Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:metalloendopeptidase activity
go back to main search page
Accession:GO:0004222 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms:narrow_synonym: metalloendoprotease activity;   metalloendoproteinase activity
 xref: EC:3.4.24;   Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";   Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";   Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";   Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";   Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";   Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";   Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";   Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14";   Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";   Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";   Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";   Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";   Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";   Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";   Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";   Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";   Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";   Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";   Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";   Reactome:R-HSA-9840532 "OMA1 self-cleaves";   Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";   Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer";   reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";   reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";   reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";   reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";   reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";   reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";   reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";   reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";   reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";   reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";   reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";   reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";   reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";   reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";   reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";   reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";   reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";   reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";   reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";   reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";   reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";   reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";   reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";   reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";   reactome:R-HSA-2022141 "Prolysyl oxidase activation";   reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";   reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";   reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";   reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";   reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";   reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";   reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";   reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";   reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";   reactome:R-HSA-2514790 "Elastin degradation by MMP14";   reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";   reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";   reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";   reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";   reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";   reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";   reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";   reactome:R-HSA-2537499 "Gelatin degradation by MMP19";   reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";   reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";   reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";   reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";   reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";   reactome:R-HSA-3791319 "NID1 degradation by MMP19";   reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";   reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";   reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";   reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";   reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";   reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";   reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";   reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";   reactome:R-HSA-5333671 "CLCAs self cleave";   reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";   reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";   reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";   reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";   reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";   reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";   reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";   reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";   reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";   reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";   reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";   reactome:R-HSA-8940554 "MMP2 cleaves OPTC";   reactome:R-HSA-8940561 "MMP7 cleaves OPTC";   reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";   reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";   reactome:R-HSA-8942302 "MMP13 cleaves OPTC";   reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";   reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";   reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";   reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"


show annotations for term's descendants           Sort by:
metalloendopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme enables IDA (PMID:6208535), (PMID:7683654) UniProt PMID:6208535 PMID:7683654 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ADAM10 ADAM metallopeptidase domain 10 enables ISO
IDA
IEA
NAS
IMP
ISS
TAS		 (PMID:18355445), (PMID:18676862)
(PMID:8694785)
(PMID:19114711)		 RGD
BHF-UCL
InterPro
UniProt
ARUK-UCL
Reactome		 PMID:8694785 PMID:10423016 PMID:18355445 PMID:18676862 PMID:19114711 GO_REF:0000002 GO_REF:0000024 RGD:631800 Reactome:R-HSA-4224014 NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791 		JBrowse link
G ADAM11 ADAM metallopeptidase domain 11 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr17:44,758,988...44,781,846
Ensembl chr17:44,758,988...44,781,846 		JBrowse link
G ADAM12 ADAM metallopeptidase domain 12 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr10:126,012,391...126,388,477
Ensembl chr10:126,012,381...126,388,477 		JBrowse link
G ADAM15 ADAM metallopeptidase domain 15 enables TAS
IBA
IEA		 Reactome
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-4224014 NCBI chr 1:155,051,316...155,062,775
Ensembl chr 1:155,050,566...155,062,775 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 enables TAS
IDA
IEA
IBA
IMP		 (PMID:14625290), (PMID:15691827), (PMID:17010968), (PMID:18355445), (PMID:24226769), (PMID:24337742), (PMID:36476876), (PMID:9774383), (PMID:9920899)
(PMID:9034190), (PMID:9034191)		 Reactome
BHF-UCL
Ensembl
GO_Central
InterPro		 PMID:9034190 PMID:9034191 PMID:9774383 PMID:9920899 PMID:14625290 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 Reactome:R-NUL-5362792 NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732 		JBrowse link
G ADAM18 ADAM metallopeptidase domain 18 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:39,584,568...39,730,065
Ensembl chr 8:39,584,489...39,730,065 		JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables IMP
IBA
IEA		 (PMID:11162584), (PMID:17112471) ARUK-UCL
GO_Central
InterPro		 PMID:11162584 PMID:17112471 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:157,477,304...157,575,775
Ensembl chr 5:157,395,534...157,575,775 		JBrowse link
G ADAM2 ADAM metallopeptidase domain 2 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:39,743,735...39,838,227
Ensembl chr 8:39,743,735...39,838,227 		JBrowse link
G ADAM20 ADAM metallopeptidase domain 20 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr14:70,522,358...70,579,452
Ensembl chr14:70,522,358...70,535,015 		JBrowse link
G ADAM21 ADAM metallopeptidase domain 21 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr14:70,452,174...70,459,905
Ensembl chr14:70,417,107...70,460,427 		JBrowse link
G ADAM22 ADAM metallopeptidase domain 22 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:87,934,251...88,202,889
