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ONTOLOGY REPORT - ANNOTATIONS


Term:metalloendopeptidase activity
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Accession:GO:0004222 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms:narrow_synonym: metalloendoprotease activity;   metalloendoproteinase activity
 xref: EC:3.4.24;   Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";   Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";   Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";   Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";   Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";   Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";   Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";   Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14";   Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";   Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";   Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";   Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";   Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";   Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";   Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";   Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";   Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";   Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";   Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";   Reactome:R-HSA-9840532 "OMA1 self-cleaves";   Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";   Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer";   reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";   reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";   reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";   reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";   reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";   reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";   reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";   reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";   reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";   reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";   reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";   reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";   reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";   reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";   reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";   reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";   reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";   reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";   reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";   reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";   reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";   reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";   reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";   reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";   reactome:R-HSA-2022141 "Prolysyl oxidase activation";   reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";   reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";   reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";   reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";   reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";   reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";   reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";   reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";   reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";   reactome:R-HSA-2514790 "Elastin degradation by MMP14";   reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";   reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";   reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";   reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";   reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";   reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";   reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";   reactome:R-HSA-2537499 "Gelatin degradation by MMP19";   reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";   reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";   reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";   reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";   reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";   reactome:R-HSA-3791319 "NID1 degradation by MMP19";   reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";   reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";   reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";   reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";   reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";   reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";   reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";   reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";   reactome:R-HSA-5333671 "CLCAs self cleave";   reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";   reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";   reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";   reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";   reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";   reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";   reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";   reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";   reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";   reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";   reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";   reactome:R-HSA-8940554 "MMP2 cleaves OPTC";   reactome:R-HSA-8940561 "MMP7 cleaves OPTC";   reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";   reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";   reactome:R-HSA-8942302 "MMP13 cleaves OPTC";   reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";   reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";   reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";   reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"



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metalloendopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme enables ISS
ISO
IEA
GO_REF:0000024
(PMID:6208535), (PMID:7683654)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:6208535 PMID:7683654 GO_REF:0000024 GO_REF:0000107 NCBI chr10:91,410,129...91,430,246 JBrowse link
G Adam10 ADAM metallopeptidase domain 10 enables IDA
IEA
ISO
GO_REF:0000002
(PMID:18676862), (PMID:19114711)
InterPro
RGD
PMID:18676862 PMID:19114711 PMID:10423016 GO_REF:0000002, RGD:631800 NCBI chr 8:71,346,008...71,477,889 JBrowse link
G Adam11 ADAM metallopeptidase domain 11 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:87,724,115...87,742,773 JBrowse link
G Adam12 ADAM metallopeptidase domain 12 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:188,686,984...189,014,206 JBrowse link
G Adam15 ADAM metallopeptidase domain 15 enables TAS
IBA
IEA
GO_REF:0000033
GO_REF:0000002
GO_Central
InterPro
RGD
PMID:11102971 GO_REF:0000002 GO_REF:0000033, RGD:632016 NCBI chr 2:174,754,629...174,765,136 JBrowse link
G Adam17 ADAM metallopeptidase domain 17 enables ISO
IBA
ISS
IEA
(PMID:9034191)
GO_REF:0000033
(PMID:14993236)
(PMID:14625290), (PMID:15691827), (PMID:17010968), (PMID:24226769), (PMID:24337742), (PMID:36476876), (PMID:9034190), (PMID:9034191), (PMID:9774383), (PMID:9920899)
GO_REF:0000024
GO_REF:0000002
RGD
GO_Central
UniProt
InterPro
PMID:9034190 PMID:9034191 PMID:9774383 PMID:9920899 PMID:14625290 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:40,872,936...40,920,700 JBrowse link
G Adam18 ADAM metallopeptidase domain 18 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:67,352,360...67,425,820 JBrowse link
G Adam19 ADAM metallopeptidase domain 19 enables ISO
IBA
(PMID:11162584), (PMID:17112471)
GO_REF:0000033
RGD
GO_Central
PMID:11162584 PMID:17112471 GO_REF:0000033 NCBI chr10:30,491,362...30,583,115 JBrowse link
G Adam1a ADAM metallopeptidase domain 1a enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr12:35,017,433...35,020,300 JBrowse link
G Adam1b a disintegrin and metallopeptidase domain 1b enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:35,037,161...35,040,574 JBrowse link
G Adam2 ADAM metallopeptidase domain 2 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr15:40,242,651...40,284,025 JBrowse link
G Adam21 ADAM metallopeptidase domain 21 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:36,625,324...36,627,657 JBrowse link
G Adam22 ADAM metallopeptidase domain 22 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:25,716,055...25,970,932 JBrowse link
G Adam23 ADAM metallopeptidase domain 23 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:64,862,649...65,009,718 JBrowse link
G Adam24 ADAM metallopeptidase domain 24 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:51,578,278...51,584,265 JBrowse link
G Adam25 a disintegrin and metallopeptidase domain 25 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:51,488,764...51,492,790 JBrowse link
