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ONTOLOGY REPORT - ANNOTATIONS

Term:aldo-keto reductase (NADPH) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase (NADP) activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"

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aldo-keto reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 enables ISO PMID:18222921 UniProt PMID:18222921 RGD:10047381 NCBI chrNW_004955448:7,145,471...7,553,090
Ensembl chrNW_004955448:7,309,717...7,551,432 		JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 enables ISO PMID:18672894 UniProt PMID:18672894 RGD:10047329 NCBI chrNW_004955486:6,371,212...6,442,888
Ensembl chrNW_004955486:6,369,288...6,442,885 		JBrowse link
G Miox myo-inositol oxygenase enables ISO (PMID:10944187) MGI PMID:10944187 NCBI chrNW_004955413:33,476,097...33,478,539
Ensembl chrNW_004955413:33,476,033...33,478,539 		JBrowse link
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh3a1 aldehyde dehydrogenase 3 family member A1 enables ISO (PMID:1737758) UniProt PMID:1737758 NCBI chrNW_004955467:96,140...105,738
Ensembl chrNW_004955467:96,140...105,738 		JBrowse link
G Rdh14 retinol dehydrogenase 14 enables ISO (PMID:25533474) MGI PMID:25533474 NCBI chrNW_004955469:1,281,391...1,287,334
Ensembl chrNW_004955469:1,281,791...1,286,147 		JBrowse link
aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 enables ISO (PMID:14667815), (PMID:15769935) MGI PMID:14667815 PMID:15769935 NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662 		JBrowse link
G Akr7a2 aldo-keto reductase family 7 member A2 ISO RGD PMID:12071861 RGD:625492 NCBI chrNW_004955452:6,844...13,868 JBrowse link
all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs3 dehydrogenase/reductase 3 enables ISO (PMID:24005908) MGI PMID:24005908 NCBI chrNW_004955486:1,439,179...1,473,476
Ensembl chrNW_004955486:1,439,179...1,474,130 		JBrowse link
G Rdh11 retinol dehydrogenase 11 enables ISO (PMID:12226107), (PMID:12807874) UniProt PMID:12226107 PMID:12807874 NCBI chrNW_004955466:2,506,641...2,521,506
Ensembl chrNW_004955466:2,508,338...2,520,903 		JBrowse link
G Rdh12 retinol dehydrogenase 12 enables ISO (PMID:12226107) UniProt PMID:12226107 NCBI chrNW_004955466:2,473,145...2,485,779
Ensembl chrNW_004955466:2,473,096...2,487,623 		JBrowse link
G Rdh13 retinol dehydrogenase 13 enables ISO (PMID:18039331) UniProt PMID:18039331 NCBI chrNW_004955567:1,091,636...1,108,648
Ensembl chrNW_004955567:1,091,636...1,108,732 		JBrowse link
G Rdh14 retinol dehydrogenase 14 enables ISO (PMID:12435598)
(PMID:12226107)		 UniProt PMID:12226107 PMID:12435598 NCBI chrNW_004955469:1,281,391...1,287,334
Ensembl chrNW_004955469:1,281,791...1,286,147 		JBrowse link
carbonyl reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr1 carbonyl reductase 1 enables ISO (PMID:18449627), (PMID:1921984) UniProt PMID:1921984 PMID:18449627 NCBI chrNW_004955407:35,351,601...35,354,510 JBrowse link
G Cbr3 carbonyl reductase 3 enables ISO (PMID:18493841) RGD
UniProt		 PMID:18493841 PMID:18983987 RGD:2316293 NCBI chrNW_004955407:35,419,674...35,428,270
Ensembl chrNW_004955407:35,419,674...35,428,270 		JBrowse link
G Dhrs1 dehydrogenase/reductase 1 enables ISO (PMID:30031147) UniProt PMID:30031147 NCBI chrNW_004955409:36,002,576...36,040,595
Ensembl chrNW_004955409:36,002,576...36,009,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14366
    catalytic activity 3755
      oxidoreductase activity 477
        oxidoreductase activity, acting on CH-OH group of donors 85
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 77
            alcohol dehydrogenase [NAD(P)+] activity 24
              aldo-keto reductase (NADPH) activity 14
                alcohol dehydrogenase (NADP+) activity + 11
                pyridoxine:NADP 4-dehydrogenase activity 0
paths to the root