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ONTOLOGY REPORT - ANNOTATIONS
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Term:
aldose reductase (NADPH) activity
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Accession:
GO:0004032
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Definition:
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:
exact_synonym:
alditol:NADP+ 1-oxidoreductase activity
related_synonym:
aldehyde reductase activity; aldose reductase activity; polyol dehydrogenase (NADP(+)) activity
xref:
KEGG_REACTION:R02820; RHEA:12789; reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol"; reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"
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Genes (4)
aldose reductase (NADPH) activity
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Akr1a1
aldo-keto reductase family 1 member A1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936474:26,680,736...26,696,996
Ensembl chrNW_004936474:26,680,676...26,697,214
G
Akr1b1
aldo-keto reductase family 1 member B
enables
ISO
(PMID:7851421)
(PMID:17727625)
(PMID:8435445)
(PMID:1420136), (PMID:2112546), (PMID:8645003)
MGI
UniProt
Reactome
RGD
PMID:1420136
PMID:2112546
PMID:2114645
PMID:7851421
PMID:8435445
PMID:8645003
PMID:17727625
More...
RGD:1626085
NCBI chrNW_004936579:1,312,175...1,328,397
G
LOC101969767
all-trans-retinol dehydrogenase [NAD(+)] ADH4
enables
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936520:3,763,849...3,777,177
Ensembl chrNW_004936520:3,760,755...3,775,873
G
LOC101974041
aflatoxin B1 aldehyde reductase member 2
ISO
RGD
PMID:12071861
RGD:625492
NCBI chrNW_004936474:5,565,715...5,573,048
Term paths to the root
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Path 1
Term
Annotations
molecular_function
17124
catalytic activity
5251
oxidoreductase activity
692
oxidoreductase activity, acting on CH-OH group of donors
117
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
109
alcohol dehydrogenase [NAD(P)+] activity
36
aldo-keto reductase (NADPH) activity
22
alcohol dehydrogenase (NADP+) activity
18
aldose reductase (NADPH) activity
4
D-xylose reductase (NADPH) activity
0
L-arabinose reductase (NADPH) activity
0