ONTOLOGY REPORT - ANNOTATIONS
Term: all-trans-retinol dehydrogenase (NAD+) activity
Accession: GO:0004745
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Definition: Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms: broad_synonym: all-trans retinol dehydrogenase activity; retinal reductase activity; retinene reductase activity; retinol (vitamin A1) dehydrogenase activity; retinol dehydrogenase activity
xref: EC:1.1.1.105; MetaCyc:RETINOL-DEHYDROGENASE-RXN; RHEA:48488; Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA"; reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL"; reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL"; reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro"; reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"
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ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr32:21,282,526...21,299,387
Ensembl chr32:21,282,890...21,299,328
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AKR1A1
aldo-keto reductase family 1 member A1
NOT|enables
ISO
(PMID:12732097)
UniProt
PMID:12732097
NCBI chr15:14,792,398...14,808,805
Ensembl chr15:14,742,012...14,808,592
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AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
enables
ISO
(PMID:21851338)
UniProt
PMID:21851338
NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043
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DHRS3
dehydrogenase/reductase 3
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 2:83,826,361...83,865,412
Ensembl chr 2:83,826,374...83,865,426
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DHRS7C
dehydrogenase/reductase 7C
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:34,224,699...34,239,847
Ensembl chr 5:34,224,700...34,239,798
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DHRS9
dehydrogenase/reductase 9
enables
ISO IEA
RGD Ensembl
PMID:12390888
GO_REF:0000107 RGD:633755
NCBI chr36:13,859,935...13,881,432
Ensembl chr36:13,866,959...13,880,179
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HSD17B6
hydroxysteroid 17-beta dehydrogenase 6
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr10:948,982...1,016,651
Ensembl chr10:1,000,199...1,016,420
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LOC100856515
alcohol dehydrogenase 1-like
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr32:21,383,276...21,397,237
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LOC100856533
alcohol dehydrogenase E chain
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr32:21,422,428...21,437,058
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RDH10
retinol dehydrogenase 10
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr29:21,886,014...21,912,451
Ensembl chr29:21,885,012...21,911,303
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RDH12
retinol dehydrogenase 12
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:41,685,045...41,696,120
Ensembl chr 8:41,684,996...41,695,447
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RDH16
retinol dehydrogenase 16
enables
ISO IEA IBA
RGD Ensembl GO_Central
PMID:7499345
GO_REF:0000033 GO_REF:0000107 RGD:1299624
NCBI chr10:1,124,322...1,134,138
Ensembl chr10:1,124,320...1,130,453
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RDH5
retinol dehydrogenase 5
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr10:120,386...125,195
Ensembl chr10:120,057...125,197
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RDH8
retinol dehydrogenase 8
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr20:51,029,633...51,035,910
Ensembl chr20:51,029,609...51,035,951
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SDR16C5
short chain dehydrogenase/reductase family 16C member 5
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr29:7,660,882...7,679,705
Ensembl chr29:7,661,633...7,679,622
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SDR9C7
short chain dehydrogenase/reductase family 9C member 7
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr10:1,112,832...1,121,238
Ensembl chr10:1,112,896...1,120,720
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