Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:aldo-keto reductase (NADPH) activity
go back to main search page
Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase (NADP) activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
aldo-keto reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:33,701,386...34,141,269
Ensembl chrNW_004624730:33,876,381...34,139,594 		JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624818:5,251,304...5,326,796
Ensembl chrNW_004624818:5,253,773...5,327,000 		JBrowse link
G Kcnab3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624786:10,504,135...10,512,383
Ensembl chrNW_004624786:10,504,147...10,511,695 		JBrowse link
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 NCBI chrNW_004624906:1,463,201...1,474,001
Ensembl chrNW_004624906:1,462,693...1,474,214 		JBrowse link
G Rdh14 retinol dehydrogenase 14 enables ISO (PMID:25533474) MGI PMID:25533474 NCBI chrNW_004624738:1,393,157...1,397,587 JBrowse link
aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 enables ISO (PMID:14667815), (PMID:15769935) MGI PMID:14667815 PMID:15769935 NCBI chrNW_004624906:1,463,201...1,474,001
Ensembl chrNW_004624906:1,462,693...1,474,214 		JBrowse link
G LOC101720124 aldose reductase enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624783:1,945,173...1,958,073
Ensembl chrNW_004624783:1,945,073...1,958,155 		JBrowse link
all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs3 dehydrogenase/reductase 3 enables ISO (PMID:24005908) MGI PMID:24005908 NCBI chrNW_004624818:557,399...590,872
Ensembl chrNW_004624818:557,409...590,872 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 enables ISO (PMID:26466768) UniProt PMID:26466768 NCBI chrNW_004624734:40,994,786...41,006,001
Ensembl chrNW_004624734:40,993,587...41,006,074 		JBrowse link
G Rdh10 retinol dehydrogenase 10 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624744:17,838,047...17,868,423
Ensembl chrNW_004624744:17,837,609...17,868,431 		JBrowse link
G Rdh11 retinol dehydrogenase 11 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:33,283,336...33,295,797
Ensembl chrNW_004624734:33,283,497...33,295,091 		JBrowse link
G Rdh12 retinol dehydrogenase 12 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:33,256,469...33,266,085
Ensembl chrNW_004624734:33,254,432...33,266,140 		JBrowse link
G Rdh13 retinol dehydrogenase 13 enables ISO (PMID:18039331) UniProt PMID:18039331 NCBI chrNW_004624832:2,141,906...2,159,009
Ensembl chrNW_004624832:2,141,902...2,159,009 		JBrowse link
G Rdh14 retinol dehydrogenase 14 enables ISO (PMID:12435598)
(PMID:12226107)		 UniProt PMID:12226107 PMID:12435598 NCBI chrNW_004624738:1,393,157...1,397,587 JBrowse link
carbonyl reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr3 carbonyl reductase 3 enables ISO (PMID:18493841) UniProt
RGD		 PMID:18493841 PMID:18983987 RGD:2316293 NCBI chrNW_004624745:27,298,714...27,305,606
Ensembl chrNW_004624745:27,294,222...27,305,109 		JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624801:10,866,264...10,868,064
Ensembl chrNW_004624801:10,865,219...10,868,060 		JBrowse link
G Dhrs1 dehydrogenase/reductase 1 enables ISO (PMID:30031147) UniProt PMID:30031147 NCBI chrNW_004624820:8,204,627...8,213,512 JBrowse link
G Dhrs7 dehydrogenase/reductase 7 enables ISO (PMID:24246760), (PMID:26466768), (PMID:28457967), (PMID:28687384) UniProt PMID:24246760 PMID:26466768 PMID:28457967 PMID:28687384 NCBI chrNW_004624734:40,994,786...41,006,001
Ensembl chrNW_004624734:40,993,587...41,006,074 		JBrowse link
G LOC101705747 dehydrogenase/reductase SDR family member 2, mitochondrial enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624820:8,570,571...8,579,181
Ensembl chrNW_004624820:8,570,571...8,579,127 		JBrowse link
G LOC101708169 dehydrogenase/reductase SDR family member 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624820:8,478,036...8,490,227
Ensembl chrNW_004624820:8,477,878...8,490,533 		JBrowse link
G LOC101726221 carbonyl reductase [NADPH] 2-like enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624801:10,870,138...10,872,337 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16462
    catalytic activity 5198
      oxidoreductase activity 640
        oxidoreductase activity, acting on CH-OH group of donors 110
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 101
            alcohol dehydrogenase [NAD(P)+] activity 30
              aldo-keto reductase (NADPH) activity 18
                alcohol dehydrogenase (NADP+) activity + 15
                pyridoxine:NADP 4-dehydrogenase activity 0
paths to the root