ONTOLOGY REPORT - ANNOTATIONS
Term: metalloendopeptidase activity
Accession: GO:0004222
browse the term
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms: narrow_synonym: metalloendoprotease activity; metalloendoproteinase activity
xref: EC:3.4.24; Reactome:R-HSA-181567 "botC LC cleaves target cell STX1"; Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25"; Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2"; Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25"; Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1"; Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1"; Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25"; Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14"; Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)"; Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2"; Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2"; Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2"; Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2"; Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1"; Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)"; Reactome:R-HSA-9624272 "MMPs cleave HB-EGF"; Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer"; Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer"; Reactome:R-HSA-9840408 "OMA1 cleaves DELE1"; Reactome:R-HSA-9840532 "OMA1 self-cleaves"; Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1"; Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer"; reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR"; reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17"; reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors"; reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors"; reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13"; reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2"; reactome:R-HSA-1458433 "Collagen type I degradation by MMP14"; reactome:R-HSA-1474196 "Collagen type II degradation by MMP14"; reactome:R-HSA-1474210 "Collagen type III degradation by MMP14"; reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13"; reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11"; reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13"; reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3"; reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12"; reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2"; reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10"; reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1"; reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9"; reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13"; reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs"; reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2"; reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF"; reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides"; reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides"; reactome:R-HSA-2022141 "Prolysyl oxidase activation"; reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12"; reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9"; reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF"; reactome:R-HSA-2473584 "Collagen type III degradation by MMP15"; reactome:R-HSA-2473594 "Collagen type II degradation by MMP15"; reactome:R-HSA-2473596 "Collagen type I degradation by MMP15"; reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13"; reactome:R-HSA-2485111 "Collagen type III degradation by MMP10"; reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13"; reactome:R-HSA-2514790 "Elastin degradation by MMP14"; reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14"; reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14"; reactome:R-HSA-2533944 "Fibronectin degradation by MMP10"; reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15"; reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7"; reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15"; reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7"; reactome:R-HSA-2537499 "Gelatin degradation by MMP19"; reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1"; reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5"; reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19"; reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14"; reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13"; reactome:R-HSA-3791319 "NID1 degradation by MMP19"; reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS"; reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4"; reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS"; reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7"; reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14"; reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7"; reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)"; reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15"; reactome:R-HSA-5333671 "CLCAs self