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ONTOLOGY REPORT - ANNOTATIONS


Term:metalloendopeptidase activity
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Accession:GO:0004222 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms:narrow_synonym: metalloendoprotease activity;   metalloendoproteinase activity
 xref: EC:3.4.24;   Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";   Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";   Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";   Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";   Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";   Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";   Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";   Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14";   Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";   Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";   Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";   Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";   Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";   Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";   Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";   Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";   Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";   Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";   Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";   Reactome:R-HSA-9840532 "OMA1 self-cleaves";   Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";   Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer";   reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";   reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";   reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";   reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";   reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";   reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";   reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";   reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";   reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";   reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";   reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";   reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";   reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";   reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";   reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";   reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";   reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";   reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";   reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";   reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";   reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";   reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";   reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";   reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";   reactome:R-HSA-2022141 "Prolysyl oxidase activation";   reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";   reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";   reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";   reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";   reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";   reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";   reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";   reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";   reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";   reactome:R-HSA-2514790 "Elastin degradation by MMP14";   reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";   reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";   reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";   reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";   reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";   reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";   reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";   reactome:R-HSA-2537499 "Gelatin degradation by MMP19";   reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";   reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";   reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";   reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";   reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";   reactome:R-HSA-3791319 "NID1 degradation by MMP19";   reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";   reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";   reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";   reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";   reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";   reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";   reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";   reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";   reactome:R-HSA-5333671 "CLCAs self cleave";   reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";   reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";   reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";   reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";   reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";   reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";   reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";   reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";   reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";   reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";   reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";   reactome:R-HSA-8940554 "MMP2 cleaves OPTC";   reactome:R-HSA-8940561 "MMP7 cleaves OPTC";   reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";   reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";   reactome:R-HSA-8942302 "MMP13 cleaves OPTC";   reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";   reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";   reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";   reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"



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metalloendopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme enables IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
JBrowse link
G ADAM10 ADAM metallopeptidase domain 10 enables ISO
IEA
ISS
RGD
Ensembl
InterPro
UniProt
PMID:10423016 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 RGD:631800 NCBI chr 1:113,289,480...113,407,940
Ensembl chr 1:113,289,209...113,412,798
JBrowse link
G ADAM11 ADAM metallopeptidase domain 11 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr12:18,575,716...18,597,415
Ensembl chr12:18,575,719...18,597,356
JBrowse link
G ADAM12 ADAM metallopeptidase domain 12 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:135,302,188...135,682,144
Ensembl chr14:135,302,813...135,682,159
JBrowse link
G ADAM15 ADAM metallopeptidase domain 15 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 4:94,736,639...94,748,093
Ensembl chr 4:94,736,646...94,748,098
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 enables IEA
IBA
ISS
IMP
(PMID:9034191) InterPro
GO_Central
UniProt
Ensembl
BHF-UCL
PMID:9034191 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995
JBrowse link
G ADAM18 ADAM metallopeptidase domain 18 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr17:9,178,152...9,233,147
Ensembl chr17:9,166,119...9,233,952
JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr16:65,715,445...65,814,761
Ensembl chr16:65,715,517...65,814,758
JBrowse link
G ADAM2 ADAM metallopeptidase domain 2 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr15:47,207,727...47,278,315
Ensembl chr15:47,207,722...47,278,315
JBrowse link
G ADAM22 ADAM metallopeptidase domain 22 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 9:68,253,023...68,490,327
Ensembl chr 9:68,253,065...68,487,619
JBrowse link
G ADAM23 ADAM metallopeptidase domain 23 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr15:109,695,250...109,886,154
Ensembl chr15:109,695,282...109,886,148
JBrowse link
G ADAM28 ADAM metallopeptidase domain 28 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:8,375,169...8,438,622
Ensembl chr14:8,375,212...8,438,615
JBrowse link
G ADAM29 ADAM metallopeptidase domain 29 enables IEA InterPro GO_REF:0000002 NCBI chr14:15,302,879...15,307,649 JBrowse link
G ADAM29 ADAM metallopeptidase domain 29 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 Ensembl chr14:15,382,020...15,384,818 JBrowse link
G ADAM30 ADAM metallopeptidase domain 30 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 4:101,314,710...101,316,974
Ensembl chr 4:101,314,710...101,316,893
JBrowse link
G ADAM32 disintegrin and metalloproteinase domain-containing protein 32 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr15:47,388,085...47,521,808
Ensembl chr15:47,388,412...47,520,413
JBrowse link
G ADAM33 ADAM metallopeptidase domain 33 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr17:32,023,102...32,038,464
Ensembl chr17:32,023,091...32,037,880
JBrowse link
G ADAM3A ADAM metallopeptidase domain 3A (cyritestin 1) enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr17:9,088,864...9,166,263
Ensembl chr17:9,088,860...9,166,340
JBrowse link
G ADAM7 ADAM metallopeptidase domain 7 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:8,484,391...8,554,879
Ensembl chr14:8,483,329...8,554,869
JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:141,221,177...141,233,728
Ensembl chr14:141,221,198...141,232,306
JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,771...47,601,710
JBrowse link
G ADAMDEC1 ADAM like decysin 1 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:8,455,964...8,483,308
Ensembl chr14:8,456,134...8,471,088
JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr13:190,277,175...190,285,957
Ensembl chr13:190,276,430...190,286,214
JBrowse link
G ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 2:70,734,234...70,751,205
Ensembl chr 2:70,730,172...70,751,837
JBrowse link
G ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr16:19,547,003...19,920,780
