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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear receptor activity
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Accession:GO:0004879 term browser browse the term
Definition:A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Comment:Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
Synonyms:exact_synonym: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
 narrow_synonym: 1,25-(OH)2D3 receptor activity;   9-cis retinoic acid receptor activity;   RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding;   RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding;   RXR;   androgen receptor activity;   calcitriol receptor activity;   ecdysteroid hormone receptor activity;   estrogen nuclear receptor activity;   glucocorticoid receptor activity;   juvenile hormone receptor activity;   nuclear hormone receptor;   retinoic acid receptor activity;   retinoid-X receptor activity;   thyroid hormone receptor activity;   vitamin A receptor activity;   vitamin D receptor activity;   vitamin D3 receptor activity
 related_synonym: ligand-dependent nuclear receptor activity;   ligand-dependent transcription factor activity
 alt_id: GO:0003708;   GO:0004880;   GO:0004882;   GO:0004884;   GO:0004886;   GO:0004887;   GO:0008434;   GO:0038050;   GO:0038051;   GO:0038052

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nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor enables
contributes_to		 IEA
ISO		 (PMID:34521881) Ensembl
TreeGrafter
UniProt
UniProt		 PMID:34521881 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr21:40,778,198...40,826,491
Ensembl chr21:40,778,218...40,826,478 		JBrowse link
G AHRR aryl-hydrocarbon receptor repressor enables IEA TreeGrafter GO_REF:0000118 NCBI chr 4:220,523...329,973
Ensembl chr 4:243,026...326,722 		JBrowse link
G AR androgen receptor enables
NOT|enables		 ISO
IEA		 (PMID:19244107) RGD
Ensembl
InterPro
UniProt		 PMID:2341409 PMID:19244107 GO_REF:0000002 GO_REF:0000107 RGD:1298681 NCBI chr  X:57,380,587...57,553,613
Ensembl chr  X:57,380,611...57,546,776 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator enables
contributes_to		 IEA
ISO		 (PMID:11043581)
(PMID:34521881)		 Ensembl
MGI
UniProt		 PMID:11043581 PMID:34521881 GO_REF:0000107
G ESR1 estrogen receptor 1 enables IEA Ensembl GO_REF:0000107 NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549 		JBrowse link
G ESR2 estrogen receptor 2 enables IEA Ensembl GO_REF:0000107 NCBI chr24:41,426,333...41,513,802
Ensembl chr24:41,447,224...41,512,486 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha enables IEA Ensembl GO_REF:0000107 NCBI chr 2:19,390,870...19,466,300
Ensembl chr 2:19,388,891...19,421,664 		JBrowse link
G LOC103223491 peroxisome proliferator-activated receptor alpha enables ISO
IEA		 RGD
InterPro
TreeGrafter
Ensembl		 PMID:12189208 PMID:12966092 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1580224 RGD:729665 NCBI chr19:28,614,892...28,709,272
Ensembl chr19:28,615,413...28,708,763 		JBrowse link
G LOC103230356 uncharacterized LOC103230356 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:8668203 GO_REF:0000002 GO_REF:0000107 RGD:68248 NCBI chr25:29,230,358...29,380,617
Ensembl chr25:29,233,558...29,379,922 		JBrowse link
G NKX3-1 NK3 homeobox 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:21,792,069...21,797,258
Ensembl chr 8:21,791,422...21,796,319 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr16:66,078,990...66,086,927
Ensembl chr16:66,079,089...66,090,685 		JBrowse link
G NR1D2 nuclear receptor subfamily 1 group D member 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:68,632,142...68,668,467
Ensembl chr15:68,632,197...68,665,258 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:43,438,428...43,445,190
Ensembl chr 6:43,437,950...43,446,063 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 enables
contributes_to		 IEA
ISO		 (PMID:17107947) Ensembl
BHF-UCL
TreeGrafter
InterPro		 PMID:17107947 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:18,041,495...18,061,196
Ensembl chr 1:18,041,830...18,051,501 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:95,792,428...95,877,989
Ensembl chr11:95,792,996...95,878,293 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:10967130 GO_REF:0000107 GO_REF:0000118 RGD:61490 NCBI chr22:61,005,404...61,043,016
Ensembl chr22:61,006,667...61,040,832 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 enables IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:2,724,843...2,752,999
