ONTOLOGY REPORT - ANNOTATIONS
Term: metalloendopeptidase activity
Accession: GO:0004222
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Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms: narrow_synonym: metalloendoprotease activity; metalloendoproteinase activity
xref: EC:3.4.24; Reactome:R-HSA-181567 "botC LC cleaves target cell STX1"; Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25"; Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2"; Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25"; Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1"; Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1"; Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25"; Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14"; Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)"; Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2"; Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2"; Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2"; Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2"; Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1"; Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)"; Reactome:R-HSA-9624272 "MMPs cleave HB-EGF"; Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer"; Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer"; Reactome:R-HSA-9840408 "OMA1 cleaves DELE1"; Reactome:R-HSA-9840532 "OMA1 self-cleaves"; Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1"; Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer"; reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR"; reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17"; reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors"; reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors"; reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13"; reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2"; reactome:R-HSA-1458433 "Collagen type I degradation by MMP14"; reactome:R-HSA-1474196 "Collagen type II degradation by MMP14"; reactome:R-HSA-1474210 "Collagen type III degradation by MMP14"; reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13"; reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11"; reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13"; reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3"; reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12"; reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2"; reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10"; reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1"; reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9"; reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13"; reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs"; reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2"; reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF"; reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides"; reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides"; reactome:R-HSA-2022141 "Prolysyl oxidase activation"; reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12"; reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9"; reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF"; reactome:R-HSA-2473584 "Collagen type III degradation by MMP15"; reactome:R-HSA-2473594 "Collagen type II degradation by MMP15"; reactome:R-HSA-2473596 "Collagen type I degradation by MMP15"; reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13"; reactome:R-HSA-2485111 "Collagen type III degradation by MMP10"; reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13"; reactome:R-HSA-2514790 "Elastin degradation by MMP14"; reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14"; reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14"; reactome:R-HSA-2533944 "Fibronectin degradation by MMP10"; reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15"; reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7"; reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15"; reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7"; reactome:R-HSA-2537499 "Gelatin degradation by MMP19"; reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1"; reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5"; reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19"; reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14"; reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13"; reactome:R-HSA-3791319 "NID1 degradation by MMP19"; reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS"; reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4"; reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS"; reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7"; reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14"; reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7"; reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)"; reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15"; reactome:R-HSA-5333671 "CLCAs self cleave"; reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding"; reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3"; reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)"; reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1"; reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2"; reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3"; reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1"; reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4"; reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3"; reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)"; reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)"; reactome:R-HSA-8940554 "MMP2 cleaves OPTC"; reactome:R-HSA-8940561 "MMP7 cleaves OPTC"; reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)"; reactome:R-HSA-8940959 "Neurolysin degrades neurotensin"; reactome:R-HSA-8942302 "MMP13 cleaves OPTC"; reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3"; reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)"; reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU"; reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"