Ensembl chr16:19,547,011...19,920,513
JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 1:273,022,014...273,066,916
Ensembl chr 1:273,024,009...273,056,039
JBrowse link
G ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:73,565,158...73,657,257
Ensembl chr14:73,565,391...73,654,982
JBrowse link
G ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 9:57,127,527...57,152,550
Ensembl chr 9:57,127,442...57,152,547
JBrowse link
G ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif 16 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr16:76,326,718...76,491,050
Ensembl chr16:76,326,721...76,491,003
JBrowse link
G ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 1:138,619,701...139,015,681
Ensembl chr 1:138,619,706...139,015,473
JBrowse link
G ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 6:10,488,504...10,652,508
Ensembl chr 6:10,488,374...10,652,504
JBrowse link
G ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif 19 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 2:132,145,266...132,413,116
Ensembl chr 2:132,145,310...132,410,801
JBrowse link
G ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 2:79,182,901...79,406,879
Ensembl chr 2:79,182,943...79,406,875
JBrowse link
G ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:74,502,098...74,672,703
Ensembl chr 5:74,503,113...74,672,703
JBrowse link
G ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 8:68,675,067...68,948,537
Ensembl chr 8:68,675,070...68,948,414
JBrowse link
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 4:89,260,354...89,269,238
Ensembl chr 4:89,260,461...89,269,244
JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr13:190,353,019...190,413,110
Ensembl chr13:190,361,744...190,413,110
JBrowse link
G ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif 6 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr16:43,702,519...44,010,820
Ensembl chr16:43,702,521...44,019,704
JBrowse link
G ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif 7 enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:47,919,398...47,994,528
Ensembl chr 7:47,929,033...47,994,453
JBrowse link
G ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 9:57,090,313...57,113,077
Ensembl chr 9:57,090,617...57,110,414
JBrowse link
G ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif 9 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr13:46,033,753...46,209,238
Ensembl chr13:46,034,833...46,207,006
JBrowse link
G ADAMTSL2 ADAMTS like 2 NOT|enables IBA GO_Central GO_REF:0000033 NCBI chr 1:273,119,826...273,155,412
Ensembl chr 1:273,119,904...273,155,409
JBrowse link
G AFG3L2 AFG3 like matrix AAA peptidase subunit 2 enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:97,200,890...97,234,577
Ensembl chr 6:97,200,922...97,235,366
JBrowse link
G ASTL astacin like metalloendopeptidase enables IEA
IBA
InterPro
GO_Central
UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 3:47,058,104...47,071,681
Ensembl chr 3:47,059,040...47,070,664
JBrowse link
G ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog enables IEA InterPro GO_REF:0000002 NCBI chr 5:23,176,854...23,276,251
Ensembl chr 5:23,233,895...23,276,036
JBrowse link
G BMP1 bone morphogenetic protein 1 enables IEA
IBA
UniProt
GO_Central
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr14:6,443,773...6,489,066
Ensembl chr14:6,443,912...6,489,063
JBrowse link
G ECE1 endothelin converting enzyme 1 enables IEA
IBA
InterPro
GO_Central
UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr 6:79,408,322...79,465,827
Ensembl chr 6:79,408,326...79,466,152
JBrowse link
G ECE2 endothelin converting enzyme 2 enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr13:122,148,928...122,179,522
Ensembl chr13:122,165,152...122,179,498
Ensembl chr13:122,165,152...122,179,498
JBrowse link
G ECEL1 endothelin converting enzyme like 1 enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr15:132,988,705...132,997,924
Ensembl chr15:132,988,657...132,997,825
JBrowse link
G IDE insulin degrading enzyme enables ISO
IBA
IEA
atrial natriuretic peptide cleaved at the Ser25-Phe26 bond RGD
GO_Central
Ensembl
InterPro
PMID:15494400 PMID:15749695 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1626704 RGD:1626705 NCBI chr14:103,992,035...104,106,571
Ensembl chr14:103,992,039...104,106,576
JBrowse link
G KEL Kell metallo-endopeptidase enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr18:7,242,378...7,279,345
Ensembl chr18:7,259,144...7,279,328
JBrowse link
G LMLN leishmanolysin like peptidase enables IEA UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 NCBI chr13:134,596,116...134,656,751
Ensembl chr13:134,596,150...134,656,744
JBrowse link
G LOC100049687 ADAM3b enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr15:47,104,604...47,195,186 JBrowse link
G LOC100515389 disintegrin and metalloproteinase domain-containing protein 21 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 7:94,084,019...94,087,956 JBrowse link
G LOC100516390 ankyrin repeat domain-containing protein 26 enables IEA InterPro GO_REF:0000002 NCBI chr10:48,694,806...48,795,783 JBrowse link
