ONTOLOGY REPORT - ANNOTATIONS
Term: metalloendopeptidase activity
Accession: GO:0004222
browse the term
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms: narrow_synonym: metalloendoprotease activity; metalloendoproteinase activity
xref: EC:3.4.24; Reactome:R-HSA-181567 "botC LC cleaves target cell STX1"; Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25"; Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2"; Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25"; Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1"; Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1"; Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25"; Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14"; Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)"; Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2"; Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2"; Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2"; Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2"; Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1"; Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)"; Reactome:R-HSA-9624272 "MMPs cleave HB-EGF"; Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer"; Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer"; Reactome:R-HSA-9840408 "OMA1 cleaves DELE1"; Reactome:R-HSA-9840532 "OMA1 self-cleaves"; Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1"; Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer"; reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR"; reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17"; reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors"; reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors"; reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13"; reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2"; reactome:R-HSA-1458433 "Collagen type I degradation by MMP14"; reactome:R-HSA-1474196 "Collagen type II degradation by MMP14"; reactome:R-HSA-1474210 "Collagen type III degradation by MMP14"; reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13"; reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11"; reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13"; reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3"; reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12"; reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2"; reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10"; reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1"; reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9"; reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13"; reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs"; reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2"; reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF"; reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides"; reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides"; reactome:R-HSA-2022141 "Prolysyl oxidase activation"; reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12"; reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9"; reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF"; reactome:R-HSA-2473584 "Collagen type III degradation by MMP15"; reactome:R-HSA-2473594 "Collagen type II degradation by MMP15"; reactome:R-HSA-2473596 "Collagen type I degradation by MMP15"; reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13"; reactome:R-HSA-2485111 "Collagen type III degradation by MMP10"; reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13"; reactome:R-HSA-2514790 "Elastin degradation by MMP14"; reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14"; reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14"; reactome:R-HSA-2533944 "Fibronectin degradation by MMP10"; reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15"; reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7"; reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15"; reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7"; reactome:R-HSA-2537499 "Gelatin degradation by MMP19"; reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1"; reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5"; reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19"; reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14"; reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13"; reactome:R-HSA-3791319 "NID1 degradation by MMP19"; reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS"; reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4"; reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS"; reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7"; reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14"; reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7"; reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)"; reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15"; reactome:R-HSA-5333671 "CLCAs self cleave"; reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding"; reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3"; reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)"; reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1"; reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2"; reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3"; reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1"; reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4"; reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3"; reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)"; reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)"; reactome:R-HSA-8940554 "MMP2 cleaves OPTC"; reactome:R-HSA-8940561 "MMP7 cleaves OPTC"; reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)"; reactome:R-HSA-8940959 "Neurolysin degrades neurotensin"; reactome:R-HSA-8942302 "MMP13 cleaves OPTC"; reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3"; reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)"; reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU"; reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"
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ACE
angiotensin I converting enzyme
