261182 PMID:30113650 GO_REF:0000002 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 enables IEA
IBA
IDA		 (PMID:15539556), (PMID:15705806) Ensembl
GO_Central
UniProt		 PMID:15539556 PMID:15705806 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815 		JBrowse link
G PDE3A phosphodiesterase 3A enables IDA (PMID:31420216), (PMID:35104454) UniProt PMID:31420216 PMID:35104454 NCBI chr12:20,368,537...20,688,583
Ensembl chr12:20,368,537...20,688,583 		JBrowse link
nuclear glucocorticoid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 enables TAS
IEA		 (PMID:8621628) PINC
InterPro
Ensembl		 PMID:8621628 GO_REF:0000002 GO_REF:0000107 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
nuclear steroid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD2 abhydrolase domain containing 2, acylglycerol lipase enables IDA (PMID:26989199) UniProt PMID:26989199 NCBI chr15:89,040,998...89,202,355
Ensembl chr15:89,087,459...89,202,355 		JBrowse link
G ESR1 estrogen receptor 1 enables ISO
IEA
NAS		 17-beta-estradiol (E2)
(PMID:11004670)		 RGD
InterPro
UniProt		 PMID:11004670 PMID:17928626 GO_REF:0000002 RGD:5128669 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 enables ISO
TAS
IEA		 17-beta-estradiol (E2)
(PMID:10749889)		 RGD
PINC
InterPro		 PMID:10749889 PMID:17928626 GO_REF:0000002 RGD:5128669 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G ESRRA estrogen related receptor alpha enables IEA InterPro GO_REF:0000002 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743 		JBrowse link
G ESRRB estrogen related receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr14:76,310,777...76,501,837
Ensembl chr14:76,310,712...76,501,837 		JBrowse link
G ESRRG estrogen related receptor gamma enables IEA InterPro GO_REF:0000002 NCBI chr 1:216,503,246...217,137,702
Ensembl chr 1:216,503,246...217,137,755 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha enables IEA InterPro GO_REF:0000002 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 enables TAS (PMID:1971514) PINC PMID:1971514 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589 		JBrowse link
G NR2C1 nuclear receptor subfamily 2 group C member 1 enables TAS (PMID:2597158) PINC PMID:2597158 NCBI chr12:95,020,229...95,073,618
Ensembl chr12:95,020,229...95,073,628 		JBrowse link
G NR2E1 nuclear receptor subfamily 2 group E member 1 enables TAS (PMID:9628820) PINC PMID:9628820 NCBI chr 6:108,166,022...108,188,809
Ensembl chr 6:108,166,022...108,188,805 		JBrowse link
G NR2E3 nuclear receptor subfamily 2 group E member 3 enables IEA InterPro GO_REF:0000002 NCBI chr15:71,810,554...71,818,253
Ensembl chr15:71,792,638...71,818,259 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 enables ISO
TAS		 (PMID:9662404) RGD
PINC		 PMID:9662404 PMID:17260968 RGD:1600931 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698 		JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 enables TAS (PMID:8570200) PINC PMID:8570200 NCBI chr 9:99,821,885...99,866,891
Ensembl chr 9:99,821,855...99,866,891 		JBrowse link
G OR51E2 olfactory receptor family 51 subfamily E member 2 enables IDA (PMID:19389702) UniProt PMID:19389702 NCBI chr11:4,680,171...4,697,853
Ensembl chr11:4,680,171...4,697,854 		JBrowse link
G PAQR7 progestin and adipoQ receptor family member 7 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:25,861,484...25,875,708
Ensembl chr 1:25,861,484...25,875,708 		JBrowse link
G PAQR8 progestin and adipoQ receptor family member 8 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:52,362,151...52,407,777
Ensembl chr 6:52,361,421...52,407,777 		JBrowse link
G PGR progesterone receptor enables ISO
IDA
TAS
IEA		 (PMID:10757795), (PMID:9620806)
(PMID:10840043)		 RGD
UniProt
PINC
InterPro
Ensembl		 PMID:9620806 PMID:10757795 PMID:10840043 PMID:11113338 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1601290 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PGRMC2 progesterone receptor membrane component 2 enables TAS (PMID:9705155) PINC PMID:9705155 NCBI chr 4:128,269,242...128,287,813
Ensembl chr 4:128,269,237...128,288,829 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha enables IDA (PMID:19955185) BHF-UCL PMID:19955185 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta enables TAS (PMID:1333051) PINC PMID:1333051 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G RXRA retinoid X receptor alpha enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G RXRB retinoid X receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr 6:33,193,588...33,200,853
Ensembl chr 6:33,193,588...33,200,665 		JBrowse link
G RXRG retinoid X receptor gamma enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 1:165,400,922...165,445,126
Ensembl chr 1:165,400,922...165,445,355 		JBrowse link
G VDR vitamin D receptor enables IDA (PMID:10678179), (PMID:12016314), (PMID:17082781) UniProt PMID:10678179 PMID:12016314 PMID:17082781 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19683
    molecular transducer activity 1616
      signaling receptor activity 1616
        nuclear receptor activity 61
          bile acid nuclear receptor activity 2
          nuclear steroid receptor activity + 27
Path 2
Term Annotations click to browse term
  molecular_function 19683
    transcription regulator activity 1982
      DNA-binding transcription factor activity 1461
        DNA-binding transcription factor activity, RNA polymerase II-specific 1362
          nuclear receptor activity 61
            bile acid nuclear receptor activity 2
            nuclear steroid receptor activity + 27
paths to the root