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ONTOLOGY REPORT - ANNOTATIONS


Term:all-trans-retinol dehydrogenase (NAD+) activity
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Accession:GO:0004745 term browser browse the term
Definition:Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms:broad_synonym: all-trans retinol dehydrogenase activity;   retinal reductase activity;   retinene reductase activity;   retinol (vitamin A1) dehydrogenase activity;   retinol dehydrogenase activity
 xref: EC:1.1.1.105;   MetaCyc:RETINOL-DEHYDROGENASE-RXN;   RHEA:48488;   Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA";   reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL";   reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL";   reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro";   reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"


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all-trans-retinol dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide enables IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936520:3,467,003...3,489,754
Ensembl chrNW_004936520:3,467,003...3,490,997
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 NOT|enables ISO (PMID:12732097) UniProt PMID:12732097 NCBI chrNW_004936474:26,680,736...26,696,996
Ensembl chrNW_004936474:26,680,676...26,697,214
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:1,237,177...1,270,299
Ensembl chrNW_004936474:1,235,962...1,269,510
JBrowse link
G Dhrs7c dehydrogenase/reductase 7C enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:2,732,106...2,769,782
Ensembl chrNW_004936595:2,732,103...2,752,131
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 enables ISO
IEA
RGD
Ensembl
PMID:12390888 GO_REF:0000107 RGD:633755 NCBI chrNW_004936469:10,465,701...10,487,534
Ensembl chrNW_004936469:10,465,701...10,487,534
JBrowse link
G LOC101965278 retinol dehydrogenase 16 enables ISO
IEA
RGD
Ensembl
PMID:7499345 GO_REF:0000107 RGD:1299624 NCBI chrNW_004936646:1,195,200...1,200,778
Ensembl chrNW_004936646:1,194,547...1,200,897
JBrowse link
G LOC101969767 all-trans-retinol dehydrogenase [NAD(+)] ADH4 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936520:3,763,849...3,777,177
Ensembl chrNW_004936520:3,760,755...3,775,873
JBrowse link
G LOC101970041 short chain dehydrogenase/reductase family 16C member 5 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936496:2,919,611...2,937,274
Ensembl chrNW_004936496:2,919,522...2,937,274
JBrowse link
G LOC101976546 alcohol dehydrogenase E chain enables IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936520:3,508,821...3,552,938 JBrowse link
G LOC101976827 alcohol dehydrogenase 1-like enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936520:3,651,829...3,677,841 JBrowse link
G Rdh10 retinol dehydrogenase 10 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936648:2,060,131...2,088,021
Ensembl chrNW_004936648:2,060,125...2,088,833
JBrowse link
G Rdh12 retinol dehydrogenase 12 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:11,111,247...11,121,976
Ensembl chrNW_004936495:11,111,105...11,121,341
JBrowse link
G Rdh5 retinol dehydrogenase 5 enables IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936646:191,136...195,279
Ensembl chrNW_004936646:191,128...199,777
JBrowse link
G Rdh8 retinol dehydrogenase 8 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936659:439,541...445,645 JBrowse link
G Sdr9c7 short chain dehydrogenase/reductase family 9C member 7 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:1,170,855...1,190,797
Ensembl chrNW_004936646:1,171,736...1,182,929
JBrowse link

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  molecular_function 18185
    catalytic activity 5255
      oxidoreductase activity 691
        oxidoreductase activity, acting on CH-OH group of donors 117
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 109
            alcohol dehydrogenase [NAD(P)+] activity 36
              alcohol dehydrogenase (NAD+) activity 18
                all-trans-retinol dehydrogenase (NAD+) activity 15
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