Ensembl chr20:2,744,908...2,756,658 		JBrowse link
G NR2F2 nuclear receptor subfamily 2 group F member 2 enables IEA Ensembl GO_REF:0000107 NCBI chr29:14,889,526...14,901,848
Ensembl chr29:14,891,737...14,903,813 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 enables IEA InterPro GO_REF:0000002 NCBI chr11:48,208,354...48,232,857
Ensembl chr11:48,208,587...48,233,063 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 enables IEA InterPro GO_REF:0000002 NCBI chr10:41,715,092...41,724,411
Ensembl chr10:41,715,086...41,723,685 		JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 enables IEA InterPro GO_REF:0000002 NCBI chr12:39,568,085...39,611,704
Ensembl chr12:39,567,852...39,606,837 		JBrowse link
G NR5A1 nuclear receptor subfamily 5 group A member 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr12:13,640,453...13,666,748
Ensembl chr12:13,640,473...13,666,863 		JBrowse link
G PGR progesterone receptor enables IEA Ensembl GO_REF:0000107 NCBI chr 1:92,420,970...92,519,128
Ensembl chr 1:92,430,453...92,517,296 		JBrowse link
G POU5F1 POU class 5 homeobox 1 enables IEA Ensembl GO_REF:0000107 Ensembl chr17:41,311,005...41,315,373 JBrowse link
G PPARA peroxisome proliferator activated receptor alpha enables ISO (PMID:12955147), (PMID:19955185) UniProt PMID:12955147 PMID:19955185
G PPARD peroxisome proliferator activated receptor delta enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr17:36,695,546...36,779,554
Ensembl chr17:36,695,494...36,779,577 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G RARA retinoic acid receptor alpha enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr16:65,817,849...65,866,862
Ensembl chr16:65,817,757...65,866,878 		JBrowse link
G RARB retinoic acid receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr15:69,851,447...70,266,215
Ensembl chr15:70,096,117...70,264,905 		JBrowse link
G RARG retinoic acid receptor gamma enables ISO
IEA		 RGD
InterPro		 PMID:11072095 GO_REF:0000002 RGD:1300463 NCBI chr11:49,319,104...49,340,725
Ensembl chr11:49,319,839...49,328,656 		JBrowse link
G RORA RAR related orphan receptor A enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr26:22,263,889...23,002,224
Ensembl chr26:22,812,445...22,993,021 		JBrowse link
G RORB RAR related orphan receptor B enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr12:85,545,609...85,735,804
Ensembl chr12:85,545,608...85,732,780 		JBrowse link
G RORC RAR related orphan receptor C enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr20:11,854,911...11,880,221
Ensembl chr20:11,855,005...11,879,717 		JBrowse link
G RXRA retinoid X receptor alpha contributes_to
enables		 ISO
IEA		 (PMID:17107947) BHF-UCL
Ensembl		 PMID:17107947 GO_REF:0000107 NCBI chr12:3,704,129...3,814,707
Ensembl chr12:3,699,923...3,814,678 		JBrowse link
G RXRB retinoid X receptor beta enables ISO
IEA		 RGD
Ensembl		 PMID:1662118 GO_REF:0000107 RGD:729677 NCBI chr17:38,874,467...38,881,527
Ensembl chr17:38,874,681...38,881,653 		JBrowse link
G RXRG retinoid X receptor gamma enables IEA Ensembl GO_REF:0000107 NCBI chr25:63,444,128...63,490,594
Ensembl chr25:63,443,944...63,490,635 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 enables IEA Ensembl GO_REF:0000107 NCBI chr16:16,847,603...16,874,239
Ensembl chr16:16,845,491...16,859,554 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 enables IEA Ensembl GO_REF:0000107 NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984 		JBrowse link
G THRA thyroid hormone receptor alpha enables ISO (PMID:15466465), (PMID:18052923), (PMID:8710870)
(PMID:15322135)		 UniProt
MGI		 PMID:8710870 PMID:15322135 PMID:15466465 PMID:18052923 NCBI chr16:66,087,071...66,118,137 JBrowse link
G THRA thyroid hormone receptor alpha enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 Ensembl chr16:66,085,067...66,118,079 JBrowse link
G THRB thyroid hormone receptor beta enables ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro		 PMID:2457590 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:729962 NCBI chr15:68,797,410...69,161,256
Ensembl chr15:68,802,078...68,902,292 		JBrowse link
G VDR vitamin D receptor enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:9579411 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:70308 NCBI chr11:44,062,198...44,126,295
Ensembl chr11:44,065,457...44,166,684 		JBrowse link