enables
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
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ADAM10
ADAM metallopeptidase domain 10
enables
ISO IEA ISS
RGD Ensembl InterPro UniProt
PMID:10423016
GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 RGD:631800
NCBI chr 1:113,289,480...113,407,940
Ensembl chr 1:113,289,209...113,412,798
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ADAM11
ADAM metallopeptidase domain 11
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr12:18,575,716...18,597,415
Ensembl chr12:18,575,719...18,597,356
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ADAM12
ADAM metallopeptidase domain 12
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:135,302,188...135,682,144
Ensembl chr14:135,302,813...135,682,159
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ADAM15
ADAM metallopeptidase domain 15
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 4:94,736,639...94,748,093
Ensembl chr 4:94,736,646...94,748,098
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ADAM17
ADAM metallopeptidase domain 17
enables
IEA IBA ISS IMP
(PMID:9034191)
InterPro GO_Central UniProt Ensembl BHF-UCL
PMID:9034191
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995
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ADAM18
ADAM metallopeptidase domain 18
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr17:9,178,152...9,233,147
Ensembl chr17:9,166,119...9,233,952
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ADAM19
ADAM metallopeptidase domain 19
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr16:65,715,445...65,814,761
Ensembl chr16:65,715,517...65,814,758
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ADAM2
ADAM metallopeptidase domain 2
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr15:47,207,727...47,278,315
Ensembl chr15:47,207,722...47,278,315
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ADAM22
ADAM metallopeptidase domain 22
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:68,253,023...68,490,327
Ensembl chr 9:68,253,065...68,487,619
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ADAM23
ADAM metallopeptidase domain 23
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr15:109,695,250...109,886,154
Ensembl chr15:109,695,282...109,886,148
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ADAM28
ADAM metallopeptidase domain 28
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:8,375,169...8,438,622
Ensembl chr14:8,375,212...8,438,615
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ADAM29
ADAM metallopeptidase domain 29
enables
IEA
InterPro
GO_REF:0000002
NCBI chr14:15,302,879...15,307,649
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ADAM29
ADAM metallopeptidase domain 29
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
Ensembl chr14:15,382,020...15,384,818
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ADAM30
ADAM metallopeptidase domain 30
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 4:101,314,710...101,316,974
Ensembl chr 4:101,314,710...101,316,893
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ADAM32
disintegrin and metalloproteinase domain-containing protein 32
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr15:47,388,085...47,521,808
Ensembl chr15:47,388,412...47,520,413
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ADAM33
ADAM metallopeptidase domain 33
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr17:32,023,102...32,038,464
Ensembl chr17:32,023,091...32,037,880
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ADAM3A
ADAM metallopeptidase domain 3A (cyritestin 1)
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr17:9,088,864...9,166,263
Ensembl chr17:9,088,860...9,166,340
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ADAM7
ADAM metallopeptidase domain 7
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:8,484,391...8,554,879
Ensembl chr14:8,483,329...8,554,869
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ADAM8
ADAM metallopeptidase domain 8
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:141,221,177...141,233,728
Ensembl chr14:141,221,198...141,232,306
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ADAM9
ADAM metallopeptidase domain 9
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,771...47,601,710
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ADAMDEC1
ADAM like decysin 1
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:8,455,964...8,483,308
Ensembl chr14:8,456,134...8,471,088
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ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr13:190,277,175...190,285,957
Ensembl chr13:190,276,430...190,286,214
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ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif 10
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 2:70,734,234...70,751,205
Ensembl chr 2:70,730,172...70,751,837
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ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif 12
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr16:19,547,003...19,920,780
Ensembl chr16:19,547,011...19,920,513
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ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif 13
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 1:273,022,014...273,066,916
Ensembl chr 1:273,024,009...273,056,039
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ADAMTS14
ADAM metallopeptidase with thrombospondin type 1 motif 14
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:73,565,158...73,657,257
Ensembl chr14:73,565,391...73,654,982
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ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif 15
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:57,127,527...57,152,550
Ensembl chr 9:57,127,442...57,152,547
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ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif 16
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr16:76,326,718...76,491,050
Ensembl chr16:76,326,721...76,491,003
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ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif 17
