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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear receptor activity
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Accession:GO:0004879 term browser browse the term
Definition:A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Comment:Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
Synonyms:exact_synonym: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
 narrow_synonym: 1,25-(OH)2D3 receptor activity;   9-cis retinoic acid receptor activity;   RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding;   RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding;   RXR;   androgen receptor activity;   calcitriol receptor activity;   ecdysteroid hormone receptor activity;   estrogen nuclear receptor activity;   glucocorticoid receptor activity;   juvenile hormone receptor activity;   nuclear hormone receptor;   retinoic acid receptor activity;   retinoid-X receptor activity;   thyroid hormone receptor activity;   vitamin A receptor activity;   vitamin D receptor activity;   vitamin D3 receptor activity
 related_synonym: ligand-dependent nuclear receptor activity;   ligand-dependent transcription factor activity
 alt_id: GO:0003708;   GO:0004880;   GO:0004882;   GO:0004884;   GO:0004886;   GO:0004887;   GO:0008434;   GO:0038050;   GO:0038051;   GO:0038052


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nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor enables
contributes_to		 IEA
ISO		 (PMID:34521881) Ensembl
TreeGrafter
UniProt
UniProt		 PMID:34521881 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171 		JBrowse link
G AHRR aryl hydrocarbon receptor repressor enables IEA TreeGrafter GO_REF:0000118 Ensembl chr 5:436,542...567,310 JBrowse link
G AR androgen receptor enables
NOT|enables		 ISO
IEA		 (PMID:19244107) RGD
InterPro
Ensembl
UniProt		 PMID:2341409 PMID:19244107 GO_REF:0000002 GO_REF:0000107 RGD:1298681 NCBI chr  X:56,722,828...56,909,004
Ensembl chr  X:66,791,081...66,969,357 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator enables
contributes_to		 IEA
ISO		 (PMID:11043581)
(PMID:34521881)		 Ensembl
MGI
UniProt		 PMID:11043581 PMID:34521881 GO_REF:0000107 NCBI chr 1:126,160,017...126,226,222
Ensembl chr 1:129,809,431...129,875,629 		JBrowse link
G ESR1 estrogen receptor 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551 		JBrowse link
G ESR2 estrogen receptor 2 enables IEA Ensembl GO_REF:0000107 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha enables IEA Ensembl GO_REF:0000107 NCBI chr20:40,684,450...40,763,824
Ensembl chr20:41,779,034...41,856,536 		JBrowse link
G NKX3-1 NK3 homeobox 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:22,926,145...22,930,396
Ensembl chr 8:19,863,275...19,864,942 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr17:17,188,390...17,196,315
Ensembl chr17:17,409,669...17,417,600 		JBrowse link
G NR1D2 nuclear receptor subfamily 1 group D member 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 3:23,857,317...23,892,533
Ensembl chr 3:24,185,798...24,215,831 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr19:47,340,077...47,346,737
Ensembl chr19:56,243,124...56,250,024 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 enables
contributes_to		 IEA
ISO		 (PMID:17107947) Ensembl
TreeGrafter
BHF-UCL
InterPro		 PMID:17107947 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr12:98,052,778...98,144,085
Ensembl chr12:101,457,885...101,548,058 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:10967130 GO_REF:0000107 GO_REF:0000118 RGD:61490 NCBI chr 3:116,901,579...116,940,366
Ensembl chr 3:123,815,135...123,853,129 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:136,642,126...136,651,074
Ensembl chr 1:140,553,951...140,562,799 		JBrowse link
G NR2F2 nuclear receptor subfamily 2 group F member 2 enables ISO (PMID:18798693) UniProt PMID:18798693 NCBI chr15:75,008,879...75,021,981 JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 enables IEA InterPro GO_REF:0000002 NCBI chr12:36,703,903...36,740,211
