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ONTOLOGY REPORT - ANNOTATIONS

Term:aldo-keto reductase (NADPH) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase (NADP) activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"


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aldo-keto reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1, member C1 enables ISO (PMID:9792917) UniProt PMID:9792917 NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 ISO RGD PMID:8977402 RGD:10053609 NCBI chr10:65,650,223...65,679,878
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 enables ISO PMID:17574202 UniProt PMID:17574202 RGD:13792520 NCBI chr10:65,559,508...65,572,892
Ensembl chr10:65,559,508...65,572,895 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:77,754,172...77,761,609
Ensembl chr 6:77,754,174...77,761,667 		JBrowse link
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 enables IBA GO_Central GO_REF:0000033 NCBI chr13:95,981,820...96,375,089
Ensembl chr13:95,959,378...96,375,856 		JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 enables ISO PMID:18672894 UniProt PMID:18672894 RGD:10047329 NCBI chr 6:66,928,374...67,016,846
Ensembl chr 6:66,928,381...67,016,845 		JBrowse link
G KCNAB3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 enables IBA GO_Central GO_REF:0000033 NCBI chr12:53,171,315...53,178,924
Ensembl chr12:53,171,319...53,180,823 		JBrowse link
G MIOX myo-inositol oxygenase enables IEA Ensembl GO_REF:0000107 NCBI chr 5:249,312...251,547
Ensembl chr 5:248,235...251,553 		JBrowse link
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA RHEA
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 6:165,811,245...165,825,168
Ensembl chr 6:165,811,247...165,824,896 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 enables IEA Ensembl GO_REF:0000107 NCBI chr12:59,895,476...59,905,900
Ensembl chr12:59,897,496...59,905,897 		JBrowse link
G RDH14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:119,453,986...119,458,787
Ensembl chr 3:119,453,995...119,458,778 		JBrowse link
aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA Ensembl GO_REF:0000107 NCBI chr 8:121,225,485...121,259,262
NCBI chr  X:98,582,002...98,583,002
Ensembl chr 8:121,225,656...121,261,746 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:165,811,245...165,825,168
Ensembl chr 6:165,811,247...165,824,896 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B enables IEA
IBA		 RHEA
GO_Central
Ensembl
UniProt		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr18:14,593,516...14,752,316
Ensembl chr18:14,684,036...14,752,310 		JBrowse link
G AKR1C1 aldo-keto reductase family 1, member C1 enables ISO (PMID:21232532) UniProt PMID:21232532 NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 enables ISO
IBA		 RGD
GO_Central		 PMID:8977402 GO_REF:0000033 RGD:10053609 NCBI chr10:65,650,223...65,679,878
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 enables IBA GO_Central GO_REF:0000033 NCBI chr18:11,416,065...11,532,846
Ensembl chr18:11,416,068...11,531,726 		JBrowse link
G AKR1E2 aldo-keto reductase family 1 member E2 enables IBA GO_Central GO_REF:0000033 NCBI chr10:65,680,314...65,704,701
Ensembl chr10:65,680,332...65,702,190 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 ISO RGD PMID:12071861 RGD:625492 NCBI chr 6:77,754,172...77,761,609
Ensembl chr 6:77,754,174...77,761,667 		JBrowse link
all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr18:14,593,516...14,752,316
Ensembl chr18:14,684,036...14,752,310 		JBrowse link
G DHRS3 dehydrogenase/reductase 3 enables ISO (PMID:24005908) MGI PMID:24005908 NCBI chr 6:72,556,234...72,599,233
Ensembl chr 6:72,556,236...72,598,815 		JBrowse link
G DHRS4 dehydrogenase/reductase (SDR family) member 4 enables IDA
IEA		 (PMID:12604222) UniProt
RHEA		 PMID:12604222 GO_REF:0000116 NCBI chr 7:75,242,121...75,255,594
Ensembl chr 7:75,242,124...75,255,598 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:189,153,579...189,170,745
Ensembl chr 1:189,151,131...189,170,534 		JBrowse link
G RDH10 retinol dehydrogenase 10 enables IEA UniProt GO_REF:0000003 NCBI chr 4:62,569,877...62,600,981
Ensembl chr 4:62,569,885...62,601,439 		JBrowse link
G RDH11 retinol dehydrogenase 11 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:91,415,041...91,452,530
Ensembl chr 7:91,415,042...91,452,405 		JBrowse link
G RDH12 retinol dehydrogenase 12 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:91,481,238...91,493,838
Ensembl chr 7:91,481,272...91,493,809 		JBrowse link
G RDH13 retinol dehydrogenase 13 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:59,274,383...59,293,139
Ensembl chr 6:59,274,387...59,292,765 		JBrowse link
G RDH14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:119,453,986...119,458,787
Ensembl chr 3:119,453,995...119,458,778 		JBrowse link
G RDH8 retinol dehydrogenase 8 enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000104 GO_REF:0000116 NCBI chr 2:68,871,707...68,878,222
Ensembl chr 2:68,871,707...68,877,675 		JBrowse link
carbonyl reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBR1 carbonyl reductase 1 enables IEA
IBA
ISS
IDA		 (PMID:1597188) RHEA
GO_Central
UniProt		 PMID:1597188 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116 NCBI chr13:199,617,406...199,622,407
Ensembl chr13:199,617,199...199,622,407 		JBrowse link
G CBR2 carbonyl reductase 2 enables IEA
IBA		 RHEA
GO_Central
Ensembl
UniProt		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr12:973,780...976,017
Ensembl chr12:973,760...976,017 		JBrowse link
G CBR3 carbonyl reductase 3 enables ISO
IBA
IEA		 RGD
GO_Central
UniProt
Ensembl		 PMID:18983987 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 RGD:2316293 NCBI chr13:199,830,690...199,840,444
Ensembl chr13:199,830,668...199,840,442 		JBrowse link
G DCXR dicarbonyl and L-xylulose reductase enables IBA GO_Central GO_REF:0000033 NCBI chr12:978,131...980,042
Ensembl chr12:978,139...982,259 		JBrowse link
G DHRS1 dehydrogenase/reductase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:74,992,120...75,002,154
Ensembl chr 7:74,992,115...75,002,148 		JBrowse link
G DHRS4 dehydrogenase/reductase (SDR family) member 4 enables IEA
IBA		 RHEA
GO_Central
UniProt		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 7:75,242,121...75,255,594
Ensembl chr 7:75,242,124...75,255,598 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:189,153,579...189,170,745
Ensembl chr 1:189,151,131...189,170,534 		JBrowse link
G LOC100622246 carbonyl reductase [NADPH] 1 enables IEA UniProt GO_REF:0000104 NCBI chr13:199,600,768...199,606,618 JBrowse link
G LOC110256480 carbonyl reductase [NADPH] 1-like enables IEA UniProt GO_REF:0000104 NCBI chr13:199,653,760...199,659,199 JBrowse link
G LOC110256481 carbonyl reductase [NADPH] 1-like enables IEA UniProt GO_REF:0000104 NCBI chr13:199,665,279...199,673,271 JBrowse link
G LOC110256483 carbonyl reductase [NADPH] 1-like enables IEA UniProt GO_REF:0000104 NCBI chr13:199,713,741...199,719,535 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18634
    catalytic activity 5562
      oxidoreductase activity 729
        oxidoreductase activity, acting on CH-OH group of donors 133
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 125
            alcohol dehydrogenase [NAD(P)+] activity 47
              aldo-keto reductase (NADPH) activity 32
                alcohol dehydrogenase (NADP+) activity + 27
                pyridoxine:NADP 4-dehydrogenase activity 0
paths to the root