cleave"; reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding"; reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3"; reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)"; reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1"; reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2"; reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3"; reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1"; reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4"; reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3"; reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)"; reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)"; reactome:R-HSA-8940554 "MMP2 cleaves OPTC"; reactome:R-HSA-8940561 "MMP7 cleaves OPTC"; reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)"; reactome:R-HSA-8940959 "Neurolysin degrades neurotensin"; reactome:R-HSA-8942302 "MMP13 cleaves OPTC"; reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3"; reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)"; reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU"; reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"
GViewer not supported for the selected species.
G
Adam10
ADAM metallopeptidase domain 10
enables
ISO IEA
RGD InterPro Ensembl
PMID:10423016
GO_REF:0000002 GO_REF:0000107 RGD:631800
NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759
G
Adam11
ADAM metallopeptidase domain 11
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936541:1,138,797...1,159,016
Ensembl chrNW_004936541:1,138,790...1,159,054
G
Adam12
ADAM metallopeptidase domain 12
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936486:13,963,000...14,189,948
Ensembl chrNW_004936486:13,963,091...14,279,796
G
Adam15
ADAM metallopeptidase domain 15
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936580:4,588,182...4,598,659
Ensembl chrNW_004936580:4,588,039...4,599,014
G
Adam17
ADAM metallopeptidase domain 17
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936532:5,864,851...5,904,005
Ensembl chrNW_004936532:5,864,867...5,904,003
G
Adam18
ADAM metallopeptidase domain 18
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936843:805,614...836,657
Ensembl chrNW_004936843:707,093...836,657
G
Adam19
ADAM metallopeptidase domain 19
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936515:5,603,095...5,683,347
G
Adam2
ADAM metallopeptidase domain 2
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936675:393,160...451,851
Ensembl chrNW_004936675:397,161...451,153
G
Adam22
ADAM metallopeptidase domain 22
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936763:738,051...952,435
Ensembl chrNW_004936763:739,629...952,435
G
Adam23
ADAM metallopeptidase domain 23
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936631:2,777,595...2,946,191
Ensembl chrNW_004936631:2,778,849...2,946,187
G
Adam28
ADAM metallopeptidase domain 28
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936555:7,615,639...7,660,776
Ensembl chrNW_004936555:7,617,822...7,664,215
G
Adam33
ADAM metallopeptidase domain 33
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936485:15,005,329...15,018,063
Ensembl chrNW_004936485:15,007,485...15,017,497
G
Adam7
ADAM metallopeptidase domain 7
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936555:7,724,565...7,770,986
Ensembl chrNW_004936555:7,724,565...7,770,149
G
Adam8
ADAM metallopeptidase domain 8
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936486:19,389,925...19,403,577
Ensembl chrNW_004936486:19,391,324...19,402,332
G
Adam9
ADAM metallopeptidase domain 9
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chrNW_004936710:2,301,470...2,388,533
Ensembl chrNW_004936710:2,301,730...2,387,695
G
Adamdec1
ADAM like decysin 1
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936555:7,686,841...7,697,084
Ensembl chrNW_004936555:7,686,841...7,697,078
G
Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif 1
enables
IEA
TreeGrafter Ensembl InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936640:959,405...967,305
Ensembl chrNW_004936640:959,417...968,842
G
Adamts10
ADAM metallopeptidase with thrombospondin type 1 motif 10
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936588:5,337,519...5,356,978
Ensembl chrNW_004936588:5,337,877...5,354,848
G
Adamts12
ADAM metallopeptidase with thrombospondin type 1 motif 12
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936518:7,180,262...7,483,416
Ensembl chrNW_004936518:7,180,428...7,480,802
G
Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif 13
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936669:3,449,259...3,478,471
Ensembl chrNW_004936669:3,456,494...3,478,512
G
Adamts14
ADAM metallopeptidase with thrombospondin type 1 motif 14
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936521:7,951,176...8,025,666
Ensembl chrNW_004936521:7,952,365...8,025,614
G
Adamts15
ADAM metallopeptidase with thrombospondin type 1 motif 15
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936572:1,935,780...1,960,888
Ensembl chrNW_004936572:1,936,529...1,960,800
G
Adamts16
ADAM metallopeptidase with thrombospondin type 1 motif 16
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936634:1,830,252...1,925,622
Ensembl chrNW_004936634:1,830,593...1,958,640
G
Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif 17
