ONTOLOGY REPORT - ANNOTATIONS
Term: all-trans-retinol dehydrogenase (NAD+) activity
Accession: GO:0004745
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Definition: Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms: broad_synonym: all-trans retinol dehydrogenase activity; retinal reductase activity; retinene reductase activity; retinol (vitamin A1) dehydrogenase activity; retinol dehydrogenase activity
xref: EC:1.1.1.105; MetaCyc:RETINOL-DEHYDROGENASE-RXN; RHEA:48488; Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA"; reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL"; reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL"; reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro"; reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
enables
ISO
(PMID:15193143)
MGI RGD
PMID:2940107 PMID:15193143
RGD:2315740
NCBI chrNW_004955496:8,136,279...8,149,496
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Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
enables
ISO
(PMID:3663136) (PMID:11997393), (PMID:15369820), (PMID:16787387), (PMID:7876099), (PMID:9600267)
MGI UniProt
PMID:3663136 PMID:7876099 PMID:9600267 PMID:11997393 PMID:15369820 PMID:16787387 More...
NCBI chrNW_004955496:8,065,943...8,100,878
Ensembl chrNW_004955496:8,065,943...8,102,066
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Akr1a1
aldo-keto reductase family 1 member A1
NOT|enables
ISO
(PMID:12732097)
UniProt
PMID:12732097
NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662
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Dhrs3
dehydrogenase/reductase 3
enables
ISO
(PMID:24005908)
MGI
PMID:24005908
NCBI chrNW_004955486:1,439,179...1,473,476
Ensembl chrNW_004955486:1,439,179...1,474,130
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Dhrs7c
dehydrogenase/reductase 7C
enables
ISO
(PMID:21995425)
MGI
PMID:21995425
NCBI chrNW_004955467:7,330,267...7,341,897
Ensembl chrNW_004955467:7,330,188...7,342,053
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Dhrs9
dehydrogenase/reductase 9
enables
ISO
(PMID:11304534)
RGD UniProt
PMID:11304534 PMID:12390888
RGD:633755
NCBI chrNW_004955449:5,360,486...5,380,279
Ensembl chrNW_004955449:5,359,617...5,380,267
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Rdh10
retinol dehydrogenase 10
enables
ISO
(PMID:12407145), (PMID:19458327) (PMID:17473173)
MGI
PMID:12407145 PMID:17473173 PMID:19458327
NCBI chrNW_004955444:6,878,722...6,909,421
Ensembl chrNW_004955444:6,878,722...6,909,421
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Rdh12
retinol dehydrogenase 12
enables
ISO
(PMID:12226107) (PMID:22621924)
UniProt
PMID:12226107 PMID:22621924
NCBI chrNW_004955466:2,473,145...2,485,779
Ensembl chrNW_004955466:2,473,096...2,487,623
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Rdh5
retinol dehydrogenase 5
enables
ISO
(PMID:11675386) (PMID:10588954)
UniProt
PMID:10588954 PMID:11675386
NCBI chrNW_004955458:3,356,324...3,361,701
Ensembl chrNW_004955458:3,352,012...3,365,080
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Rdh8
retinol dehydrogenase 8
enables
ISO
(PMID:15755727)
MGI
PMID:15755727
NCBI chrNW_004955495:1,388,385...1,393,209
Ensembl chrNW_004955495:1,388,424...1,392,552
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Sdr16c5
short chain dehydrogenase/reductase family 16C member 5
enables
ISO
(PMID:18926804), (PMID:19102727)
UniProt
PMID:18926804 PMID:19102727
NCBI chrNW_004955454:15,339,353...15,349,180
Ensembl chrNW_004955454:15,339,297...15,351,628
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Sdr9c7
short chain dehydrogenase/reductase family 9C member 7
enables
ISO
(PMID:19703561)
UniProt
PMID:19703561
NCBI chrNW_004955458:4,538,113...4,551,586
Ensembl chrNW_004955458:4,537,943...4,551,704
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