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ONTOLOGY REPORT - ANNOTATIONS


Term:metalloendopeptidase activity
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Accession:GO:0004222 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms:narrow_synonym: metalloendoprotease activity;   metalloendoproteinase activity
 xref: EC:3.4.24;   Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";   Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";   Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";   Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";   Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";   Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";   Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";   Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14";   Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";   Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";   Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";   Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";   Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";   Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";   Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";   Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";   Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";   Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";   Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";   Reactome:R-HSA-9840532 "OMA1 self-cleaves";   Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";   Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer";   reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";   reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";   reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";   reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";   reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";   reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";   reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";   reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";   reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";   reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";   reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";   reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";   reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";   reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";   reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";   reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";   reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";   reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";   reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";   reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";   reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";   reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";   reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";   reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";   reactome:R-HSA-2022141 "Prolysyl oxidase activation";   reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";   reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";   reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";   reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";   reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";   reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";   reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";   reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";   reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";   reactome:R-HSA-2514790 "Elastin degradation by MMP14";   reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";   reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";   reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";   reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";   reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";   reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";   reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";   reactome:R-HSA-2537499 "Gelatin degradation by MMP19";   reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";   reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";   reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";   reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";   reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";   reactome:R-HSA-3791319 "NID1 degradation by MMP19";   reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";   reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";   reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";   reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";   reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";   reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";   reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";   reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";   reactome:R-HSA-5333671 "CLCAs self cleave";   reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";   reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";   reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";   reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";   reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";   reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";   reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";   reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";   reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";   reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";   reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";   reactome:R-HSA-8940554 "MMP2 cleaves OPTC";   reactome:R-HSA-8940561 "MMP7 cleaves OPTC";   reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";   reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";   reactome:R-HSA-8942302 "MMP13 cleaves OPTC";   reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";   reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";   reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";   reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"


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metalloendopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 enables ISO
IEA
RGD
InterPro
Ensembl
PMID:10423016 GO_REF:0000002 GO_REF:0000107 RGD:631800 NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759
JBrowse link
G Adam11 ADAM metallopeptidase domain 11 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936541:1,138,797...1,159,016
Ensembl chrNW_004936541:1,138,790...1,159,054
JBrowse link
G Adam12 ADAM metallopeptidase domain 12 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936486:13,963,000...14,189,948
Ensembl chrNW_004936486:13,963,091...14,279,796
JBrowse link
G Adam15 ADAM metallopeptidase domain 15 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936580:4,588,182...4,598,659
Ensembl chrNW_004936580:4,588,039...4,599,014
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 enables IEA Ensembl
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936532:5,864,851...5,904,005
Ensembl chrNW_004936532:5,864,867...5,904,003
JBrowse link
G Adam18 ADAM metallopeptidase domain 18 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936843:805,614...836,657
Ensembl chrNW_004936843:707,093...836,657
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936515:5,603,095...5,683,347 JBrowse link
G Adam2 ADAM metallopeptidase domain 2 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936675:393,160...451,851
Ensembl chrNW_004936675:397,161...451,153
JBrowse link
G Adam22 ADAM metallopeptidase domain 22 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936763:738,051...952,435
Ensembl chrNW_004936763:739,629...952,435
JBrowse link
G Adam23 ADAM metallopeptidase domain 23 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936631:2,777,595...2,946,191
Ensembl chrNW_004936631:2,778,849...2,946,187
JBrowse link
G Adam28 ADAM metallopeptidase domain 28 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936555:7,615,639...7,660,776
Ensembl chrNW_004936555:7,617,822...7,664,215
JBrowse link
G Adam33 ADAM metallopeptidase domain 33 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936485:15,005,329...15,018,063
Ensembl chrNW_004936485:15,007,485...15,017,497
JBrowse link
G Adam7 ADAM metallopeptidase domain 7 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936555:7,724,565...7,770,986
Ensembl chrNW_004936555:7,724,565...7,770,149
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936486:19,389,925...19,403,577
Ensembl chrNW_004936486:19,391,324...19,402,332
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 enables IEA Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936710:2,301,470...2,388,533
Ensembl chrNW_004936710:2,301,730...2,387,695
JBrowse link
G Adamdec1 ADAM like decysin 1 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936555:7,686,841...7,697,084
Ensembl chrNW_004936555:7,686,841...7,697,078
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 enables IEA TreeGrafter
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936640:959,405...967,305
Ensembl chrNW_004936640:959,417...968,842
JBrowse link
G Adamts10 ADAM metallopeptidase with thrombospondin type 1 motif 10 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936588:5,337,519...5,356,978
Ensembl chrNW_004936588:5,337,877...5,354,848
JBrowse link
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif 12 enables IEA InterPro
TreeGrafter
Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936518:7,180,262...7,483,416
Ensembl chrNW_004936518:7,180,428...7,480,802
JBrowse link
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936669:3,449,259...3,478,471
Ensembl chrNW_004936669:3,456,494...3,478,512
JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif 14 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936521:7,951,176...8,025,666
Ensembl chrNW_004936521:7,952,365...8,025,614
JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif 15 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936572:1,935,780...1,960,888
Ensembl chrNW_004936572:1,936,529...1,960,800
JBrowse link
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif 16 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936634:1,830,252...1,925,622
Ensembl chrNW_004936634:1,830,593...1,958,640
JBrowse link
G Adamts17 ADAM metallopeptidase with thrombospondin type 1 motif 17 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936483:3,388,269...3,735,169
Ensembl chrNW_004936483:3,388,342...3,732,639
JBrowse link
G Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif 18 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936475:25,698,117...25,831,291
