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ONTOLOGY REPORT - ANNOTATIONS

Term:methyltransferase cap1 activity
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Accession:GO:0004483 term browser browse the term
Definition:Catalysis of the reaction: a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA or snRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA or snRNA + S-adenosyl-L-homocysteine + H+. This activity catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNAs and snRNAs.
Synonyms:related_synonym: S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity;   mRNA (adenosine-2'-O-)-methyltransferase activity;   mRNA (nucleoside-2'-O-)-methyltransferase activity;   messenger RNA (nucleoside-2'-)-methyltransferase activity;   messenger ribonucleate nucleoside 2'-methyltransferase activity
 xref: EC:2.1.1.57;   MetaCyc:2.1.1.57-RXN;   Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)";   Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)";   Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs";   Reactome:R-HSA-9694499 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs";   Reactome:R-HSA-9694521 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)";   Reactome:R-HSA-9694721 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)";   Reactome:R-HSA-9834003 "L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs"


show annotations for term's descendants           Sort by:
methyltransferase cap1 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmtr1 cap methyltransferase 1 enables ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:20713356), (PMID:21310715)
GO_REF:0000003
GO_REF:0000117
GO_REF:0000033
GO_REF:0000104 		UniProt
RGD
GO_Central		 PMID:20713356 PMID:21310715 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000117 NCBI chr20:7,722,729...7,782,579
Ensembl chr20:7,709,713...7,766,302 		JBrowse link
G Cmtr2 cap methyltransferase 2 enables ISO
IBA
IEA 		(PMID:21310715)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000107 		RGD
GO_Central
UniProt
Ensembl		 PMID:21310715 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr19:38,190,718...38,197,549
Ensembl chr19:38,190,642...38,197,804 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21054
    catalytic activity 6213
      catalytic activity, acting on a nucleic acid 677
        catalytic activity, acting on RNA 413
          RNA methyltransferase activity 64
            methyltransferase cap1 activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21054
    catalytic activity 6213
      transferase activity 2477
        transferase activity, transferring one-carbon groups 215
          methyltransferase activity 204
            O-methyltransferase activity 26
              methyltransferase cap1 activity 2
paths to the root