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ONTOLOGY REPORT - ANNOTATIONS

Term:aldo-keto reductase (NADPH) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase (NADP) activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"


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aldo-keto reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 enables TAS Reactome Reactome:R-HSA-5692232 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 enables TAS (PMID:9565553) UniProt PMID:9565553 Reactome:R-HSA-2855252 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 enables TAS (PMID:7789999) UniProt PMID:7789999 Reactome:R-HSA-2855252 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 enables ISO
TAS
IDA		 (PMID:9792917) RGD
Reactome
UniProt		 PMID:8977402 PMID:9792917 RGD:10053609 Reactome:R-HSA-2855252 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 enables TAS (PMID:7650035) Reactome PMID:7650035 Reactome:R-HSA-192036 Reactome:R-HSA-192160 Reactome:R-HSA-193758 Reactome:R-HSA-193781 Reactome:R-HSA-193800 Reactome:R-HSA-193841 Reactome:R-HSA-2855252 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949 		JBrowse link
G AKR1C8 aldo-keto reductase family 1 member C8 enables IEA Ensembl GO_REF:0000107 NCBI chr10:5,115,813...5,185,150
Ensembl chr10:5,153,920...5,185,187 		JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 enables TAS Reactome Reactome:R-HSA-192033 Reactome:R-HSA-192067 Reactome:R-HSA-193746 Reactome:R-HSA-193755 Reactome:R-HSA-193821 Reactome:R-HSA-193824 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,301,991...19,312,144 		JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 enables ISO
IBA
TAS		 (PMID:10383892) RGD
GO_Central
PINC		 PMID:8234296 PMID:10383892 GO_REF:0000033 RGD:632009 NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770 		JBrowse link
G AKR7L aldo-keto reductase family 7 like (gene/pseudogene) enables IBA GO_Central GO_REF:0000033 NCBI chr 1:19,265,982...19,274,122
Ensembl chr 1:19,265,982...19,274,194 		JBrowse link
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 enables ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr 3:156,118,211...156,539,138
Ensembl chr 3:156,037,701...156,538,756 		JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 enables ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:5,992,676...6,101,180
Ensembl chr 1:5,990,927...6,101,193 		JBrowse link
G KCNAB3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 enables IBA GO_Central GO_REF:0000033 NCBI chr17:7,921,859...7,929,856
Ensembl chr17:7,921,859...7,929,856 		JBrowse link
G MIOX myo-inositol oxygenase enables ISS
IEA
TAS		 (PMID:10944187) UniProt
Ensembl
PINC		 PMID:10944187 GO_REF:0000024 GO_REF:0000107 NCBI chr22:50,486,859...50,490,648
Ensembl chr22:50,486,784...50,490,648 		JBrowse link
G SPR sepiapterin reductase enables TAS (PMID:1883349) UniProt PMID:1883349 NCBI chr 2:72,887,408...72,892,158
Ensembl chr 2:72,887,382...72,892,158 		JBrowse link
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA UniProt
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 enables IDA (PMID:19013440) UniProt PMID:19013440 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 enables IDA (PMID:1737758) UniProt PMID:1737758 NCBI chr17:19,737,984...19,748,298
Ensembl chr17:19,737,984...19,748,943 		JBrowse link
G RDH14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:18,554,723...18,560,653
Ensembl chr 2:18,554,723...18,560,679 		JBrowse link
aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,123,658...99,144,297
Ensembl chr 4:99,123,657...99,157,792 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA
IBA