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ACE
angiotensin I converting enzyme
enables
IEA
Ensembl
GO_REF:0000107
Ensembl chr16:57,700,977...57,806,815
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ADAM10
ADAM metallopeptidase domain 10
enables
ISO IEA
RGD InterPro Ensembl
PMID:10423016
GO_REF:0000002 GO_REF:0000107 RGD:631800
NCBI chr26:24,768,827...24,921,169
Ensembl chr26:24,768,915...24,919,009
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ADAM11
ADAM metallopeptidase domain 11
enables
IEA
InterPro
GO_REF:0000002
NCBI chr16:61,621,707...61,644,813
Ensembl chr16:61,621,673...61,644,723
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ADAM12
ADAM metallopeptidase domain 12
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 9:118,641,551...119,014,280
Ensembl chr 9:118,646,539...118,749,351
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ADAM15
ADAM metallopeptidase domain 15
enables
IEA
InterPro
GO_REF:0000002
NCBI chr20:8,767,836...8,779,399
Ensembl chr20:8,768,112...8,779,311
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ADAM17
ADAM metallopeptidase domain 17
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr14:98,092,093...98,157,657
Ensembl chr14:98,092,044...98,157,217
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ADAM18
ADAM metallopeptidase domain 18
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 8:37,600,595...37,743,772
Ensembl chr 8:37,601,156...37,743,650
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ADAM19
ADAM metallopeptidase domain 19
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr23:59,867,949...59,966,873
Ensembl chr23:59,867,596...59,966,802
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ADAM2
ADAM metallopeptidase domain 2
enables
IEA
InterPro
GO_REF:0000002
Ensembl chr 8:37,759,402...37,809,910
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ADAM22
ADAM metallopeptidase domain 22
enables
IEA
InterPro
GO_REF:0000002
NCBI chr21:60,753,344...60,999,283
Ensembl chr21:60,759,980...60,998,600
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ADAM23
ADAM metallopeptidase domain 23
enables
IEA
InterPro
GO_REF:0000002
NCBI chr10:92,218,999...92,390,905
Ensembl chr10:92,219,253...92,391,091
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ADAM28
ADAM metallopeptidase domain 28
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 8:22,424,260...22,483,878
Ensembl chr 8:22,430,579...22,488,257
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ADAM29
ADAM metallopeptidase domain 29
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 7:121,006,675...121,053,292
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ADAM30
ADAM metallopeptidase domain 30
enables
IEA
InterPro
GO_REF:0000002
NCBI chr20:13,887,509...13,890,543
Ensembl chr20:13,887,666...13,890,095
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ADAM33
ADAM metallopeptidase domain 33
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 2:34,352,514...34,366,694
Ensembl chr 2:34,353,505...34,366,559
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ADAM7
ADAM metallopeptidase domain 7
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 8:22,573,508...22,631,657
Ensembl chr 8:22,574,681...22,633,039
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ADAM8
ADAM metallopeptidase domain 8
enables
IEA
InterPro
GO_REF:0000002
NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900
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ADAM9
ADAM metallopeptidase domain 9
enables
IEA
InterPro Ensembl
GO_REF:0000002 GO_REF:0000107
NCBI chr 8:37,017,827...37,131,462
Ensembl chr 8:37,017,545...37,131,615
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ADAMDEC1
ADAM like decysin 1
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 8:22,516,511...22,537,706
Ensembl chr 8:22,516,639...22,537,731
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ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 2:65,376,288...65,385,398
Ensembl chr 2:65,376,310...65,385,918
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ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif 10
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 6:7,923,429...7,954,733
Ensembl chr 6:7,924,076...7,949,685
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ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif 12
enables
IEA
Ensembl InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 4:32,757,699...33,129,116
Ensembl chr 4:32,757,684...33,129,059
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ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif 13
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr12:4,677,237...4,718,825
Ensembl chr12:4,677,229...4,714,386
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ADAMTS14
ADAM metallopeptidase with thrombospondin type 1 motif 14
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 9:60,538,718...60,625,903
Ensembl chr 9:60,540,303...60,625,570
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ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif 15
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:121,510,798...121,538,715
Ensembl chr 1:121,510,849...121,535,609
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ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif 16
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
Ensembl chr 4:4,866,477...4,967,550
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ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif 17
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr29:18,484,341...18,842,210
Ensembl chr29:18,481,449...18,841,568
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ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif 18
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 5:62,764,081...62,921,394
Ensembl chr 5:62,765,939...62,918,697
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ADAMTS19
