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ONTOLOGY REPORT - ANNOTATIONS


Term:glycine hydroxymethyltransferase activity
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Accession:GO:0004372 term browser browse the term
Definition:Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
Synonyms:related_synonym: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity;   L-serine hydroxymethyltransferase activity;   allothreonine aldolase activity;   serine aldolase activity;   serine hydroxymethylase activity;   serine hydroxymethyltransferase activity;   serine transhydroxymethylase activity
 xref: EC:2.1.2.1;   MetaCyc:GLYOHMETRANS-RXN;   RHEA:15481;   Reactome:R-HSA-5694137 "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser"



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glycine hydroxymethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000065410 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 2:178,497,468...178,499,169 JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 enables TAS
IDA
ISO
IBA
(PMID:10995219), (PMID:17482557), (PMID:24698160), (PMID:8505317)
GO_REF:0000033
MGI:1277989 (PMID:19513116)
RGD
GO_Central
PMID:8505317 PMID:10995219 PMID:17482557 PMID:19513116 PMID:24698160 More... GO_REF:0000033, RGD:1359815, RGD:1359815, RGD:2300383 NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,468,700...45,497,820
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 enables TAS
IDA
ISO
IBA
(PMID:17482557), (PMID:24075985), (PMID:25619277), (PMID:29180469), (PMID:29364879), (PMID:29452640), (PMID:33015733), (PMID:8505317)
GO_REF:0000033
MGI:98299 (PMID:19513116)
RGD
GO_Central
PMID:8505317 PMID:17482557 PMID:19513116 PMID:24075985 PMID:25619277 More... GO_REF:0000033, RGD:1359815, RGD:1359815, RGD:2300380, RGD:2300383 NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:63,358,961...63,364,236
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 21088
    catalytic activity 6122
      transferase activity 2441
        transferase activity, transferring one-carbon groups 214
          hydroxymethyl-, formyl- and related transferase activity 9
            glycine hydroxymethyltransferase activity 3
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