TAS		 (PMID:2498333) Ensembl
GO_Central
PINC		 PMID:2498333 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B enables IDA
IBA
IEA
EXP
TAS		 (PMID:8435445)
(PMID:1420136), (PMID:2112546), (PMID:8645003)
(PMID:2112546)		 UniProt
GO_Central
Ensembl
Reactome
PINC
RHEA		 PMID:1420136 PMID:2112546 PMID:8435445 PMID:8645003 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 enables ISO
IBA		 RGD
GO_Central		 PMID:20709016 GO_REF:0000033 RGD:6903952 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G AKR1B15 aldo-keto reductase family 1 member B15 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875 		JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 enables IDA
IBA		 (PMID:21232532) UniProt
GO_Central		 PMID:21232532 GO_REF:0000033 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 enables IDA
IBA		 (PMID:21232532) UniProt
GO_Central		 PMID:21232532 GO_REF:0000033 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 enables ISO
IBA
IDA		 (PMID:21232532) RGD
GO_Central
UniProt		 PMID:8977402 PMID:21232532 GO_REF:0000033 RGD:10053609 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 enables IBA GO_Central GO_REF:0000033 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949 		JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305 		JBrowse link
G AKR1E2 aldo-keto reductase family 1 member E2 enables IBA GO_Central GO_REF:0000033 NCBI chr10:4,824,973...4,873,237
Ensembl chr10:4,786,629...4,848,062 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 enables ISO
TAS		 (PMID:9576847) RGD
PINC		 PMID:9576847 PMID:12071861 RGD:625492 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,301,991...19,312,144 		JBrowse link
all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 enables ISO
IEA
IDA		 (PMID:12732097) RGD
UniProt
RHEA		 PMID:12732097 PMID:20709016 GO_REF:0000003 GO_REF:0000116 RGD:6903952 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G AKR1B15 aldo-keto reductase family 1 member B15 enables IEA RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 enables TAS Reactome Reactome:R-HSA-5615668 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G DHRS3 dehydrogenase/reductase 3 enables TAS
IEA		 Reactome
RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 Reactome:R-HSA-2465940 Reactome:R-HSA-5419165 NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,909...12,620,133 		JBrowse link
G DHRS4 dehydrogenase/reductase 4 enables TAS Reactome Reactome:R-HSA-5419165 NCBI chr14:23,953,770...23,969,279
Ensembl chr14:23,953,734...23,969,279 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 enables IDA
IEA		 (PMID:26466768) UniProt
RHEA		 PMID:26466768 GO_REF:0000116 NCBI chr14:60,144,119...60,169,889
Ensembl chr14:60,144,119...60,169,856 		JBrowse link
G RDH10 retinol dehydrogenase 10 enables IEA
TAS		 RHEA
UniProt
Reactome		 GO_REF:0000003 GO_REF:0000116 Reactome:R-HSA-74872 NCBI chr 8:73,294,602...73,325,281
Ensembl chr 8:73,294,602...73,325,281 		JBrowse link
G RDH11 retinol dehydrogenase 11 enables TAS
IEA
IDA		 (PMID:12226107), (PMID:12807874) Reactome
RHEA
UniProt		 PMID:12226107 PMID:12807874 GO_REF:0000003 GO_REF:0000116 Reactome:R-HSA-5419165 Reactome:R-HSA-74872 NCBI chr14:67,676,800...67,695,764
Ensembl chr14:67,676,800...67,695,793 		JBrowse link
G RDH12 retinol dehydrogenase 12 enables IEA
TAS
IDA		 (PMID:12226107) RHEA
Reactome
UniProt		 PMID:12226107 GO_REF:0000003 GO_REF:0000116 Reactome:R-HSA-2464822 Reactome:R-HSA-2466861 Reactome:R-HSA-2471670 NCBI chr14:67,701,886...67,734,451
Ensembl chr14:67,701,886...67,734,451 		JBrowse link
G RDH13 retinol dehydrogenase 13 enables IEA
IBA
IDA
TAS		 (PMID:18039331) RHEA
GO_Central
UniProt