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 1:138,619,701...139,015,681
Ensembl chr 1:138,619,706...139,015,473
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ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif 18
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 6:10,488,504...10,652,508
Ensembl chr 6:10,488,374...10,652,504
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ADAMTS19
ADAM metallopeptidase with thrombospondin type 1 motif 19
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 2:132,145,266...132,413,116
Ensembl chr 2:132,145,310...132,410,801
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ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif 2
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 2:79,182,901...79,406,879
Ensembl chr 2:79,182,943...79,406,875
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ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif 20
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 5:74,502,098...74,672,703
Ensembl chr 5:74,503,113...74,672,703
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ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif 3
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 8:68,675,067...68,948,537
Ensembl chr 8:68,675,070...68,948,414
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ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif 4
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 4:89,260,354...89,269,238
Ensembl chr 4:89,260,461...89,269,244
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ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif 5
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr13:190,353,019...190,413,110
Ensembl chr13:190,361,744...190,413,110
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ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif 6
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr16:43,702,519...44,010,820
Ensembl chr16:43,702,521...44,019,704
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ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif 7
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 7:47,919,398...47,994,528
Ensembl chr 7:47,929,033...47,994,453
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ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif 8
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:57,090,313...57,113,077
Ensembl chr 9:57,090,617...57,110,414
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ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif 9
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr13:46,033,753...46,209,238
Ensembl chr13:46,034,833...46,207,006
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ADAMTSL2
ADAMTS like 2
NOT|enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 1:273,119,826...273,155,412
Ensembl chr 1:273,119,904...273,155,409
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AFG3L2
AFG3 like matrix AAA peptidase subunit 2
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 6:97,200,890...97,234,577
Ensembl chr 6:97,200,922...97,235,366
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ASTL
astacin like metalloendopeptidase
enables
IEA IBA
InterPro GO_Central UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104
NCBI chr 3:47,058,104...47,071,681
Ensembl chr 3:47,059,040...47,070,664
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ATP23
ATP23 metallopeptidase and ATP synthase assembly factor homolog
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 5:23,176,854...23,276,251
Ensembl chr 5:23,233,895...23,276,036
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BMP1
bone morphogenetic protein 1
enables
IEA IBA
UniProt GO_Central Ensembl InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107
NCBI chr14:6,443,773...6,489,066
Ensembl chr14:6,443,912...6,489,063
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ECE1
endothelin converting enzyme 1
enables
IEA IBA
InterPro GO_Central UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033
NCBI chr 6:79,408,322...79,465,827
Ensembl chr 6:79,408,326...79,466,152
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ECE2
endothelin converting enzyme 2
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr13:122,148,928...122,179,522
Ensembl chr13:122,165,152...122,179,498 Ensembl chr13:122,165,152...122,179,498
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ECEL1
endothelin converting enzyme like 1
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr15:132,988,705...132,997,924
Ensembl chr15:132,988,657...132,997,825
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IDE
insulin degrading enzyme
enables
ISO IBA IEA
atrial natriuretic peptide cleaved at the Ser25-Phe26 bond
RGD GO_Central Ensembl InterPro
PMID:15494400 PMID:15749695
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1626704 RGD:1626705
NCBI chr14:103,992,035...104,106,571
Ensembl chr14:103,992,039...104,106,576
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KEL
Kell metallo-endopeptidase
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr18:7,242,378...7,279,345
Ensembl chr18:7,259,144...7,279,328
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LMLN
leishmanolysin like peptidase
enables
IEA
UniProt InterPro
GO_REF:0000002 GO_REF:0000104
NCBI chr13:134,596,116...134,656,751
Ensembl chr13:134,596,150...134,656,744
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LOC100049687
ADAM3b
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr15:47,104,604...47,195,186
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LOC100515389
disintegrin and metalloproteinase domain-containing protein 21
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 7:94,084,019...94,087,956
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LOC100516390
ankyrin repeat domain-containing protein 26
enables
IEA
InterPro
GO_REF:0000002
NCBI chr10:48,694,806...48,795,783
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LOC100525409
disintegrin and metalloproteinase domain-containing protein 20-like
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 7:94,025,685...94,028,015