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936483:3,388,269...3,735,169
Ensembl chrNW_004936483:3,388,342...3,732,639
G
Adamts18
ADAM metallopeptidase with thrombospondin type 1 motif 18
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936475:25,698,117...25,831,291
Ensembl chrNW_004936475:25,699,840...25,831,284
G
Adamts19
ADAM metallopeptidase with thrombospondin type 1 motif 19
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936504:2,567,433...2,823,087
Ensembl chrNW_004936504:2,567,552...2,821,576
G
Adamts2
ADAM metallopeptidase with thrombospondin type 1 motif 2
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936739:1,394,119...1,643,422
Ensembl chrNW_004936739:1,394,119...1,641,130
G
Adamts20
ADAM metallopeptidase with thrombospondin type 1 motif 20
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936512:1,942,902...2,088,122
Ensembl chrNW_004936512:1,943,196...2,088,122
G
Adamts3
ADAM metallopeptidase with thrombospondin type 1 motif 3
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936598:2,680,623...2,901,308
Ensembl chrNW_004936598:2,680,087...2,901,330
G
Adamts4
ADAM metallopeptidase with thrombospondin type 1 motif 4
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936903:490,718...500,443
Ensembl chrNW_004936903:491,139...500,443
G
Adamts5
ADAM metallopeptidase with thrombospondin type 1 motif 5
enables
IEA
InterPro Ensembl TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936640:857,565...899,355
Ensembl chrNW_004936640:858,322...898,182
G
Adamts6
ADAM metallopeptidase with thrombospondin type 1 motif 6
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936480:3,798,044...3,965,203
Ensembl chrNW_004936480:3,675,805...3,965,210
G
Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif 7
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936471:36,978,555...37,025,733
Ensembl chrNW_004936471:36,978,667...37,025,773
G
Adamts8
ADAM metallopeptidase with thrombospondin type 1 motif 8
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936572:1,978,642...1,999,411
G
Adamts9
ADAM metallopeptidase with thrombospondin type 1 motif 9
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936637:1,787,987...1,946,250
Ensembl chrNW_004936637:1,788,276...1,942,833
G
Adamtsl4
ADAMTS like 4
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004936580:782,146...791,388
Ensembl chrNW_004936580:782,112...791,605
G
Adamtsl5
ADAMTS like 5
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004936588:810,880...817,636
Ensembl chrNW_004936588:810,234...817,656
G
Afg3l2
AFG3 like matrix AAA peptidase subunit 2
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chrNW_004936626:150,953...189,980
Ensembl chrNW_004936626:150,974...189,218
G
Astl
astacin like metalloendopeptidase
enables
IEA
UniProt TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118
NCBI chrNW_004936744:259,188...268,919
Ensembl chrNW_004936744:259,188...268,928
G
Atp23
ATP23 metallopeptidase and ATP synthase assembly factor homolog
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936646:2,057,112...2,074,382
Ensembl chrNW_004936646:2,060,552...2,074,687
G
Bmp1
bone morphogenetic protein 1
enables
IEA
InterPro UniProt Ensembl
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107
NCBI chrNW_004936555:5,990,822...6,023,864
Ensembl chrNW_004936555:5,990,836...6,023,878
G
Ece1
endothelin converting enzyme 1
enables
IEA
InterPro TreeGrafter UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000118
NCBI chrNW_004936474:7,034,134...7,083,005
Ensembl chrNW_004936474:7,034,134...7,083,005
G
Ecel1
endothelin converting enzyme like 1
enables
IEA
TreeGrafter InterPro Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936525:4,599,840...4,608,469
Ensembl chrNW_004936525:4,600,246...4,608,508
G
Ide
insulin degrading enzyme
enables
ISO IEA
atrial natriuretic peptide cleaved at the Ser25-Phe26 bond
RGD TreeGrafter Ensembl InterPro
PMID:15494400 PMID:15749695
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1626704 RGD:1626705
NCBI chrNW_004936601:2,230,477...2,318,562
Ensembl chrNW_004936601:2,230,283...2,318,752
G
Kel
Kell metallo-endopeptidase (Kell blood group)
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936527:406,061...431,142
Ensembl chrNW_004936527:406,132...427,186
G
Lmln
leishmanolysin like peptidase
enables
IEA
UniProt InterPro
GO_REF:0000002 GO_REF:0000104
NCBI chrNW_004936784:93,734...164,686
Ensembl chrNW_004936784:93,725...164,968
G
LOC101955597
disintegrin and metalloproteinase domain-containing protein 1a-like
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936558:4,452,828...4,456,389
G
LOC101957150
stromelysin-1
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936551:5,137,801...5,145,934
Ensembl chrNW_004936551:5,137,801...5,145,934
G
LOC101957314
disintegrin and metalloproteinase domain-containing protein 20-like
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936488:43,210...45,441
G
LOC101958582
disintegrin and metalloproteinase domain-containing protein 25-like
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936554:1,884,125...1,971,070
G
LOC101959620