Ensembl chr12:37,480,300...37,501,188 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 enables IEA InterPro GO_REF:0000002 NCBI chr2B:43,584,835...43,593,118
Ensembl chr2B:160,826,091...160,837,162 		JBrowse link
G NR5A1 nuclear receptor subfamily 5 group A member 1 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 9:95,605,282...95,628,773
Ensembl chr 9:124,122,968...124,149,292 		JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:8668203 GO_REF:0000002 GO_REF:0000107 RGD:68248 NCBI chr 1:175,625,140...175,775,955
Ensembl chr 1:179,934,573...180,083,607 		JBrowse link
G PGR progesterone receptor enables ISO (PMID:14681235) MGI PMID:14681235 NCBI chr11:95,997,677...96,098,866 JBrowse link
G PPARA peroxisome proliferator activated receptor alpha enables ISO
IEA		 RGD
Ensembl
TreeGrafter
InterPro		 PMID:12189208 PMID:12966092 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1580224 RGD:729665 Ensembl chr22:45,218,364...45,302,970 JBrowse link
G PPARD peroxisome proliferator activated receptor delta enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:34,903,798...34,987,208
Ensembl chr 6:36,003,988...36,081,132 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
G RARA retinoic acid receptor alpha enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:16,932,485...16,980,958 JBrowse link
G RARB retinoic acid receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr 3:24,729,220...25,499,187
Ensembl chr 3:25,660,922...25,833,297 		JBrowse link
G RARG retinoic acid receptor gamma enables ISO
IEA		 RGD
InterPro		 PMID:11072095 GO_REF:0000002 RGD:1300463 NCBI chr12:35,521,276...35,542,814
Ensembl chr12:36,303,359...36,325,111 		JBrowse link
G RORA RAR related orphan receptor A enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr15:39,461,553...40,200,118
Ensembl chr15:57,771,735...57,980,460 		JBrowse link
G RORB RAR related orphan receptor B enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 9:50,144,836...50,340,910
Ensembl chr 9:73,469,767...73,543,030 		JBrowse link
G RORC RAR related orphan receptor C enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:127,164,725...127,190,479
Ensembl chr 1:130,808,705...130,834,490 		JBrowse link
G RXRA retinoid X receptor alpha enables
contributes_to		 IEA
ISO		 (PMID:17107947) Ensembl
BHF-UCL		 PMID:17107947 GO_REF:0000107 NCBI chr 9:105,424,046...105,539,241
Ensembl chr 9:134,082,865...134,144,704 		JBrowse link
G RXRB retinoid X receptor beta enables ISO
IEA		 RGD
Ensembl		 PMID:1662118 GO_REF:0000107 RGD:729677 NCBI chr 6:32,765,818...32,772,876
Ensembl chr 6:33,880,758...33,887,820 		JBrowse link
G RXRG retinoid X receptor gamma enables IEA Ensembl GO_REF:0000107 NCBI chr 1:140,832,717...140,877,046
Ensembl chr 1:144,623,133...144,723,494 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 enables IEA Ensembl GO_REF:0000107 NCBI chr17:33,458,196...33,484,643
Ensembl chr17:38,405,794...38,432,045 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 enables IEA Ensembl GO_REF:0000107 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
G THRA thyroid hormone receptor alpha enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr17:17,196,459...17,226,263 JBrowse link
G THRB thyroid hormone receptor beta enables ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro		 PMID:2457590 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:729962 NCBI chr 3:24,024,025...24,401,024
Ensembl chr 3:24,346,824...24,564,960 		JBrowse link
G VDR vitamin D receptor enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:9579411 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:70308 NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192 		JBrowse link
bile acid nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1H4 nuclear receptor subfamily 1 group H member 4 enables IEA Ensembl GO_REF:0000107 NCBI chr12:98,052,778...98,144,085
Ensembl chr12:101,457,885...101,548,058 		JBrowse link
G VDR vitamin D receptor enables IEA Ensembl GO_REF:0000107 NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192 		JBrowse link
nuclear estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551 		JBrowse link
