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ONTOLOGY REPORT - ANNOTATIONS

Term:hydroxymethylglutaryl-CoA reductase (NADPH) activity
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Accession:GO:0004420 term browser browse the term
Definition:Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH.
Synonyms:broad_synonym: 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity;   HMG-CoA reductase activity
 related_synonym: hydroxymethylglutaryl-CoA reductase activity
 alt_id: GO:0042282
 xref: EC:1.1.1.34;   KEGG_REACTION:R02082;   MetaCyc:1.1.1.34-RXN;   RHEA:15989;   Reactome:R-HSA-191352 "HMGCR dimer reduces bHMG-CoA to MVA"


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hydroxymethylglutaryl-CoA reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase enables ISO
IEA
IBA		 (PMID:21357570), (PMID:2991281)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
(PMID:11792727), (PMID:12114517), (PMID:12920113), (PMID:1352323), (PMID:15845870), (PMID:16100574), (PMID:7798939), (PMID:8647961), (PMID:9186920)		 RGD
InterPro
Ensembl
GO_Central		 PMID:1352323 PMID:2991281 PMID:7798939 PMID:8647961 PMID:9186920 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            hydroxymethylglutaryl-CoA reductase (NADPH) activity 1
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