Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:all-trans-retinol dehydrogenase (NAD+) activity
go back to main search page
Accession:GO:0004745 term browser browse the term
Definition:Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms:broad_synonym: all-trans retinol dehydrogenase activity;   retinal reductase activity;   retinene reductase activity;   retinol (vitamin A1) dehydrogenase activity;   retinol dehydrogenase activity
 xref: EC:1.1.1.105;   MetaCyc:RETINOL-DEHYDROGENASE-RXN;   RHEA:48488;   Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA";   reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL";   reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL";   reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro";   reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"


show annotations for term's descendants           Sort by:
all-trans-retinol dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1-ps1 alcohol dehydrogenase 1C (class I), gamma polypeptide, pseudogene 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:226,862,836...226,881,171
Ensembl chr 2:226,862,725...226,881,162 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide enables IDA
ISO
IEA
IBA		 MGI:97876 (PMID:15193143)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:15193143 PMID:2940107 GO_REF:0000033 GO_REF:0000107, RGD:2315740 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide enables ISS
ISO		 GO_REF:0000024
(PMID:10514444), (PMID:15369820), (PMID:16787387), (PMID:17279314)		 UniProt
RGD		 PMID:10514444 PMID:15369820 PMID:16787387 PMID:17279314 GO_REF:0000024 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh6 alcohol dehydrogenase 6 (class V) enables IBA
IEA		 GO_REF:0000033
GO_REF:0000107		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534 		JBrowse link
G Adh6a alcohol dehydrogenase 6A (class V) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:226,823,775...226,846,005
Ensembl chr 2:226,823,730...226,846,003 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide enables ISO
IEA
ISS
IBA		 (PMID:11997393), (PMID:15369820), (PMID:16787387), (PMID:7876099), (PMID:9600267)
GO_REF:0000107
GO_REF:0000024
(PMID:3663136)
GO_REF:0000033		 RGD
Ensembl
UniProt
GO_Central		 PMID:3663136 PMID:7876099 PMID:9600267 PMID:11997393 PMID:15369820 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 NOT|enables ISO
ISS		 (PMID:12732097)
GO_REF:0000024		 RGD
UniProt		 PMID:12732097 GO_REF:0000024 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 enables ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 enables ISO MGI:5007106 (PMID:24005908) RGD PMID:24005908 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Dhrs7c dehydrogenase/reductase 7C enables ISS
ISO		 GO_REF:0000024
(PMID:21995425)		 UniProt
RGD		 PMID:21995425 GO_REF:0000024 NCBI chr10:52,495,262...52,513,338
Ensembl chr10:52,495,262...52,513,338 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 enables IMP
ISS
ISO		 GO_REF:0000024
(PMID:11304534)		 UniProt
RGD		 PMID:11304534 PMID:12390888 GO_REF:0000024, RGD:633755 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 enables ISO
IBA		 (PMID:10896656), (PMID:11360992)
GO_REF:0000033		 RGD
GO_Central		 PMID:10896656 PMID:11360992 GO_REF:0000033 NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425 		JBrowse link
G Rdh10 retinol dehydrogenase 10 enables ISO (PMID:12407145), (PMID:19458327)
(PMID:17473173)		 RGD PMID:12407145 PMID:17473173 PMID:19458327 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
G Rdh12 retinol dehydrogenase 12 enables ISO (PMID:12226107)
(PMID:22621924)		 RGD PMID:12226107 PMID:22621924 NCBI chr 6:98,015,465...98,028,388
Ensembl chr 6:98,015,465...98,028,388 		JBrowse link
G Rdh16 retinol dehydrogenase 16 enables IDA
ISO
IBA		 (PMID:10329026), (PMID:12534290), (PMID:9677409)
GO_REF:0000033		 RGD
GO_Central		 PMID:9677409 PMID:10329026 PMID:12534290 PMID:7499345 GO_REF:0000033, RGD:1299624 NCBI chr 7:63,616,711...63,625,053
Ensembl chr 7:63,597,536...63,624,124 		JBrowse link
G Rdh5 retinol dehydrogenase 5 enables ISO (PMID:11675386)
(PMID:10588954)		 RGD PMID:10588954 PMID:11675386 NCBI chr 7:1,341,172...1,346,863
Ensembl chr 7:1,340,934...1,351,558 		JBrowse link
G Rdh7 retinol dehydrogenase 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:63,676,016...63,689,375
Ensembl chr 7:63,675,579...63,689,392 		JBrowse link
G Rdh8 retinol dehydrogenase 8 enables IBA
ISO		 GO_REF:0000033
(PMID:15755727)		 GO_Central
RGD		 PMID:15755727 GO_REF:0000033 NCBI chr 8:19,353,191...19,360,462
Ensembl chr 8:19,353,191...19,360,462 		JBrowse link
G Rdh9 retinol dehydrogenase 9 enables ISO (PMID:11876656) RGD PMID:11876656 NCBI chr 7:63,642,305...63,645,149 JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 enables ISO
IBA		 (PMID:18926804), (PMID:19102727)
GO_REF:0000033		 RGD
GO_Central		 PMID:18926804 PMID:19102727 GO_REF:0000033 NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970 		JBrowse link
G Sdr9c7 short chain dehydrogenase/reductase family 9C, member 7 enables ISO
IBA		 (PMID:19703561)
GO_REF:0000033		 RGD
GO_Central		 PMID:19703561 GO_REF:0000033 NCBI chr 7:63,703,788...63,720,325
Ensembl chr 7:63,707,071...63,721,480 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21086
    catalytic activity 6121
      oxidoreductase activity 868
        oxidoreductase activity, acting on CH-OH group of donors 165
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 156
            alcohol dehydrogenase [NAD(P)+] activity 67
              alcohol dehydrogenase (NAD+) activity 25
                all-trans-retinol dehydrogenase (NAD+) activity 22
paths to the root