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ONTOLOGY REPORT - ANNOTATIONS

Term:aldo-keto reductase (NADPH) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase (NADP) activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"


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aldo-keto reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) enables ISO (PMID:9792917) RGD
UniProt		 PMID:8977402 PMID:9792917 RGD:10053609 NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043 		JBrowse link
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 enables ISO PMID:18222921 UniProt PMID:18222921 RGD:10047381 NCBI chr23:49,775,790...50,135,372
Ensembl chr23:49,776,089...50,133,707 		JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 enables ISO PMID:18672894 UniProt PMID:18672894 RGD:10047329 NCBI chr 5:59,936,432...60,021,945
Ensembl chr 5:59,936,528...60,021,957 		JBrowse link
G MIOX myo-inositol oxygenase enables IEA Ensembl GO_REF:0000107 NCBI chr10:16,813,532...16,815,930
Ensembl chr10:16,813,545...16,818,015 		JBrowse link
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA InterPro GO_REF:0000002 NCBI chr15:14,792,398...14,808,805
Ensembl chr15:14,742,012...14,808,592 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:40,466,237...40,474,272
Ensembl chr 5:40,466,237...40,474,457 		JBrowse link
G LOC475374 alcohol dehydrogenase [NADP+] pseudogene enables IEA InterPro GO_REF:0000002 NCBI chr13:61,866,069...61,867,289 JBrowse link
G NASP nuclear autoantigenic sperm protein enables IEA InterPro GO_REF:0000002 NCBI chr15:14,742,008...14,782,186
Ensembl chr15:14,742,012...14,808,592 		JBrowse link
G RDH14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 NCBI chr17:13,843,278...13,848,498 JBrowse link
aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA Ensembl GO_REF:0000107 NCBI chr32:21,282,526...21,299,387
Ensembl chr32:21,282,890...21,299,328 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 enables ISO (PMID:14667815), (PMID:15769935) MGI PMID:14667815 PMID:15769935 NCBI chr15:14,792,398...14,808,805
Ensembl chr15:14,742,012...14,808,592 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B enables ISO (PMID:7851421)
(PMID:1420136), (PMID:2112546), (PMID:8645003)
(PMID:17727625)
(PMID:8435445)		 MGI
Reactome
RGD
UniProt		 PMID:1420136 PMID:2112546 PMID:2114645 PMID:7851421 PMID:8435445 More... RGD:1626085 NCBI chr14:2,991,888...3,006,941
Ensembl chr14:2,991,888...3,006,940 		JBrowse link
G AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) enables ISO (PMID:21232532) RGD
UniProt		 PMID:8977402 PMID:21232532 RGD:10053609 NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 ISO RGD PMID:12071861 RGD:625492 NCBI chr 2:79,334,179...79,343,880
Ensembl chr 2:79,334,205...79,343,007 		JBrowse link
all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 enables ISO (PMID:12604222) UniProt PMID:12604222 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
G DHRS3 dehydrogenase/reductase 3 enables ISO (PMID:24005908) MGI PMID:24005908 NCBI chr 2:83,826,361...83,865,412
Ensembl chr 2:83,826,374...83,865,426 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:35,251,988...35,269,880
Ensembl chr 8:35,251,975...35,269,869 		JBrowse link
G RDH11 retinol dehydrogenase 11 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:41,651,970...41,669,661
Ensembl chr 8:41,614,921...41,669,576 		JBrowse link
G RDH12 retinol dehydrogenase 12 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:41,685,045...41,696,120
Ensembl chr 8:41,684,996...41,695,447 		JBrowse link
G RDH13 retinol dehydrogenase 13 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:102,539,363...102,552,749
Ensembl chr 1:102,539,124...102,554,027 		JBrowse link
G RDH14 retinol dehydrogenase 14 enables IEA Ensembl GO_REF:0000107 NCBI chr17:13,843,278...13,848,498 JBrowse link
G RDH8 retinol dehydrogenase 8 enables IEA UniProt GO_REF:0000104 NCBI chr20:51,029,633...51,035,910
Ensembl chr20:51,029,609...51,035,951 		JBrowse link
carbonyl reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBR3 carbonyl reductase 3 enables ISO
IEA		 RGD
UniProt
Ensembl		 PMID:18983987 GO_REF:0000104 GO_REF:0000107 RGD:2316293 NCBI chr31:31,416,441...31,423,797
Ensembl chr31:31,416,333...31,423,739 		JBrowse link
G CPNE6 copine 6 enables ISO (PMID:18571493), (PMID:19056333), (PMID:23128527) UniProt PMID:18571493 PMID:19056333 PMID:23128527 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
G DHRS1 dehydrogenase/reductase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:4,263,707...4,269,453
Ensembl chr 8:4,263,700...4,270,271 		JBrowse link
G DHRS2 dehydrogenase/reductase 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:3,820,269...3,847,217
Ensembl chr 8:3,836,476...3,845,916 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:35,251,988...35,269,880
Ensembl chr 8:35,251,975...35,269,869 		JBrowse link
G LOC119867057 carbonyl reductase [NADPH] 1-like enables IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107
G LOC119867058 carbonyl reductase [NADPH] 1-like enables IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107
G LOC607806 carbonyl reductase [NADPH] 2-like enables IEA Ensembl GO_REF:0000107 NCBI chr 9:284,608...287,274 JBrowse link
G LOC610164 carbonyl reductase [NADPH] 1 enables IEA UniProt GO_REF:0000104 NCBI chr31:31,316,573...31,321,413 JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 18607
    catalytic activity 5535
      oxidoreductase activity 762
        oxidoreductase activity, acting on CH-OH group of donors 135
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 126
            alcohol dehydrogenase [NAD(P)+] activity 40
              aldo-keto reductase (NADPH) activity 26
                alcohol dehydrogenase (NADP+) activity + 23
                pyridoxine:NADP 4-dehydrogenase activity 0
paths to the root