Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:all-trans-retinol dehydrogenase (NAD+) activity
go back to main search page
Accession:GO:0004745 term browser browse the term
Definition:Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms:broad_synonym: all-trans retinol dehydrogenase activity;   retinal reductase activity;   retinene reductase activity;   retinol (vitamin A1) dehydrogenase activity;   retinol dehydrogenase activity
 xref: EC:1.1.1.105;   MetaCyc:RETINOL-DEHYDROGENASE-RXN;   RHEA:48488;   Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA";   reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL";   reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL";   reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro";   reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"


GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
all-trans-retinol dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide enables ISO (PMID:15193143) MGI
RGD
PMID:2940107 PMID:15193143 RGD:2315740 NCBI chrNW_004955496:8,136,279...8,149,496 JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide enables ISO (PMID:3663136)
(PMID:11997393), (PMID:15369820), (PMID:16787387), (PMID:7876099), (PMID:9600267)
MGI
UniProt
PMID:3663136 PMID:7876099 PMID:9600267 PMID:11997393 PMID:15369820 More... NCBI chrNW_004955496:8,065,943...8,100,878
Ensembl chrNW_004955496:8,065,943...8,102,066
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 NOT|enables ISO (PMID:12732097) UniProt PMID:12732097 NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 enables ISO (PMID:24005908) MGI PMID:24005908 NCBI chrNW_004955486:1,439,179...1,473,476
Ensembl chrNW_004955486:1,439,179...1,474,130
JBrowse link
G Dhrs7c dehydrogenase/reductase 7C enables ISO (PMID:21995425) MGI PMID:21995425 NCBI chrNW_004955467:7,330,267...7,341,897
Ensembl chrNW_004955467:7,330,188...7,342,053
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 enables ISO (PMID:11304534) RGD
UniProt
PMID:11304534 PMID:12390888 RGD:633755 NCBI chrNW_004955449:5,360,486...5,380,279
Ensembl chrNW_004955449:5,359,617...5,380,267
JBrowse link
G Rdh10 retinol dehydrogenase 10 enables ISO (PMID:12407145), (PMID:19458327)
(PMID:17473173)
MGI PMID:12407145 PMID:17473173 PMID:19458327 NCBI chrNW_004955444:6,878,722...6,909,421
Ensembl chrNW_004955444:6,878,722...6,909,421
JBrowse link
G Rdh12 retinol dehydrogenase 12 enables ISO (PMID:12226107)
(PMID:22621924)
UniProt PMID:12226107 PMID:22621924 NCBI chrNW_004955466:2,473,145...2,485,779
Ensembl chrNW_004955466:2,473,096...2,487,623
JBrowse link
G Rdh5 retinol dehydrogenase 5 enables ISO (PMID:11675386)
(PMID:10588954)
UniProt PMID:10588954 PMID:11675386 NCBI chrNW_004955458:3,356,324...3,361,701
Ensembl chrNW_004955458:3,352,012...3,365,080
JBrowse link
G Rdh8 retinol dehydrogenase 8 enables ISO (PMID:15755727) MGI PMID:15755727 NCBI chrNW_004955495:1,388,385...1,393,209
Ensembl chrNW_004955495:1,388,424...1,392,552
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C member 5 enables ISO (PMID:18926804), (PMID:19102727) UniProt PMID:18926804 PMID:19102727 NCBI chrNW_004955454:15,339,353...15,349,180
Ensembl chrNW_004955454:15,339,297...15,351,628
JBrowse link
G Sdr9c7 short chain dehydrogenase/reductase family 9C member 7 enables ISO (PMID:19703561) UniProt PMID:19703561 NCBI chrNW_004955458:4,538,113...4,551,586
Ensembl chrNW_004955458:4,537,943...4,551,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14380
    catalytic activity 3774
      oxidoreductase activity 479
        oxidoreductase activity, acting on CH-OH group of donors 85
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 77
            alcohol dehydrogenase [NAD(P)+] activity 24
              alcohol dehydrogenase (NAD+) activity 13
                all-trans-retinol dehydrogenase (NAD+) activity 12
paths to the root