Ensembl chrNW_004936475:25,699,840...25,831,284
JBrowse link
G Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif 19 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936504:2,567,433...2,823,087
Ensembl chrNW_004936504:2,567,552...2,821,576
JBrowse link
G Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif 2 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936739:1,394,119...1,643,422
Ensembl chrNW_004936739:1,394,119...1,641,130
JBrowse link
G Adamts20 ADAM metallopeptidase with thrombospondin type 1 motif 20 enables IEA InterPro
TreeGrafter
Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936512:1,942,902...2,088,122
Ensembl chrNW_004936512:1,943,196...2,088,122
JBrowse link
G Adamts3 ADAM metallopeptidase with thrombospondin type 1 motif 3 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936598:2,680,623...2,901,308
Ensembl chrNW_004936598:2,680,087...2,901,330
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936903:490,718...500,443
Ensembl chrNW_004936903:491,139...500,443
JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 enables IEA InterPro
Ensembl
TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936640:857,565...899,355
Ensembl chrNW_004936640:858,322...898,182
JBrowse link
G Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif 6 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936480:3,798,044...3,965,203
Ensembl chrNW_004936480:3,675,805...3,965,210
JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif 7 enables IEA InterPro
TreeGrafter
Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936471:36,978,555...37,025,733
Ensembl chrNW_004936471:36,978,667...37,025,773
JBrowse link
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif 8 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936572:1,978,642...1,999,411 JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif 9 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936637:1,787,987...1,946,250
Ensembl chrNW_004936637:1,788,276...1,942,833
JBrowse link
G Adamtsl4 ADAMTS like 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936580:782,146...791,388
Ensembl chrNW_004936580:782,112...791,605
JBrowse link
G Adamtsl5 ADAMTS like 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936588:810,880...817,636
Ensembl chrNW_004936588:810,234...817,656
JBrowse link
G Afg3l2 AFG3 like matrix AAA peptidase subunit 2 enables IEA Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936626:150,953...189,980
Ensembl chrNW_004936626:150,974...189,218
JBrowse link
G Astl astacin like metalloendopeptidase enables IEA UniProt
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936744:259,188...268,919
Ensembl chrNW_004936744:259,188...268,928
JBrowse link
G Atp23 ATP23 metallopeptidase and ATP synthase assembly factor homolog enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936646:2,057,112...2,074,382
Ensembl chrNW_004936646:2,060,552...2,074,687
JBrowse link
G Bmp1 bone morphogenetic protein 1 enables IEA InterPro
UniProt
Ensembl
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936555:5,990,822...6,023,864
Ensembl chrNW_004936555:5,990,836...6,023,878
JBrowse link
G Ece1 endothelin converting enzyme 1 enables IEA InterPro
TreeGrafter
UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chrNW_004936474:7,034,134...7,083,005
Ensembl chrNW_004936474:7,034,134...7,083,005
JBrowse link
G Ecel1 endothelin converting enzyme like 1 enables IEA TreeGrafter
InterPro
Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936525:4,599,840...4,608,469
Ensembl chrNW_004936525:4,600,246...4,608,508
JBrowse link
G Ide insulin degrading enzyme enables ISO
IEA
atrial natriuretic peptide cleaved at the Ser25-Phe26 bond RGD
TreeGrafter
Ensembl
InterPro
PMID:15494400 PMID:15749695 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1626704 RGD:1626705 NCBI chrNW_004936601:2,230,477...2,318,562
Ensembl chrNW_004936601:2,230,283...2,318,752
JBrowse link
G Kel Kell metallo-endopeptidase (Kell blood group) enables IEA Ensembl
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936527:406,061...431,142
Ensembl chrNW_004936527:406,132...427,186
JBrowse link
G Lmln leishmanolysin like peptidase enables IEA UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936784:93,734...164,686
Ensembl chrNW_004936784:93,725...164,968
JBrowse link
G LOC101955597 disintegrin and metalloproteinase domain-containing protein 1a-like enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936558:4,452,828...4,456,389 JBrowse link
G LOC101957150 stromelysin-1 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936551:5,137,801...5,145,934
Ensembl chrNW_004936551:5,137,801...5,145,934
JBrowse link
G LOC101957314 disintegrin and metalloproteinase domain-containing protein 20-like enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936488:43,210...45,441 JBrowse link
G LOC101958582 disintegrin and metalloproteinase domain-containing protein 25-like enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936554:1,884,125...1,971,070 JBrowse link
G LOC101959620 disintegrin and metalloproteinase domain-containing protein 29-like enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936516:5,927,900...5,930,263
Ensembl chrNW_004936516:5,927,900...5,930,256
JBrowse link
G LOC101959833 endothelin-converting enzyme 2 enables IEA InterPro
TreeGrafter
Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936578:5,586,086...5,615,940