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LOC100525589
disintegrin and metalloproteinase domain-containing protein 20-like
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 7:94,014,154...94,018,715
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LOC100737404
disintegrin and metalloproteinase domain-containing protein 1a-like
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:39,813,497...39,817,367
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LOC100739754
disintegrin and metalloproteinase domain-containing protein 20
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 7:94,125,901...94,131,479
Ensembl chr 7:94,127,736...94,129,904
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LOC110255249
disintegrin and metalloproteinase domain-containing protein 20-like
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 7:93,892,897...93,898,402
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LOC110256875
disintegrin and metalloproteinase domain-containing protein 1a-like
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:39,828,431...39,832,844
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LOC110258345
disintegrin and metalloproteinase domain-containing protein 20-like
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
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LOC110258836
disintegrin and metalloproteinase domain-containing protein 29-like
enables
IEA
InterPro
GO_REF:0000002
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MBTPS2
membrane bound transcription factor peptidase, site 2
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr X:18,013,360...18,054,250
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MEP1A
meprin A subunit alpha
enables
IEA IBA
UniProt GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104
NCBI chr 7:41,587,698...41,625,014
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MEP1B
meprin A subunit beta
enables
ISO IBA IEA
RGD GO_Central InterPro UniProt
PMID:12437103
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 RGD:633322
NCBI chr 6:116,015,021...116,049,796
Ensembl chr 6:116,015,021...116,049,791
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MIPEP
mitochondrial intermediate peptidase
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr11:2,675,604...2,790,760
Ensembl chr11:2,670,000...2,790,727
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MME
membrane metalloendopeptidase
enables
IEA IBA ISS
UniProt GO_Central Ensembl InterPro
GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045
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MMEL1
membrane metalloendopeptidase like 1
enables
ISO IBA IEA
RGD GO_Central InterPro
PMID:11964170
GO_REF:0000002 GO_REF:0000033 RGD:2314417
NCBI chr 6:64,436,778...64,470,888
Ensembl chr 6:64,436,642...64,472,759
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MMP1
matrix metallopeptidase 1
enables
IEA IBA
InterPro GO_Central UniProt Ensembl
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107
NCBI chr 9:33,411,738...33,420,205
Ensembl chr 9:33,411,065...33,420,076
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MMP11
matrix metallopeptidase 11
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:49,907,684...49,917,494
Ensembl chr14:49,907,687...49,912,617
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MMP12
matrix metallopeptidase 12
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 9:33,473,625...33,483,630
Ensembl chr 9:33,473,093...33,483,679
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MMP13
matrix metallopeptidase 13
enables
ISO IBA IEA
RGD GO_Central InterPro Ensembl
PMID:8910479 PMID:17941091
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:2296055 RGD:2298541
NCBI chr 9:33,549,003...33,616,700
Ensembl chr 9:33,549,008...33,561,162
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MMP14
matrix metallopeptidase 14
enables
IEA IBA ISS
InterPro GO_Central Ensembl UniProt
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 7:76,174,502...76,185,931
Ensembl chr 7:76,172,971...76,185,928
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MMP15
matrix metallopeptidase 15
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 6:19,890,867...19,912,941
Ensembl chr 6:19,891,107...19,912,913
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MMP16
matrix metallopeptidase 16
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 4:48,556,826...48,867,959
Ensembl chr 4:48,556,967...48,862,985
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MMP17
matrix metallopeptidase 17
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:23,481,220...23,506,936
Ensembl chr14:23,481,227...23,506,919
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MMP19
matrix metallopeptidase 19
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 5:21,279,514...21,285,943
Ensembl chr 5:21,280,130...21,285,774
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MMP2
matrix metallopeptidase 2
enables
IEA IBA
UniProt GO_Central Ensembl InterPro
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107
NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
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MMP20
matrix metallopeptidase 20
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 9:33,261,448...33,308,047
Ensembl chr 9:33,261,443...33,308,047
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MMP23
matrix metallopeptidase 23
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 6:63,801,668...63,804,275
Ensembl chr 6:63,801,965...63,805,046
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MMP24
matrix metallopeptidase 24
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr17:38,587,230...38,636,628
Ensembl chr17:38,588,081...38,636,627
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MMP25
matrix metallopeptidase 25
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 3:39,129,452...39,143,621
Ensembl chr 3:39,130,777...39,142,303
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MMP27
matrix metallopeptidase 27
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:33,366,342...33,379,828
Ensembl chr 9:33,366,345...33,379,789
