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ONTOLOGY REPORT - ANNOTATIONS

Term:malate dehydrogenase (decarboxylating) (NAD+) activity
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Accession:GO:0004471 term browser browse the term
Definition:Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH.
Comment:For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
Synonyms:exact_synonym: malate dehydrogenase (oxaloacetate-decarboxylating) activity
 broad_synonym: NAD-malic enzyme activity
 related_synonym: 'malic' enzyme;   (S)-malate:NAD+ oxidoreductase (decarboxylating);   (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating);   NAD-linked malic enzyme;   NAD-specific malic enzyme;   malate dehydrogenase (decarboxylating) activity
 alt_id: GO:0004472;   GO:0016619
 xref: EC:1.1.1.39;   KEGG_REACTION:R00214;   MetaCyc:1.1.1.39-RXN;   RHEA:12653;   Reactome:R-HSA-9012268 "ME2 tetramer decarboxylates MAL to PYR"


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malate dehydrogenase (decarboxylating) (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Me2 malic enzyme 2 enables ISO (PMID:19691144), (PMID:6725250) RGD PMID:6725250 PMID:19691144 NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            malate dehydrogenase (decarboxylating) (NAD+) activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          malate dehydrogenase activity 7
            malic enzyme activity 3
              malate dehydrogenase (decarboxylating) (NAD+) activity 1
paths to the root