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ONTOLOGY REPORT - ANNOTATIONS

Term:sepiapterin reductase (NADP+) activity
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Accession:GO:0004757 term browser browse the term
Definition:Catalysis of the reactions: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H+ + 2 NADPH.
Synonyms:related_synonym: 7,8-dihydrobiopterin:NADP+ oxidoreductase activity
 xref: EC:1.1.1.153;   MetaCyc:SEPIAPTERIN-REDUCTASE-RXN;   Reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to q-BH2";   reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)"


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sepiapterin reductase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spr sepiapterin reductase enables TAS
IDA
IBA		 PMID:10350607
GO_REF:0000033		 GO_Central
RGD		 PMID:2201030 PMID:2179471 PMID:2201030 PMID:10350607 GO_REF:0000033, RGD:70022, RGD:1600056, RGD:70022, RGD:8554741 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
G Spr-ps1 sepiapterin reductase, pseudogene 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:117,689,458...117,693,286
Ensembl chr 4:117,689,458...117,692,891 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            sepiapterin reductase (NADP+) activity 2
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