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ONTOLOGY REPORT - ANNOTATIONS

Term:aldo-keto reductase (NADPH) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase (NADP) activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"

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aldo-keto reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1 member C3 enables IEA Ensembl GO_REF:0000107 Ensembl chr 9:5,248,610...5,263,474 JBrowse link
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:34,223,250...34,467,924
Ensembl chr15:34,221,890...34,468,001 		JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:125,636,352...125,743,821
Ensembl chr20:125,638,962...125,708,768 		JBrowse link
G KCNAB3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 enables IEA TreeGrafter GO_REF:0000118 Ensembl chr16:7,311,185...7,317,855 JBrowse link
G MIOX myo-inositol oxygenase enables IEA Ensembl GO_REF:0000107 NCBI chr19:32,953,268...32,960,123
Ensembl chr19:32,957,256...32,961,023 		JBrowse link
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 NCBI chr20:87,228,348...87,245,511
Ensembl chr20:87,228,189...87,245,466 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 enables IEA Ensembl GO_REF:0000107 NCBI chr16:18,302,145...18,312,768
Ensembl chr16:18,302,142...18,312,756 		JBrowse link
G RDH14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 NCBI chr14:89,128,850...89,134,879
Ensembl chr14:89,128,828...89,135,033 		JBrowse link
aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA Ensembl GO_REF:0000107 NCBI chr 7:47,226,787...47,248,518
Ensembl chr 7:47,226,191...47,248,234 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA Ensembl GO_REF:0000107 NCBI chr20:87,228,348...87,245,511
Ensembl chr20:87,228,189...87,245,466 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 enables IEA Ensembl GO_REF:0000107 Ensembl chr 9:5,248,610...5,263,474 JBrowse link
G LOC103225480 aflatoxin B1 aldehyde reductase member 2 ISO RGD PMID:12071861 RGD:625492 NCBI chr20:113,234,257...113,242,445 JBrowse link
G LOC103226928 aldo-keto reductase family 1 member B1 enables IEA Ensembl GO_REF:0000107 NCBI chr21:103,060,018...103,076,844
Ensembl chr21:103,059,991...103,077,341 		JBrowse link
all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS3 dehydrogenase/reductase 3 enables ISO (PMID:24005908) MGI PMID:24005908 NCBI chr20:119,183,453...119,236,953
Ensembl chr20:119,184,996...119,237,015 		JBrowse link
G DHRS4 dehydrogenase/reductase 4 enables ISO (PMID:12604222) UniProt PMID:12604222 NCBI chr29:24,170,090...24,185,509
Ensembl chr29:24,169,818...24,185,634 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 enables IEA Ensembl GO_REF:0000107 NCBI chr24:37,368,792...37,389,433
Ensembl chr24:37,368,982...37,389,403 		JBrowse link
G RDH10 retinol dehydrogenase 10 enables IEA UniProt GO_REF:0000003 NCBI chr 8:68,903,665...68,933,536
Ensembl chr 8:68,904,352...68,933,792 		JBrowse link
G RDH11 retinol dehydrogenase 11 enables IEA Ensembl GO_REF:0000107 NCBI chr24:44,911,830...44,932,632
Ensembl chr24:44,909,001...44,932,611 		JBrowse link
G RDH12 retinol dehydrogenase 12 enables IEA Ensembl GO_REF:0000107 NCBI chr24:44,957,854...44,971,855
Ensembl chr24:44,959,921...44,971,836 		JBrowse link
G RDH13 retinol dehydrogenase 13 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:47,634,909...47,652,829
Ensembl chr 6:47,636,094...47,652,772 		JBrowse link
G RDH14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 NCBI chr14:89,128,850...89,134,879
Ensembl chr14:89,128,828...89,135,033 		JBrowse link
carbonyl reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBR1 carbonyl reductase 1 enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 Ensembl chr 2:80,096,955...80,102,721 JBrowse link
G CBR3 carbonyl reductase 3 enables ISO
IEA		 RGD
Ensembl
TreeGrafter
UniProt		 PMID:18983987 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:2316293 NCBI chr 2:80,158,842...80,164,208
Ensembl chr 2:80,158,806...80,164,248 		JBrowse link
G DCXR dicarbonyl and L-xylulose reductase enables IEA TreeGrafter GO_REF:0000118 NCBI chr16:73,923,170...73,925,025
Ensembl chr16:73,919,463...73,925,277 		JBrowse link
G DHRS1 dehydrogenase/reductase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr24:1,273,717...1,282,761
Ensembl chr24:1,273,659...1,282,812 		JBrowse link
G DHRS2 dehydrogenase/reductase 2 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr29:24,015,535...24,022,897
Ensembl chr29:24,016,071...24,022,500 		JBrowse link
G DHRS4 dehydrogenase/reductase 4 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr29:24,170,090...24,185,509
Ensembl chr29:24,169,818...24,185,634 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 enables IEA Ensembl GO_REF:0000107 NCBI chr24:37,368,792...37,389,433
Ensembl chr24:37,368,982...37,389,403 		JBrowse link
G LOC103218526 carbonyl reductase [NADPH] 1 enables ISO (PMID:18449627), (PMID:1921984) UniProt PMID:1921984 PMID:18449627 NCBI chr 2:80,096,743...80,099,982 JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 18124
    catalytic activity 5456
      oxidoreductase activity 716
        oxidoreductase activity, acting on CH-OH group of donors 127
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 119
            alcohol dehydrogenase [NAD(P)+] activity 40
              aldo-keto reductase (NADPH) activity 24
                alcohol dehydrogenase (NADP+) activity + 20
                pyridoxine:NADP 4-dehydrogenase activity 0
paths to the root