Ensembl chr 7:87,934,143...88,202,889 		JBrowse link
G ADAM23 ADAM metallopeptidase domain 23 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:206,443,532...206,621,127
Ensembl chr 2:206,443,532...206,621,127 		JBrowse link
G ADAM28 ADAM metallopeptidase domain 28 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:24,294,069...24,359,014
Ensembl chr 8:24,294,069...24,359,014 		JBrowse link
G ADAM29 ADAM metallopeptidase domain 29 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 4:174,918,358...174,978,180
Ensembl chr 4:174,829,668...174,978,180 		JBrowse link
G ADAM30 ADAM metallopeptidase domain 30 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:119,893,533...119,896,515
Ensembl chr 1:119,893,533...119,896,515 		JBrowse link
G ADAM32 ADAM metallopeptidase domain 32 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:39,107,529...39,284,917
Ensembl chr 8:39,106,990...39,284,917 		JBrowse link
G ADAM33 ADAM metallopeptidase domain 33 enables NAS
IBA
IEA		 (PMID:11814695) UniProt
GO_Central
InterPro		 PMID:11814695 GO_REF:0000002 GO_REF:0000033 NCBI chr20:3,667,975...3,682,010
Ensembl chr20:3,667,965...3,682,246 		JBrowse link
G ADAM7 ADAM metallopeptidase domain 7 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:24,441,026...24,509,565
Ensembl chr 8:24,440,930...24,526,970 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables IMP
IBA
IEA
IDA		 (PMID:22480688)
(PMID:12054541), (PMID:9920899)		 BHF-UCL
GO_Central
InterPro
ARUK-UCL		 PMID:9920899 PMID:12054541 PMID:22480688 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:38,996,973...39,105,261
Ensembl chr 8:38,996,754...39,105,445 		JBrowse link
G ADAMDEC1 ADAM like decysin 1 enables NAS
IBA
IEA		 (PMID:12037602), (PMID:9271581) UniProt
GO_Central
InterPro		 PMID:9271581 PMID:12037602 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:24,384,285...24,406,013
Ensembl chr 8:24,384,285...24,406,013 		JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 enables IEA
IBA
IDA		 (PMID:11278559), (PMID:25122765) Ensembl
GO_Central
UniProt
InterPro		 PMID:11278559 PMID:25122765 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr21:26,835,755...26,845,409
Ensembl chr21:26,835,755...26,845,409 		JBrowse link
G ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr19:8,580,240...8,610,715
Ensembl chr19:8,580,240...8,610,735 		JBrowse link
G ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 enables IDA
IBA
IEA		 (PMID:16611630), (PMID:17895370), (PMID:18485748) BHF-UCL
GO_Central
InterPro		 PMID:16611630 PMID:17895370 PMID:18485748 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:33,523,535...33,891,990
Ensembl chr 5:33,523,535...33,892,019 		JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 enables IEA
IBA
TAS
EXP		 (PMID:12775718), (PMID:18983500), (PMID:31439947) InterPro
GO_Central
Reactome		 PMID:12775718 PMID:18983500 PMID:31439947 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-9824402 Reactome:R-HSA-9844241 NCBI chr 9:133,414,337...133,459,386
Ensembl chr 9:133,414,358...133,459,402 		JBrowse link
G ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 enables TAS
IBA
IEA		 Reactome
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-2002428 NCBI chr10:70,672,506...70,762,441
Ensembl chr10:70,672,506...70,762,441 		JBrowse link
G ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:130,448,645...130,476,645
Ensembl chr11:130,448,645...130,476,645 		JBrowse link
G ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif 16 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:5,140,330...5,320,304
Ensembl chr 5:5,140,330...5,320,304 		JBrowse link
G ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr15:99,971,437...100,341,975
Ensembl chr15:99,971,437...100,342,005 		JBrowse link
G ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr16:77,282,128...77,435,034
Ensembl chr16:77,247,813...77,435,034 		JBrowse link
G ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif 19 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:129,460,298...129,738,683
Ensembl chr 5:129,460,281...129,738,683 		JBrowse link
G ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 enables TAS
IBA
IEA		 (PMID:10417273) PINC
GO_Central
InterPro
UniProt		 PMID:10417273 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-2002428 NCBI chr 5:179,110,853...179,345,461
Ensembl chr 5:179,110,853...179,345,461 		JBrowse link
G ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 enables IEA