Reactome		 PMID:18039331 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 Reactome:R-HSA-5623643 NCBI chr19:55,039,103...55,069,520
Ensembl chr19:55,039,108...55,071,291 		JBrowse link
G RDH14 retinol dehydrogenase 14 enables IEA
TAS
IDA		 (PMID:12435598) Ensembl
UniProt
Reactome
RHEA		 PMID:12435598 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 Reactome:R-HSA-5419165 NCBI chr 2:18,554,723...18,560,653
Ensembl chr 2:18,554,723...18,560,679 		JBrowse link
G RDH8 retinol dehydrogenase 8 enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000104 GO_REF:0000116 NCBI chr19:10,013,483...10,022,279
Ensembl chr19:10,013,249...10,022,279 		JBrowse link
carbonyl reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBR1 carbonyl reductase 1 enables IEA
IBA
ISO
IDA
TAS		 (PMID:18449627), (PMID:1921984)
(PMID:9740676)		 UniProt
GO_Central
RGD
PINC
RHEA		 PMID:1921984 PMID:7705364 PMID:9740676 PMID:12396270 PMID:18449627 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116 RGD:634703 RGD:69801 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166 		JBrowse link
G CBR3 carbonyl reductase 3 enables ISO
IBA
IEA
TAS
IDA		 (PMID:9740676)
(PMID:18493841)		 RGD
GO_Central
Ensembl
UniProt
Reactome
RHEA		 PMID:9740676 PMID:18493841 PMID:18983987 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 RGD:2316293 Reactome:R-HSA-8937419 NCBI chr21:36,135,079...36,146,562
Ensembl chr21:36,135,079...36,146,562 		JBrowse link
G DCXR dicarbonyl and L-xylulose reductase enables IBA GO_Central GO_REF:0000033 NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709 		JBrowse link
G DHRS1 dehydrogenase/reductase 1 enables IDA (PMID:30031147) UniProt PMID:30031147 NCBI chr14:24,290,598...24,299,780
Ensembl chr14:24,290,598...24,299,780 		JBrowse link
G DHRS2 dehydrogenase/reductase 2 enables IDA
IBA		 (PMID:16685466) UniProt
GO_Central		 PMID:16685466 GO_REF:0000033 NCBI chr14:23,630,115...23,645,639
Ensembl chr14:23,630,115...23,645,639 		JBrowse link
G DHRS4 dehydrogenase/reductase 4 enables IEA
IBA
IDA		 (PMID:18571493), (PMID:19056333), (PMID:23128527) UniProt
GO_Central
RHEA		 PMID:18571493 PMID:19056333 PMID:23128527 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr14:23,953,770...23,969,279
Ensembl chr14:23,953,734...23,969,279 		JBrowse link
G DHRS4L1 dehydrogenase/reductase 4 like 1 (pseudogene) enables IBA GO_Central GO_REF:0000033 NCBI chr14:24,007,084...24,051,377
Ensembl chr14:23,969,931...24,051,377
Ensembl chr14:23,969,931...24,051,377
Ensembl chr14:23,969,931...24,051,377 		JBrowse link
G DHRS4L2 dehydrogenase/reductase 4 like 2 enables IEA
IBA		 UniProt
GO_Central		 GO_REF:0000003 GO_REF:0000033 NCBI chr14:23,969,874...24,006,408
Ensembl chr14:23,969,874...24,006,408 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 enables IDA (PMID:24246760), (PMID:26466768), (PMID:28457967), (PMID:28687384) UniProt PMID:24246760 PMID:26466768 PMID:28457967 PMID:28687384 NCBI chr14:60,144,119...60,169,889
Ensembl chr14:60,144,119...60,169,856 		JBrowse link
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 enables IEA RHEA GO_REF:0000116 NCBI chr 3:156,118,211...156,539,138
Ensembl chr 3:156,037,701...156,538,756 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19524
    catalytic activity 6003
      oxidoreductase activity 769
        oxidoreductase activity, acting on CH-OH group of donors 136
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 126
            alcohol dehydrogenase [NAD(P)+] activity 53
              aldo-keto reductase (NADPH) activity 37
                alcohol dehydrogenase (NADP+) activity + 30
                pyridoxine:NADP 4-dehydrogenase activity 0
paths to the root