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ONTOLOGY REPORT - ANNOTATIONS

Term:aldo-keto reductase (NADPH) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase (NADP) activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"

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aldo-keto reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936519:3,354,001...3,553,904
Ensembl chrNW_004936519:3,354,987...3,553,181 		JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936623:972,288...987,949
Ensembl chrNW_004936623:940,678...985,388 		JBrowse link
G Kcnab3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936595:1,164,609...1,172,964
Ensembl chrNW_004936595:1,162,438...1,172,016 		JBrowse link
G Miox myo-inositol oxygenase enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936629:355,517...357,678
Ensembl chrNW_004936629:355,362...357,697 		JBrowse link
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 NCBI chrNW_004936474:26,680,736...26,696,996
Ensembl chrNW_004936474:26,680,676...26,697,214 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family member A1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936881:71,047...77,543
Ensembl chrNW_004936881:70,951...77,839 		JBrowse link
G Rdh14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 Ensembl chrNW_004936493:12,542,144...12,546,977 JBrowse link
aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:26,680,736...26,696,996
Ensembl chrNW_004936474:26,680,676...26,697,214 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B enables ISO (PMID:7851421)
(PMID:1420136), (PMID:2112546), (PMID:8645003)
(PMID:8435445)
(PMID:17727625)		 MGI
RGD
Reactome
UniProt		 PMID:1420136 PMID:2112546 PMID:2114645 PMID:7851421 PMID:8435445 More... RGD:1626085 NCBI chrNW_004936579:1,312,175...1,328,397 JBrowse link
G LOC101969767 all-trans-retinol dehydrogenase [NAD(+)] ADH4 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936520:3,763,849...3,777,177
Ensembl chrNW_004936520:3,760,755...3,775,873 		JBrowse link
G LOC101974041 aflatoxin B1 aldehyde reductase member 2 ISO RGD PMID:12071861 RGD:625492 NCBI chrNW_004936474:5,565,715...5,573,048 JBrowse link
all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs3 dehydrogenase/reductase 3 enables ISO (PMID:24005908) MGI PMID:24005908 NCBI chrNW_004936474:1,237,177...1,270,299
Ensembl chrNW_004936474:1,235,962...1,269,510 		JBrowse link
G LOC101966596 dehydrogenase/reductase SDR family member 7 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:4,341,261...4,358,279
Ensembl chrNW_004936495:4,339,700...4,358,547 		JBrowse link
G Rdh10 retinol dehydrogenase 10 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004936648:2,060,131...2,088,021
Ensembl chrNW_004936648:2,060,125...2,088,833 		JBrowse link
G Rdh11 retinol dehydrogenase 11 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:11,065,946...11,082,104
Ensembl chrNW_004936495:11,066,660...11,082,044 		JBrowse link
G Rdh12 retinol dehydrogenase 12 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:11,111,247...11,121,976
Ensembl chrNW_004936495:11,111,105...11,121,341 		JBrowse link
G Rdh13 retinol dehydrogenase 13 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936886:356,068...368,525
Ensembl chrNW_004936886:355,879...368,608 		JBrowse link
G Rdh14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 Ensembl chrNW_004936493:12,542,144...12,546,977 JBrowse link
carbonyl reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr1 carbonyl reductase 1 enables IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936500:6,569,708...6,591,266
Ensembl chrNW_004936500:6,458,721...6,591,928 		JBrowse link
G Cbr3 carbonyl reductase 3 enables ISO
IEA		 RGD
TreeGrafter
UniProt
Ensembl		 PMID:18983987 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:2316293 NCBI chrNW_004936500:6,461,776...6,469,063
Ensembl chrNW_004936500:6,458,721...6,591,928 		JBrowse link
G Dhrs1 dehydrogenase/reductase 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936722:255,977...265,980
Ensembl chrNW_004936722:256,192...265,985 		JBrowse link
G LOC101961668 dehydrogenase/reductase SDR family member 2, mitochondrial enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936722:760,542...809,409 JBrowse link
G LOC101966596 dehydrogenase/reductase SDR family member 7 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:4,341,261...4,358,279
Ensembl chrNW_004936495:4,339,700...4,358,547 		JBrowse link
G LOC101967786 L-xylulose reductase enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936594:5,532,264...5,534,129
Ensembl chrNW_004936594:5,531,560...5,538,105 		JBrowse link
G LOC101968060 carbonyl reductase [NADPH] 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936594:5,536,032...5,539,261
Ensembl chrNW_004936594:5,531,560...5,538,105 		JBrowse link
G LOC101969633 dehydrogenase/reductase SDR family member 4-like enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936722:481,510...493,330
Ensembl chrNW_004936722:481,481...493,405 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17128
    catalytic activity 5251
      oxidoreductase activity 692
        oxidoreductase activity, acting on CH-OH group of donors 117
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 109
            alcohol dehydrogenase [NAD(P)+] activity 36
              aldo-keto reductase (NADPH) activity 23
                alcohol dehydrogenase (NADP+) activity + 19
                pyridoxine:NADP 4-dehydrogenase activity 0
paths to the root