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ONTOLOGY REPORT - ANNOTATIONS

Term:isocitrate dehydrogenase (NADP+) activity
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Accession:GO:0004450 term browser browse the term
Definition:Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
Synonyms:related_synonym: NADP isocitric dehydrogenase activity;   NADP(+)-ICDH activity;   NADP(+)-IDH activity;   NADP-dependent isocitrate dehydrogenase activity;   NADP-dependent isocitric dehydrogenase activity;   NADP-linked isocitrate dehydrogenase activity;   NADP-specific isocitrate dehydrogenase activity;   dual-cofactor-specific isocitrate dehydrogenase activity;   isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity;   isocitrate:NADP+ oxidoreductase (decarboxylating);   triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity
 xref: EC:1.1.1.42;   MetaCyc:ISOCITDEH-RXN;   RHEA:19629;   Reactome:R-HSA-450984 "IDH2 dimer decarboxylates isocitrate";   reactome:R-HSA-389540 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+";   reactome:R-HSA-389550 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+"


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isocitrate dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 enables TAS
IEA
ISO
IBA
ISS
IDA		 GO_REF:0000002
GO_REF:0000003
GO_REF:0000116
GO_REF:0000107
(PMID:1180875), (PMID:12031902), (PMID:14327193), (PMID:18275837), (PMID:1914521)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000024
(PMID:10521434), (PMID:19935646), (PMID:20171178)		 InterPro
UniProt
RHEA
Ensembl
RGD
GO_Central		 PMID:1180875 PMID:1914521 PMID:10521434 PMID:12031902 PMID:14327193 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:633072, RGD:1624966 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 enables IDA
IEA
ISS
ISO
IBA		 GO_REF:0000116
GO_REF:0000003
GO_REF:0000024
GO_REF:0000117
GO_REF:0000002
(PMID:22416140), (PMID:23226729)
GO_REF:0000033
(PMID:18275837), (PMID:7323947), (PMID:8867815)
GO_REF:0000107		 RHEA
UniProt
InterPro
RGD
GO_Central
Ensembl		 PMID:7323947 PMID:8867815 PMID:18275837 PMID:22416140 PMID:23226729 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:11522739 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      oxidoreductase activity 868
        oxidoreductase activity, acting on CH-OH group of donors 165
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 156
            isocitrate dehydrogenase [NAD(P)+] activity 4
              isocitrate dehydrogenase (NADP+) activity 2
paths to the root