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ONTOLOGY REPORT - ANNOTATIONS


Term:malate dehydrogenase (decarboxylating) (NADP+) activity
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Accession:GO:0004473 term browser browse the term
Definition:Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH.
Comment:For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
Synonyms:related_synonym: 'malic' enzyme;   (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating);   L-malate:NADP oxidoreductase activity;   NADP-linked decarboxylating malic enzyme;   NADP-malic enzyme activity;   NADP-specific malate dehydrogenase activity;   NADP-specific malic enzyme;   malate dehydrogenase (decarboxylating, NADP)
 xref: EC:1.1.1.40;   KEGG_REACTION:R00216;   MetaCyc:MALIC-NADP-RXN;   RHEA:18253;   Reactome:R-HSA-9012036 "ME1 tetramer decarboxylates MAL to PYR";   Reactome:R-HSA-9012349 "ME3 tetramer decarboxylates MAL to PYR"



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malate dehydrogenase (decarboxylating) (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Me1 malic enzyme 1 enables IEA
ISS
IDA
ISO
IBA
GO_REF:0000107
PMID:8187880
PMID:2416344
(PMID:7757881), (PMID:8187880), (PMID:8804575)
GO_REF:0000033
(PMID:18802677), (PMID:6838491)
Ensembl
RGD
GO_Central
PMID:6838491 PMID:7757881 PMID:8187880 PMID:8804575 PMID:18802677 More... GO_REF:0000033 GO_REF:0000107, RGD:8554832, RGD:8554490 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Me2 malic enzyme 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987
JBrowse link
G Me3 malic enzyme 3 enables ISO
IBA
(PMID:7818469)
GO_REF:0000033
(PMID:25711)
RGD
GO_Central
PMID:25711 PMID:7818469 GO_REF:0000033 NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            malate dehydrogenase (decarboxylating) (NADP+) activity 3
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          malate dehydrogenase activity 7
            malic enzyme activity 3
              malate dehydrogenase (decarboxylating) (NADP+) activity 3
paths to the root