ADAM metallopeptidase with thrombospondin type 1 motif 19
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr23:32,372,312...32,646,070
Ensembl chr23:32,372,515...32,646,071
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ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif 2
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr23:80,852,588...81,081,593
Ensembl chr23:80,852,331...81,080,218
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ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif 20
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr11:39,571,228...39,768,386
Ensembl chr11:39,572,013...39,767,590
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ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif 3
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 7:20,793,392...21,068,712
Ensembl chr 7:20,793,399...21,048,515
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ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif 4
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr20:2,781,184...2,791,464
Ensembl chr20:2,783,855...2,792,170
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ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif 5
enables
IEA
InterPro Ensembl TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 2:65,252,922...65,359,167
Ensembl chr 2:65,254,285...65,299,800
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ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif 7
enables
ISO
(PMID:18485748)
BHF-UCL
PMID:18485748
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ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif 8
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:121,465,341...121,491,301
Ensembl chr 1:121,465,883...121,489,200
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ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif 9
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr22:25,545,518...25,720,512
Ensembl chr22:25,545,420...25,719,362
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ADAMTSL4
ADAMTS like 4
enables
IEA
TreeGrafter
GO_REF:0000118
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ADAMTSL5
ADAMTS like 5
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:1,278,045...1,287,257
Ensembl chr 6:1,279,036...1,284,946
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AFG3L2
AFG3 like matrix AAA peptidase subunit 2
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr18:70,890,939...70,939,504
Ensembl chr18:70,891,554...70,939,352
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ASTL
astacin like metalloendopeptidase
enables
IEA
InterPro TreeGrafter UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118
NCBI chr14:568,071...577,182
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ATP23
ATP23 metallopeptidase and ATP synthase assembly factor homolog
enables
IEA
InterPro
GO_REF:0000002
NCBI chr11:53,854,424...53,868,494
Ensembl chr11:53,854,418...53,868,628
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BMP1
bone morphogenetic protein 1
enables
IEA
InterPro Ensembl UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107
NCBI chr 8:20,234,242...20,281,768
Ensembl chr 8:20,234,184...20,283,467
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ECE1
endothelin converting enzyme 1
enables
IEA
InterPro TreeGrafter UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000118
NCBI chr20:111,212,567...111,342,755
Ensembl chr20:111,212,594...111,342,821
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ECE2
endothelin converting enzyme 2
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr15:5,131,038...5,148,829
Ensembl chr15:5,130,385...5,148,811
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ECEL1
endothelin converting enzyme like 1
enables
IEA
InterPro Ensembl TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr10:118,500,297...118,507,775
Ensembl chr10:118,500,233...118,507,238
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IDE
insulin degrading enzyme
enables
ISO IEA
atrial natriuretic peptide cleaved at the Ser25-Phe26 bond
RGD TreeGrafter Ensembl InterPro
PMID:15494400 PMID:15749695
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1626704 RGD:1626705
NCBI chr 9:85,722,728...85,843,247
Ensembl chr 9:85,721,886...85,843,117
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KEL
Kell metallo-endopeptidase (Kell blood group)
enables
IEA
Ensembl InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr21:111,819,230...111,846,966
Ensembl chr21:111,819,368...111,840,142
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LMLN
leishmanolysin like peptidase
enables
IEA
UniProt InterPro
GO_REF:0000002 GO_REF:0000104
NCBI chr15:91,676,060...91,745,251
Ensembl chr15:91,676,379...91,744,928
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LOC103215661
disintegrin and metalloproteinase domain-containing protein 32
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 8:37,132,409...37,284,974
Ensembl chr 8:37,133,791...37,283,751
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LOC103215662
disintegrin and metalloproteinase domain-containing protein 5
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 8:37,324,591...37,444,377
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LOC103215663
A disintegrin and metallopeptidase domain 3-like
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 8:37,481,622...37,551,729
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LOC103225750
membrane metallo-endopeptidase-like 1
enables
ISO IEA
RGD TreeGrafter InterPro
PMID:11964170
GO_REF:0000002 GO_REF:0000118 RGD:2314417
NCBI chr20:128,916,051...128,963,545
Ensembl chr20:128,921,369...128,963,188
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LOC103229265
disintegrin and metalloproteinase domain-containing protein 20
enables
IEA
InterPro
GO_REF:0000002
NCBI chr24:47,730,284...47,733,329
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MBTPS2
membrane bound transcription factor peptidase, site 2
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr X:20,319,731...20,364,603
