glycine hydroxymethyltransferase activity - Ontology Report

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Term:	glycine hydroxymethyltransferase activity	go back to main search page
Accession:	GO:0004372	browse the term
Definition:	Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine.
Synonyms:	related_synonym:	5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity; L-serine hydroxymethyltransferase activity; allothreonine aldolase activity; serine aldolase activity; serine hydroxymethylase activity; serine hydroxymethyltransferase activity; serine transhydroxymethylase activity
	xref:	MetaCyc:GLYOHMETRANS-RXN; RHEA:15481; Reactome:R-HSA-5694137 "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser"

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Genes (2)

glycine hydroxymethyltransferase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Shmt1

serine hydroxymethyltransferase 1

enables

TAS
IDA
IBA
IEA
ISO

GO_REF:0000033
GO_REF:0000003
GO_REF:0000002
GO_REF:0000117
(PMID:10995219), (PMID:17482557), (PMID:24698160), (PMID:30035852), (PMID:38996576), (PMID:8505317)
MGI:1277989 (PMID:19513116)

GO_Central
UniProt
InterPro
RGD

PMID:8505317 PMID:10995219 PMID:17482557 PMID:19513116 PMID:24698160 More...

GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000117, RGD:1359815, RGD:1359815, RGD:2300383

NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,960,434...45,997,326

Shmt2

serine hydroxymethyltransferase 2

enables

TAS
IDA
ISO
IBA
IEA

(PMID:17482557), (PMID:24075985), (PMID:25619277), (PMID:29180469), (PMID:29364879), (PMID:29452640), (PMID:33015733), (PMID:8505317)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
GO_REF:0000003
GO_REF:0000117
MGI:98299 (PMID:19513116)
(PMID:34383924)

RGD
GO_Central
Ensembl
InterPro
UniProt

PMID:8505317 PMID:17482557 PMID:19513116 PMID:24075985 PMID:25619277 More...

GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:1359815, RGD:1359815, RGD:2300380, RGD:2300383

NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:65,244,247...65,249,567

Term paths to the root

Path 1
Term	Annotations
molecular_function	19971
catalytic activity	5918
transferase activity	2382
transferase activity, transferring one-carbon groups	212
hydroxymethyl-, formyl- and related transferase activity	8
glycine hydroxymethyltransferase activity	2

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ONTOLOGY REPORT - ANNOTATIONS