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MMP28
matrix metallopeptidase 28
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr12:39,739,074...39,766,794
Ensembl chr12:39,739,630...39,766,791
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MMP3
matrix metallopeptidase 3
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:33,446,969...33,453,995
Ensembl chr 9:33,446,836...33,454,000
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MMP7
matrix metallopeptidase 7
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:33,214,590...33,225,080
Ensembl chr 9:33,214,594...33,225,080
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MMP8
matrix metallopeptidase 8
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:33,384,034...33,397,637
Ensembl chr 9:33,384,033...33,396,947
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MMP9
matrix metallopeptidase 9
enables
IEA IBA
UniProt GO_Central InterPro Ensembl
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107
NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
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NLN
neurolysin
enables
ISO IBA IEA
RGD GO_Central InterPro
PMID:7836437
GO_REF:0000002 GO_REF:0000033 RGD:9831155
NCBI chr16:44,225,706...44,333,623
Ensembl chr16:44,225,677...44,334,610
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NRDC
nardilysin convertase
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 6:160,299,101...160,388,511
Ensembl chr 6:160,299,131...160,388,502
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OMA1
OMA1 zinc metallopeptidase
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 6:153,882,398...153,950,460
Ensembl chr 6:153,882,451...153,949,468
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PAPPA
pappalysin 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 1:256,544,496...256,784,813
Ensembl chr 1:256,544,928...256,780,760
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PAPPA2
pappalysin 2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 9:118,362,663...118,635,972
Ensembl chr 9:118,365,303...118,635,964
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PHEX
phosphate regulating endopeptidase X-linked
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr X:18,199,396...18,420,985
Ensembl chr X:18,203,174...18,418,004
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PITRM1
pitrilysin metallopeptidase 1
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr10:66,996,919...67,021,692
Ensembl chr10:66,996,954...67,047,235
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PMPCA
peptidase, mitochondrial processing subunit alpha
enables
IEA
InterPro
GO_REF:0000002
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PMPCB
peptidase, mitochondrial processing subunit beta
enables
IEA IBA
Ensembl GO_Central InterPro UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107
NCBI chr 9:103,316,161...103,329,653
Ensembl chr 9:103,316,190...103,330,290
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RCE1
Ras converting CAAX endopeptidase 1
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 2:5,587,853...5,595,408
Ensembl chr 2:5,588,546...5,593,142
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SPG7
SPG7 matrix AAA peptidase subunit, paraplegin
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 6:414,930...439,206
Ensembl chr 6:414,932...439,212
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SPRTN
SprT-like N-terminal domain
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr14:59,177,801...59,192,221
Ensembl chr14:59,171,192...59,192,269
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THOP1
thimet oligopeptidase 1
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 2:75,857,788...75,877,430
Ensembl chr 2:75,853,429...75,877,494
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TLL1
tolloid like 1
enables
IEA IBA
InterPro GO_Central UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104
NCBI chr 8:42,855,883...43,094,215
Ensembl chr 8:42,856,469...43,092,692
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TLL2
tolloid like 2
enables
IEA IBA
InterPro GO_Central UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104
NCBI chr14:107,812,938...107,961,192
Ensembl chr14:107,812,945...107,961,155
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TRABD2B
TraB domain containing 2B
enables
IEA IBA
Ensembl GO_Central UniProt
GO_REF:0000033 GO_REF:0000104 GO_REF:0000107
NCBI chr 6:163,624,078...163,836,829
Ensembl chr 6:163,624,072...163,837,863
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UQCRC2
ubiquinol-cytochrome c reductase core protein 2
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 3:24,197,743...24,228,831
Ensembl chr 3:24,197,747...24,228,832
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YBEY
ybeY metalloendoribonuclease
enables
IEA
InterPro
GO_REF:0000002
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YME1L1
YME1 like 1 ATPase
enables
IEA
InterPro
GO_REF:0000002
NCBI chr10:48,807,654...48,855,228
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ZMPSTE24
zinc metallopeptidase STE24
enables
IEA IBA
Ensembl GO_Central InterPro UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107
NCBI chr 6:96,008,307...96,057,131
Ensembl chr 6:96,008,455...96,062,951
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ADAM10
ADAM metallopeptidase domain 10
enables
IBA IEA
GO_Central Ensembl
GO_REF:0000033 GO_REF:0000107
NCBI chr 1:113,289,480...113,407,940
Ensembl chr 1:113,289,209...113,412,798
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ADAM17
ADAM metallopeptidase domain 17
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995
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ADAM19
ADAM metallopeptidase domain 19
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr16:65,715,445...65,814,761
Ensembl chr16:65,715,517...65,814,758
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ADAM9
ADAM metallopeptidase domain 9
enables
ISO
(PMID:12054541)
ARUK-UCL
PMID:12054541
NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,771...47,601,710
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