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ONTOLOGY REPORT - ANNOTATIONS

Term:L-lactate dehydrogenase activity
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Accession:GO:0004459 term browser browse the term
Definition:Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
Synonyms:related_synonym: L-lactic acid dehydrogenase activity;   L-lactic dehydrogenase activity
 xref: EC:1.1.1.27;   MetaCyc:L-LACTATE-DEHYDROGENASE-RXN;   RHEA:23444;   reactome:R-HSA-6807826 "LDHAL6B reduces PYR to LACT";   reactome:R-HSA-70510 "LDH tetramer oxidises LACT to PYR";   reactome:R-HSA-71849 "LDH tetramer reduces PYR to LACT"


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L-lactate dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC098459.1 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 Ensembl chr 6:75,727,440...75,728,627 JBrowse link
G Ldha lactate dehydrogenase A enables IDA
ISO
IEA
IBA		 (PMID:34381247)
GO_REF:0000117
MGI:2384559|MGI:3776263 (PMID:21041631), (PMID:3796661), (PMID:7323947), (PMID:7534515), (PMID:8224816)
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:3796661 PMID:7323947 PMID:7534515 PMID:8224816 PMID:21041631 More... GO_REF:0000033 GO_REF:0000117, RGD:1624966 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldhal1 lactate dehydrogenase A like 1 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 8:30,363,220...30,364,836 JBrowse link
G Ldhal6b lactate dehydrogenase A-like 6B enables IEA GO_REF:0000003
GO_REF:0000117		 UniProt GO_REF:0000003 GO_REF:0000117 NCBI chr 1:45,997,845...45,999,268
Ensembl chr 1:45,991,991...45,999,272 		JBrowse link
G Ldhb lactate dehydrogenase B enables IDA
ISO
IBA		 (PMID:27618187)
(PMID:16582413), (PMID:1914521), (PMID:5764873)
GO_REF:0000033		 RGD
GO_Central		 PMID:1914521 PMID:5764873 PMID:16582413 PMID:27618187 PMID:17447164 GO_REF:0000033, RGD:1624966 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Ldhc lactate dehydrogenase C enables IEA
ISO
IBA		 GO_REF:0000003
GO_REF:0000117
MGI:3775042 (PMID:18367675)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:18367675 GO_REF:0000003 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            L-lactate dehydrogenase activity 6
paths to the root