ONTOLOGY REPORT - ANNOTATIONS
Term: aldo-keto reductase (NADPH) activity
Accession: GO:0004033
browse the term
Definition: Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms: exact_synonym: NADPH-dependent aldo-keto reductase activity; aldo-keto reductase (NADP) activity; aldo-keto reductase activity
narrow_synonym: alcohol dehydrogenase (NADP+) activity
xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-"; reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one"; reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol"; reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one"; reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol"; reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one"; reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one"; reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol"; reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol"; reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol"; reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one"; reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one"; reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol"; reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL"; reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH"; reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione"; reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA"; reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA"; reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3"; reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"
G
AKR1C1
aldo-keto reductase family 1, member C1
enables
ISO
(PMID:9792917)
UniProt
PMID:9792917
NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248
G
AKR1C3
aldo-keto reductase family 1 member C3
ISO
RGD
PMID:8977402
RGD:10053609
NCBI chr10:65,650,223...65,679,878
Ensembl chr10:65,576,464...65,678,248
G
AKR1C4
aldo-keto reductase family 1 member C4
enables
ISO
PMID:17574202
UniProt
PMID:17574202
RGD:13792520
NCBI chr10:65,559,508...65,572,892
Ensembl chr10:65,559,508...65,572,895
G
AKR7A2
aldo-keto reductase family 7 member A2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 6:77,754,172...77,761,609
Ensembl chr 6:77,754,174...77,761,667
G
KCNAB1
potassium voltage-gated channel subfamily A regulatory beta subunit 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr13:95,981,820...96,375,089
Ensembl chr13:95,959,378...96,375,856
G
KCNAB2
potassium voltage-gated channel subfamily A regulatory beta subunit 2
enables
ISO
PMID:18672894
UniProt
PMID:18672894
RGD:10047329
NCBI chr 6:66,928,374...67,016,846
Ensembl chr 6:66,928,381...67,016,845
G
KCNAB3
potassium voltage-gated channel subfamily A regulatory beta subunit 3
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr12:53,171,315...53,178,924
Ensembl chr12:53,171,319...53,180,823
G
MIOX
myo-inositol oxygenase
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:249,312...251,547
Ensembl chr 5:248,235...251,553
G
AKR1A1
aldo-keto reductase family 1 member A1
enables
IEA
RHEA InterPro UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000116
NCBI chr 6:165,811,245...165,825,168
Ensembl chr 6:165,811,247...165,824,896
G
ALDH3A1
aldehyde dehydrogenase 3 family member A1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr12:59,895,476...59,905,900
Ensembl chr12:59,897,496...59,905,897
G
RDH14
retinol dehydrogenase 14
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:119,453,986...119,458,787
Ensembl chr 3:119,453,995...119,458,778
G
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:121,225,485...121,259,262 NCBI chr X:98,582,002...98,583,002
Ensembl chr 8:121,225,656...121,261,746
G
AKR1A1
aldo-keto reductase family 1 member A1
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 6:165,811,245...165,825,168
Ensembl chr 6:165,811,247...165,824,896
G
AKR1B1
aldo-keto reductase family 1 member B
enables
IEA IBA
RHEA GO_Central Ensembl UniProt
GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116
NCBI chr18:14,593,516...14,752,316
Ensembl chr18:14,684,036...14,752,310
G
AKR1C1
aldo-keto reductase family 1, member C1
enables
ISO
(PMID:21232532)
UniProt
PMID:21232532
NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248