G LOC100525409 disintegrin and metalloproteinase domain-containing protein 20-like enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 7:94,025,685...94,028,015 JBrowse link
G LOC100525589 disintegrin and metalloproteinase domain-containing protein 20-like enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 7:94,014,154...94,018,715 JBrowse link
G LOC100737404 disintegrin and metalloproteinase domain-containing protein 1a-like enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:39,813,497...39,817,367 JBrowse link
G LOC100739754 disintegrin and metalloproteinase domain-containing protein 20 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 7:94,125,901...94,131,479
Ensembl chr 7:94,127,736...94,129,904
JBrowse link
G LOC110255249 disintegrin and metalloproteinase domain-containing protein 20-like enables IEA InterPro GO_REF:0000002 NCBI chr 7:93,892,897...93,898,402 JBrowse link
G LOC110256875 disintegrin and metalloproteinase domain-containing protein 1a-like enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:39,828,431...39,832,844 JBrowse link
G LOC110258345 disintegrin and metalloproteinase domain-containing protein 20-like enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033
G LOC110258836 disintegrin and metalloproteinase domain-containing protein 29-like enables IEA InterPro GO_REF:0000002
G MBTPS2 membrane bound transcription factor peptidase, site 2 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr  X:18,013,360...18,054,250 JBrowse link
G MEP1A meprin A subunit alpha enables IEA
IBA
UniProt
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 7:41,587,698...41,625,014 JBrowse link
G MEP1B meprin A subunit beta enables ISO
IBA
IEA
RGD
GO_Central
InterPro
UniProt
PMID:12437103 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 RGD:633322 NCBI chr 6:116,015,021...116,049,796
Ensembl chr 6:116,015,021...116,049,791
JBrowse link
G MIPEP mitochondrial intermediate peptidase enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr11:2,675,604...2,790,760
Ensembl chr11:2,670,000...2,790,727
JBrowse link
G MME membrane metalloendopeptidase enables IEA
IBA
ISS
UniProt
GO_Central
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045
JBrowse link
G MMEL1 membrane metalloendopeptidase like 1 enables ISO
IBA
IEA
RGD
GO_Central
InterPro
PMID:11964170 GO_REF:0000002 GO_REF:0000033 RGD:2314417 NCBI chr 6:64,436,778...64,470,888
Ensembl chr 6:64,436,642...64,472,759
JBrowse link
G MMP1 matrix metallopeptidase 1 enables IEA
IBA
InterPro
GO_Central
UniProt
Ensembl
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:33,411,738...33,420,205
Ensembl chr 9:33,411,065...33,420,076
JBrowse link
G MMP11 matrix metallopeptidase 11 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:49,907,684...49,917,494
Ensembl chr14:49,907,687...49,912,617
JBrowse link
G MMP12 matrix metallopeptidase 12 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:33,473,625...33,483,630
Ensembl chr 9:33,473,093...33,483,679
JBrowse link
G MMP13 matrix metallopeptidase 13 enables ISO
IBA
IEA
RGD
GO_Central
InterPro
Ensembl
PMID:8910479 PMID:17941091 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:2296055 RGD:2298541 NCBI chr 9:33,549,003...33,616,700
Ensembl chr 9:33,549,008...33,561,162
JBrowse link
G MMP14 matrix metallopeptidase 14 enables IEA
IBA
ISS
InterPro
GO_Central
Ensembl
UniProt
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:76,174,502...76,185,931
Ensembl chr 7:76,172,971...76,185,928
JBrowse link
G MMP15 matrix metallopeptidase 15 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 6:19,890,867...19,912,941
Ensembl chr 6:19,891,107...19,912,913
JBrowse link
G MMP16 matrix metallopeptidase 16 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:48,556,826...48,867,959
Ensembl chr 4:48,556,967...48,862,985
JBrowse link
G MMP17 matrix metallopeptidase 17 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:23,481,220...23,506,936
Ensembl chr14:23,481,227...23,506,919
JBrowse link
G MMP19 matrix metallopeptidase 19 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 5:21,279,514...21,285,943
Ensembl chr 5:21,280,130...21,285,774
JBrowse link
G MMP2 matrix metallopeptidase 2 enables IEA
IBA
UniProt
GO_Central
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
JBrowse link
G MMP20 matrix metallopeptidase 20 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:33,261,448...33,308,047
Ensembl chr 9:33,261,443...33,308,047
JBrowse link
G MMP23 matrix metallopeptidase 23 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:63,801,668...63,804,275
Ensembl chr 6:63,801,965...63,805,046
JBrowse link
G MMP24 matrix metallopeptidase 24 enables IEA
IBA
Ensembl
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr17:38,587,230...38,636,628
Ensembl chr17:38,588,081...38,636,627
JBrowse link
G MMP25 matrix metallopeptidase 25 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 3:39,129,452...39,143,621
Ensembl chr 3:39,130,777...39,142,303
JBrowse link
G MMP27 matrix metallopeptidase 27 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 9:33,366,342...33,379,828
Ensembl chr 9:33,366,345...33,379,789
JBrowse link