IBA		 Ensembl
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:43,352,763...43,552,203
Ensembl chr12:43,353,866...43,552,203 		JBrowse link
G ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 enables TAS
IBA
IEA
NAS		 (PMID:11812023) Reactome
GO_Central
InterPro
UniProt		 PMID:11812023 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-2002428 NCBI chr 4:72,280,969...72,569,221
Ensembl chr 4:72,280,969...72,569,221 		JBrowse link
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 enables TAS
IEA
IDA
IBA		 (PMID:14744861) Reactome
Ensembl
BHF-UCL
GO_Central
InterPro		 PMID:14744861 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 Reactome:R-HSA-3788075 Reactome:R-NUL-2533988 NCBI chr 1:161,184,302...161,199,054
Ensembl chr 1:161,184,302...161,199,054 		JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 enables TAS
IBA
IDA
IEA		 (PMID:25122765), (PMID:26668318) Reactome
GO_Central
UniProt
InterPro		 PMID:25122765 PMID:26668318 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-3788075 Reactome:R-NUL-2533988 NCBI chr21:26,917,922...26,967,088
Ensembl chr21:26,917,922...26,967,088 		JBrowse link
G ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif 6 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:65,148,738...65,481,920
Ensembl chr 5:65,148,738...65,481,920 		JBrowse link
G ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif 7 enables IDA
IBA
IEA		 (PMID:18485748) BHF-UCL
GO_Central
InterPro		 PMID:18485748 GO_REF:0000002 GO_REF:0000033 NCBI chr15:78,759,206...78,811,464
Ensembl chr15:78,759,206...78,811,464 		JBrowse link
G ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:130,404,923...130,428,609
Ensembl chr11:130,404,923...130,428,609 		JBrowse link
G ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif 9 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 3:64,515,654...64,688,000
Ensembl chr 3:64,515,654...64,688,000 		JBrowse link
G ADAMTSL2 ADAMTS like 2 NOT|enables IBA GO_Central GO_REF:0000033 NCBI chr 9:133,532,164...133,575,519
Ensembl chr 9:133,532,164...133,575,519 		JBrowse link
G AFG3L2 AFG3 like matrix AAA peptidase subunit 2 enables IEA
IBA
IDA		 (PMID:19748354), (PMID:22354088), (PMID:27642048), (PMID:28396416), (PMID:29545505), (PMID:29932645), (PMID:31327635), (PMID:37917749), (PMID:38157846) InterPro
GO_Central
UniProt		 PMID:19748354 PMID:22354088 PMID:27642048 PMID:28396416 PMID:29545505 More... GO_REF:0000002 GO_REF:0000033 NCBI chr18:12,328,944...12,377,227
Ensembl chr18:12,328,944...12,377,227 		JBrowse link
G ASTL astacin like metalloendopeptidase enables IEA
IBA		 InterPro
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 2:96,122,818...96,138,564
Ensembl chr 2:96,122,818...96,138,502 		JBrowse link
G ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog enables IEA InterPro GO_REF:0000002 NCBI chr12:57,941,567...57,959,148
Ensembl chr12:57,906,039...57,959,148 		JBrowse link
G BMP1 bone morphogenetic protein 1 enables IEA
IBA
TAS		 UniProt
GO_Central
InterPro
Reactome
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 Reactome:R-HSA-2002428 Reactome:R-HSA-2002440 Reactome:R-HSA-2022141 NCBI chr 8:22,165,372...22,212,326
Ensembl chr 8:22,165,140...22,212,326 		JBrowse link
G CIROP ciliated left-right organizer metallopeptidase enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr14:23,099,062...23,104,989
Ensembl chr14:23,099,062...23,104,989 		JBrowse link
G CLCA1 chloride channel accessory 1 enables TAS Reactome Reactome:R-HSA-5333671 NCBI chr 1:86,468,927...86,500,259
Ensembl chr 1:86,468,368...86,500,259 		JBrowse link
G CLCA2 chloride channel accessory 2 enables TAS Reactome Reactome:R-HSA-5333671 NCBI chr 1:86,424,171...86,456,553
Ensembl chr 1:86,424,171...86,456,553 		JBrowse link
G CLCA4 chloride channel accessory 4 enables TAS Reactome Reactome:R-HSA-5333671 NCBI chr 1:86,547,078...86,580,754
Ensembl chr 1:86,547,078...86,580,754 		JBrowse link
G ECE1 endothelin converting enzyme 1 enables TAS
IBA
IEA
ISS		 (PMID:8062389) Reactome
GO_Central
UniProt
InterPro
BHF-UCL		 PMID:8062389 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-8876868 NCBI chr 1:21,217,250...21,345,504
Ensembl chr 1:21,217,247...21,345,572 		JBrowse link
G ECE2 endothelin converting enzyme 2 enables IEA
IBA
TAS
IDA		 (PMID:11718899) InterPro
GO_Central
Reactome
UniProt		 PMID:11718899 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-8877620 NCBI chr 3:184,276,022...184,293,031
Ensembl chr 3:184,276,011...184,293,031 		JBrowse link