G Adam26a a disintegrin and metallopeptidase domain 26A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:48,600,998...48,608,314 JBrowse link
G Adam28 ADAM metallopeptidase domain 28 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:43,774,463...43,840,726 JBrowse link
G Adam30 ADAM metallopeptidase domain 30 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:185,752,183...185,755,623 JBrowse link
G Adam32 ADAM metallopeptidase domain 32 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:67,102,384...67,212,163 JBrowse link
G Adam33 ADAM metallopeptidase domain 33 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:118,262,395...118,283,456 JBrowse link
G Adam34 a disintegrin and metallopeptidase domain 34 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:48,557,385...48,561,744 JBrowse link
G Adam34l a disintegrin and metalloprotease domain 34-like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:48,536,456...48,542,246 JBrowse link
G Adam3a ADAM metallopeptidase domain 3A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:67,299,949...67,349,970 JBrowse link
G Adam5 ADAM metallopeptidase domain 5 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr16:67,223,095...67,298,733 JBrowse link
G Adam7 ADAM metallopeptidase domain 7 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr15:42,833,796...42,882,201 JBrowse link
G Adam8 ADAM metallopeptidase domain 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:194,776,559...194,789,330 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 enables ISO
IBA
(PMID:22480688), (PMID:9920899)
GO_REF:0000033
(PMID:12054541)
RGD
GO_Central
PMID:9920899 PMID:12054541 PMID:22480688 GO_REF:0000033 NCBI chr16:73,725,186...73,804,284 JBrowse link
G Adamdec1 ADAM-like, decysin 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:42,900,629...42,921,684 JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 enables IEA
IBA
ISO
ISS
GO_REF:0000107
GO_REF:0000033
MGI:3609982 (PMID:16061471)
(PMID:11278559), (PMID:25122765)
GO_REF:0000024
Ensembl
GO_Central
RGD
UniProt
PMID:11278559 PMID:16061471 PMID:25122765 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr11:38,418,565...38,427,384 JBrowse link
G Adamts10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:15,033,859...15,063,800 JBrowse link
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 enables ISO
IBA
(PMID:16611630), (PMID:17895370), (PMID:18485748)
GO_REF:0000033
RGD
GO_Central
PMID:16611630 PMID:17895370 PMID:18485748 GO_REF:0000033 NCBI chr 2:60,032,873...60,327,629 JBrowse link
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 enables ISO
IBA
(PMID:12775718), (PMID:18983500), (PMID:31439947)
GO_REF:0000033
RGD
GO_Central
PMID:12775718 PMID:18983500 PMID:31439947 GO_REF:0000033 NCBI chr 3:10,299,264...10,338,464 JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:29,143,029...29,219,846 JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:29,307,864...29,331,249 JBrowse link
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:32,430,436...32,562,481 JBrowse link
G Adamts17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:120,445,800...120,768,204 JBrowse link
G Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:41,686,951...41,840,035 JBrowse link
G Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:52,346,448...52,531,245 JBrowse link
G Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:34,920,992...35,126,465 JBrowse link
G Adamts20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 enables ISO
IBA
(PMID:12562771)
GO_REF:0000033
RGD
GO_Central
PMID:12562771 GO_REF:0000033 NCBI chr 7:125,396,227...125,528,020 JBrowse link
G Adamts3 ADAM metallopeptidase with thrombospondin type 1, motif 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:18,231,128...18,437,771 JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 enables IEA
IBA
ISO
GO_REF:0000002
GO_REF:0000033
(PMID:23684986)
InterPro
GO_Central
RGD
PMID:23684986 GO_REF:0000002 GO_REF:0000033 NCBI chr13:86,203,011...86,212,500 JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 enables ISO
IBA
(PMID:25122765), (PMID:26668318)
GO_REF:0000033
RGD
GO_Central
PMID:25122765 PMID:26668318 GO_REF:0000033 NCBI chr11:25,000,627...25,047,205 JBrowse link
G Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:35,421,483...35,633,305 JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 enables ISO
IBA
IEA
(PMID:18485748)
GO_REF:0000033
GO_REF:0000002
RGD
GO_Central
InterPro
PMID:18485748 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:90,704,727...90,744,333 JBrowse link
