ONTOLOGY REPORT - ANNOTATIONS
Term: all-trans-retinol dehydrogenase (NAD+) activity
Accession: GO:0004745
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Definition: Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms: broad_synonym: all-trans retinol dehydrogenase activity; retinal reductase activity; retinene reductase activity; retinol (vitamin A1) dehydrogenase activity; retinol dehydrogenase activity
xref: EC:1.1.1.105; MetaCyc:RETINOL-DEHYDROGENASE-RXN; RHEA:48488; Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA"; reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL"; reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL"; reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro"; reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"
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ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
enables
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TreeGrafter
GO_REF:0000118
NCBI chr 4:91,726,870...91,741,824
Ensembl chr 4:102,388,575...102,435,079
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ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
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GO_REF:0000107
NCBI chr 4:91,522,444...91,543,086
Ensembl chr 4:102,183,956...102,206,923
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ADH6
alcohol dehydrogenase 6 (class V)
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GO_REF:0000118
NCBI chr 4:91,604,422...91,621,342
Ensembl chr 4:102,264,224...102,283,210
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ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
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GO_REF:0000107 GO_REF:0000118
NCBI chr 4:91,833,111...91,856,325
Ensembl chr 4:102,494,784...102,518,215
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AKR1A1
aldo-keto reductase family 1 member A1
NOT|enables
ISO
(PMID:12732097)
UniProt
PMID:12732097
NCBI chr 1:44,853,867...44,871,764
Ensembl chr 1:46,211,859...46,230,072
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AKR1C3
aldo-keto reductase family 1 member C3
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GO_REF:0000107
NCBI chr10:5,079,580...5,157,572
Ensembl chr10:5,081,214...5,139,812
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DHRS3
dehydrogenase/reductase 3
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GO_REF:0000107 GO_REF:0000118
NCBI chr 1:11,319,109...11,370,463
Ensembl chr 1:12,533,696...12,584,381
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DHRS7C
dehydrogenase/reductase 7C
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GO_REF:0000107
NCBI chr17:41,864,761...41,884,938
Ensembl chr17:46,608,656...46,628,709
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DHRS9
dehydrogenase/reductase 9
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RGD Ensembl
PMID:12390888
GO_REF:0000107 RGD:633755
NCBI chr2B:56,347,489...56,376,463
Ensembl chr2B:173,811,932...173,842,816
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HSD17B6
hydroxysteroid 17-beta dehydrogenase 6
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GO_REF:0000107
NCBI chr12:32,117,696...32,155,740
Ensembl chr12:32,371,489...32,408,860
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LOC100970753
alcohol dehydrogenase 1C
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RGD TreeGrafter
PMID:2940107
GO_REF:0000118 RGD:2315740
NCBI chr 4:91,756,817...91,773,056
Ensembl chr 4:102,388,575...102,435,079
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LOC100971436
alcohol dehydrogenase 1A
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GO_REF:0000118
NCBI chr 4:91,697,663...91,712,314
Ensembl chr 4:102,359,419...102,374,101
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RDH10
retinol dehydrogenase 10
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GO_REF:0000107
NCBI chr 8:69,833,320...69,863,536
Ensembl chr 8:71,481,089...71,510,689
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RDH12
retinol dehydrogenase 12
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GO_REF:0000107
NCBI chr14:48,297,854...48,314,502
Ensembl chr14:67,180,696...67,192,345
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RDH16
retinol dehydrogenase 16
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Ensembl RGD
PMID:7499345
GO_REF:0000107 RGD:1299624
NCBI chr12:31,958,385...31,966,319
Ensembl chr12:32,212,746...32,219,624
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RDH5
retinol dehydrogenase 5
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GO_REF:0000107 GO_REF:0000118
NCBI chr12:33,186,871...33,191,539
Ensembl chr12:33,911,309...33,920,506
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RDH8
retinol dehydrogenase 8
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GO_REF:0000107 GO_REF:0000118
NCBI chr19:9,565,918...9,575,017
Ensembl chr19:10,226,185...10,235,114
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SDR16C5
short chain dehydrogenase/reductase family 16C member 5
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GO_REF:0000107 GO_REF:0000118
NCBI chr 8:52,746,371...52,769,269
Ensembl chr 8:50,113,413...50,137,717
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SDR9C7
short chain dehydrogenase/reductase family 9C member 7
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GO_REF:0000107
NCBI chr12:31,983,412...31,994,584
Ensembl chr12:32,236,402...32,247,688
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