ONTOLOGY REPORT - ANNOTATIONS
Term: all-trans-retinol dehydrogenase (NAD+) activity
Accession: GO:0004745
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Definition: Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms: broad_synonym: all-trans retinol dehydrogenase activity; retinal reductase activity; retinene reductase activity; retinol (vitamin A1) dehydrogenase activity; retinol dehydrogenase activity
xref: EC:1.1.1.105; MetaCyc:RETINOL-DEHYDROGENASE-RXN; RHEA:48488; Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA"; reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL"; reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL"; reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro"; reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"
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Adh1
alcohol dehydrogenase 1 (class I)
enables
ISO IEA IGI IBA
(PMID:15193143)
RGD GO_Central Ensembl MGI
PMID:2940107 PMID:15193143
GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 RGD:2315740
NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
enables
ISO ISS
GO_Central UniProt
GO_REF:0000024 GO_REF:0000119
NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653
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Adh6a
alcohol dehydrogenase 6A (class V)
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 3:138,019,047...138,036,895
Ensembl chr 3:138,019,047...138,036,895
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Adh6b
alcohol dehydrogenase 6B (class V)
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 3:138,047,176...138,064,621
Ensembl chr 3:138,047,536...138,064,622
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Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
enables
IDA ISO ISS IBA
(PMID:3663136)
MGI GO_Central UniProt
PMID:3663136
GO_REF:0000024 GO_REF:0000033 GO_REF:0000119
NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143
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Akr1a1
aldo-keto reductase family 1, member A1
NOT|enables
ISS
UniProt
GO_REF:0000024
NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877
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Akr1c14
aldo-keto reductase family 1, member C14
enables
ISO
GO_Central
GO_REF:0000119
NCBI chr13:4,099,015...4,140,569
Ensembl chr13:4,099,011...4,140,688
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Akr1c18
aldo-keto reductase family 1, member C18
enables
ISO
GO_Central
GO_REF:0000119
NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
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Akr1c20
aldo-keto reductase family 1, member C20
enables
ISO
GO_Central
GO_REF:0000119
NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344
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Akr1c6
aldo-keto reductase family 1, member C6
enables
ISO
GO_Central
GO_REF:0000119
NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876
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Akr1cl
aldo-keto reductase family 1, member C-like
enables
ISO
GO_Central
GO_REF:0000119
NCBI chr 1:65,052,237...65,071,918
Ensembl chr 1:65,051,848...65,071,918
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Dhrs3
dehydrogenase/reductase 3
enables
IBA IMP
(PMID:24005908)
GO_Central MGI
PMID:24005908
GO_REF:0000033
NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779
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Dhrs7c
dehydrogenase/reductase 7C
enables
IDA
(PMID:21995425)
MGI
PMID:21995425
NCBI chr11:67,689,097...67,706,828
Ensembl chr11:67,689,013...67,706,828
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Dhrs9
dehydrogenase/reductase 9
enables
ISO ISS
RGD GO_Central UniProt
PMID:12390888
GO_REF:0000024 GO_REF:0000096 GO_REF:0000119 RGD:633755
NCBI chr 2:69,210,806...69,233,430
Ensembl chr 2:69,210,789...69,234,877
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Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
enables
IEA
RHEA
GO_REF:0000116
NCBI chr 5:104,103,308...104,125,254
Ensembl chr 5:104,103,306...104,125,276
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Hsd17b6
hydroxysteroid (17-beta) dehydrogenase 6
enables
IEA ISO IBA
RHEA UniProt GO_Central
GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000119
NCBI chr10:127,826,800...127,843,517
Ensembl chr10:127,826,805...127,843,480
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Rdh1
retinol dehydrogenase 1 (all trans)
enables
ISO IDA IBA
(PMID:11562362), (PMID:12855677)
RGD MGI GO_Central
PMID:7499345 PMID:11562362 PMID:12855677
GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1299624
NCBI chr10:127,595,595...127,604,168
Ensembl chr10:127,595,590...127,604,166
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Rdh10
retinol dehydrogenase 10 (all-trans)
enables
IMP ISO
(PMID:17473173) (PMID:12407145)
MGI GO_Central
PMID:12407145 PMID:17473173
GO_REF:0000119
NCBI chr 1:16,176,106...16,202,774
Ensembl chr 1:16,175,998...16,203,958
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Rdh11
retinol dehydrogenase 11
enables
ISS
UniProt
GO_REF:0000024
NCBI chr12:79,221,007...79,238,629
Ensembl chr12:79,221,111...79,239,067
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Rdh12
retinol dehydrogenase 12
enables
ISS ISO IDA
(PMID:22621924)
UniProt GO_Central
PMID:22621924
GO_REF:0000024 GO_REF:0000119
NCBI chr12:79,255,687...79,269,438
Ensembl chr12:79,255,688...79,269,439
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Rdh16
retinol dehydrogenase 16
enables
ISO IDA IBA
(PMID:11876656), (PMID:16223484), (PMID:9407098)
GO_Central UniProt
PMID:9407098 PMID:11876656 PMID:16223484
GO_REF:0000033 GO_REF:0000096 GO_REF:0000119
NCBI chr10:127,636,959...127,651,715
Ensembl chr10:127,637,021...127,682,434
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Rdh16f2
RDH16 family member 2
enables
ISO IBA
GO_Central
GO_REF:0000033 GO_REF:0000096 GO_REF:0000119
NCBI chr10:127,702,345...127,713,188
Ensembl chr10:127,702,343...127,713,186
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Rdh19
retinol dehydrogenase 19
NOT|enables
IDA ISO
(PMID:12855677)
MGI GO_Central
PMID:12855677
GO_REF:0000096 GO_REF:0000119
NCBI chr10:127,685,797...127,697,045
Ensembl chr10:127,685,797...127,697,045
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Rdh5
retinol dehydrogenase 5
enables
ISO IDA IBA
(PMID:10588954)
GO_Central UniProt
PMID:10588954
GO_REF:0000033 GO_REF:0000119
NCBI chr10:128,749,457...128,755,906
Ensembl chr10:128,749,462...128,758,757
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Rdh7
retinol dehydrogenase 7
enables
ISO IEA IBA
GO_Central UniProt RHEA
GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000119
NCBI chr10:127,719,896...127,725,116
Ensembl chr10:127,719,897...127,724,686
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Rdh8
retinol dehydrogenase 8
enables
IDA IBA
(PMID:15755727)
MGI GO_Central
PMID:15755727
GO_REF:0000033
NCBI chr 9:20,729,790...20,739,354
Ensembl chr 9:20,729,799...20,737,413
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Rdh9
retinol dehydrogenase 9
enables
IDA ISO IBA
(PMID:11876656)
MGI GO_Central
PMID:11876656
GO_REF:0000033 GO_REF:0000096 GO_REF:0000119
NCBI chr10:127,612,274...127,628,566
Ensembl chr10:127,612,255...127,628,566
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Sdr16c5
short chain dehydrogenase/reductase family 16C, member 5
enables
IBA IEA ISO
GO_Central RHEA UniProt
GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000119
NCBI chr 4:3,995,942...4,019,663
Ensembl chr 4:3,995,936...4,019,663
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Sdr9c7
4short chain dehydrogenase/reductase family 9C, member 7
enables
IEA ISO IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107 GO_REF:0000119
NCBI chr10:127,734,404...127,747,630
Ensembl chr10:127,734,387...127,747,630
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