glucose-6-phosphate dehydrogenase activity - Ontology Report

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Term:	glucose-6-phosphate dehydrogenase activity	go back to main search page
Accession:	GO:0004345	browse the term
Definition:	Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
Synonyms:	exact_synonym:	6-phosphoglucose dehydrogenase activity; D-glucose 6-phosphate dehydrogenase activity; G6PDH; NADP-dependent glucose 6-phosphate dehydrogenase activity; NADP-glucose-6-phosphate dehydrogenase activity; glucose-6-phosphate 1-dehydrogenase activity
	related_synonym:	6-phosphoglucose dehydrogenas; D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity; Entner-doudoroff enzyme; G6PD activity; GDH; zwischenferment
	xref:	EC:1.1.1.49; MetaCyc:GLU6PDEHYDROG-RXN; RHEA:15841; reactome:R-HSA-70377 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+"

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Genes (2)

glucose-6-phosphate dehydrogenase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G6pd

glucose-6-phosphate dehydrogenase

enables

IDA
IMP
ISO

PMID:21930213
PMID:21569266
(PMID:15858258), (PMID:2420826), (PMID:35122041), (PMID:38066190), (PMID:5643703), (PMID:743300)
MGI:2182739|MGI:2387672 (PMID:10627286), (PMID:12466018), (PMID:12521604), (PMID:14751857), (PMID:14757696), (PMID:15155459), (PMID:15271799), (PMID:15998684), (PMID:1953691), (PMID:22829586), (PMID:3243423), (PMID:3377761), (PMID:5764873), (PMID:7439685), (PMID:7489710), (PMID:8491670), (PMID:9067418), (PMID:9169132), (PMID:9330624), (PMID:943046), (PMID:9539108), (PMID:9627357)

RGD

PMID:743300 PMID:943046 PMID:1953691 PMID:2420826 PMID:3243423 More...

RGD:1599371, RGD:1599574, RGD:1624966, RGD:1624987, RGD:2317315, RGD:2317316, RGD:10047267, RGD:10047183

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

H6pd

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

enables

IDA
ISO

(PMID:18628520), (PMID:23132696)
MGI:3624665 (PMID:12831846), (PMID:18222920)

RGD

PMID:12831846 PMID:18222920 PMID:18628520 PMID:23132696 PMID:6813321

RGD:1641956

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

Term paths to the root

Path 1
Term	Annotations
molecular_function	20634
catalytic activity	6032
oxidoreductase activity	854
oxidoreductase activity, acting on CH-OH group of donors	161
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	152
glucose-6-phosphate dehydrogenase activity	2

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ONTOLOGY REPORT - ANNOTATIONS