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:29,349,078...29,368,413 JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:125,290,633...125,462,988 JBrowse link
G Adamtsl2 ADAMTS-like 2 NOT|enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:10,397,774...10,434,557 JBrowse link
G Afg3l1 AFG3 (ATPase family gene 3)-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:51,508,612...51,535,773 JBrowse link
G Afg3l2 AFG3 like matrix AAA peptidase subunit 2 enables ISO
IBA
(PMID:19748354), (PMID:22354088), (PMID:27642048), (PMID:28396416), (PMID:29545505), (PMID:29932645), (PMID:31327635), (PMID:37917749), (PMID:38157846)
GO_REF:0000033
RGD
GO_Central
PMID:19748354 PMID:22354088 PMID:27642048 PMID:28396416 PMID:29545505 More... GO_REF:0000033 NCBI chr18:63,224,163...63,269,000 JBrowse link
G Astl astacin like metalloendopeptidase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:114,563,135...114,580,295 JBrowse link
G Atp23 ATP23 metallopeptidase and ATP synthase assembly factor homolog enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:62,714,752...62,729,893 JBrowse link
G Bmp1 bone morphogenetic protein 1 enables ISO
IBA
(PMID:19079247)
GO_REF:0000033
RGD
GO_Central
PMID:19079247 GO_REF:0000033 NCBI chr15:45,551,603...45,595,862 JBrowse link
G Cirop ciliated left-right organizer metallopeptidase enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr15:28,151,018...28,158,149 JBrowse link
G Ece1 endothelin converting enzyme 1 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 5:155,361,031...155,462,723 JBrowse link
G Ece2 endothelin-converting enzyme 2 enables ISO
IBA
(PMID:11718899)
GO_REF:0000033
RGD
GO_Central
PMID:11718899 GO_REF:0000033 NCBI chr11:80,259,130...80,278,446 JBrowse link
G Ecel1 endothelin converting enzyme-like 1 enables TAS
ISO
IBA
IEA
(PMID:10759559)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
RGD
GO_Central
Ensembl
InterPro
PMID:10759559 PMID:12417666 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:628377 NCBI chr 9:95,267,417...95,276,508 JBrowse link
G Ide insulin degrading enzyme enables IMP
IBA
IEA
ISO
ISS
IDA
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
(PMID:17051221), (PMID:17613531)
GO_REF:0000024
atrial natriuretic peptide cleaved at the Ser25-Phe26 bond
GO_Central
Ensembl
InterPro
RGD
UniProt
PMID:17051221 PMID:17613531 PMID:15749695 PMID:15494400 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:1626704, RGD:1626705 NCBI chr 1:244,415,495...244,516,925 JBrowse link
G Kel Kell metallo-endopeptidase (Kell blood group) enables ISO
IBA
(PMID:15769748)
GO_REF:0000033
RGD
GO_Central
PMID:15769748 GO_REF:0000033 NCBI chr 4:70,568,241...70,585,666 JBrowse link
G Lmln leishmanolysin like peptidase enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr11:67,656,241...67,725,889 JBrowse link
G LOC103690152 disintegrin and metalloproteinase domain-containing protein 21-like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:101,256,441...101,265,828 JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 enables ISO (PMID:11163209) RGD PMID:11163209 NCBI chr  X:37,410,914...37,461,130 JBrowse link
G Mep1a meprin A subunit alpha enables IEA
IBA
GO_REF:0000104
GO_REF:0000033
UniProt
GO_Central
GO_REF:0000033 GO_REF:0000104 NCBI chr 9:17,474,634...17,504,147 JBrowse link
G Mep1b meprin A subunit beta enables IDA
IBA
IEA
GO_REF:0000033
GO_REF:0000104
GO_Central
UniProt
RGD
PMID:12437103 GO_REF:0000033 GO_REF:0000104, RGD:633322 NCBI chr18:12,366,126...12,392,840 JBrowse link
G Mipep mitochondrial intermediate peptidase enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr15:34,926,198...35,051,722 JBrowse link
G Mme membrane metallo-endopeptidase enables ISS
IBA
ISO
IEA
GO_REF:0000024
GO_REF:0000033
(PMID:15283675), (PMID:2521388), (PMID:27588448), (PMID:6208535), (PMID:6349683)
GO_REF:0000003
UniProt
GO_Central
RGD
PMID:2521388 PMID:6208535 PMID:6349683 PMID:15283675 PMID:27588448 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:149,806,826...149,957,381 JBrowse link
G Mmel1 membrane metallo-endopeptidase-like 1 enables IDA
IBA
IEA
GO_REF:0000033
GO_REF:0000002
GO_Central
InterPro
RGD
PMID:11964170 GO_REF:0000002 GO_REF:0000033, RGD:2314417 NCBI chr 5:170,713,602...170,744,058 JBrowse link
G Mmp1 matrix metallopeptidase 1 enables ISO
IEA
(PMID:9920899)
GO_REF:0000002
RGD
InterPro
PMID:9920899 GO_REF:0000002 NCBI chr 8:12,943,453...12,963,966 JBrowse link
G Mmp10 matrix metallopeptidase 10 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 8:12,974,707...12,982,613 JBrowse link
