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ONTOLOGY REPORT - ANNOTATIONS


Term:aldose reductase (NADPH) activity
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Accession:GO:0004032 term browser browse the term
Definition:Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:exact_synonym: alditol:NADP+ 1-oxidoreductase activity
 related_synonym: aldehyde reductase activity;   aldose reductase activity;   polyol dehydrogenase (NADP(+)) activity
 xref: KEGG_REACTION:R02820;   RHEA:12789;   reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol";   reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"


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aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:26,680,736...26,696,996
Ensembl chrNW_004936474:26,680,676...26,697,214
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B enables ISO (PMID:7851421)
(PMID:17727625)
(PMID:8435445)
(PMID:1420136), (PMID:2112546), (PMID:8645003)
MGI
UniProt
Reactome
RGD
PMID:1420136 PMID:2112546 PMID:2114645 PMID:7851421 PMID:8435445 More... RGD:1626085 NCBI chrNW_004936579:1,312,175...1,328,397 JBrowse link
G LOC101969767 all-trans-retinol dehydrogenase [NAD(+)] ADH4 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936520:3,763,849...3,777,177
Ensembl chrNW_004936520:3,760,755...3,775,873
JBrowse link
G LOC101974041 aflatoxin B1 aldehyde reductase member 2 ISO RGD PMID:12071861 RGD:625492 NCBI chrNW_004936474:5,565,715...5,573,048 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 17124
    catalytic activity 5251
      oxidoreductase activity 692
        oxidoreductase activity, acting on CH-OH group of donors 117
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 109
            alcohol dehydrogenase [NAD(P)+] activity 36
              aldo-keto reductase (NADPH) activity 22
                alcohol dehydrogenase (NADP+) activity 18
                  aldose reductase (NADPH) activity 4
                    D-xylose reductase (NADPH) activity 0
                    L-arabinose reductase (NADPH) activity 0
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