ONTOLOGY REPORT - ANNOTATIONS
Term: aldo-keto reductase (NADPH) activity
Accession: GO:0004033
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Definition: Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms: exact_synonym: NADPH-dependent aldo-keto reductase activity; aldo-keto reductase (NADP) activity; aldo-keto reductase activity
narrow_synonym: alcohol dehydrogenase (NADP+) activity
xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-"; reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one"; reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol"; reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one"; reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol"; reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one"; reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one"; reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol"; reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol"; reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol"; reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one"; reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one"; reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol"; reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL"; reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH"; reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione"; reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA"; reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA"; reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3"; reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"
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Akr1b7
aldo-keto reductase family 1, member B7
TAS
RGD
PMID:12193556
RGD:628357
NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
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Akr1c1
aldo-keto reductase family 1, member C1
enables
ISO
(PMID:12562828)
RGD
PMID:12562828
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c15
aldo-keto reductase family 1, member C15
enables
IDA
PMID:17574202
UniProt
PMID:17574202
RGD:13792520
NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061
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Akr1c3
aldo-keto reductase family 1, member C3
enables
IDA ISO
(PMID:9792917)
RGD
PMID:9792917 PMID:8977402
RGD:10053609
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Akr7a2
aldo-keto reductase family 7, member A2
enables
NAS IBA TAS
GO_REF:0000033
GO_Central RGD
PMID:12071861 PMID:12071861
GO_REF:0000033, RGD:625492 , RGD:625492
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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Akr7a3
aldo-keto reductase family 7 member A3
enables
IDA IBA
GO_REF:0000033
GO_Central RGD
PMID:8234296
GO_REF:0000033, RGD:632009
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Kcnab1
potassium voltage-gated channel subfamily A regulatory beta subunit 1
enables
IDA IBA
PMID:18222921 GO_REF:0000033
GO_Central
PMID:18222921
GO_REF:0000033, RGD:10047381
NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534
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Kcnab2
potassium voltage-gated channel subfamily A regulatory beta subunit 2
enables
IDA IBA
PMID:18672894 GO_REF:0000033
GO_Central
PMID:18672894
GO_REF:0000033, RGD:10047329
NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243
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Kcnab3
potassium voltage-gated channel subfamily A regulatory beta subunit 3
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:54,047,830...54,056,401
Ensembl chr10:54,047,825...54,054,174
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Miox
myo-inositol oxygenase
enables
ISS ISO IEA
GO_REF:0000024 (PMID:10944187) GO_REF:0000107
UniProt RGD Ensembl
PMID:10944187
GO_REF:0000024 GO_REF:0000107
NCBI chr 7:120,405,031...120,407,529
Ensembl chr 7:120,405,031...120,407,537
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Akr1a1
aldo-keto reductase family 1 member A1
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
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Akr1b10
aldo-keto reductase family 1 member B10
enables
ISO
(PMID:19013440)
RGD
PMID:19013440
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Aldh3a1
aldehyde dehydrogenase 3 family, member A1
enables
ISO ISS
(PMID:1737758) GO_REF:0000024
RGD UniProt
PMID:1737758
GO_REF:0000024
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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Rdh14
retinol dehydrogenase 14
enables
ISO
(PMID:25533474)
RGD
PMID:25533474
NCBI chr 6:33,156,569...33,161,712
Ensembl chr 6:33,156,569...33,161,712
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
enables
ISO
(PMID:10514444)
RGD
PMID:10514444
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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Akr1a1
aldo-keto reductase family 1 member A1
enables
ISO IBA
(PMID:14667815), (PMID:15769935) GO_REF:0000033
RGD GO_Central
PMID:14667815 PMID:15769935
GO_REF:0000033
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
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Akr1b1
aldo-keto reductase family 1 member B1
enables
IDA IBA ISO
GO_REF:0000033 (PMID:17727625), (PMID:7851421) (PMID:1420136), (PMID:2112546), (PMID:8435445), (PMID:8645003)
GO_Central RGD
PMID:1420136 PMID:2112546 PMID:7851421 PMID:8435445 PMID:8645003 PMID:17727625 PMID:2114645 More...