G ESR2 estrogen receptor 2 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 enables ISO (PMID:15539556), (PMID:15705806)
(PMID:23545157)		 UniProt PMID:15539556 PMID:15705806 PMID:23545157 NCBI chr 7:1,331,586...1,338,194 JBrowse link
G PDE3A phosphodiesterase 3A enables IEA Ensembl GO_REF:0000107 NCBI chr12:20,380,213...20,690,540
Ensembl chr12:20,763,999...21,064,391 		JBrowse link
nuclear glucocorticoid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269 		JBrowse link
nuclear steroid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD2 abhydrolase domain containing 2, acylglycerol lipase enables IEA Ensembl GO_REF:0000107 NCBI chr15:67,780,453...67,891,454
Ensembl chr15:86,987,070...87,095,818 		JBrowse link
G ESR1 estrogen receptor 1 enables ISO
IEA		 17-beta-estradiol (E2) RGD
InterPro		 PMID:17928626 GO_REF:0000002 RGD:5128669 NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551 		JBrowse link
G ESR2 estrogen receptor 2 enables ISO
IEA		 17-beta-estradiol (E2) RGD
InterPro		 PMID:17928626 GO_REF:0000002 RGD:5128669 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303 		JBrowse link
G ESRRA estrogen related receptor alpha enables IEA InterPro GO_REF:0000002 NCBI chr11:59,662,565...59,673,789
Ensembl chr11:63,009,295...63,018,744 		JBrowse link
G ESRRB estrogen related receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr14:56,868,361...57,060,552
Ensembl chr14:75,839,333...76,266,895 		JBrowse link
G ESRRG estrogen related receptor gamma enables IEA InterPro GO_REF:0000002 NCBI chr 1:192,074,260...192,667,610
Ensembl chr 1:196,929,197...197,153,195 		JBrowse link
G LOC100976603 olfactory receptor 51E2 enables IEA Ensembl GO_REF:0000107 NCBI chr11:4,853,325...4,871,457
Ensembl chr11:4,520,050...4,521,012 		JBrowse link
G NR2E3 nuclear receptor subfamily 2 group E member 3 enables IEA InterPro GO_REF:0000002 NCBI chr15:50,759,707...50,767,703
Ensembl chr15:69,525,351...69,533,034 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 ISO RGD PMID:17260968 RGD:1600931 NCBI chr 4:140,418,624...140,785,180
Ensembl chr 4:152,108,508...152,430,298 		JBrowse link
G PAQR7 progestin and adipoQ receptor family member 7 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:25,119,805...25,134,395
Ensembl chr 1:26,188,822...26,189,862
Ensembl chr 1:26,188,822...26,189,862 		JBrowse link
G PAQR8 progestin and adipoQ receptor family member 8 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 6:51,914,374...51,959,594
Ensembl chr 6:53,222,557...53,223,621 		JBrowse link
G PGR progesterone receptor enables ISO
IEA		 RGD
InterPro		 PMID:11113338 GO_REF:0000002 RGD:1601290 NCBI chr11:95,997,677...96,098,866 JBrowse link
G PPARA peroxisome proliferator activated receptor alpha enables IEA Ensembl GO_REF:0000107 Ensembl chr22:45,218,364...45,302,970 JBrowse link
G RXRA retinoid X receptor alpha enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 9:105,424,046...105,539,241
Ensembl chr 9:134,082,865...134,144,704 		JBrowse link
G RXRB retinoid X receptor beta enables IEA InterPro GO_REF:0000002 NCBI chr 6:32,765,818...32,772,876
Ensembl chr 6:33,880,758...33,887,820 		JBrowse link
G RXRG retinoid X receptor gamma enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 1:140,832,717...140,877,046
Ensembl chr 1:144,623,133...144,723,494 		JBrowse link
G VDR vitamin D receptor enables ISO (PMID:10678179), (PMID:12016314), (PMID:17082781) UniProt PMID:10678179 PMID:12016314 PMID:17082781 NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19165
    molecular transducer activity 1277
      signaling receptor activity 1277
        nuclear receptor activity 50
          bile acid nuclear receptor activity 2
          nuclear steroid receptor activity + 20
Path 2
Term Annotations click to browse term
  molecular_function 19165
    transcription regulator activity 1687
      DNA-binding transcription factor activity 1242
        DNA-binding transcription factor activity, RNA polymerase II-specific 1160
          nuclear receptor activity 50
            bile acid nuclear receptor activity 2
            nuclear steroid receptor activity + 20
paths to the root