G Mmp11 matrix metallopeptidase 11 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr20:12,730,846...12,739,629 JBrowse link
G Mmp12 matrix metallopeptidase 12 enables IEA
IBA
ISO
GO_REF:0000107
GO_REF:0000033
GO_REF:0000002
(PMID:19932771), (PMID:24784232)
Ensembl
GO_Central
InterPro
RGD
PMID:19932771 PMID:24784232 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:4,581,785...4,591,687 JBrowse link
G Mmp13 matrix metallopeptidase 13 enables IDA
IBA
ISO
IEA
GO_REF:0000033
(PMID:11953314), (PMID:14702107)
GO_REF:0000107
(PMID:8576151), (PMID:9065415)
GO_Central
RGD
Ensembl
PMID:8576151 PMID:9065415 PMID:11953314 PMID:14702107 PMID:17941091 More... GO_REF:0000033 GO_REF:0000107, RGD:2296055, RGD:2298541 NCBI chr 8:4,497,960...4,508,239 JBrowse link
G Mmp14 matrix metallopeptidase 14 enables ISS
IBA
ISO
IEA
GO_REF:0000024
GO_REF:0000033
(PMID:10737763), (PMID:21572390), (PMID:24990232)
(PMID:35177851), (PMID:8015608)
GO_REF:0000002
UniProt
GO_Central
RGD
InterPro
PMID:8015608 PMID:10737763 PMID:21572390 PMID:24990232 PMID:35177851 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr15:27,887,795...27,897,020 JBrowse link
G Mmp15 matrix metallopeptidase 15 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:9,663,449...9,684,943 JBrowse link
G Mmp16 matrix metallopeptidase 16 enables ISO
IBA
IEA
(PMID:27229514)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:27229514 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:31,312,280...31,556,276 JBrowse link
G Mmp17 matrix metallopeptidase 17 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:27,074,398...27,099,317 JBrowse link
G Mmp19 matrix metallopeptidase 19 enables ISO (PMID:10809722) RGD PMID:10809722 NCBI chr 7:1,221,229...1,229,555 JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:4,598,326...4,606,965 JBrowse link
G Mmp2 matrix metallopeptidase 2 enables IEA
IBA
ISO
GO_REF:0000003
GO_REF:0000033
(PMID:12419962), (PMID:15212943)
GO_REF:0000002
UniProt
GO_Central
RGD
InterPro
PMID:12419962 PMID:15212943 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Mmp20 matrix metallopeptidase 20 enables ISO
IBA
(PMID:9398237)
GO_REF:0000033
RGD
GO_Central
PMID:9398237 GO_REF:0000033 NCBI chr 8:4,789,415...4,830,035 JBrowse link
G Mmp21 matrix metallopeptidase 21 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:188,480,186...188,485,855 JBrowse link
G Mmp23 matrix metallopeptidase 23 enables ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:9988691)
UniProt
GO_Central
RGD
PMID:9988691 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:171,521,905...171,525,007 JBrowse link
G Mmp24 matrix metallopeptidase 24 enables ISS
IBA
ISO
IEA
GO_REF:0000024
GO_REF:0000033
(PMID:24952463)
GO_REF:0000002
GO_REF:0000107
UniProt
GO_Central
RGD
InterPro
Ensembl
PMID:24952463 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:144,279,096...144,323,572 JBrowse link
G Mmp25 matrix metallopeptidase 25 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,164,974...13,180,503 JBrowse link
G Mmp27 matrix metallopeptidase 27 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:4,745,887...4,755,806 JBrowse link
G Mmp28 matrix metallopeptidase 28 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:68,241,138...68,264,866 JBrowse link
G Mmp3 matrix metallopeptidase 3 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 8:12,925,267...12,938,828 JBrowse link
G Mmp7 matrix metallopeptidase 7 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 8:13,133,043...13,140,761 JBrowse link
G Mmp8 matrix metallopeptidase 8 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 8:4,724,009...4,733,864 JBrowse link
G Mmp9 matrix metallopeptidase 9 enables TAS
IBA
ISO
ISS
IEA
GO_REF:0000033
(PMID:12419962), (PMID:14707083), (PMID:23142597), (PMID:9291580)
(PMID:16192646), (PMID:24164424), (PMID:2551898), (PMID:9789069)
GO_REF:0000024
GO_REF:0000003
GO_Central
RGD
UniProt
PMID:2551898 PMID:9291580 PMID:9789069 PMID:12419962 PMID:14707083 More... GO_REF:0000003 GO_REF:0000024 GO_REF:0000033, RGD:628551 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Nln neurolysin enables IDA
IBA
IEA
GO_REF:0000033
GO_REF:0000002
GO_Central
InterPro
RGD
PMID:7836437 GO_REF:0000002 GO_REF:0000033, RGD:9831155 NCBI chr 2:35,133,634...35,232,927 JBrowse link
G Nrdc nardilysin convertase enables IEA GO_REF:0000003
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002 GO_REF:0000003 NCBI chr 5:123,755,807...123,818,910 JBrowse link
G Oma1 OMA1 zinc metallopeptidase enables ISO
IBA
IDA
IEA
ISS
(PMID:20038677), (PMID:25275009), (PMID:32132706), (PMID:32132707)
GO_REF:0000033
(PMID:22433842), (PMID:24550258), (PMID:24719224), (PMID:33200421)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000024