G ECEL1 endothelin converting enzyme like 1 enables IEA
IBA		 UniProt
GO_Central
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:232,479,827...232,487,834
Ensembl chr 2:232,479,827...232,487,834 		JBrowse link
G EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough enables IDA
IBA
IEA
TAS		 (PMID:11718899) UniProt
GO_Central
InterPro
Reactome		 PMID:11718899 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-8877620 NCBI chr 3:184,249,672...184,293,031
Ensembl chr 3:184,249,695...184,293,031 		JBrowse link
G IDE insulin degrading enzyme enables ISO
IEA
IBA
IDA
TAS		 atrial natriuretic peptide cleaved at the Ser25-Phe26 bond
(PMID:17051221), (PMID:17613531)
(PMID:10684867)		 RGD
Ensembl
GO_Central
UniProt
InterPro
ARUK-UCL		 PMID:10684867 PMID:15494400 PMID:15749695 PMID:17051221 PMID:17613531 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 RGD:1626704 RGD:1626705 NCBI chr10:92,451,684...92,574,093
Ensembl chr10:92,451,684...92,574,096 		JBrowse link
G KEL Kell metallo-endopeptidase (Kell blood group) enables IDA
IBA
IEA		 (PMID:15769748) HGNC-UCL
GO_Central
InterPro		 PMID:15769748 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:142,941,114...142,962,363
Ensembl chr 7:142,941,114...142,962,363 		JBrowse link
G KLK7 kallikrein related peptidase 7 enables TAS Reactome Reactome:R-HSA-3827958 NCBI chr19:50,976,468...50,984,064
Ensembl chr19:50,976,468...50,984,099 		JBrowse link
G LMLN leishmanolysin like peptidase enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr 3:197,960,217...198,043,720
Ensembl chr 3:197,960,200...198,043,720 		JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 enables TAS
IBA
IEA
IDA
EXP		 (PMID:9659902)
(PMID:11163209)		 PINC
GO_Central
InterPro
UniProt
Reactome		 PMID:9659902 PMID:11163209 GO_REF:0000002 GO_REF:0000033 NCBI chr  X:21,839,617...21,885,423
Ensembl chr  X:21,839,617...21,885,423 		JBrowse link
G MEP1A meprin A subunit alpha enables IEA
IBA		 UniProt
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 NCBI chr 6:46,793,389...46,845,984
Ensembl chr 6:46,793,389...46,839,778 		JBrowse link
G MEP1B meprin A subunit beta enables ISO
IBA
IEA		 RGD
GO_Central
UniProt
InterPro		 PMID:12437103 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 RGD:633322 NCBI chr18:32,190,039...32,220,404
Ensembl chr18:32,185,069...32,220,404 		JBrowse link
G MIPEP mitochondrial intermediate peptidase enables TAS
IBA
IEA		 (PMID:9073519) PINC
GO_Central
InterPro
UniProt		 PMID:9073519 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr13:23,730,189...23,889,400
Ensembl chr13:23,730,189...23,889,400 		JBrowse link
G MME membrane metalloendopeptidase enables IMP
IBA
IEA
IDA		 (PMID:2521388)
(PMID:15283675), (PMID:27588448), (PMID:6208535), (PMID:6349683)		 UniProt
GO_Central
InterPro		 PMID:2521388 PMID:6208535 PMID:6349683 PMID:15283675 PMID:27588448 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704 		JBrowse link
G MMEL1 membrane metalloendopeptidase like 1 enables ISO
IBA
IEA		 RGD
GO_Central
InterPro
UniProt		 PMID:11964170 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 RGD:2314417 NCBI chr 1:2,590,639...2,633,016
Ensembl chr 1:2,590,639...2,633,016 		JBrowse link
G MMP1 matrix metallopeptidase 1 enables IDA
IBA
IEA
TAS		 (PMID:9920899)
(PMID:3027129)		 BHF-UCL
GO_Central
UniProt
PINC
InterPro		 PMID:3027129 PMID:9920899 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-1454757 Reactome:R-HSA-1454822 Reactome:R-HSA-1474213 Reactome:R-HSA-1564120 Reactome:R-HSA-1564169 Reactome:R-HSA-3791149 Reactome:R-HSA-381435 Reactome:R-NUL-2484859 Reactome:R-NUL-2484869 Reactome:R-NUL-3814821 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP10 matrix metallopeptidase 10 enables IEA
IBA
TAS		 (PMID:2844164) UniProt
GO_Central
Reactome
InterPro		 PMID:2844164 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-1564142 Reactome:R-HSA-1564164 Reactome:R-HSA-3791149 Reactome:R-NUL-2485115 Reactome:R-NUL-2533858 NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628 		JBrowse link
G MMP11 matrix metallopeptidase 11 enables TAS
IBA
IEA		 (PMID:7746327) Reactome
GO_Central
InterPro		 PMID:7746327 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-1564112 NCBI chr22:23,772,849...23,784,316
Ensembl chr22:23,768,226...23,784,316 		JBrowse link
G MMP12 matrix metallopeptidase 12 enables TAS
IEA
IBA
IDA
IMP		 (PMID:8226919)
(PMID:24784232)
(PMID:19932771)		 Reactome
UniProt
GO_Central
CAFA
