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ONTOLOGY REPORT - ANNOTATIONS

Term:estradiol 17-beta-dehydrogenase [NAD(P)+] activity
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Accession:GO:0004303 term browser browse the term
Definition:Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor.
Synonyms:broad_synonym: 17-beta-HSD activity;   17-beta-hydroxysteroid dehydrogenase activity;   20alpha-hydroxysteroid dehydrogenase
 related_synonym: 17-beta-estradiol dehydrogenase activity;   17beta,20alpha-hydroxysteroid dehydrogenase activity;   17beta-HSD;   17beta-estradiol dehydrogenase activity;   17beta-hydroxysteroid dehydrogenase activity;   estradiol dehydrogenase activity;   estradiol-17beta:NAD(P)+ 17-oxidoreductase activity;   estrogen 17-oxidoreductase activity
 xref: EC:1.1.1.62;   MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN;   reactome:R-HSA-5693390 "HSD17B11 dehydrogenates EST17b to E1";   reactome:R-HSA-5696822 "AKR1B15 reduces EST17b to E1";   reactome:R-HSA-6810594 "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)";   reactome:R-HSA-804969 "HSD17B1 hydrogenates E1 to EST17b";   reactome:R-HSA-8862137 "HSD17B2 oxidises estradiol (E2) to estrone (E1)"


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estradiol 17-beta-dehydrogenase [NAD(P)+] activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 enables ISO (PMID:25577493) RGD PMID:25577493 NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 enables ISO
IEA		 (PMID:7737980)
GO_REF:0000003		 RGD
UniProt		 PMID:7737980 GO_REF:0000003 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 enables ISO
IEA		 (PMID:26920053)
GO_REF:0000107		 RGD
Ensembl		 PMID:26920053 GO_REF:0000107 NCBI chr10:70,195,637...70,205,735
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 enables IDA
ISO
IBA
IEA		 (PMID:10625652), (PMID:4396689), (PMID:8994190), (PMID:9525918)
GO_REF:0000033
(PMID:9658408)
GO_REF:0000107
GO_REF:0000003
GO_REF:0000116
GO_REF:0000002		 RGD
GO_Central
Ensembl
UniProt
RHEA
InterPro		 PMID:4396689 PMID:8994190 PMID:9525918 PMID:9658408 PMID:10625652 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:728619 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 enables IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000116
GO_REF:0000003		 GO_Central
RHEA
UniProt
RGD		 PMID:11023795 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116, RGD:2302237 NCBI chr  X:24,568,551...24,571,012
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 enables ISO
IEA		 (PMID:12697717)
GO_REF:0000003
GO_REF:0000116
GO_REF:0000107		 RGD
UniProt
RHEA
Ensembl		 PMID:12697717 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr14:5,997,893...6,047,816
Ensembl chr14:5,711,964...5,743,161 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr14:6,056,708...6,071,463
Ensembl chr14:5,752,132...5,768,166 		JBrowse link
G Hsd17b14 hydroxysteroid (17-beta) dehydrogenase 14 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:105,165,695...105,176,045
Ensembl chr 1:96,029,284...96,039,883 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 enables IDA
ISO
IEA
IBA		 (PMID:17538076), (PMID:8099587)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000003
GO_REF:0000116		 RGD
Ensembl
GO_Central
UniProt
RHEA		 PMID:8099587 PMID:17538076 PMID:8612487 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:728619 NCBI chr19:62,662,320...62,733,944
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 enables IDA
IEA		 GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA
RGD		 PMID:10433209 GO_REF:0000003 GO_REF:0000116, RGD:727276 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 enables IDA
ISO
IEA		 (PMID:7487879)
GO_REF:0000107		 RGD
Ensembl		 PMID:7487879 PMID:12225901 GO_REF:0000107, RGD:10411898 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 enables IDA
ISO
IEA		 PMID:9188497
(PMID:10537158)
GO_REF:0000116
GO_REF:0000003		 RGD
RHEA
UniProt		 PMID:10537158 PMID:9188497 GO_REF:0000003 GO_REF:0000116, RGD:1299376 NCBI chr 7:831,407...850,950
Ensembl chr 7:422,480...442,425 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 enables ISO
IEA
IDA
IBA		 (PMID:12732193), (PMID:19772289)
GO_REF:0000107
PMID:9658408
GO_REF:0000033
(PMID:12732193), (PMID:9658408)
GO_REF:0000003
GO_REF:0000116		 RGD
Ensembl
GO_Central
UniProt
RHEA		 PMID:9658408 PMID:12732193 PMID:19772289 PMID:9658408 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:30309934 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 enables ISO
ISS
IBA
IEA		 (PMID:17978863)
GO_REF:0000024
GO_REF:0000033
(PMID:9712896)
GO_REF:0000003
GO_REF:0000116		 RGD
UniProt
GO_Central
RHEA		 PMID:9712896 PMID:17978863 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 NCBI chr20:4,828,571...4,830,635
Ensembl chr20:4,822,026...4,828,742 		JBrowse link
G Rdh8 retinol dehydrogenase 8 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:27,629,380...27,636,651
Ensembl chr 8:19,353,191...19,360,462 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21102
    catalytic activity 7309
      oxidoreductase activity 885
        steroid dehydrogenase activity 45
          steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 38
            estradiol 17-beta-dehydrogenase [NAD(P)+] activity 16
Path 2
Term Annotations click to browse term
  molecular_function 21102
    catalytic activity 7309
      oxidoreductase activity 885
        oxidoreductase activity, acting on CH-OH group of donors 165
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 156
            steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 38
              estradiol 17-beta-dehydrogenase [NAD(P)+] activity 16
paths to the root