RGD
GO_Central
Ensembl
InterPro
UniProt
PMID:20038677 PMID:22433842 PMID:24550258 PMID:24719224 PMID:25275009 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:405650318 NCBI chr 5:118,083,728...118,136,980 JBrowse link
G Pappa pappalysin enables ISO
IBA
(PMID:11513734)
GO_REF:0000033
RGD
GO_Central
PMID:11513734 GO_REF:0000033 NCBI chr 5:78,497,660...78,735,873 JBrowse link
G Pappa2 pappalysin 2 enables ISO
IBA
(PMID:11513734)
GO_REF:0000033
RGD
GO_Central
PMID:11513734 GO_REF:0000033 NCBI chr13:70,873,918...71,147,874 JBrowse link
G Phex phosphate regulating endopeptidase X-linked enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:41,422,561...41,671,226 JBrowse link
G Pitrm1 pitrilysin metallopeptidase 1 enables ISO
IBA
(PMID:10360838), (PMID:16849325), (PMID:19196155), (PMID:24931469)
GO_REF:0000033
RGD
GO_Central
PMID:10360838 PMID:16849325 PMID:19196155 PMID:24931469 GO_REF:0000033 NCBI chr17:63,795,670...63,827,317 JBrowse link
G Pmpca peptidase, mitochondrial processing subunit alpha enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:29,605,823...29,614,936 JBrowse link
G Pmpcb peptidase, mitochondrial processing subunit beta enables ISO
IBA
IEA
IDA
(PMID:22354088)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
PMID:12433926
PMID:10942759
RGD
GO_Central
Ensembl
InterPro
PMID:22354088 PMID:12433926 PMID:22354088 PMID:10942759 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:13463464, RGD:14995326, RGD:38501073 NCBI chr 4:13,297,583...13,310,363 JBrowse link
G Rce1 Ras converting CAAX endopeptidase 1 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 1:201,899,358...201,902,593 JBrowse link
G Spg7 SPG7 matrix AAA peptidase subunit, paraplegin enables IEA
IBA
ISS
GO_REF:0000002
GO_REF:0000033
GO_REF:0000024
GO_REF:0000107
InterPro
GO_Central
UniProt
Ensembl
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr19:51,117,088...51,151,228 JBrowse link
G Sprtn SprT-like N-terminal domain enables IEA
ISO
ISS
GO_REF:0000002
(PMID:27852435), (PMID:27871365), (PMID:27871366), (PMID:32649882), (PMID:36608669)
GO_REF:0000107
GO_REF:0000024
InterPro
RGD
Ensembl
UniProt
PMID:27852435 PMID:27871365 PMID:27871366 PMID:32649882 PMID:36608669 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr19:52,857,612...52,864,864 JBrowse link
G Thop1 thimet oligopeptidase 1 enables TAS
ISO
IBA
IEA
(PMID:10969067)
GO_REF:0000033
GO_REF:0000002
RGD
GO_Central
InterPro
PMID:10969067 PMID:11177571 GO_REF:0000002 GO_REF:0000033, RGD:730190 NCBI chr 7:9,283,617...9,295,957 JBrowse link
G Tll1 tolloid-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:25,509,146...25,710,330 JBrowse link
G Tll2 tolloid-like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:239,912,648...240,028,168 JBrowse link
G Trabd2b TraB domain containing 2B enables ISO
IBA
(PMID:22726442)
GO_REF:0000033
RGD
GO_Central
PMID:22726442 GO_REF:0000033 NCBI chr 5:127,941,198...128,158,946 JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:175,167,933...175,198,499 JBrowse link
G Ybey ybeY metalloendoribonuclease enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:12,165,192...12,174,713 JBrowse link
G Yme1l1 YME1-like 1 ATPase enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:90,195,485...90,235,675 JBrowse link
G Zmpste24 zinc metallopeptidase STE24 enables IBA
ISO
GO_REF:0000033
MGI:2158363 (PMID:11399759), (PMID:12235369), (PMID:27462105)
GO_Central
RGD
PMID:11399759 PMID:12235369 PMID:27462105 GO_REF:0000033 NCBI chr 5:139,912,395...139,945,532 JBrowse link
metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 enables ISO
IEA
IBA
(PMID:28164773)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:28164773 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:71,346,008...71,477,889 JBrowse link
G Adam17 ADAM metallopeptidase domain 17 enables ISO
IEA
(PMID:9774383)
GO_REF:0000107
RGD
Ensembl
PMID:9774383 GO_REF:0000107 NCBI chr 6:40,872,936...40,920,700 JBrowse link
G Adam19 ADAM metallopeptidase domain 19 enables ISO (PMID:17112471) RGD PMID:17112471 NCBI chr10:30,491,362...30,583,115 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 enables ISO (PMID:12054541) RGD PMID:12054541 NCBI chr16:73,725,186...73,804,284 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21086
    catalytic activity 6122
      hydrolase activity 2607
        peptidase activity 701
          endopeptidase activity 465
            metalloendopeptidase activity 111
              metalloendopeptidase activity involved in amyloid precursor protein catabolic process 4
paths to the root