InterPro		 PMID:8226919 PMID:19932771 PMID:24784232 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-1454757 Reactome:R-HSA-1564142 Reactome:R-HSA-2168046 Reactome:R-HSA-2485148 Reactome:R-NUL-3814821 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982 		JBrowse link
G MMP13 matrix metallopeptidase 13 enables ISO
IBA
IEA
TAS
IDA		 (PMID:8609233)
(PMID:8576151), (PMID:9065415)		 RGD
GO_Central
InterPro
Reactome
UniProt
Ensembl		 PMID:8576151 PMID:8609233 PMID:8910479 PMID:9065415 PMID:17941091 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:2296055 RGD:2298541 Reactome:R-HSA-1454757 Reactome:R-HSA-1454822 Reactome:R-HSA-1474213 Reactome:R-HSA-2485148 Reactome:R-HSA-3791149 Reactome:R-HSA-8942302 Reactome:R-NUL-2482219 Reactome:R-NUL-2484854 Reactome:R-NUL-2484948 Reactome:R-NUL-3814821 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP14 matrix metallopeptidase 14 enables IEA
IBA
IDA
ISS
TAS		 (PMID:35177851), (PMID:8015608)
(PMID:8015608)		 Ensembl
GO_Central
UniProt
InterPro
Reactome		 PMID:8015608 PMID:35177851 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 Reactome:R-HSA-1474210 Reactome:R-HSA-2514790 Reactome:R-HSA-2514831 Reactome:R-HSA-2533950 Reactome:R-HSA-2534240 Reactome:R-HSA-3791155 Reactome:R-HSA-3828025 Reactome:R-NUL-2473583 Reactome:R-NUL-2473590 Reactome:R-NUL-2533890 Reactome:R-NUL-2533964 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041 		JBrowse link
G MMP15 matrix metallopeptidase 15 enables TAS
IBA
IEA		 (PMID:7649159) Reactome
GO_Central
InterPro		 PMID:7649159 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-2473584 Reactome:R-HSA-2473594 Reactome:R-HSA-2473596 Reactome:R-HSA-2534240 Reactome:R-NUL-2533964 NCBI chr16:58,025,754...58,046,901
Ensembl chr16:58,025,754...58,046,901 		JBrowse link
G MMP16 matrix metallopeptidase 16 enables IDA
IBA
IEA
TAS		 (PMID:27229514)
(PMID:7559440)		 ParkinsonsUK-UCL
GO_Central
InterPro
PINC		 PMID:7559440 PMID:27229514 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:88,032,011...88,327,483
Ensembl chr 8:88,032,011...88,328,025 		JBrowse link
G MMP17 matrix metallopeptidase 17 enables TAS
IBA
IEA		 (PMID:8640782) PINC
GO_Central
InterPro		 PMID:8640782 GO_REF:0000002 GO_REF:0000033 NCBI chr12:131,828,393...131,851,771
Ensembl chr12:131,828,393...131,851,783 		JBrowse link
G MMP19 matrix metallopeptidase 19 enables EXP
IBA
IEA
TAS		 (PMID:10809722) Reactome
GO_Central
InterPro		 PMID:10809722 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-3791149 NCBI chr12:55,835,433...55,842,936
Ensembl chr12:55,835,433...55,842,966 		JBrowse link
G MMP2 matrix metallopeptidase 2 enables IEA
IBA
TAS		 (PMID:2834383) Ensembl
GO_Central
InterPro
UniProt
Reactome		 PMID:2834383 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 Reactome:R-HSA-1454757 Reactome:R-HSA-1454822 Reactome:R-HSA-1564112 Reactome:R-HSA-1564120 Reactome:R-HSA-1564142 Reactome:R-HSA-1564164 Reactome:R-HSA-2485148 Reactome:R-HSA-2534248 Reactome:R-HSA-3791149 Reactome:R-HSA-381435 Reactome:R-HSA-8940554 Reactome:R-HSA-8943959 Reactome:R-NUL-2484859 Reactome:R-NUL-2484869 Reactome:R-NUL-3814821 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP20 matrix metallopeptidase 20 enables TAS
IBA
IEA
IDA		 (PMID:9398237) PINC
GO_Central
InterPro
CACAO		 PMID:9398237 GO_REF:0000002 GO_REF:0000033 NCBI chr11:102,576,832...102,625,332
Ensembl chr11:102,576,832...102,625,332 		JBrowse link
G MMP21 matrix metallopeptidase 21 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr10:125,766,453...125,775,821
Ensembl chr10:125,753,580...125,775,821 		JBrowse link
G MMP23B matrix metallopeptidase 23B enables NAS
IBA
IEA
IDA		 (PMID:9740677)
(PMID:9988691)		 UniProt
GO_Central
InterPro		 PMID:9740677 PMID:9988691 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:1,632,173...1,634,654
Ensembl chr 1:1,632,163...1,635,263 		JBrowse link
G MMP24 matrix metallopeptidase 24 enables ISS
IBA
IEA
TAS		 (PMID:10363975) UniProt
GO_Central
InterPro
Ensembl
PINC		 PMID:10363975 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:35,226,690...35,276,998
Ensembl chr20:35,226,690...35,276,998 		JBrowse link
G MMP25 matrix metallopeptidase 25 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr16:3,046,561...3,060,726
Ensembl chr16:3,046,062...3,060,729 		JBrowse link
G MMP26 matrix metallopeptidase 26 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:4,704,784...4,992,429
Ensembl chr11:4,704,784...4,992,431 		JBrowse link
G MMP27 matrix metallopeptidase 27 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:102,691,487...102,705,769