GO_REF:0000033, RGD:1626085
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10
aldo-keto reductase family 1 member B10
enables
IDA IBA
GO_REF:0000033
GO_Central RGD
PMID:20709016
GO_REF:0000033, RGD:6903952
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr1b7
aldo-keto reductase family 1, member B7
enables
TAS IBA
GO_REF:0000033
GO_Central RGD
PMID:12193556
GO_REF:0000033, RGD:628357
NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
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Akr1b8
aldo-keto reductase family 1, member B8
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097
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Akr1c1
aldo-keto reductase family 1, member C1
enables
ISO IBA
(PMID:21232532) GO_REF:0000033
RGD GO_Central
PMID:21232532
GO_REF:0000033
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c12
aldo-keto reductase family 1, member C12
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:66,045,376...66,061,496
Ensembl chr17:66,045,378...66,108,329
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Akr1c12l1
aldo-keto reductase family 1, member C12-like 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:65,937,834...65,948,344
Ensembl chr17:65,937,814...65,997,595
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Akr1c13
aldo-keto reductase family 1, member C13
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:65,964,186...65,997,598
Ensembl chr17:65,964,975...65,997,591
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Akr1c14
aldo-keto reductase family 1, member C14
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:66,156,286...66,173,277
Ensembl chr17:66,156,288...66,173,277
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Akr1c15
aldo-keto reductase family 1, member C15
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061
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Akr1c19
aldo-keto reductase family 1, member C19
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:66,001,358...66,027,226
Ensembl chr17:66,004,002...66,025,047
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Akr1c2
aldo-keto reductase family 1, member C2
enables
ISO IBA
(PMID:21232532) GO_REF:0000033
RGD GO_Central
PMID:21232532
GO_REF:0000033
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
enables
IDA IBA ISO
GO_REF:0000033 (PMID:21232532)
GO_Central RGD
PMID:21232532 PMID:8977402
GO_REF:0000033, RGD:10053609
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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AKR1C3l1
aldo-keto reductase family 1 member C3-like 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
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Akr1d1
aldo-keto reductase family 1, member D1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
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Akr1e2
aldo-keto reductase family 1, member E2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441
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Akr7a2
aldo-keto reductase family 7, member A2
IDA
RGD
PMID:12071861
RGD:625492
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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Akr1b1
aldo-keto reductase family 1 member B1
enables
IEA
GO_REF:0000003 GO_REF:0000116
UniProt RHEA
GO_REF:0000003 GO_REF:0000116
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10
aldo-keto reductase family 1 member B10
enables
IDA ISO
(PMID:12732097)
RGD
PMID:12732097 PMID:20709016
RGD:6903952
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Dhrs4
dehydrogenase/reductase 4
enables
ISO ISS
(PMID:12604222) GO_REF:0000024
RGD UniProt
PMID:12604222
GO_REF:0000024
NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127
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Dhrs7
dehydrogenase/reductase 7
enables
ISO
(PMID:26466768)
RGD
PMID:26466768
NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
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Rdh10
retinol dehydrogenase 10
enables
IEA
GO_REF:0000116 GO_REF:0000003
RHEA UniProt
GO_REF:0000003 GO_REF:0000116
NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572
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Rdh11
retinol dehydrogenase 11
enables
ISO
(PMID:12226107), (PMID:12807874)
RGD
PMID:12226107 PMID:12807874
NCBI chr 6:97,979,377...97,995,252