G MMP28 matrix metallopeptidase 28 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr12:39,739,074...39,766,794
Ensembl chr12:39,739,630...39,766,791
JBrowse link
G MMP3 matrix metallopeptidase 3 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 9:33,446,969...33,453,995
Ensembl chr 9:33,446,836...33,454,000
JBrowse link
G MMP7 matrix metallopeptidase 7 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 9:33,214,590...33,225,080
Ensembl chr 9:33,214,594...33,225,080
JBrowse link
G MMP8 matrix metallopeptidase 8 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 9:33,384,034...33,397,637
Ensembl chr 9:33,384,033...33,396,947
JBrowse link
G MMP9 matrix metallopeptidase 9 enables IEA
IBA
UniProt
GO_Central
InterPro
Ensembl
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
JBrowse link
G NLN neurolysin enables ISO
IBA
IEA
RGD
GO_Central
InterPro
PMID:7836437 GO_REF:0000002 GO_REF:0000033 RGD:9831155 NCBI chr16:44,225,706...44,333,623
Ensembl chr16:44,225,677...44,334,610
JBrowse link
G NRDC nardilysin convertase enables IEA InterPro GO_REF:0000002 NCBI chr 6:160,299,101...160,388,511
Ensembl chr 6:160,299,131...160,388,502
JBrowse link
G OMA1 OMA1 zinc metallopeptidase enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:153,882,398...153,950,460
Ensembl chr 6:153,882,451...153,949,468
JBrowse link
G PAPPA pappalysin 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:256,544,496...256,784,813
Ensembl chr 1:256,544,928...256,780,760
JBrowse link
G PAPPA2 pappalysin 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 9:118,362,663...118,635,972
Ensembl chr 9:118,365,303...118,635,964
JBrowse link
G PHEX phosphate regulating endopeptidase X-linked enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr  X:18,199,396...18,420,985
Ensembl chr  X:18,203,174...18,418,004
JBrowse link
G PITRM1 pitrilysin metallopeptidase 1 enables IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr10:66,996,919...67,021,692
Ensembl chr10:66,996,954...67,047,235
JBrowse link
G PMPCA peptidase, mitochondrial processing subunit alpha enables IEA InterPro GO_REF:0000002
G PMPCB peptidase, mitochondrial processing subunit beta enables IEA
IBA
Ensembl
GO_Central
InterPro
UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:103,316,161...103,329,653
Ensembl chr 9:103,316,190...103,330,290
JBrowse link
G RCE1 Ras converting CAAX endopeptidase 1 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 2:5,587,853...5,595,408
Ensembl chr 2:5,588,546...5,593,142
JBrowse link
G SPG7 SPG7 matrix AAA peptidase subunit, paraplegin enables IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:414,930...439,206
Ensembl chr 6:414,932...439,212
JBrowse link
G SPRTN SprT-like N-terminal domain enables IEA Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chr14:59,177,801...59,192,221
Ensembl chr14:59,171,192...59,192,269
JBrowse link
G THOP1 thimet oligopeptidase 1 enables IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 2:75,857,788...75,877,430
Ensembl chr 2:75,853,429...75,877,494
JBrowse link
G TLL1 tolloid like 1 enables IEA
IBA
InterPro
GO_Central
UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 8:42,855,883...43,094,215
Ensembl chr 8:42,856,469...43,092,692
JBrowse link
G TLL2 tolloid like 2 enables IEA
IBA
InterPro
GO_Central
UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr14:107,812,938...107,961,192
Ensembl chr14:107,812,945...107,961,155
JBrowse link
G TRABD2B TraB domain containing 2B enables IEA
IBA
Ensembl
GO_Central
UniProt
GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:163,624,078...163,836,829
Ensembl chr 6:163,624,072...163,837,863
JBrowse link
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 enables IEA InterPro GO_REF:0000002 NCBI chr 3:24,197,743...24,228,831
Ensembl chr 3:24,197,747...24,228,832
JBrowse link
G YBEY ybeY metalloendoribonuclease enables IEA InterPro GO_REF:0000002
G YME1L1 YME1 like 1 ATPase enables IEA InterPro GO_REF:0000002 NCBI chr10:48,807,654...48,855,228 JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 enables IEA
IBA
Ensembl
GO_Central
InterPro
UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:96,008,307...96,057,131
Ensembl chr 6:96,008,455...96,062,951
JBrowse link
metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 enables IBA
IEA
GO_Central
Ensembl
GO_REF:0000033 GO_REF:0000107 NCBI chr 1:113,289,480...113,407,940
Ensembl chr 1:113,289,209...113,412,798
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995
JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables IEA Ensembl GO_REF:0000107 NCBI chr16:65,715,445...65,814,761
Ensembl chr16:65,715,517...65,814,758
JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables ISO (PMID:12054541) ARUK-UCL PMID:12054541 NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,771...47,601,710
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19430
    catalytic activity 5613
      hydrolase activity 2376
        peptidase activity 611
          endopeptidase activity 401
            metalloendopeptidase activity 109
              metalloendopeptidase activity involved in amyloid precursor protein catabolic process 4
paths to the root