Ensembl chr11:102,691,487...102,705,769 		JBrowse link
G MMP28 matrix metallopeptidase 28 enables IEA
IBA
TAS		 (PMID:11121398), (PMID:11255011) InterPro
GO_Central
UniProt		 PMID:11121398 PMID:11255011 GO_REF:0000002 GO_REF:0000033 NCBI chr17:35,756,249...35,795,641
Ensembl chr17:35,756,249...35,795,707 		JBrowse link
G MMP3 matrix metallopeptidase 3 enables IEA
IBA
TAS		 (PMID:3360803) UniProt
GO_Central
InterPro
Reactome		 PMID:3360803 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-1454757 Reactome:R-HSA-1564120 Reactome:R-HSA-1564142 Reactome:R-HSA-2534248 Reactome:R-HSA-3791149 Reactome:R-HSA-4086205 Reactome:R-NUL-2482219 Reactome:R-NUL-2484854 Reactome:R-NUL-2484859 Reactome:R-NUL-3814821 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609 		JBrowse link
G MMP7 matrix metallopeptidase 7 enables IEA
IBA
TAS		 (PMID:1497627) UniProt
GO_Central
InterPro
Reactome		 PMID:1497627 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-1454757 Reactome:R-HSA-1564142 Reactome:R-HSA-2534248 Reactome:R-HSA-3791149 Reactome:R-HSA-4086205 Reactome:R-HSA-8940561 Reactome:R-NUL-3814821 NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750 		JBrowse link
G MMP8 matrix metallopeptidase 8 enables TAS
IBA
IEA		 Reactome
GO_Central
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-1454757 Reactome:R-HSA-1454822 Reactome:R-HSA-1474213 Reactome:R-HSA-3791149 NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050 		JBrowse link
G MMP9 matrix metallopeptidase 9 enables IEA
IBA
IDA
TAS		 (PMID:16192646), (PMID:24164424), (PMID:2551898), (PMID:9789069) Ensembl
GO_Central
InterPro
MGI
UniProt
Reactome		 PMID:2551898 PMID:9789069 PMID:16192646 PMID:24164424 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 Reactome:R-HSA-1454757 Reactome:R-HSA-1474213 Reactome:R-HSA-1564112 Reactome:R-HSA-1564142 Reactome:R-HSA-1564164 Reactome:R-HSA-2485148 Reactome:R-HSA-3827958 Reactome:R-HSA-8943959 Reactome:R-NUL-2484859 Reactome:R-NUL-2484927 Reactome:R-NUL-2484948 Reactome:R-NUL-3814821 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NLN neurolysin enables ISO
IBA
TAS
IEA		 RGD
GO_Central
Reactome
InterPro		 PMID:7836437 GO_REF:0000002 GO_REF:0000033 RGD:9831155 Reactome:R-HSA-8940959 NCBI chr 5:65,722,205...65,829,283
Ensembl chr 5:65,722,205...65,871,725 		JBrowse link
G NRDC nardilysin convertase enables IEA
NAS		 (PMID:9581555) UniProt
InterPro		 PMID:9581555 GO_REF:0000002 GO_REF:0000003 NCBI chr 1:51,789,210...51,878,727
Ensembl chr 1:51,789,191...51,878,805 		JBrowse link
G OMA1 OMA1 zinc metallopeptidase enables IDA
IBA
IEA
IMP		 (PMID:25275009), (PMID:32132706), (PMID:32132707)
(PMID:20038677)		 UniProt
GO_Central
InterPro
Ensembl		 PMID:20038677 PMID:25275009 PMID:32132706 PMID:32132707 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:58,480,719...58,546,726
Ensembl chr 1:58,415,384...58,546,802 		JBrowse link
G PAPPA pappalysin 1 enables EXP
IBA
TAS		 (PMID:11513734) Reactome
GO_Central		 PMID:11513734 GO_REF:0000033 Reactome:R-HSA-381537 NCBI chr 9:116,153,791...116,402,321
Ensembl chr 9:116,153,791...116,402,321 		JBrowse link
G PAPPA2 pappalysin 2 enables EXP
IBA
TAS		 (PMID:11513734) Reactome
GO_Central		 PMID:11513734 GO_REF:0000033 Reactome:R-HSA-381537 NCBI chr 1:176,463,175...176,845,601
Ensembl chr 1:176,463,171...176,845,601 		JBrowse link
G PHEX phosphate regulating endopeptidase X-linked enables IEA
IBA
TAS		 (PMID:9593714) InterPro
GO_Central
PINC		 PMID:9593714 GO_REF:0000002 GO_REF:0000033 NCBI chr  X:22,032,325...22,251,310
Ensembl chr  X:22,032,325...22,494,713 		JBrowse link
G PITRM1 pitrilysin metallopeptidase 1 enables IMP
IBA
IDA		 (PMID:16849325), (PMID:24931469)
(PMID:10360838), (PMID:19196155)		 UniProt
GO_Central		 PMID:10360838 PMID:16849325 PMID:19196155 PMID:24931469 GO_REF:0000033 NCBI chr10:3,137,727...3,172,841
Ensembl chr10:3,137,728...3,172,841 		JBrowse link
G PMPCA peptidase, mitochondrial processing subunit alpha enables IEA InterPro GO_REF:0000002 NCBI chr 9:136,410,658...136,423,761
Ensembl chr 9:136,410,630...136,427,992 		JBrowse link
G PMPCB peptidase, mitochondrial processing subunit beta enables TAS
IBA
IEA
IDA		 (PMID:22354088) Reactome
GO_Central
InterPro
UniProt		 PMID:22354088 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 Reactome:R-HSA-8949649 NCBI chr 7:103,297,435...103,347,542
Ensembl chr 7:103,297,407...103,331,818 		JBrowse link
G PRSS2 serine protease 2 enables TAS Reactome Reactome:R-HSA-1454822 NCBI chr 7:142,770,970...142,774,560