Ensembl chr 6:97,979,378...97,995,252
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Rdh12
retinol dehydrogenase 12
enables
ISO
(PMID:12226107)
RGD
PMID:12226107
NCBI chr 6:98,015,465...98,028,388
Ensembl chr 6:98,015,465...98,028,388
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Rdh13
retinol dehydrogenase 13
enables
ISO IBA
(PMID:18039331) GO_REF:0000033
RGD GO_Central
PMID:18039331
GO_REF:0000033
NCBI chr 1:69,373,014...69,401,454
Ensembl chr 1:69,373,113...69,400,908
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Rdh14
retinol dehydrogenase 14
enables
ISO
(PMID:12435598) (PMID:12226107)
RGD
PMID:12226107 PMID:12435598
NCBI chr 6:33,156,569...33,161,712
Ensembl chr 6:33,156,569...33,161,712
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Rdh8
retinol dehydrogenase 8
enables
IEA
GO_REF:0000003
UniProt
GO_REF:0000003
NCBI chr 8:19,353,191...19,360,462
Ensembl chr 8:19,353,191...19,360,462
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Cbr1
carbonyl reductase 1
enables
IDA IBA ISO ISS
GO_REF:0000033 (PMID:18449627), (PMID:1921984) GO_REF:0000024
GO_Central RGD UniProt
PMID:1921984 PMID:18449627 PMID:12396270 PMID:7705364
GO_REF:0000024 GO_REF:0000033, RGD:634703 , RGD:69801
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cbr1l1
carbonyl reductase 1 like 1
enables
IEA IBA
GO_REF:0000104 GO_REF:0000033
UniProt GO_Central
GO_REF:0000033 GO_REF:0000104
NCBI chr11:32,876,563...32,884,234
Ensembl chr11:32,857,991...32,895,275
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Cbr1l2
carbonyl reductase 1 like 2
enables
IBA IEA
GO_REF:0000033 GO_REF:0000104
GO_Central UniProt
GO_REF:0000033 GO_REF:0000104
NCBI chr11:32,892,640...32,895,277
Ensembl chr11:32,857,991...32,895,275
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Cbr1l3
carbonyl reductase 1 like 3
enables
IEA
GO_REF:0000104
UniProt
GO_REF:0000104
NCBI chr11:32,985,136...32,992,000
Ensembl chr11:32,985,707...32,992,000
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Cbr2
carbonyl reductase 2
enables
IBA ISO
GO_REF:0000033 (PMID:7705352)
GO_Central RGD
PMID:7705352
GO_REF:0000033
NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001
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Cbr2l1
carbonyl reductase 2 like 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:106,033,250...106,036,852
Ensembl chr10:106,033,255...106,036,919
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Cbr3
carbonyl reductase 3
enables
IDA IBA ISO
GO_REF:0000033 (PMID:18493841)
GO_Central RGD
PMID:18493841 PMID:18983987
GO_REF:0000033, RGD:2316293
NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
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Dcxr
dicarbonyl and L-xylulose reductase
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:106,006,404...106,008,293
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Dhrs1
dehydrogenase/reductase 1
enables
ISO
(PMID:30031147)
RGD
PMID:30031147
NCBI chr15:29,236,522...29,243,807
Ensembl chr15:29,236,522...29,243,838
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Dhrs2
dehydrogenase/reductase 2
enables
ISO IBA
(PMID:16685466) GO_REF:0000033
RGD GO_Central
PMID:16685466
GO_REF:0000033
NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
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Dhrs2l1
dehydrogenase/reductase member 2 like 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr15:28,635,197...28,638,087
Ensembl chr15:28,635,197...28,638,087
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Dhrs4
dehydrogenase/reductase 4
enables
ISO IBA
(PMID:18571493), (PMID:19056333) GO_REF:0000033 (PMID:23128527)
RGD GO_Central
PMID:18571493 PMID:19056333 PMID:23128527
GO_REF:0000033
NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127
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Dhrs7
dehydrogenase/reductase 7
enables
ISO
(PMID:24246760), (PMID:26466768), (PMID:28457967), (PMID:28687384)
RGD
PMID:24246760 PMID:26466768 PMID:28457967 PMID:28687384
NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
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Kcnab1
potassium voltage-gated channel subfamily A regulatory beta subunit 1
enables
IEA
GO_REF:0000116
RHEA
GO_REF:0000116
NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534
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