bile acid nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1H4 nuclear receptor subfamily 1 group H member 4 enables IEA Ensembl GO_REF:0000107 NCBI chr11:95,792,428...95,877,989
Ensembl chr11:95,792,996...95,878,293 		JBrowse link
G VDR vitamin D receptor enables IEA Ensembl GO_REF:0000107 NCBI chr11:44,062,198...44,126,295
Ensembl chr11:44,065,457...44,166,684 		JBrowse link
nuclear estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549 		JBrowse link
G ESR2 estrogen receptor 2 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr24:41,426,333...41,513,802
Ensembl chr24:41,447,224...41,512,486 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr28:20,491,874...20,497,966
Ensembl chr28:20,492,188...20,493,315 		JBrowse link
G PDE3A phosphodiesterase 3A enables IEA Ensembl GO_REF:0000107 NCBI chr11:20,235,814...20,545,740
Ensembl chr11:20,236,430...20,540,900 		JBrowse link
nuclear glucocorticoid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125 		JBrowse link
nuclear steroid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD2 abhydrolase domain containing 2, acylglycerol lipase enables IEA Ensembl GO_REF:0000107 NCBI chr29:7,631,436...7,742,209
Ensembl chr29:7,631,412...7,740,394 		JBrowse link
G ESR1 estrogen receptor 1 ISO 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549 		JBrowse link
G ESR2 estrogen receptor 2 ISO 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chr24:41,426,333...41,513,802
Ensembl chr24:41,447,224...41,512,486 		JBrowse link
G ESRRA estrogen related receptor alpha enables IEA InterPro GO_REF:0000002 NCBI chr 1:9,918,741...9,929,481
Ensembl chr 1:9,917,436...9,929,450 		JBrowse link
G ESRRB estrogen related receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr24:53,630,998...53,762,098 JBrowse link
G ESRRG estrogen related receptor gamma enables IEA InterPro GO_REF:0000002 NCBI chr25:12,495,234...13,090,739
Ensembl chr25:12,866,321...13,090,733 		JBrowse link
G LOC103223491 peroxisome proliferator-activated receptor alpha enables IEA Ensembl GO_REF:0000107 NCBI chr19:28,614,892...28,709,272
Ensembl chr19:28,615,413...28,708,763 		JBrowse link
G LOC103247947 olfactory receptor 51E2 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:62,172,573...62,180,085
Ensembl chr 1:62,177,553...62,178,515 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 ISO RGD PMID:17260968 RGD:1600931 NCBI chr 7:94,574,010...94,935,348 JBrowse link
G PAQR7 progestin and adipoQ receptor family member 7 enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:106,897,141...106,909,225
Ensembl chr20:106,908,063...106,909,118 		JBrowse link
G PAQR8 progestin and adipoQ receptor family member 8 enables IEA TreeGrafter GO_REF:0000118 NCBI chr17:20,096,407...20,142,477
Ensembl chr17:20,099,906...20,100,970 		JBrowse link
G PGR progesterone receptor enables ISO
IEA		 RGD
Ensembl
UniProt
InterPro		 PMID:11113338 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1601290 NCBI chr 1:92,420,970...92,519,128
Ensembl chr 1:92,430,453...92,517,296 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha enables ISO (PMID:19955185) BHF-UCL PMID:19955185
G RXRA retinoid X receptor alpha enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr12:3,704,129...3,814,707
Ensembl chr12:3,699,923...3,814,678 		JBrowse link
G RXRB retinoid X receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr17:38,874,467...38,881,527
Ensembl chr17:38,874,681...38,881,653 		JBrowse link
G RXRG retinoid X receptor gamma enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr25:63,444,128...63,490,594
Ensembl chr25:63,443,944...63,490,635 		JBrowse link
G VDR vitamin D receptor enables ISO (PMID:10678179), (PMID:12016314), (PMID:17082781) UniProt PMID:10678179 PMID:12016314 PMID:17082781 NCBI chr11:44,062,198...44,126,295
Ensembl chr11:44,065,457...44,166,684 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19845
    molecular transducer activity 1247
      signaling receptor activity 1247
        nuclear receptor activity 53
          bile acid nuclear receptor activity 2
          nuclear steroid receptor activity + 20
Path 2
Term Annotations click to browse term
  molecular_function 19845
    transcription regulator activity 1721
      DNA-binding transcription factor activity 1268
        DNA-binding transcription factor activity, RNA polymerase II-specific 1194
          nuclear receptor activity 53
            bile acid nuclear receptor activity 2
            nuclear steroid receptor activity + 20
paths to the root