disintegrin and metalloproteinase domain-containing protein 29-like
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936516:5,927,900...5,930,263
Ensembl chrNW_004936516:5,927,900...5,930,256
G
LOC101959833
endothelin-converting enzyme 2
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936578:5,586,086...5,615,940
Ensembl chrNW_004936578:5,585,443...5,616,099
G
LOC101967362
mediator of RNA polymerase II transcription subunit 6
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936488:195,629...218,762
Ensembl chrNW_004936488:97,118...99,286 Ensembl chrNW_004936488:97,118...99,286
G
LOC101968921
angiotensin-converting enzyme
enables
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
G
LOC101973430
cytochrome b-c1 complex subunit 2, mitochondrial
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936501:6,947,985...6,968,846
Ensembl chrNW_004936501:6,947,985...6,970,254
G
LOC101977589
AFG3-like protein 1
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936641:126,441...140,366
G
Mbtps2
membrane bound transcription factor peptidase, site 2
enables
IEA
TreeGrafter Ensembl InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936624:2,464,152...2,510,984
Ensembl chrNW_004936624:2,463,909...2,511,158
G
Mep1a
meprin A subunit alpha
enables
IEA
UniProt TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118
NCBI chrNW_004936476:13,514,965...13,553,209
G
Mep1b
meprin A subunit beta
enables
ISO IEA
RGD InterPro UniProt TreeGrafter
PMID:12437103
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:633322
NCBI chrNW_004936682:1,102,365...1,132,404
Ensembl chrNW_004936682:1,105,243...1,132,404
G
Mipep
mitochondrial intermediate peptidase
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936688:1,592,810...1,736,896
Ensembl chrNW_004936688:1,592,821...1,737,282
G
Mme
membrane metalloendopeptidase
enables
IEA
InterPro TreeGrafter Ensembl UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936519:2,513,896...2,595,896
Ensembl chrNW_004936519:2,513,704...2,595,971
G
Mmel1
membrane metalloendopeptidase like 1
enables
ISO IEA
RGD TreeGrafter InterPro
PMID:11964170
GO_REF:0000002 GO_REF:0000118 RGD:2314417
NCBI chrNW_004936737:970,504...997,452
Ensembl chrNW_004936737:970,504...997,067
G
Mmp1
matrix metallopeptidase 1
enables
IEA
TreeGrafter Ensembl InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857
G
Mmp10
matrix metallopeptidase 10
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936551:5,188,395...5,197,477
G
Mmp11
matrix metallopeptidase 11
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936619:1,309,013...1,320,062
Ensembl chrNW_004936619:1,310,846...1,320,062
G
Mmp12
matrix metallopeptidase 12
enables
IEA
TreeGrafter Ensembl InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936551:5,107,567...5,117,843
Ensembl chrNW_004936551:5,106,285...5,117,843
G
Mmp13
matrix metallopeptidase 13
enables
ISO IEA
RGD TreeGrafter Ensembl InterPro
PMID:8910479 PMID:17941091
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2296055 RGD:2298541
NCBI chrNW_004936551:5,040,084...5,050,384
Ensembl chrNW_004936551:5,040,084...5,050,384
G
Mmp14
matrix metallopeptidase 14
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936722:1,447,189...1,457,632
Ensembl chrNW_004936722:1,447,335...1,457,611
G
Mmp15
matrix metallopeptidase 15
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936475:9,951,876...9,971,631
Ensembl chrNW_004936475:9,951,778...9,971,666
G
Mmp16
matrix metallopeptidase 16
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936544:2,297,698...2,546,683
Ensembl chrNW_004936544:2,298,028...2,546,689
G
Mmp17
matrix metallopeptidase 17
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936660:2,139,777...2,152,159
Ensembl chrNW_004936660:2,139,129...2,150,741
G
Mmp19
matrix metallopeptidase 19
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936646:298,854...304,479
Ensembl chrNW_004936646:299,059...304,430
G
Mmp2
matrix metallopeptidase 2
enables
IEA
InterPro TreeGrafter Ensembl UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936475:7,801,356...7,825,831
Ensembl chrNW_004936475:7,801,277...7,825,851
G
Mmp20
matrix metallopeptidase 20
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936551:5,310,426...5,352,883
Ensembl chrNW_004936551:5,310,426...5,352,883
G
Mmp21
matrix metallopeptidase 21
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936486:13,781,441...13,789,018
Ensembl chrNW_004936486:13,781,616...13,788,955
G
Mmp23b
matrix metallopeptidase 23B
enables
IEA
TreeGrafter Ensembl InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936737:1,628,915...1,632,023
Ensembl chrNW_004936737:1,629,639...1,632,023
G
Mmp24
matrix metallopeptidase 24
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936561:5,479,107...5,501,559
Ensembl chrNW_004936561:5,478,145...5,502,529
G
Mmp25
matrix metallopeptidase 25
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936694:1,118,432...1,128,315
Ensembl chrNW_004936694:1,118,670...1,128,261
G
Mmp27
matrix metallopeptidase 27
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936551:5,253,762...5,262,426