Ensembl chr 7:142,760,398...142,774,564 		JBrowse link
G RCE1 Ras converting CAAX endopeptidase 1 enables IBA
IEA		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:66,843,441...66,846,552
Ensembl chr11:66,842,835...66,846,552 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 enables IEA InterPro GO_REF:0000002 NCBI chr  X:23,783,173...23,786,210
Ensembl chr  X:23,783,173...23,786,210 		JBrowse link
G SPG7 SPG7 matrix AAA peptidase subunit, paraplegin enables IEA InterPro GO_REF:0000002 NCBI chr16:89,490,970...89,499,282
Ensembl chr16:89,490,719...89,557,766 		JBrowse link
G SPG7 SPG7 matrix AAA peptidase subunit, paraplegin enables IEA
IBA
IDA		 (PMID:11549317), (PMID:28396416), (PMID:31097542) InterPro
GO_Central
UniProt		 PMID:11549317 PMID:28396416 PMID:31097542 GO_REF:0000002 GO_REF:0000033 NCBI chr16:89,508,388...89,557,768
Ensembl chr16:89,490,719...89,557,766 		JBrowse link
G SPRTN SprT-like N-terminal domain enables IEA
IDA		 (PMID:27852435), (PMID:27871365), (PMID:27871366), (PMID:32649882), (PMID:36608669) InterPro
UniProt		 PMID:27852435 PMID:27871365 PMID:27871366 PMID:32649882 PMID:36608669 GO_REF:0000002 NCBI chr 1:231,338,293...231,355,023
Ensembl chr 1:231,337,104...231,355,023 		JBrowse link
G THOP1 thimet oligopeptidase 1 enables IEA
IBA
TAS		 (PMID:7639763) InterPro
GO_Central
PINC		 PMID:7639763 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-8940641 NCBI chr19:2,785,503...2,815,807
Ensembl chr19:2,785,503...2,815,807 		JBrowse link
G TLL1 tolloid like 1 enables IEA
IBA
TAS		 UniProt
GO_Central
InterPro
Reactome		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 Reactome:R-HSA-2002440 Reactome:R-HSA-2022141 NCBI chr 4:165,873,237...166,104,457
Ensembl chr 4:165,873,237...166,104,457 		JBrowse link
G TLL2 tolloid like 2 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr10:96,364,608...96,513,926
Ensembl chr10:96,364,608...96,513,926 		JBrowse link
G TMPRSS6 transmembrane serine protease 6 enables TAS Reactome Reactome:R-HSA-1474210 Reactome:R-HSA-2514790 Reactome:R-HSA-2514831 Reactome:R-HSA-3791155 Reactome:R-HSA-3828025 Reactome:R-NUL-2473583 Reactome:R-NUL-2473590 Reactome:R-NUL-2533890 NCBI chr22:37,065,436...37,110,536
Ensembl chr22:37,065,436...37,109,713 		JBrowse link
G TRABD2A TraB domain containing 2A enables IDA
IBA
IEA
ISS		 (PMID:22726442) UniProt
GO_Central
ParkinsonsUK-UCL		 PMID:22726442 GO_REF:0000033 GO_REF:0000104 NCBI chr 2:84,821,666...84,881,084
Ensembl chr 2:84,821,650...84,907,008 		JBrowse link
G TRABD2B TraB domain containing 2B enables IDA
IBA		 (PMID:22726442) ParkinsonsUK-UCL
GO_Central		 PMID:22726442 GO_REF:0000033 NCBI chr 1:47,760,528...47,997,385
Ensembl chr 1:47,760,528...47,997,385 		JBrowse link
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 enables IEA InterPro GO_REF:0000002 NCBI chr16:21,953,361...21,983,660
Ensembl chr16:21,953,288...21,983,660 		JBrowse link
G YBEY ybeY metalloendoribonuclease enables IEA InterPro GO_REF:0000002 NCBI chr21:46,286,342...46,313,225
Ensembl chr21:46,286,342...46,297,751 		JBrowse link
G YME1L1 YME1 like 1 ATPase enables IEA InterPro GO_REF:0000002 NCBI chr10:27,110,111...27,154,384
Ensembl chr10:27,110,088...27,155,266 		JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 enables IEA
IBA		 UniProt
GO_Central
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 1:40,258,236...40,294,180
Ensembl chr 1:40,258,041...40,294,180 		JBrowse link
metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 enables ISS
IBA
IMP		 (PMID:28164773) ARUK-UCL
GO_Central
UniProt		 PMID:28164773 GO_REF:0000024 GO_REF:0000033 NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 enables IDA (PMID:9774383) ARUK-UCL PMID:9774383 NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732 		JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables IMP (PMID:17112471) ARUK-UCL PMID:17112471 NCBI chr 5:157,477,304...157,575,775
Ensembl chr 5:157,395,534...157,575,775 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables IDA (PMID:12054541) ARUK-UCL PMID:12054541 NCBI chr 8:38,996,973...39,105,261
Ensembl chr 8:38,996,754...39,105,445 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19689
    catalytic activity 6077
      hydrolase activity 2649
        peptidase activity 676
          endopeptidase activity 419
            metalloendopeptidase activity 112
              metalloendopeptidase activity involved in amyloid precursor protein catabolic process 4
paths to the root