Ensembl chrNW_004936578:5,585,443...5,616,099
JBrowse link
G LOC101967362 mediator of RNA polymerase II transcription subunit 6 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936488:195,629...218,762
Ensembl chrNW_004936488:97,118...99,286
Ensembl chrNW_004936488:97,118...99,286
JBrowse link
G LOC101968921 angiotensin-converting enzyme enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
JBrowse link
G LOC101973430 cytochrome b-c1 complex subunit 2, mitochondrial enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936501:6,947,985...6,968,846
Ensembl chrNW_004936501:6,947,985...6,970,254
JBrowse link
G LOC101977589 AFG3-like protein 1 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936641:126,441...140,366 JBrowse link
G Mbtps2 membrane bound transcription factor peptidase, site 2 enables IEA TreeGrafter
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936624:2,464,152...2,510,984
Ensembl chrNW_004936624:2,463,909...2,511,158
JBrowse link
G Mep1a meprin A subunit alpha enables IEA UniProt
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936476:13,514,965...13,553,209 JBrowse link
G Mep1b meprin A subunit beta enables ISO
IEA
RGD
InterPro
UniProt
TreeGrafter
PMID:12437103 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:633322 NCBI chrNW_004936682:1,102,365...1,132,404
Ensembl chrNW_004936682:1,105,243...1,132,404
JBrowse link
G Mipep mitochondrial intermediate peptidase enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936688:1,592,810...1,736,896
Ensembl chrNW_004936688:1,592,821...1,737,282
JBrowse link
G Mme membrane metalloendopeptidase enables IEA InterPro
TreeGrafter
Ensembl
UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936519:2,513,896...2,595,896
Ensembl chrNW_004936519:2,513,704...2,595,971
JBrowse link
G Mmel1 membrane metalloendopeptidase like 1 enables ISO
IEA
RGD
TreeGrafter
InterPro
PMID:11964170 GO_REF:0000002 GO_REF:0000118 RGD:2314417 NCBI chrNW_004936737:970,504...997,452
Ensembl chrNW_004936737:970,504...997,067
JBrowse link
G Mmp1 matrix metallopeptidase 1 enables IEA TreeGrafter
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857
JBrowse link
G Mmp10 matrix metallopeptidase 10 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936551:5,188,395...5,197,477 JBrowse link
G Mmp11 matrix metallopeptidase 11 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936619:1,309,013...1,320,062
Ensembl chrNW_004936619:1,310,846...1,320,062
JBrowse link
G Mmp12 matrix metallopeptidase 12 enables IEA TreeGrafter
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936551:5,107,567...5,117,843
Ensembl chrNW_004936551:5,106,285...5,117,843
JBrowse link
G Mmp13 matrix metallopeptidase 13 enables ISO
IEA
RGD
TreeGrafter
Ensembl
InterPro
PMID:8910479 PMID:17941091 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2296055 RGD:2298541 NCBI chrNW_004936551:5,040,084...5,050,384
Ensembl chrNW_004936551:5,040,084...5,050,384
JBrowse link
G Mmp14 matrix metallopeptidase 14 enables IEA InterPro
TreeGrafter
Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936722:1,447,189...1,457,632
Ensembl chrNW_004936722:1,447,335...1,457,611
JBrowse link
G Mmp15 matrix metallopeptidase 15 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936475:9,951,876...9,971,631
Ensembl chrNW_004936475:9,951,778...9,971,666
JBrowse link
G Mmp16 matrix metallopeptidase 16 enables IEA Ensembl
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936544:2,297,698...2,546,683
Ensembl chrNW_004936544:2,298,028...2,546,689
JBrowse link
G Mmp17 matrix metallopeptidase 17 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936660:2,139,777...2,152,159
Ensembl chrNW_004936660:2,139,129...2,150,741
JBrowse link
G Mmp19 matrix metallopeptidase 19 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936646:298,854...304,479
Ensembl chrNW_004936646:299,059...304,430
JBrowse link
G Mmp2 matrix metallopeptidase 2 enables IEA InterPro
TreeGrafter
Ensembl
UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936475:7,801,356...7,825,831
Ensembl chrNW_004936475:7,801,277...7,825,851
JBrowse link
G Mmp20 matrix metallopeptidase 20 enables IEA Ensembl
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936551:5,310,426...5,352,883
Ensembl chrNW_004936551:5,310,426...5,352,883
JBrowse link
G Mmp21 matrix metallopeptidase 21 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936486:13,781,441...13,789,018
Ensembl chrNW_004936486:13,781,616...13,788,955
JBrowse link
G Mmp23b matrix metallopeptidase 23B enables IEA TreeGrafter
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936737:1,628,915...1,632,023
Ensembl chrNW_004936737:1,629,639...1,632,023
JBrowse link
G Mmp24 matrix metallopeptidase 24 enables IEA Ensembl
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936561:5,479,107...5,501,559
Ensembl chrNW_004936561:5,478,145...5,502,529
JBrowse link
G Mmp25 matrix metallopeptidase 25 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936694:1,118,432...1,128,315
Ensembl chrNW_004936694:1,118,670...1,128,261
JBrowse link
G Mmp27 matrix metallopeptidase 27 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936551:5,253,762...5,262,426
Ensembl chrNW_004936551:5,253,762...5,262,426
JBrowse link
G Mmp28 matrix metallopeptidase 28 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936490:165,462...188,788
Ensembl chrNW_004936490:165,376...188,823
JBrowse link