G
AKR1C3
aldo-keto reductase family 1 member C3
enables
ISO IBA
RGD GO_Central
PMID:8977402
GO_REF:0000033 RGD:10053609
NCBI chr10:65,650,223...65,679,878
Ensembl chr10:65,576,464...65,678,248
G
AKR1D1
aldo-keto reductase family 1 member D1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr18:11,416,065...11,532,846
Ensembl chr18:11,416,068...11,531,726
G
AKR1E2
aldo-keto reductase family 1 member E2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr10:65,680,314...65,704,701
Ensembl chr10:65,680,332...65,702,190
G
AKR7A2
aldo-keto reductase family 7 member A2
ISO
RGD
PMID:12071861
RGD:625492
NCBI chr 6:77,754,172...77,761,609
Ensembl chr 6:77,754,174...77,761,667
G
AKR1B1
aldo-keto reductase family 1 member B
enables
IEA
UniProt RHEA
GO_REF:0000003 GO_REF:0000116
NCBI chr18:14,593,516...14,752,316
Ensembl chr18:14,684,036...14,752,310
G
DHRS3
dehydrogenase/reductase 3
enables
ISO
(PMID:24005908)
MGI
PMID:24005908
NCBI chr 6:72,556,234...72,599,233
Ensembl chr 6:72,556,236...72,598,815
G
DHRS4
dehydrogenase/reductase (SDR family) member 4
enables
IDA IEA
(PMID:12604222)
UniProt RHEA
PMID:12604222
GO_REF:0000116
NCBI chr 7:75,242,121...75,255,594
Ensembl chr 7:75,242,124...75,255,598
G
DHRS7
dehydrogenase/reductase 7
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:189,153,579...189,170,745
Ensembl chr 1:189,151,131...189,170,534
G
RDH10
retinol dehydrogenase 10
enables
IEA
UniProt
GO_REF:0000003
NCBI chr 4:62,569,877...62,600,981
Ensembl chr 4:62,569,885...62,601,439
G
RDH11
retinol dehydrogenase 11
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:91,415,041...91,452,530
Ensembl chr 7:91,415,042...91,452,405
G
RDH12
retinol dehydrogenase 12
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:91,481,238...91,493,838
Ensembl chr 7:91,481,272...91,493,809
G
RDH13
retinol dehydrogenase 13
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 6:59,274,383...59,293,139
Ensembl chr 6:59,274,387...59,292,765
G
RDH14
retinol dehydrogenase 14
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:119,453,986...119,458,787
Ensembl chr 3:119,453,995...119,458,778
G
RDH8
retinol dehydrogenase 8
enables
IEA
UniProt RHEA
GO_REF:0000003 GO_REF:0000104 GO_REF:0000116
NCBI chr 2:68,871,707...68,878,222
Ensembl chr 2:68,871,707...68,877,675
G
CBR1
carbonyl reductase 1
enables
IEA IBA ISS IDA
(PMID:1597188)
RHEA GO_Central UniProt
PMID:1597188
GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116
NCBI chr13:199,617,406...199,622,407
Ensembl chr13:199,617,199...199,622,407
G
CBR2
carbonyl reductase 2
enables
IEA IBA
RHEA GO_Central Ensembl UniProt
GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116
NCBI chr12:973,780...976,017
Ensembl chr12:973,760...976,017
G
CBR3
carbonyl reductase 3
enables
ISO IBA IEA
RGD GO_Central UniProt Ensembl
PMID:18983987
GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 RGD:2316293
NCBI chr13:199,830,690...199,840,444
Ensembl chr13:199,830,668...199,840,442
G
DCXR
dicarbonyl and L-xylulose reductase
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr12:978,131...980,042
Ensembl chr12:978,139...982,259
G
DHRS1
dehydrogenase/reductase 1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:74,992,120...75,002,154
Ensembl chr 7:74,992,115...75,002,148
G
DHRS4
dehydrogenase/reductase (SDR family) member 4
enables
IEA IBA
RHEA GO_Central UniProt
GO_REF:0000003 GO_REF:0000033 GO_REF:0000116
NCBI chr 7:75,242,121...75,255,594
Ensembl chr 7:75,242,124...75,255,598
G
DHRS7
dehydrogenase/reductase 7
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:189,153,579...189,170,745
Ensembl chr 1:189,151,131...189,170,534
G
LOC100622246
carbonyl reductase [NADPH] 1
enables
IEA
UniProt
GO_REF:0000104
NCBI chr13:199,600,768...199,606,618
G
LOC110256480
carbonyl reductase [NADPH] 1-like
enables
IEA
UniProt
GO_REF:0000104
NCBI chr13:199,653,760...199,659,199
G
LOC110256481
carbonyl reductase [NADPH] 1-like
enables
IEA
UniProt
GO_REF:0000104
NCBI chr13:199,665,279...199,673,271
G
LOC110256483
carbonyl reductase [NADPH] 1-like
enables
IEA
UniProt
GO_REF:0000104
NCBI chr13:199,713,741...199,719,535
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all