Ensembl chrNW_004936551:5,253,762...5,262,426
G
Mmp28
matrix metallopeptidase 28
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936490:165,462...188,788
Ensembl chrNW_004936490:165,376...188,823
G
Mmp7
matrix metallopeptidase 7
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936551:5,388,456...5,395,071
Ensembl chrNW_004936551:5,388,459...5,395,071
G
Mmp8
matrix metallopeptidase 8
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936551:5,228,950...5,238,948
Ensembl chrNW_004936551:5,228,950...5,238,948
G
Mmp9
matrix metallopeptidase 9
enables
IEA
TreeGrafter InterPro Ensembl UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793
G
Nln
neurolysin
enables
ISO IEA
RGD InterPro TreeGrafter
PMID:7836437
GO_REF:0000002 GO_REF:0000118 RGD:9831155
NCBI chrNW_004936480:3,383,514...3,480,991
Ensembl chrNW_004936480:3,383,540...3,481,009
G
Nrdc
nardilysin convertase
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936522:9,041,204...9,129,674
Ensembl chrNW_004936522:9,041,111...9,129,327
G
Oma1
OMA1 zinc metallopeptidase
enables
IEA
TreeGrafter InterPro Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936522:3,232,877...3,294,832
Ensembl chrNW_004936522:3,233,510...3,294,798
G
Papln
papilin, proteoglycan like sulfated glycoprotein
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004936488:2,558,007...2,578,173
Ensembl chrNW_004936488:2,558,289...2,577,942
G
Pappa
pappalysin 1
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004936487:5,000,279...5,379,786
Ensembl chrNW_004936487:5,144,044...5,376,367
G
Pappa2
pappalysin 2
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004936481:11,756,580...11,998,919
Ensembl chrNW_004936481:11,756,085...11,997,132
G
Phex
phosphate regulating endopeptidase X-linked
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936624:2,124,479...2,312,847
Ensembl chrNW_004936624:2,126,253...2,312,847
G
Pitrm1
pitrilysin metallopeptidase 1
enables
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936484:11,071,407...11,104,828
Ensembl chrNW_004936484:11,071,372...11,104,828
G
Pmpca
peptidase, mitochondrial processing subunit alpha
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936669:1,385,010...1,395,715
Ensembl chrNW_004936669:1,386,817...1,395,597
G
Pmpcb
peptidase, mitochondrial processing subunit beta
enables
IEA
TreeGrafter InterPro UniProt Ensembl
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936479:20,198,417...20,210,160
Ensembl chrNW_004936479:20,198,417...20,210,202
G
Rce1
Ras converting CAAX endopeptidase 1
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936599:2,794,947...2,798,121
Ensembl chrNW_004936599:2,793,215...2,798,707
G
Spg7
SPG7 matrix AAA peptidase subunit, paraplegin
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chrNW_004936641:451,762...484,229
Ensembl chrNW_004936641:452,475...484,220
G
Sprtn
SprT-like N-terminal domain
enables
IEA
InterPro Ensembl
GO_REF:0000002 GO_REF:0000107
NCBI chrNW_004936484:19,391,685...19,402,938
Ensembl chrNW_004936484:19,391,420...19,402,944
G
Thop1
thimet oligopeptidase 1
enables
IEA
TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004936588:1,618,585...1,637,788
Ensembl chrNW_004936588:1,618,541...1,637,821
G
Thsd4
thrombospondin type 1 domain containing 4
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004936471:31,002,241...31,213,057
Ensembl chrNW_004936471:30,654,136...31,207,266
G
Tll1
tolloid like 1
enables
IEA
InterPro UniProt
GO_REF:0000002 GO_REF:0000104
NCBI chrNW_004936555:7...198,382
Ensembl chrNW_004936555:193...96,729
G
Tll2
tolloid like 2
enables
IEA
UniProt InterPro
GO_REF:0000002 GO_REF:0000104
NCBI chrNW_004936636:3,010,774...3,126,402
Ensembl chrNW_004936636:3,011,007...3,125,714
G
Trabd2b
TraB domain containing 2B
enables
IEA
TreeGrafter Ensembl UniProt
GO_REF:0000104 GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936474:28,565,563...28,752,370
Ensembl chrNW_004936474:28,531,931...28,752,736
G
Ybey
ybeY metalloendoribonuclease
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936778:265,855...273,053
Ensembl chrNW_004936778:266,151...272,955
G
Yme1l1
YME1 like 1 ATPase
enables
IEA
InterPro
GO_REF:0000002
NCBI chrNW_004936484:2,306,937...2,352,671
Ensembl chrNW_004936484:2,306,760...2,353,507
G
Zmpste24
zinc metallopeptidase STE24
enables
IEA
UniProt InterPro Ensembl
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107
NCBI chrNW_004936474:22,035,059...22,077,846
Ensembl chrNW_004936474:22,034,801...22,077,986
G
Adam10
ADAM metallopeptidase domain 10
enables
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759
G
Adam17
ADAM metallopeptidase domain 17
enables
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936532:5,864,851...5,904,005
Ensembl chrNW_004936532:5,864,867...5,904,003
G
Adam19
ADAM metallopeptidase domain 19
enables
ISO
(PMID:17112471)
ARUK-UCL
PMID:17112471
NCBI chrNW_004936515:5,603,095...5,683,347
G
Adam9
ADAM metallopeptidase domain 9
enables
ISO
(PMID:12054541)
ARUK-UCL
PMID:12054541
NCBI chrNW_004936710:2,301,470...2,388,533
Ensembl chrNW_004936710:2,301,730...2,387,695
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all