Ensembl chr X:20,319,807...20,361,847
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MEP1A
meprin A subunit alpha
enables
IEA
InterPro TreeGrafter UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118
NCBI chr17:25,439,415...25,479,092
Ensembl chr17:25,439,442...25,473,681
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MEP1B
meprin A subunit beta
enables
ISO IEA
RGD TreeGrafter UniProt InterPro
PMID:12437103
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:633322
NCBI chr18:48,519,933...48,551,223
Ensembl chr18:48,518,403...48,550,604
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MIPEP
mitochondrial intermediate peptidase
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 3:3,578,057...3,726,783
Ensembl chr 3:3,578,193...3,726,746
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MME
membrane metalloendopeptidase
enables
IEA
UniProt TreeGrafter InterPro Ensembl
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118
NCBI chr15:35,577,460...35,681,730
Ensembl chr15:35,580,714...35,633,914
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MMP1
matrix metallopeptidase 1
enables
IEA
InterPro Ensembl TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 1:94,167,507...94,177,357
Ensembl chr 1:94,167,219...94,176,767
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MMP10
matrix metallopeptidase 10
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:94,147,995...94,158,315
Ensembl chr 1:94,148,087...94,158,097
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MMP11
matrix metallopeptidase 11
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr19:6,889,343...6,900,563
Ensembl chr19:6,889,385...6,899,788
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MMP12
matrix metallopeptidase 12
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 1:94,243,061...94,261,035
Ensembl chr 1:94,243,875...94,259,591
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MMP13
matrix metallopeptidase 13
enables
ISO IEA
RGD TreeGrafter InterPro Ensembl
PMID:8910479 PMID:17941091
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2296055 RGD:2298541
NCBI chr 1:94,322,473...94,370,665
Ensembl chr 1:94,322,979...94,334,747
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MMP14
matrix metallopeptidase 14
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr29:23,201,425...23,212,408
Ensembl chr29:23,201,112...23,212,679
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MMP15
matrix metallopeptidase 15
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 5:43,961,288...43,982,182
Ensembl chr 5:43,960,891...43,982,261
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MMP16
matrix metallopeptidase 16
enables
IEA
Ensembl InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 8:83,122,904...83,407,910
Ensembl chr 8:83,132,315...83,407,933
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MMP17
matrix metallopeptidase 17
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr11:127,204,811...127,229,202
Ensembl chr11:127,214,890...127,230,731
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MMP19
matrix metallopeptidase 19
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr11:51,786,076...51,794,325
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MMP2
matrix metallopeptidase 2
enables
IEA
Ensembl TreeGrafter InterPro UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118
NCBI chr 5:41,264,382...41,291,657
Ensembl chr 5:41,264,354...41,291,004
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MMP20
matrix metallopeptidase 20
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 1:93,946,136...93,997,656
Ensembl chr 1:93,947,582...93,996,815
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MMP21
matrix metallopeptidase 21
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 9:118,387,926...118,400,048
Ensembl chr 9:118,389,666...118,398,807
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MMP23B
matrix metallopeptidase 23B
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr20:129,873,838...129,876,521
Ensembl chr20:129,873,867...129,876,524
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MMP24
matrix metallopeptidase 24
enables
IEA
Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr 2:56,153,277...56,183,026
Ensembl chr 2:56,152,944...56,184,605
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MMP25
matrix metallopeptidase 25
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 5:2,792,249...2,806,357
Ensembl chr 5:2,792,389...2,804,728
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MMP26
matrix metallopeptidase 26
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:61,826,835...61,832,152
Ensembl chr 1:61,827,321...61,831,374
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MMP27
matrix metallopeptidase 27
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:94,075,524...94,091,080
Ensembl chr 1:94,075,605...94,090,215
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MMP28
matrix metallopeptidase 28
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr16:29,241,938...29,272,231
Ensembl chr16:29,240,569...29,272,077
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MMP3
matrix metallopeptidase 3
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:94,216,156...94,224,437
Ensembl chr 1:94,216,173...94,224,264
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MMP7
matrix metallopeptidase 7
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:93,889,189...93,901,077
Ensembl chr 1:93,889,198...93,899,587
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MMP8
matrix metallopeptidase 8
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:94,097,620...94,110,114
Ensembl chr 1:94,097,896...94,109,432
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MMP9
matrix metallopeptidase 9
enables
IEA
Ensembl TreeGrafter InterPro UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118
NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712
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NLN
