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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin activating enzyme activity
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Accession:GO:0004839 term browser browse the term
Definition:Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
Comment:The ubiquitin activating enzyme catalyzes a ligation reaction.
Synonyms:related_synonym: E1 ubiquitin-activating enzyme
 xref: EC:6.2.1.45;   reactome:R-HSA-8852132 "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol";   reactome:R-HSA-8852133 "UBA1 conjugates ubiquitin to UBA1 in the cytosol";   reactome:R-HSA-8852134 "UBA1 adenylates ubiquitin in the cytosol";   reactome:R-HSA-8865050 "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol";   reactome:R-HSA-8865090 "UBA6 adenylates ubiquitin in the cytosol";   reactome:R-HSA-8865098 "UBA6 conjugates ubiquitin to UBA6 in the cytosol"


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ubiquitin activating enzyme activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uba1 ubiquitin-like modifier activating enzyme 1 enables ISO
IEA
IBA		 (PMID:12629039), (PMID:21685362), (PMID:33108101)
GO_REF:0000107
GO_REF:0000033
(PMID:1511901)		 RGD
Ensembl
GO_Central		 PMID:1511901 PMID:12629039 PMID:21685362 PMID:33108101 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636 		JBrowse link
G Uba1y ubiquitin-activating enzyme, Chr Y enables TAS
ISO
IBA		 (PMID:6327059)
GO_REF:0000033		 RGD
GO_Central		 PMID:6327059 PMID:11882492 GO_REF:0000033, RGD:724779 NCBI chr  Y:457,617...480,306
Ensembl chr  Y:459,843...480,216 		JBrowse link
G Uba6 ubiquitin-like modifier activating enzyme 6 enables IBA
ISO		 GO_REF:0000033
(PMID:23499007)		 GO_Central
RGD		 PMID:23499007 GO_REF:0000033 NCBI chr14:21,884,039...21,947,857
Ensembl chr14:21,884,039...21,947,857 		JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:108,665,289...108,674,097
Ensembl chr 8:108,665,292...108,674,099 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    ATP-dependent activity 629
      ubiquitin-like modifier activating enzyme activity 14
        ubiquitin activating enzyme activity 4
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      ligase activity 178
        ligase activity, forming carbon-sulfur bonds 43
          ubiquitin-like modifier activating enzyme activity 14
            ubiquitin activating enzyme activity 4
paths to the root