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ONTOLOGY REPORT - ANNOTATIONS

Term:L-lactate dehydrogenase activity
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Accession:GO:0004459 term browser browse the term
Definition:Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
Synonyms:related_synonym: L-lactic acid dehydrogenase activity;   L-lactic dehydrogenase activity
 xref: EC:1.1.1.27;   MetaCyc:L-LACTATE-DEHYDROGENASE-RXN;   RHEA:23444;   reactome:R-HSA-6807826 "LDHAL6B reduces PYR to LACT";   reactome:R-HSA-70510 "LDH tetramer oxidises LACT to PYR";   reactome:R-HSA-71849 "LDH tetramer reduces PYR to LACT"


show annotations for term's descendants           Sort by:
L-lactate dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC098459.1 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000002
GO_REF:0000117		 GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 Ensembl chr 6:75,727,440...75,728,627 JBrowse link
G ENSRNOG00000063729 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr  X:124,938,505...124,939,338 JBrowse link
G ENSRNOG00000068011 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 3:127,090,749...127,092,597 JBrowse link
G ENSRNOG00000068651 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 7:11,641,997...11,643,393 JBrowse link
G Ldha lactate dehydrogenase A enables IDA
IEA
IBA
ISO		 GO_REF:0000116
GO_REF:0000003
GO_REF:0000002
GO_REF:0000033
MGI:2384559|MGI:3776263 (PMID:21041631), (PMID:3796661), (PMID:7323947), (PMID:7534515), (PMID:8224816)
GO_REF:0000117
(PMID:34381247)		 RHEA
UniProt
InterPro
GO_Central
RGD		 PMID:3796661 PMID:7323947 PMID:7534515 PMID:8224816 PMID:21041631 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:1624966 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldhal1 lactate dehydrogenase A like 1 enables IEA GO_REF:0000117
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000117 NCBI chr 8:38,621,351...38,622,975 JBrowse link
G Ldhal6b lactate dehydrogenase A-like 6B enables IBA
IEA		 GO_REF:0000033
GO_REF:0000002
GO_REF:0000117
GO_REF:0000003		 GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:48,402,997...48,404,420
Ensembl chr 1:45,991,991...45,999,272 		JBrowse link
G Ldhb lactate dehydrogenase B enables IDA
IEA
IBA
ISO		 GO_REF:0000003
GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
GO_REF:0000116
GO_REF:0000033
(PMID:16582413), (PMID:1914521), (PMID:5764873)
(PMID:27618187)		 UniProt
Ensembl
InterPro
RHEA
GO_Central
RGD		 PMID:1914521 PMID:5764873 PMID:16582413 PMID:27618187 PMID:17447164 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:1624966 NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Ldhc lactate dehydrogenase C enables IEA
IBA
ISO		 GO_REF:0000003
GO_REF:0000107
GO_REF:0000116
GO_REF:0000002
GO_REF:0000033
MGI:3775042 (PMID:18367675)
GO_REF:0000117		 UniProt
Ensembl
RHEA
InterPro
GO_Central
RGD		 PMID:18367675 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 NCBI chr 1:106,522,140...106,539,649
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      oxidoreductase activity 868
        oxidoreductase activity, acting on CH-OH group of donors 165
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 156
            L-lactate dehydrogenase activity 9
paths to the root