neurolysin
enables
ISO IEA
RGD InterPro TreeGrafter
PMID:7836437
GO_REF:0000002 GO_REF:0000118 RGD:9831155
NCBI chr 4:61,918,079...62,022,517
Ensembl chr 4:61,918,137...62,016,144
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NRDC
nardilysin convertase
enables
IEA
InterPro
GO_REF:0000002
NCBI chr20:81,075,671...81,175,469
Ensembl chr20:81,075,869...81,175,447
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OMA1
OMA1 zinc metallopeptidase
enables
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr20:74,435,190...74,500,220
Ensembl chr20:74,442,696...74,499,969
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PAPLN
papilin, proteoglycan like sulfated glycoprotein
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr24:50,479,932...50,528,284
Ensembl chr24:50,493,117...50,526,322
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PAPPA
pappalysin 1
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr12:23,182,856...23,427,092
Ensembl chr12:23,184,704...23,427,165
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PAPPA2
pappalysin 2
enables
ISO
(PMID:11513734)
Reactome
PMID:11513734
NCBI chr25:52,432,178...52,729,671
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PHEX
phosphate regulating endopeptidase X-linked
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr X:20,507,619...20,733,367
Ensembl chr X:20,522,498...20,734,599
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PITRM1
pitrilysin metallopeptidase 1
enables
ISO
(PMID:16849325), (PMID:24931469) (PMID:10360838), (PMID:19196155)
UniProt
PMID:10360838 PMID:16849325 PMID:19196155 PMID:24931469
NCBI chr 9:3,192,692...3,239,667
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PITRM1
pitrilysin metallopeptidase 1
enables
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
Ensembl chr 9:3,192,523...3,238,361
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PMPCA
peptidase, mitochondrial processing subunit alpha
enables
IEA
InterPro
GO_REF:0000002
NCBI chr12:1,778,376...1,791,878
Ensembl chr12:1,776,983...1,791,787
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PMPCB
peptidase, mitochondrial processing subunit beta
enables
IEA
UniProt Ensembl TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118
NCBI chr21:72,271,390...72,286,559
Ensembl chr21:72,271,429...72,286,265
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RCE1
Ras converting CAAX endopeptidase 1
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 1:7,420,221...7,526,495
Ensembl chr 1:7,420,653...7,423,265
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SPG7
SPG7 matrix AAA peptidase subunit, paraplegin
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr 5:74,862,524...74,916,214
Ensembl chr 5:74,862,551...74,916,033
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SPRTN
SprT-like N-terminal domain
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr25:68,599,377...68,620,568
Ensembl chr25:68,599,780...68,620,621
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THOP1
thimet oligopeptidase 1
enables
ISO
(PMID:10969067)
MGI
PMID:10969067
NCBI chr 6:2,564,445...2,590,029
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THOP1
thimet oligopeptidase 1
enables
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
Ensembl chr 6:2,564,481...2,583,948
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THSD4
thrombospondin type 1 domain containing 4
enables
IEA
TreeGrafter
GO_REF:0000118
NCBI chr26:11,677,332...12,207,092
Ensembl chr26:11,683,231...11,912,098
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TLL1
tolloid like 1
enables
IEA
UniProt InterPro
GO_REF:0000002 GO_REF:0000104
NCBI chr 7:112,231,084...112,455,131
Ensembl chr 7:112,233,283...112,455,803
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TRABD2A
TraB domain containing 2A
enables
IEA
Ensembl TreeGrafter UniProt
GO_REF:0000104 GO_REF:0000107 GO_REF:0000118
NCBI chr14:22,297,687...22,355,100
Ensembl chr14:22,297,888...22,354,844
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TRABD2B
TraB domain containing 2B
enables
IEA
Ensembl TreeGrafter UniProt
GO_REF:0000104 GO_REF:0000107 GO_REF:0000118
NCBI chr20:84,932,091...85,162,560
Ensembl chr20:84,932,721...85,157,167
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UQCR2
ubiquinol-cytochrome c reductase core protein II
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 5:19,622,884...19,653,667
Ensembl chr 5:19,623,410...19,653,479
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YBEY
ybeY metalloendoribonuclease
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 2:89,905,119...89,910,307
Ensembl chr 2:89,905,127...89,909,324
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YME1L1
YME1 like 1 ATPase
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 9:26,703,747...26,752,274
Ensembl chr 9:26,703,992...26,752,340
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ZMPSTE24
zinc metallopeptidase STE24
enables
IEA
Ensembl UniProt InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107
NCBI chr20:92,605,495...92,648,110
Ensembl chr20:92,605,309...92,648,114
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ADAM10
ADAM metallopeptidase domain 10
enables
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr26:24,768,827...24,921,169
Ensembl chr26:24,768,915...24,919,009
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ADAM17
ADAM metallopeptidase domain 17
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr14:98,092,093...98,157,657
Ensembl chr14:98,092,044...98,157,217
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ADAM19
ADAM metallopeptidase domain 19
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr23:59,867,949...59,966,873
Ensembl chr23:59,867,596...59,966,802
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ADAM9
ADAM metallopeptidase domain 9
enables
ISO
(PMID:12054541)
ARUK-UCL
PMID:12054541
NCBI chr 8:37,017,827...37,131,462
Ensembl chr 8:37,017,545...37,131,615
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