G Mmp7 matrix metallopeptidase 7 enables IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936551:5,388,456...5,395,071
Ensembl chrNW_004936551:5,388,459...5,395,071
JBrowse link
G Mmp8 matrix metallopeptidase 8 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936551:5,228,950...5,238,948
Ensembl chrNW_004936551:5,228,950...5,238,948
JBrowse link
G Mmp9 matrix metallopeptidase 9 enables IEA TreeGrafter
InterPro
Ensembl
UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793
JBrowse link
G Nln neurolysin enables ISO
IEA
RGD
InterPro
TreeGrafter
PMID:7836437 GO_REF:0000002 GO_REF:0000118 RGD:9831155 NCBI chrNW_004936480:3,383,514...3,480,991
Ensembl chrNW_004936480:3,383,540...3,481,009
JBrowse link
G Nrdc nardilysin convertase enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936522:9,041,204...9,129,674
Ensembl chrNW_004936522:9,041,111...9,129,327
JBrowse link
G Oma1 OMA1 zinc metallopeptidase enables IEA TreeGrafter
InterPro
Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936522:3,232,877...3,294,832
Ensembl chrNW_004936522:3,233,510...3,294,798
JBrowse link
G Papln papilin, proteoglycan like sulfated glycoprotein enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936488:2,558,007...2,578,173
Ensembl chrNW_004936488:2,558,289...2,577,942
JBrowse link
G Pappa pappalysin 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936487:5,000,279...5,379,786
Ensembl chrNW_004936487:5,144,044...5,376,367
JBrowse link
G Pappa2 pappalysin 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936481:11,756,580...11,998,919
Ensembl chrNW_004936481:11,756,085...11,997,132
JBrowse link
G Phex phosphate regulating endopeptidase X-linked enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936624:2,124,479...2,312,847
Ensembl chrNW_004936624:2,126,253...2,312,847
JBrowse link
G Pitrm1 pitrilysin metallopeptidase 1 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936484:11,071,407...11,104,828
Ensembl chrNW_004936484:11,071,372...11,104,828
JBrowse link
G Pmpca peptidase, mitochondrial processing subunit alpha enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936669:1,385,010...1,395,715
Ensembl chrNW_004936669:1,386,817...1,395,597
JBrowse link
G Pmpcb peptidase, mitochondrial processing subunit beta enables IEA TreeGrafter
InterPro
UniProt
Ensembl
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936479:20,198,417...20,210,160
Ensembl chrNW_004936479:20,198,417...20,210,202
JBrowse link
G Rce1 Ras converting CAAX endopeptidase 1 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936599:2,794,947...2,798,121
Ensembl chrNW_004936599:2,793,215...2,798,707
JBrowse link
G Spg7 SPG7 matrix AAA peptidase subunit, paraplegin enables IEA Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936641:451,762...484,229
Ensembl chrNW_004936641:452,475...484,220
JBrowse link
G Sprtn SprT-like N-terminal domain enables IEA InterPro
Ensembl
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936484:19,391,685...19,402,938
Ensembl chrNW_004936484:19,391,420...19,402,944
JBrowse link
G Thop1 thimet oligopeptidase 1 enables IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936588:1,618,585...1,637,788
Ensembl chrNW_004936588:1,618,541...1,637,821
JBrowse link
G Thsd4 thrombospondin type 1 domain containing 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:31,002,241...31,213,057
Ensembl chrNW_004936471:30,654,136...31,207,266
JBrowse link
G Tll1 tolloid like 1 enables IEA InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936555:7...198,382
Ensembl chrNW_004936555:193...96,729
JBrowse link
G Tll2 tolloid like 2 enables IEA UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936636:3,010,774...3,126,402
Ensembl chrNW_004936636:3,011,007...3,125,714
JBrowse link
G Trabd2b TraB domain containing 2B enables IEA TreeGrafter
Ensembl
UniProt
GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:28,565,563...28,752,370
Ensembl chrNW_004936474:28,531,931...28,752,736
JBrowse link
G Ybey ybeY metalloendoribonuclease enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936778:265,855...273,053
Ensembl chrNW_004936778:266,151...272,955
JBrowse link
G Yme1l1 YME1 like 1 ATPase enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936484:2,306,937...2,352,671
Ensembl chrNW_004936484:2,306,760...2,353,507
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 enables IEA UniProt
InterPro
Ensembl
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936474:22,035,059...22,077,846
Ensembl chrNW_004936474:22,034,801...22,077,986
JBrowse link
metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 enables IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:5,864,851...5,904,005
Ensembl chrNW_004936532:5,864,867...5,904,003
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 enables ISO (PMID:17112471) ARUK-UCL PMID:17112471 NCBI chrNW_004936515:5,603,095...5,683,347 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 enables ISO (PMID:12054541) ARUK-UCL PMID:12054541 NCBI chrNW_004936710:2,301,470...2,388,533
Ensembl chrNW_004936710:2,301,730...2,387,695
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18185
    catalytic activity 5255
      hydrolase activity 2223
        peptidase activity 573
          endopeptidase activity 376
            metalloendopeptidase activity 104
              metalloendopeptidase activity involved in amyloid precursor protein catabolic process 4
paths to the root