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ONTOLOGY REPORT - ANNOTATIONS


Term:all-trans-retinol dehydrogenase (NAD+) activity
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Accession:GO:0004745 term browser browse the term
Definition:Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms:broad_synonym: all-trans retinol dehydrogenase activity;   retinal reductase activity;   retinene reductase activity;   retinol (vitamin A1) dehydrogenase activity;   retinol dehydrogenase activity
 xref: EC:1.1.1.105;   MetaCyc:RETINOL-DEHYDROGENASE-RXN;   RHEA:48488;   Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA";   reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL";   reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL";   reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro";   reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"


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all-trans-retinol dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 NOT|enables ISO (PMID:12732097) UniProt PMID:12732097 NCBI chrNW_004624906:1,463,201...1,474,001
Ensembl chrNW_004624906:1,462,693...1,474,214
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624818:557,399...590,872
Ensembl chrNW_004624818:557,409...590,872
JBrowse link
G Dhrs7c dehydrogenase/reductase 7C enables ISO (PMID:21995425) MGI PMID:21995425 NCBI chrNW_004624786:12,222,735...12,236,209
Ensembl chrNW_004624786:12,222,248...12,236,301
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 enables IEA
ISO
Ensembl
RGD
PMID:12390888 GO_REF:0000107 RGD:633755 NCBI chrNW_004624787:6,751,787...6,776,181
Ensembl chrNW_004624787:6,758,478...6,776,238
JBrowse link
G Hsd17b6 hydroxysteroid 17-beta dehydrogenase 6 enables ISO (PMID:10896656), (PMID:11360992) UniProt PMID:10896656 PMID:11360992 NCBI chrNW_004624802:11,125,544...11,162,914
Ensembl chrNW_004624802:11,115,928...11,162,174
JBrowse link
G LOC101700953 alcohol dehydrogenase 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004625009:103,092...118,888 JBrowse link
G LOC101723971 short chain dehydrogenase/reductase family 16C member 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624886:3,746,074...3,762,257
Ensembl chrNW_004624886:3,746,379...3,766,774
JBrowse link
G Rdh10 retinol dehydrogenase 10 enables ISO (PMID:12407145), (PMID:19458327)
(PMID:17473173)
MGI PMID:12407145 PMID:17473173 PMID:19458327 NCBI chrNW_004624744:17,838,047...17,868,423
Ensembl chrNW_004624744:17,837,609...17,868,431
JBrowse link
G Rdh12 retinol dehydrogenase 12 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:33,256,469...33,266,085
Ensembl chrNW_004624734:33,254,432...33,266,140
JBrowse link
G Rdh5 retinol dehydrogenase 5 enables IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624802:12,293,578...12,299,981
Ensembl chrNW_004624802:12,290,688...12,304,712
JBrowse link
G Rdh8 retinol dehydrogenase 8 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624828:2,254,570...2,259,512
Ensembl chrNW_004624828:2,253,995...2,260,315
JBrowse link
G Sdr9c7 short chain dehydrogenase/reductase family 9C member 7 enables ISO (PMID:19703561) UniProt PMID:19703561 NCBI chrNW_004624802:11,008,727...11,020,651
Ensembl chrNW_004624802:11,008,800...11,019,788
JBrowse link

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Term Annotations click to browse term
  molecular_function 18442
    catalytic activity 5600
      oxidoreductase activity 698
        oxidoreductase activity, acting on CH-OH group of donors 116
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 107
            alcohol dehydrogenase [NAD(P)+] activity 35
              alcohol dehydrogenase (NAD+) activity 16
                all-trans-retinol dehydrogenase (NAD+) activity 12
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